Dr Nathan Woodling

  • Lecturer (Molecular Biosciences)

telephone: 0141 330 8299
email: Nathan.Woodling@glasgow.ac.uk
pronouns: He/him/his

Davidson Building 241, University of Glasgow, Glasgow, G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-0298-3800

Biography

Nathan completed his PhD in 2013 at Stanford University, where he studied the way that inflammatory signalling pathways in microglia contributed to the types of neurotoxicity seen in Alzheimer’s disease. He then moved to the UCL Institute of Healthy Ageing for his postdoctoral work, which investigated how both glial and neuronal cells can modulate ageing of the nervous system through different signalling pathways. In 2019, he was awarded an Alzheimer’s Society Junior Fellowship, which allowed him to investigate how age-related changes in glia may predispose the nervous system to the types of damage that occur in Alzheimer’s disease. In 2022, Nathan moved to Glasgow to start his own research group where he continues to study the connections among ageing, neuron/glia interactions, and the age-related susceptibility to neurodegenerative diseases.

Research interests

Age is by far the greatest risk factor for neurodegenerative diseases such as Alzheimer’s disease, yet surprisingly little is understood about the specific age-related changes in the brain that cause susceptibility to disease. Some initial hints have emerged from the field of biogerontology, where research using short-lived animals such as nematode worms and fruit flies has identified signalling pathways whose inhibition or activation can remarkably extend healthy lifespan and preserve behavioural function at older ages. Importantly, many of these pathways are highly evolutionarily conserved, as are their effects on longevity in animals ranging from invertebrates to mammals, and perhaps humans. My work to date has primarily used the fruit fly Drosophila to show that manipulating several of these signalling pathways solely in neurons or glia (the non-neuronal cells of the nervous system) is sufficient to extend healthy lifespan and protect against the types of toxicity that occur in Alzheimer’s disease.

My current work continues to use the power of Drosophila genetics to manipulate age-associated genes and signalling pathways in neurons and glia to see which have the capacity to preserve healthy function with age and protect the nervous system from disease-associated toxicity. In addition, I am interested in whether the same genes and pathways act outside of the nervous system to modulate the ageing of other organ systems. The ultimate goal of my research is to identify novel age-related genes and proteins for which new or repurposed pharmaceutical approaches could prevent or delay the onset of disease.

Research groups

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2018 | 2017 | 2016 | 2015
Number of items: 20.

2023

Catterson, J. H. et al. (2023) Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Neurobiology of Aging, 132, pp. 154-174. (doi: 10.1016/j.neurobiolaging.2023.09.008) (PMID:37837732)

Sahota, V. K., Stone, A., Woodling, N. S. , Spiers, J. G., Steinert, J. R., Partridge, L. and Augustin, H. (2023) Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Open Biology, 13(9), 230171. (doi: 10.1098/rsob.230171) (PMID:37699519) (PMCID:PMC10497343)

Fullerton, J. , Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N. and Kerr, F. (2023) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. Health Open Research, 4, 22. (doi: 10.12688/amrcopenres.13091.2) (PMID:37323472) (PMCID:PMC7614661)

2022

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N. and Kerr, F. (2022) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. AMRC Open Research, 4, 22. (doi: 10.12688/amrcopenres.13091.1)

2021

Bolukbasi, E. et al. (2021) Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences of the United States of America, 118(8), e201149111. (doi: 10.1073/pnas.2011491118) (PMID:33593901) (PMCID:PMC7923679)

Anoar, S., Woodling, N. S. and Niccoli, T. (2021) Mitochondria dysfunction in frontotemporal dementia/amyotrophic lateral sclerosis: lessons from drosophila models. Frontiers in Neuroscience, 15, 786076. (doi: 10.3389/fnins.2021.786076) (PMID:34899176) (PMCID:PMC8652125)

2020

Bjedov, I. et al. (2020) Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in drosophila. PLoS Genetics, 16(11), e1009083. (doi: 10.1371/journal.pgen.1009083) (PMID:33253201) (PMCID:PMC7738165)

Woodling, N. S. , Rajasingam, A., Minkley, L. J., Rizzo, A. and Partridge, L. (2020) Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biology, 18(1), 124. (doi: 10.1186/s12915-020-00854-9) (PMID:32928209) (PMCID:PMC7490873)

Yu, Y., Niccoli, T., Ren, Z., Woodling, N. S. , Aleyakpo, B., Szabadkai, G. and Partridge, L. (2020) PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity. Human Molecular Genetics, 29(14), pp. 2420-2434. (doi: 10.1093/hmg/ddaa125) (PMID:32592479) (PMCID:PMC7424762)

Woodling, N. S. et al. (2020) The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell, 19(5), e13137. (doi: 10.1111/acel.13137) (PMID:32291952) (PMCID:PMC7253064)

Gray, S. C., Kinghorn, K. J. and Woodling, N. S. (2020) Shifting equilibriums in Alzheimer's disease: The complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural Regeneration Research, 15(7), pp. 1208-1219. (doi: 10.4103/1673-5374.272571) (PMID:31960800) (PMCID:PMC7047786)

2018

Woodling, N.S. and Partridge, L. (2018) Parkinson's disease: mitochondria parked at the ER hit the snooze button. Neuron, 98(6), pp. 1059-1061. (doi: 10.1016/j.neuron.2018.06.025) (PMID:29953866)

Simone, R. et al. (2018) G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Molecular Medicine, 10(1), pp. 22-31. (doi: 10.15252/emmm.201707850) (PMID:29113975) (PMCID:PMC5760849)

2017

Tesseur, I., Nguyen, A., Chang, B., Li, L., Woodling, N.S. , Wyss-Coray, T. and Luo, J. (2017) Deficiency in neuronal TGF-β signaling leads to nigrostriatal degeneration and activation of TGF-β signaling protects against MPTP neurotoxicity in mice. Journal of Neuroscience, 37(17), pp. 4584-4592. (doi: 10.1523/JNEUROSCI.2952-16.2017) (PMID:28363982) (PMCID:PMC5413189)

Mizielinska, S., Ridler, C.E., Balendra, R., Thoeng, A., Woodling, N.S. , Grässer, F.A., Plagnol, V., Lashley, T., Partridge, L. and Isaacs, A.M. (2017) Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathologica Communications, 5(1), 29. (doi: 10.1186/s40478-017-0432-x) (PMID:28420437) (PMCID:PMC5395972)

2016

Kinghorn, K.J. et al. (2016) A Drosophila model of neuronopathic gaucher disease demonstrates lysosomal-autophagic defects and altered mTOR signalling and is functionally rescued by rapamycin. Journal of Neuroscience, 36(46), pp. 11654-11670. (doi: 10.1523/JNEUROSCI.4527-15.2016) (PMID:27852774) (PMCID:PMC5125225)

Woodling, N.S. et al. (2016) Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. Brain, 139(7), pp. 2063-2081. (doi: 10.1093/brain/aww117) (PMID:27190010) (PMCID:PMC4939702)

Woodling, N.S. and Andreasson, K.I. (2016) Untangling the web: toxic and protective effects of neuroinflammation and PGE2 signaling in Alzheimer's disease. ACS Chemical Neuroscience, 7(4), pp. 454-463. (doi: 10.1021/acschemneuro.6b00016) (PMID:26979823) (PMCID:PMC5239037)

2015

Johansson, J.U., Woodling, N.S. , Shi, J. and Andreasson, K.I. (2015) Inflammatory cyclooxygenase activity and PGE2 signaling in models of alzheimer’s disease. Current Immunology Reviews, 11(2), pp. 125-131. (doi: 10.2174/1573395511666150707181414) (PMID:28413375) (PMCID:PMC5384338)

Johansson, J.U., Woodling, N.S. , Brown, H.D., Wang, Q. and Andreasson, K.I. (2015) Microarray analysis of the in vivo response of microglia to Aβ peptides in mice with conditional deletion of the prostaglandin EP2 receptor. Genomics Data, 5, pp. 268-271. (doi: 10.1016/j.gdata.2015.06.011) (PMID:26251825) (PMCID:PMC4522932)

This list was generated on Mon Apr 22 04:49:52 2024 BST.
Jump to: Articles
Number of items: 20.

Articles

Catterson, J. H. et al. (2023) Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Neurobiology of Aging, 132, pp. 154-174. (doi: 10.1016/j.neurobiolaging.2023.09.008) (PMID:37837732)

Sahota, V. K., Stone, A., Woodling, N. S. , Spiers, J. G., Steinert, J. R., Partridge, L. and Augustin, H. (2023) Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Open Biology, 13(9), 230171. (doi: 10.1098/rsob.230171) (PMID:37699519) (PMCID:PMC10497343)

Fullerton, J. , Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N. and Kerr, F. (2023) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. Health Open Research, 4, 22. (doi: 10.12688/amrcopenres.13091.2) (PMID:37323472) (PMCID:PMC7614661)

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N. and Kerr, F. (2022) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. AMRC Open Research, 4, 22. (doi: 10.12688/amrcopenres.13091.1)

Bolukbasi, E. et al. (2021) Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences of the United States of America, 118(8), e201149111. (doi: 10.1073/pnas.2011491118) (PMID:33593901) (PMCID:PMC7923679)

Anoar, S., Woodling, N. S. and Niccoli, T. (2021) Mitochondria dysfunction in frontotemporal dementia/amyotrophic lateral sclerosis: lessons from drosophila models. Frontiers in Neuroscience, 15, 786076. (doi: 10.3389/fnins.2021.786076) (PMID:34899176) (PMCID:PMC8652125)

Bjedov, I. et al. (2020) Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in drosophila. PLoS Genetics, 16(11), e1009083. (doi: 10.1371/journal.pgen.1009083) (PMID:33253201) (PMCID:PMC7738165)

Woodling, N. S. , Rajasingam, A., Minkley, L. J., Rizzo, A. and Partridge, L. (2020) Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biology, 18(1), 124. (doi: 10.1186/s12915-020-00854-9) (PMID:32928209) (PMCID:PMC7490873)

Yu, Y., Niccoli, T., Ren, Z., Woodling, N. S. , Aleyakpo, B., Szabadkai, G. and Partridge, L. (2020) PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity. Human Molecular Genetics, 29(14), pp. 2420-2434. (doi: 10.1093/hmg/ddaa125) (PMID:32592479) (PMCID:PMC7424762)

Woodling, N. S. et al. (2020) The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell, 19(5), e13137. (doi: 10.1111/acel.13137) (PMID:32291952) (PMCID:PMC7253064)

Gray, S. C., Kinghorn, K. J. and Woodling, N. S. (2020) Shifting equilibriums in Alzheimer's disease: The complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural Regeneration Research, 15(7), pp. 1208-1219. (doi: 10.4103/1673-5374.272571) (PMID:31960800) (PMCID:PMC7047786)

Woodling, N.S. and Partridge, L. (2018) Parkinson's disease: mitochondria parked at the ER hit the snooze button. Neuron, 98(6), pp. 1059-1061. (doi: 10.1016/j.neuron.2018.06.025) (PMID:29953866)

Simone, R. et al. (2018) G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Molecular Medicine, 10(1), pp. 22-31. (doi: 10.15252/emmm.201707850) (PMID:29113975) (PMCID:PMC5760849)

Tesseur, I., Nguyen, A., Chang, B., Li, L., Woodling, N.S. , Wyss-Coray, T. and Luo, J. (2017) Deficiency in neuronal TGF-β signaling leads to nigrostriatal degeneration and activation of TGF-β signaling protects against MPTP neurotoxicity in mice. Journal of Neuroscience, 37(17), pp. 4584-4592. (doi: 10.1523/JNEUROSCI.2952-16.2017) (PMID:28363982) (PMCID:PMC5413189)

Mizielinska, S., Ridler, C.E., Balendra, R., Thoeng, A., Woodling, N.S. , Grässer, F.A., Plagnol, V., Lashley, T., Partridge, L. and Isaacs, A.M. (2017) Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathologica Communications, 5(1), 29. (doi: 10.1186/s40478-017-0432-x) (PMID:28420437) (PMCID:PMC5395972)

Kinghorn, K.J. et al. (2016) A Drosophila model of neuronopathic gaucher disease demonstrates lysosomal-autophagic defects and altered mTOR signalling and is functionally rescued by rapamycin. Journal of Neuroscience, 36(46), pp. 11654-11670. (doi: 10.1523/JNEUROSCI.4527-15.2016) (PMID:27852774) (PMCID:PMC5125225)

Woodling, N.S. et al. (2016) Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. Brain, 139(7), pp. 2063-2081. (doi: 10.1093/brain/aww117) (PMID:27190010) (PMCID:PMC4939702)

Woodling, N.S. and Andreasson, K.I. (2016) Untangling the web: toxic and protective effects of neuroinflammation and PGE2 signaling in Alzheimer's disease. ACS Chemical Neuroscience, 7(4), pp. 454-463. (doi: 10.1021/acschemneuro.6b00016) (PMID:26979823) (PMCID:PMC5239037)

Johansson, J.U., Woodling, N.S. , Shi, J. and Andreasson, K.I. (2015) Inflammatory cyclooxygenase activity and PGE2 signaling in models of alzheimer’s disease. Current Immunology Reviews, 11(2), pp. 125-131. (doi: 10.2174/1573395511666150707181414) (PMID:28413375) (PMCID:PMC5384338)

Johansson, J.U., Woodling, N.S. , Brown, H.D., Wang, Q. and Andreasson, K.I. (2015) Microarray analysis of the in vivo response of microglia to Aβ peptides in mice with conditional deletion of the prostaglandin EP2 receptor. Genomics Data, 5, pp. 268-271. (doi: 10.1016/j.gdata.2015.06.011) (PMID:26251825) (PMCID:PMC4522932)

This list was generated on Mon Apr 22 04:49:52 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Is sleep a more sex-inclusive measure than lifespan for addressing the biology of ageing?
    The Royal Society
    2023 - 2024