Dr Martin Rennie

  • Research Associate (Molecular Biosciences)

Biography

Martin completed his PhD at the University of Auckland, New Zealand, in the lab of Dr Richard Kingston. He then moved to the University of Galway, Ireland, where he did a postdoc with Prof Peter Crowley. He is currently doing a postdoc with Prof Helen Walden at the University of Glasgow in the School of Molecular Biosciences.

Research interests

Martin uses cryo-electron microscopy, biophysics, and biochemistry to understand the molecular function of proteins. He is particularly interested in proteins involved in DNA repair.

  • DNA Repair
  • Protein-Protein Interactions
  • Structural Biology
  • Multi-Body/Linkage Thermodynamics

Research groups

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020
Number of items: 9.

2025

Rennie, Martin Luke ORCID logoORCID: https://orcid.org/0000-0002-0799-3450 and Oliver, Michael R. ORCID logoORCID: https://orcid.org/0000-0002-1838-8416 (2025) Emerging frontiers in protein structure prediction following the AlphaFold revolution. Journal of the Royal Society: Interface, 22(225), 20240886. (doi: 10.1098/rsif.2024.0886) (PMID:40233800) (PMCID:PMC11999738)

2024

Rennie, Martin Luke ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Gundogdu, Mehmet, Arkinson, Connor, Liness, Steven, Frame, Sheelagh and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2024) Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01184) (PMID:39190802) (Early Online Publication)

2023

Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)

2022

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8(39), eabq6353. (doi: 10.1126/sciadv.abq6353) (PMID:36170365) (PMCID:PMC9519042)

Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Arkinson, Connor, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289(16), pp. 4811-4829. (doi: 10.1111/febs.16077) (PMID:34137174)

2021

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Toth, Rachel and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2021) Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nature Structural and Molecular Biology, 28(4), pp. 356-364. (doi: 10.1038/s41594-021-00576-8) (PMID:33795880)

2020

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Spagnolo, Laura ORCID logoORCID: https://orcid.org/0000-0002-0794-566X and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Modes of allosteric regulation of the ubiquitination machinery. Current Opinion in Structural Biology, 62, pp. 189-196. (doi: 10.1016/j.sbi.2020.02.003) (PMID:32305021)

Chaugule, Viduth K., Arkinson, Connor, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Kämäräinen, Outi, Toth, Rachel and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Allosteric mechanism for site-specific ubiquitination of FANCD2. Nature Chemical Biology, 16, pp. 291-301. (doi: 10.1038/s41589-019-0426-z) (PMID:31873223)

This list was generated on Tue Jun 17 02:38:25 2025 BST.
Jump to: Articles
Number of items: 9.

Articles

Rennie, Martin Luke ORCID logoORCID: https://orcid.org/0000-0002-0799-3450 and Oliver, Michael R. ORCID logoORCID: https://orcid.org/0000-0002-1838-8416 (2025) Emerging frontiers in protein structure prediction following the AlphaFold revolution. Journal of the Royal Society: Interface, 22(225), 20240886. (doi: 10.1098/rsif.2024.0886) (PMID:40233800) (PMCID:PMC11999738)

Rennie, Martin Luke ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Gundogdu, Mehmet, Arkinson, Connor, Liness, Steven, Frame, Sheelagh and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2024) Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01184) (PMID:39190802) (Early Online Publication)

Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8(39), eabq6353. (doi: 10.1126/sciadv.abq6353) (PMID:36170365) (PMCID:PMC9519042)

Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Arkinson, Connor, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289(16), pp. 4811-4829. (doi: 10.1111/febs.16077) (PMID:34137174)

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Toth, Rachel and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2021) Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nature Structural and Molecular Biology, 28(4), pp. 356-364. (doi: 10.1038/s41594-021-00576-8) (PMID:33795880)

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Lemonidis, Kimon ORCID logoORCID: https://orcid.org/0000-0003-1332-6002, Arkinson, Connor, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Spagnolo, Laura ORCID logoORCID: https://orcid.org/0000-0002-0794-566X and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)

Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Chaugule, Viduth K. ORCID logoORCID: https://orcid.org/0000-0001-7814-5865 and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Modes of allosteric regulation of the ubiquitination machinery. Current Opinion in Structural Biology, 62, pp. 189-196. (doi: 10.1016/j.sbi.2020.02.003) (PMID:32305021)

Chaugule, Viduth K., Arkinson, Connor, Rennie, Martin L. ORCID logoORCID: https://orcid.org/0000-0002-0799-3450, Kämäräinen, Outi, Toth, Rachel and Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810 (2020) Allosteric mechanism for site-specific ubiquitination of FANCD2. Nature Chemical Biology, 16, pp. 291-301. (doi: 10.1038/s41589-019-0426-z) (PMID:31873223)

This list was generated on Tue Jun 17 02:38:25 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Structural basis of Hsp90-CHIP association
    Wellcome Trust
    2021 - 2022
     

Selfie of Martin Rennie

Dr Martin Rennie on Twitter