Dr Michael Ormsby

  • Honorary Research Fellow (School of Infection & Immunity)

Biography

I completed my BSc (Hons) in Biological Sciences at Heriot-Watt University in 2011 before commencing a BBSRC industrial CASE PhD studentship at the University of Glasgow, later that year.

My PhD research was carried out in Dr Robert Davies' laboratory.  The primary focus of this research was to use comparative phenotypic, proteomic and genomic approaches to characterise the fish pathogen, Yersinia ruckeri, in support of improved vaccine development. Following this, I moved to the laboratory of Dr Donal Wall, also at the University of Glasgow, where I worked as a Postdoctoral Research Associate. This BBSRC-funded post involved examining the effect of the short chain fatty acid (SCFA) preservative propionic acid, on Adherent-invasive E. coli (AIEC) - a pathogen associated with Crohn’s disease. Adopting a multidisciplinary approach, we aimed to uncover any selective advantages that this common food additive may provide AIEC.

In 2020, I began working with Dr. Gill Douce. This Wellcome trust funded collaborative project (in conjunction with Dr. Robert Fagan [University of Sheffield] and Dr. Paula Salgado [Newcastle University]) involves examining the role of the S-layer in Clostridium difficile pathogenesis.

Research interests

My research has always focused on host-pathogen interaction. I am particularly interested in examining population biology and molecular evolution of bacterial pathogens to understand how these pathogens adapt to, and cause disease in, particular host species. Additionally, I am interested in understanding the effect of environmental stressors on the pathogenicity of an organism.  Ultimately, I want to learn how microbes interact with the host, with the view being to develop intervention strategies for the treatment or prevention of different diseases.

Publications

List by: Type | Date

Jump to: 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016
Number of items: 15.

2023

Li, X., Ormsby, M. J., Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Ormsby, M. J. et al. (2023) An intact S-layer is advantageous to Clostridioides difficile within the host. PLoS Pathogens, 19(6), e1011015. (doi: 10.1371/journal.ppat.1011015) (PMID:37384772) (PMCID:PMC10310040)

2021

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Ormsby, M. J. and Davies, R. L. (2021) Diversification of OmpA and OmpF of Yersinia ruckeri is independent of the underlying species phylogeny and evidence of virulence-related selection. Scientific Reports, 11, 3493. (doi: 10.1038/s41598-021-82925-7) (PMID:33568758) (PMCID:PMC7876001)

2020

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J., Grahame, E., Burchmore, R. and Davies, R. L. (2019) Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri. Journal of Proteomics, 199, pp. 135-147. (doi: 10.1016/j.jprot.2019.02.014) (PMID:30831250) (PMCID:PMC6447952)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

2018

Gulla, S. et al. (2018) Multilocus variable-number tandem-repeat analysis of Yersinia ruckeri confirms the existence of host specificity, geographic endemism, and anthropogenic dissemination of virulent clones. Applied and Environmental Microbiology, 84(16), e00730-18. (doi: 10.1128/AEM.00730-18) (PMID:29884756) (PMCID:PMC6070765)

2017

McIntosh, A., Meikle, L. M., Ormsby, M. J., McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

Ormsby, M. and Davies, R. (2017) Yersinia ruckeri. In: Woo, P. T. K. and Cipriano, R. C. (eds.) Fish Viruses and Bacteria: Pathobiology and Protection. CABI, p. 339. ISBN 9781780647784 (doi: 10.1079/9781780647784.0339)

2016

Ormsby, M. J., Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Ormsby, M. J., Caws, T., Burchmore, R. , Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi: 10.1128/aem.01173-16) (PMID:27451448) (PMCID:PMC5038039)

This list was generated on Fri Apr 19 02:14:28 2024 BST.
Jump to: Articles | Book Sections
Number of items: 15.

Articles

Li, X., Ormsby, M. J., Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Ormsby, M. J. et al. (2023) An intact S-layer is advantageous to Clostridioides difficile within the host. PLoS Pathogens, 19(6), e1011015. (doi: 10.1371/journal.ppat.1011015) (PMID:37384772) (PMCID:PMC10310040)

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Ormsby, M. J. and Davies, R. L. (2021) Diversification of OmpA and OmpF of Yersinia ruckeri is independent of the underlying species phylogeny and evidence of virulence-related selection. Scientific Reports, 11, 3493. (doi: 10.1038/s41598-021-82925-7) (PMID:33568758) (PMCID:PMC7876001)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J., Grahame, E., Burchmore, R. and Davies, R. L. (2019) Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri. Journal of Proteomics, 199, pp. 135-147. (doi: 10.1016/j.jprot.2019.02.014) (PMID:30831250) (PMCID:PMC6447952)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

Gulla, S. et al. (2018) Multilocus variable-number tandem-repeat analysis of Yersinia ruckeri confirms the existence of host specificity, geographic endemism, and anthropogenic dissemination of virulent clones. Applied and Environmental Microbiology, 84(16), e00730-18. (doi: 10.1128/AEM.00730-18) (PMID:29884756) (PMCID:PMC6070765)

McIntosh, A., Meikle, L. M., Ormsby, M. J., McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

Ormsby, M. J., Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Ormsby, M. J., Caws, T., Burchmore, R. , Wallis, T., Verner-Jeffreys, D. W. and Davies, R. L. (2016) Yersinia ruckeri isolates recovered from diseased Atlantic Salmon (Salmo salar) in Scotland are more diverse than those from Rainbow Trout (Oncorhynchus mykiss) and represent distinct subpopulations. Applied and Environmental Microbiology, 82(19), pp. 5785-5794. (doi: 10.1128/aem.01173-16) (PMID:27451448) (PMCID:PMC5038039)

Book Sections

Ormsby, M. and Davies, R. (2017) Yersinia ruckeri. In: Woo, P. T. K. and Cipriano, R. C. (eds.) Fish Viruses and Bacteria: Pathobiology and Protection. CABI, p. 339. ISBN 9781780647784 (doi: 10.1079/9781780647784.0339)

This list was generated on Fri Apr 19 02:14:28 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Elucidating the role of bacterial microcompartments in the pathogenesis of Crohns disease associated adherent-invasive Escherichia coli
    Tenovus Scotland
    2018 - 2019