Dr Madeleine Cunningham

  • Research Associate (Immunology & Infection)

telephone: 0141 330 8388
email: Madeleine.Cunningham@glasgow.ac.uk

Room B333 Sir Graeme Davies Building, 120 University Place, G12 8TA

ORCID iDhttps://orcid.org/0000-0002-7545-6868

Biography

I graduated from the University of Glasgow in 2010 with a First Class BSc (Hons) in Pharmacology. Following on from this I began an MRC-funded 1+3 programme, providing me with a MRes in Integrative mammalian biology and a PhD in the lab of Professor Hugh Willison, in which I studied the autoimmune neuropathy Guillain-Barré syndrome.

I continue to work on this rare condition in my postdoctoral career, where we aim to characterise the pathological mechanisms driving nerve damage.

Research interests

I have a particular interest in fluorescent, confocal and two-photon microscopy to visualise changes in the nervous system in response to autoimmune injury.

Publications

List by: Type | Date

Jump to: 2022 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2013
Number of items: 9.

2022

Cunningham, M. E. , McGonigal, R., Barrie, J. A., Yao, D. and Willison, H. J. (2022) Real time imaging of intra-axonal calcium flux in an explant mouse model of axonal Guillain-Barré syndrome. Experimental Neurology, 355, 114127. (doi: 10.1016/j.expneurol.2022.114127) (PMID:35640716)

2020

Cunningham, M. E. , Meehan, G. R. , Robinson, S., Yao, D., McGonigal, R. and Willison, H. J. (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

2019

McGonigal, R., Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)

2018

Meehan, G. R. , McGonigal, R., Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

2017

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

2016

Cunningham, M. , McGonigal, R., Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

McGonigal, R., Cunningham, M. E. , Yao, D., Barrie, J. A., Sankaranarayanan, S., Fewou, S. N., Furukawa, K., Yednock, T. A. and Willison, H. J. (2016) C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. Acta Neuropathologica Communications, 4, 23. (doi: 10.1186/s40478-016-0291-x) (PMID:26936605) (PMCID:PMC4776408)

2014

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

2013

Rupp, A., Cunningham, M. E. , Yao, D., Furukawa, K. and Willison, H. J. (2013) The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. Synapse, 67(7), pp. 382-389. (doi: 10.1002/syn.21648) (PMID:23401234) (PMCID:PMC4495252)

This list was generated on Tue Aug 9 21:53:31 2022 BST.
Jump to: Articles
Number of items: 9.

Articles

Cunningham, M. E. , McGonigal, R., Barrie, J. A., Yao, D. and Willison, H. J. (2022) Real time imaging of intra-axonal calcium flux in an explant mouse model of axonal Guillain-Barré syndrome. Experimental Neurology, 355, 114127. (doi: 10.1016/j.expneurol.2022.114127) (PMID:35640716)

Cunningham, M. E. , Meehan, G. R. , Robinson, S., Yao, D., McGonigal, R. and Willison, H. J. (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

McGonigal, R., Barrie, J.A., Yao, D., McLaughlin, M. , Cunningham, M.E. , Rowan, E.G. and Willison, H.J. (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity. Journal of Neuroscience, 39(1), pp. 63-77. (doi: 10.1523/JNEUROSCI.2095-18.2018) (PMID:30446529) (PMCID:PMC6325269)

Meehan, G. R. , McGonigal, R., Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Cunningham, M. , McGonigal, R., Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

McGonigal, R., Cunningham, M. E. , Yao, D., Barrie, J. A., Sankaranarayanan, S., Fewou, S. N., Furukawa, K., Yednock, T. A. and Willison, H. J. (2016) C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. Acta Neuropathologica Communications, 4, 23. (doi: 10.1186/s40478-016-0291-x) (PMID:26936605) (PMCID:PMC4776408)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

Rupp, A., Cunningham, M. E. , Yao, D., Furukawa, K. and Willison, H. J. (2013) The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. Synapse, 67(7), pp. 382-389. (doi: 10.1002/syn.21648) (PMID:23401234) (PMCID:PMC4495252)

This list was generated on Tue Aug 9 21:53:31 2022 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Developing a new mouse model to investigate the autoimmune paralytic nervous system disease Guillain-Barr syndrome
    The Carnegie Trust for the Universities of Scotland
    2019 - 2020
     

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