Dr Lauren Carruthers

  • Research Assistant (Parasitology)

telephone: 0141 330 8371
email: Lauren.Carruthers@glasgow.ac.uk

Biomedical Research Centre, Sir Graeme Davies Building

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-4346-2283

Biography

Research Experience

I graduated with a BSc (Hons) in Parasitology before undertaking two short-term research technician positions on diminazene resistance in Trypanosoma congolense parasites and the role of lipids in trypanosome cytokinesis. I then undertook a PhD exploring interactions between Schistosoma mansoni infection, gut bacteria and anti-helminthic treatment. I compared the bacterial composition of stool from individuals from a rural Ugandan community, with high and low schistosome infection intensities and explored how these bacterial structures change post-treatment with combined praziquantel and albendazole treatment. During my PhD, I also received funding to undertake an internship at the Texas Biomedical Research Centre, where I learnt about schistosome maintenance in the lab and explored the microbiota of Biomphalaria snails. I am currently characterising the role of a new family of zinc finger proteins in Plasmodium parasites in the laboratory of Dr Katarzyna Modrzynska.

Public Engagement

I am passionate about public engagement and have volunteered at a variety of events, created activites, and written blogs. I have created a booklet of science cross stitch patterns and run the 'Parasites in Stitches,' (@ParasiteXStitch) twitter and instagram accounts. I was awarded the International Society for Neglected Tropical Diseases Art award in 2019 and an MVLS engagement grant to develop activities in February 2023.

Research interests

My current research focuses on characterising the role of a new family of zinc finger proteins in Plasmodium parasites in the laboratory of Dr Katarzyna Modrzynska. I have also received an ECR Futurescope grant from the Wellcome Centre for Integrative Parasitology to explore the RNA interactome in the Plasmodium berghei ookinete.

Publications

List by: Type | Date

Jump to: 2022 | 2021 | 2019 | 2018
Number of items: 5.

2022

Clark, J. et al. (2022) Reconciling egg- and antigen-based estimates of Schistosoma mansoni clearance and reinfection: a modelling study. Clinical Infectious Diseases, 74(9), pp. 1557-1563. (doi: 10.1093/cid/ciab679) (PMID:34358299)

Clark, J. et al. (2022) Translating from egg-to antigen-based indicators for Schistosoma mansoni elimination targets: a Bayesian latent class analysis study. Frontiers in Tropical Diseases, 3, 825721. (doi: 10.3389/fitd.2022.825721) (PMID:35784267) (PMCID:PMC7612949)

2021

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

2019

Carruthers, L. V. , Moses, A., Adriko, M., Faust, C. L. , Tukahebwa, E. M., Hall, L. J., Ranford-Cartwright, L. C. and Lamberton, P. H.L. (2019) The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity. PeerJ, 7, e8133. (doi: 10.7717/peerj.8133) (PMID:31824766) (PMCID:PMC6894433)

2018

Adriko, M., Faust, C. L. , Carruthers, L. V. , Moses, A., Tukahebwa, E. M. and Lamberton, P. H.L. (2018) Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance. Tropical Medicine and Infectious Disease, 3(4), 111. (doi: 10.3390/tropicalmed3040111) (PMID:30297642) (PMCID:PMC6306755)

This list was generated on Thu Jul 18 06:48:35 2024 BST.
Jump to: Articles
Number of items: 5.

Articles

Clark, J. et al. (2022) Reconciling egg- and antigen-based estimates of Schistosoma mansoni clearance and reinfection: a modelling study. Clinical Infectious Diseases, 74(9), pp. 1557-1563. (doi: 10.1093/cid/ciab679) (PMID:34358299)

Clark, J. et al. (2022) Translating from egg-to antigen-based indicators for Schistosoma mansoni elimination targets: a Bayesian latent class analysis study. Frontiers in Tropical Diseases, 3, 825721. (doi: 10.3389/fitd.2022.825721) (PMID:35784267) (PMCID:PMC7612949)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Carruthers, L. V. , Moses, A., Adriko, M., Faust, C. L. , Tukahebwa, E. M., Hall, L. J., Ranford-Cartwright, L. C. and Lamberton, P. H.L. (2019) The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity. PeerJ, 7, e8133. (doi: 10.7717/peerj.8133) (PMID:31824766) (PMCID:PMC6894433)

Adriko, M., Faust, C. L. , Carruthers, L. V. , Moses, A., Tukahebwa, E. M. and Lamberton, P. H.L. (2018) Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance. Tropical Medicine and Infectious Disease, 3(4), 111. (doi: 10.3390/tropicalmed3040111) (PMID:30297642) (PMCID:PMC6306755)

This list was generated on Thu Jul 18 06:48:35 2024 BST.

Supervision

I have supervised the following Masters projects in the laboratory of Dr Katarzyna Modrzynska:

  • Exploring expression of a Plasmodium berghei 3xCCCH Zinc Finger Protein throughout the parasite life cycle (May - August 2022).
  • Expression analysis of an RNA-binding protein through the malaria parasite life cycle (May - August 2022).