Dr Manal Natto
- Honorary Research Fellow (School of Infection & Immunity)
email:
Manal.Natto@glasgow.ac.uk
Iii, Room B5/13, Level 5, GBRC Sir Graeme Davies Building, Glasgow, G12 8TA
Publications
2023
Ungogo, M. A. et al. (2023) Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against Animal African Trypanosomiasis. International Journal of Molecular Sciences, 24(4), 3144. (doi: 10.3390/ijms24043144) (PMID:36834557) (PMCID:PMC9960827)
2022
Aldfer, M. M., AlSiari, T. A., Elati, H. A.A. , Natto, M. J., Alfayez, I. A., Campagnaro, G. D., Sani, B., Burchmore, R. J. S. , Diallinas, G. and De Koning, H. (2022) Nucleoside transport and nucleobase uptake null mutants in Leishmania mexicana for the routine expression and characterization of purine and pyrimidine transporters. International Journal of Molecular Sciences, 23(15), 8139. (doi: 10.3390/ijms23158139) (PMID:35897714) (PMCID:PMC9331716)
Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)
Ungogo, M. A., Campagnaro, G. D., Alghamdi, A. H., Natto, M. J. and de Koning, H. P. (2022) Differences in transporters rather than drug targets are the principal determinants of the different innate sensitivities of Trypanosoma congolense and Trypanozoon subgenus trypanosomes to diamidines and melaminophenyl arsenicals. International Journal of Molecular Sciences, 23(5), 2844. (doi: 10.3390/ijms23052844) (PMID:35269985) (PMCID:PMC8911344)
Campagnaro, G. D., Elati, H. A. A. , Balaska, S., Martin Abril, M. E., Natto, M. J., Hulpia, F., Lee, K., Sheiner, L. , Van Calenbergh, S. and de Koning, H. P. (2022) A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes. International Journal of Molecular Sciences, 23(2), 710. (doi: 10.3390/ijms23020710) (PMID:35054895) (PMCID:PMC8776092)
2021
Natto, M. J., Miyamoto, Y., Munday, J. C. , AlSiari, T. A., Al-Salabi, M. I., Quashie, N. B., Eze, A. A., Eckmann, L. and De Koning, H. P. (2021) Comprehensive characterisation of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter. Molecular Microbiology, 116(6), pp. 1489-1511. (doi: 10.1111/mmi.14840) (PMID:34738285)
Alotaibi, A. et al. (2021) Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana. Molecules, 26(13), 3912. (doi: 10.3390/molecules26133912) (PMID:34206940) (PMCID:PMC8272135)
Natto, M. J., Hulpia, F., Kalkman, E. R., Baillie, S., Alhejely, A., Miyamoto, Y., Eckmann, L., Van Calenbergh, S. and de Koning, H. P. (2021) Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis. ACS Infectious Diseases, 7(6), pp. 1752-1764. (doi: 10.1021/acsinfecdis.1c00075) (PMID:33974405)
2020
Alenezi, S. S., Natto, M. J., Igoli, J. O., Gray, A. I., Fearnley, J., Fearnley, H., De Koning, H. P. and Watson, D. G. (2020) Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples. International Journal for Parasitology: Drugs and Drug Resistance, 14, pp. 201-207. (doi: 10.1016/j.ijpddr.2020.10.011) (PMID:33160277) (PMCID:PMC7649109)
Nvau, J. B., Alenezi, S., Ungogo, M. A., Alfayez, I. A.M., Natto, M. J., Gray, A. I., Ferro, V. A., Watson, D. G., De Koning, H. P. and Igoli, J. O. (2020) Antiparasitic and cytotoxic activity of bokkosin, a novel diterpene-substituted chromanyl benzoquinone from Calliandra portoricensis. Frontiers in Chemistry, 8, p. 574103. (doi: 10.3389/fchem.2020.574103) (PMID:33282826) (PMCID:PMC7705231)
2019
Khandazhinskaya, A. L. et al. (2019) Investigation of 5’-norcarbocyclic nucleoside analogues as antiprotozoal and antibacterial agents. Molecules, 24(19), e3433. (doi: 10.3390/molecules24193433) (PMID:31546633)
2015
Natto, M. J., Eze, A. A. and De Koning, H. P. (2015) Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis. In: Hempel, J. E., Williams, C. H. and Hong, C. C. (eds.) Chemical Biology. Series: Methods in molecular biology (1263). Humana Press: New York, pp. 103-110. ISBN 9781493922680 (doi: 10.1007/978-1-4939-2269-7_8)
2014
Acosta-Reyes, F. J., Dardonville, C., De Koning, H. P. , Natto, M., Subirana, J. A. and Campos, J. L. (2014) In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27. Acta Crystallographica. Section D: Biological Crystallography, 70(6), pp. 1614-1621. (doi: 10.1107/S139900471400697X)
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
2005
Natto, M.J., Wallace, L.J.M., Candlish, D., Al-Salabi, M.I., Coutts, S.E. and de Koning, H.P. (2005) Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance. Experimental Parasitology, 109(2), pp. 80-86. (doi: 10.1016/j.exppara.2004.11.004)
Articles
Ungogo, M. A. et al. (2023) Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against Animal African Trypanosomiasis. International Journal of Molecular Sciences, 24(4), 3144. (doi: 10.3390/ijms24043144) (PMID:36834557) (PMCID:PMC9960827)
Aldfer, M. M., AlSiari, T. A., Elati, H. A.A. , Natto, M. J., Alfayez, I. A., Campagnaro, G. D., Sani, B., Burchmore, R. J. S. , Diallinas, G. and De Koning, H. (2022) Nucleoside transport and nucleobase uptake null mutants in Leishmania mexicana for the routine expression and characterization of purine and pyrimidine transporters. International Journal of Molecular Sciences, 23(15), 8139. (doi: 10.3390/ijms23158139) (PMID:35897714) (PMCID:PMC9331716)
Alenezi, S. S. et al. (2022) The antiprotozoal activity of Papua New Guinea propolis and its triterpenes. Molecules, 27(5), 1622. (doi: 10.3390/molecules27051622) (PMID:35268726) (PMCID:PMC8911803)
Ungogo, M. A., Campagnaro, G. D., Alghamdi, A. H., Natto, M. J. and de Koning, H. P. (2022) Differences in transporters rather than drug targets are the principal determinants of the different innate sensitivities of Trypanosoma congolense and Trypanozoon subgenus trypanosomes to diamidines and melaminophenyl arsenicals. International Journal of Molecular Sciences, 23(5), 2844. (doi: 10.3390/ijms23052844) (PMID:35269985) (PMCID:PMC8911344)
Campagnaro, G. D., Elati, H. A. A. , Balaska, S., Martin Abril, M. E., Natto, M. J., Hulpia, F., Lee, K., Sheiner, L. , Van Calenbergh, S. and de Koning, H. P. (2022) A Toxoplasma gondii oxopurine transporter binds nucleobases and nucleosides using different binding modes. International Journal of Molecular Sciences, 23(2), 710. (doi: 10.3390/ijms23020710) (PMID:35054895) (PMCID:PMC8776092)
Natto, M. J., Miyamoto, Y., Munday, J. C. , AlSiari, T. A., Al-Salabi, M. I., Quashie, N. B., Eze, A. A., Eckmann, L. and De Koning, H. P. (2021) Comprehensive characterisation of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter. Molecular Microbiology, 116(6), pp. 1489-1511. (doi: 10.1111/mmi.14840) (PMID:34738285)
Alotaibi, A. et al. (2021) Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana. Molecules, 26(13), 3912. (doi: 10.3390/molecules26133912) (PMID:34206940) (PMCID:PMC8272135)
Natto, M. J., Hulpia, F., Kalkman, E. R., Baillie, S., Alhejely, A., Miyamoto, Y., Eckmann, L., Van Calenbergh, S. and de Koning, H. P. (2021) Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis. ACS Infectious Diseases, 7(6), pp. 1752-1764. (doi: 10.1021/acsinfecdis.1c00075) (PMID:33974405)
Alenezi, S. S., Natto, M. J., Igoli, J. O., Gray, A. I., Fearnley, J., Fearnley, H., De Koning, H. P. and Watson, D. G. (2020) Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples. International Journal for Parasitology: Drugs and Drug Resistance, 14, pp. 201-207. (doi: 10.1016/j.ijpddr.2020.10.011) (PMID:33160277) (PMCID:PMC7649109)
Nvau, J. B., Alenezi, S., Ungogo, M. A., Alfayez, I. A.M., Natto, M. J., Gray, A. I., Ferro, V. A., Watson, D. G., De Koning, H. P. and Igoli, J. O. (2020) Antiparasitic and cytotoxic activity of bokkosin, a novel diterpene-substituted chromanyl benzoquinone from Calliandra portoricensis. Frontiers in Chemistry, 8, p. 574103. (doi: 10.3389/fchem.2020.574103) (PMID:33282826) (PMCID:PMC7705231)
Khandazhinskaya, A. L. et al. (2019) Investigation of 5’-norcarbocyclic nucleoside analogues as antiprotozoal and antibacterial agents. Molecules, 24(19), e3433. (doi: 10.3390/molecules24193433) (PMID:31546633)
Acosta-Reyes, F. J., Dardonville, C., De Koning, H. P. , Natto, M., Subirana, J. A. and Campos, J. L. (2014) In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27. Acta Crystallographica. Section D: Biological Crystallography, 70(6), pp. 1614-1621. (doi: 10.1107/S139900471400697X)
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
Natto, M.J., Wallace, L.J.M., Candlish, D., Al-Salabi, M.I., Coutts, S.E. and de Koning, H.P. (2005) Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance. Experimental Parasitology, 109(2), pp. 80-86. (doi: 10.1016/j.exppara.2004.11.004)
Book Sections
Natto, M. J., Eze, A. A. and De Koning, H. P. (2015) Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis. In: Hempel, J. E., Williams, C. H. and Hong, C. C. (eds.) Chemical Biology. Series: Methods in molecular biology (1263). Humana Press: New York, pp. 103-110. ISBN 9781493922680 (doi: 10.1007/978-1-4939-2269-7_8)