Mrs Anne Orr

Affiliate Researcher (School of Infection & Immunity)

Centre for Virus Research, University of Glasgow, Garscube Campus, 464 Bearsden Road

Publications

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Number of items: 46.

2021

Kim, E. T., Dybas, J. M., Kulej, K., Reyes, E. D., Price, A. M., Akhtar, L. N., Orr, A., Garcia, B. A., Boutell, C. and Weitzman, M. D. (2021) Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription. Nature Microbiology, 6, pp. 234-245. (doi: 10.1038/s41564-020-00826-3) (PMID:33432153) (PMCID:PMC7856100)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

2019

McFarlane, S. et al. (2019) The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLoS Pathogens, 15(3), e1007667. (doi: 10.1371/journal.ppat.1007667) (PMID:30901352) (PMCID:PMC6472835)

2018

Alandijany, T., Roberts, A. P.E., Conn, K. L., Loney, C. , McFarlane, S., Orr, A. and Boutell, C. (2018) Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection. PLoS Pathogens, 14(1), e1006769. (doi: 10.1371/journal.ppat.1006769) (PMID:29309427) (PMCID:PMC5757968)

2016

Lu, Y., Orr, A. and Everett, R. D. (2016) Stimulation of the replication of ICP0-null mutant HSV-1 and pp71-deficient HCMV by EBV tegument protein BNRF1. Journal of Virology, 90(21), pp. 9664-9673. (doi: 10.1128/JVI.01224-16) (PMID:27535048) (PMCID:PMC5068519)

Sloan, E. , Orr, A. and Everett, R. (2016) MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus. Journal of Virology, 90(19), pp. 8621-8633. (doi: 10.1128/JVI.00621-16) (PMID:27440897) (PMCID:PMC5021396)

2015

Sloan, E. , Tatham, M. H., Groslambert, M., Glass, M., Orr, A., Hay, R. T. and Everett, R. D. (2015) Analysis of the SUMO2 proteome during HSV-1 infection. PLoS Pathogens, 11(7), e1005059. e1005059. (doi: 10.1371/journal.ppat.1005059) (PMID:26200910) (PMCID:PMC4511656)

2014

Everett, R. D., Chiocca, S. and Orr, A. (2014) The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1. Journal of Virology, 88(10), pp. 5873-5876. (doi: 10.1128/JVI.00080-14)

Everett, R.D., Boutell, C. , Pheasant, K., Cuchet-Lourenco, D. and Orr, A. (2014) Sequences related to SUMO interaction motifs in herpes simplex virus 1 protein ICP0 act cooperatively to stimulate virus infection. Journal of Virology, 88(5), pp. 2763-2774. (doi: 10.1128/JVI.03417-13) (PMID:24352468) (PMCID:PMC3958091)

2013

Cuchet-Lourenço, D., Anderson, G., Sloan, E. , Orr, A. and Everett, R.D. (2013) The viral ubiquitin ligase icp0 is neither sufficient nor necessary for degradation of the cellular dna sensor ifi16 during herpes simplex virus 1 infection. Journal of Virology, 87(24), pp. 13422-13432. (doi: 10.1128/JVI.02474-13) (PMID:24089555) (PMCID:PMC3838218)

Everett, R.D., Bell, A.J., Lu, Y. and Orr, A. (2013) The replication defect of ICP0-Null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71. Journal of Virology, 87(2), pp. 978-990. (doi: 10.1128/JVI.01103-12)

2012

Cuchet-Lourenco, D., Vanni, E., Glass, M., Orr, A. and Everett, R.D. (2012) Herpes simplex virus 1 ubiquitin ligase ICP0 interacts with PML isoform I and induces its SUMO-independent degradation. Journal of Virology, 86(20), pp. 11209-11222. (doi: 10.1128/JVI.01145-12)

2011

Boutell, C. , Cuchet, D., Vanni, E., Orr, A., Glass, M., McFarlane, S. and Everett, R.D. (2011) A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence. PLoS Pathogens, 7(9), e1002245. (doi: 10.1371/journal.ppat.1002245) (PMID:21949651) (PMCID:PMC3174244)

Cuchet, D., Sykes, A. , Nicolas, A., Orr, A., Murray, J., Sirma, H., Heeren, J., Bartelt, A. and Everett, R.D. (2011) PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. Journal of Cell Science, 124(2), pp. 280-291. (doi: 10.1242/jcs.075390)

Cuchet-Lourenço, D., Boutell, C. , Lukashchuk, V., Grant, K., Sykes, A. , Murray, J., Orr, A. and Everett, R.D. (2011) SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes. PLoS Pathogens, 7(7), e1002123. (doi: 10.1371/journal.ppat.1002123) (PMID:21779164) (PMCID:PMC3136452)

2010

Everett, R.D., Boutell, C., McNair, C., Grant, L. and Orr, A. (2010) Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins. Journal of Virology, 84(7), pp. 3476-3487. (doi: 10.1128/JVI.02544-09) (PMID:20106921) (PMCID:PMC2838103)

2008

Everett, R.D., Parada, C., Gripon, P., Sirma, H. and Orr, A. (2008) Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100. Journal of Virology, 82(6), pp. 2661-2672. (doi: 10.1128/JVI.02308-07)

2007

Everett, R.D., Murray, J., Orr, A. and Preston, C.M. (2007) Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Journal of Virology, 81(20), pp. 10991-11004. (doi: 10.1128/jvi.00705-07)

2006

Everett, R.D., Rechter, S., Papior, P., Tavalai, N., Stamminger, T. and Orr, A. (2006) PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. Journal of Virology, 80(16), pp. 7995-8005. (doi: 10.1128/JVI.00734-06)

Geoffroy, M.-C., Chadeuf, G., Orr, A., Salvetti, A. and Everett, R.D. (2006) Impact of the interaction between herpes simplex virus type 1 regulatory protein ICP0 and ubiquitin-specific protease USP7 on activation of adeno-associated virus type 2 rep gene expression. Journal of Virology, 80(7), pp. 3650-3654.

Geoffroy, M.-C., Chadeuf, G., Orr, A., Salvetti, A. and Everett, R.D. (2006) Impact of the interaction between herpes simplex virus type 1 regulatory protein ICP0 and ubiquitin-specific protease USP7 on activation of adeno-associated virus type 2 rep gene expression. Journal of Virology, 80(7), pp. 3650-3654. (doi: 10.1128/jvi.80.7.3650-3654.2006)

2005

Boutell, C. , Canning, M., Orr, A. and Everett, R.D. (2005) Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. Journal of Virology, 79(19), pp. 12342-12354. (doi: 10.1128/jvi.79.19.12342-12354.2005)

2004

Everett, R.D., Boutell, C. and Orr, A. (2004) Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0. Journal of Virology, 78(4), pp. 1763-1774. (doi: 10.1128/jvi.78.4.1763-1774.2004)

Everett, R.D., Sourvinos, G., Leiper, C., Clements, J.B. and Orr, A. (2004) Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: Localization, dynamics, recruitment of ICP27, and evidence for the De Novo induction of ND10-Like complexes. Journal of Virology, 78, pp. 1903-1917. (doi: 10.1128/JVI.78.4.1903-1917.2004)

2003

Everett, R.D., Sourvinos, G. and Orr, A. (2003) Recruitment of herpes simplex virus type 1 transcriptional regulatory protein ICP4 into foci juxtaposed to ND10 in live, infected cells. Journal of Virology, 77(6), pp. 3680-3689. (doi: 10.1128/jvi.77.6.3680-3689.2003)

Boutell, C.J. , Orr, A. and Everett, R.D. (2003) PML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0. Journal of Virology, 77(16), pp. 8686-8694. (doi: 10.1128/jvi.77.16.8686-8694.2003)

Engelhardt, O.G., Boutell, C.J. , Orr, A., Ullrich, E., Haller, O. and Everett, R.D. (2003) The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML. Experimental Cell Research, 283(1), pp. 36-50. (doi: 10.1016/s0014-4827(02)00025-3)

1999

Everett, R.D., Lomonte, P., Sternsdorf, T., van Driel, R. and Orr, A. (1999) Cell cycle regulation of PML modification and ND10 composition. Journal of Cell Science, 112(24), pp. 4581-8.

Everett, R.D., Earnshaw, W.C., Pluta, A.F., Sternsdorf, T., Ainsztein, A.M., Carmena, M., Ruchaud, S., Hsu, W.L. and Orr, A. (1999) A dynamic connection between centromeres and ND10 proteins. Journal of Cell Science, 112(20), pp. 3443-3454.

Everett, R.D., Meredith, M. and Orr, A. (1999) The ability of herpes simplex virus type 1 immediate-early protein Vmw110 to bind to a ubiquitin-specific protease contributes to its roles in the activation of gene expression and stimulation of virus replication. Journal of Virology, 73(1), pp. 417-26.

1998

Everett, R.D., Orr, A. and Preston, C.M. (1998) A viral activator of gene expression functions via the ubiquitin-proteasome pathway. EMBO Journal, 17(24), pp. 7161-7169. (doi: 10.1093/emboj/17.24.7161)

Everett, R.D., Freemont, P., Saitoh, H., Dasso, M., Orr, A., Kathoria, M. and Parkinson, J. (1998) The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms. Journal of Virology, 72(8), pp. 6581-91.

1997

Tyler, J.K., Orr, A. and Everett, R.D. (1997) Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth. Journal of General Virology, 78, pp. 179-88.

Everett, R.D., Meredith, M., Orr, A., Cross, A., Kathoria, M. and Parkinson, J. (1997) A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO Journal, 16(7), pp. 1519-1530. (doi: 10.1093/emboj/16.7.1519)

1995

Everett, R., O'Hare, P., O'Rourke, D., Barlow, P. and Orr, A. (1995) Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures. Journal of Virology, 69(11), pp. 7339-7344. (PMID:7474166) (PMCID:PMC189666)

Everett, R., Orr, A. and Elliott, M. (1995) The equine herpesvirus 1 gene 63 RING finger protein partially complements Vmw110, its herpes simplex virus type 1 counterpart. Journal of General Virology, 76(9), pp. 2369-2374. (doi: 10.1099/0022-1317-76-9-2369) (PMID:7561779)

Meredith, M., Orr, A., Elliott, M. and Everett, R. (1995) Separation of sequence requirements for HSV-1 Vmw110 multimerisation and interaction with a 135-kDa cellular protein. Virology, 209(1), pp. 174-187. (doi: 10.1006/viro.1995.1241) (PMID:7747467)

Everett, R.D., Maul, G.G., Orr, A. and Elliott, M. (1995) The cellular RING finger protein PML is not a functional counterpart of the herpes simplex virus type 1 RING finger protein Vmw110. Journal of General Virology, 76(4), pp. 791-798. (doi: 10.1099/0022-1317-76-4-791)

1993

Everett, R.D., Barlow, P., Milner, A., Luisi, B., Orr, A., Hope, G. and Lyon, D. (1993) A novel arrangement of zinc-binding residues and secondary structure in the C3HC4 motif of an alpha herpes virus protein family. Journal of Molecular Biology, 234(4), pp. 1038-1047. (doi: 10.1006/jmbi.1993.1657)

Everett, R.D., Cross, A. and Orr, A. (1993) A truncated form of herpes simplex virus type 1 immediate-early protein Vmw110 is expressed in a cell type dependent manner. Virology, 197(2), pp. 751-756. (doi: 10.1006/viro.1993.1651)

Everett, R., Cross, A., Tyler, J. and Orr, A. (1993) An epitope within the DNA-binding domain of the herpes simplex virus immediate early protein Vmw175 is conserved in the varicella-zoster virus gene 62 protein. Journal of General Virology, 74(9), pp. 1955-1958. (doi: 10.1099/0022-1317-74-9-1955) (PMID:7690843)

1992

Cunningham, C., Davison, A.J. , Dolan, A., Frame, M.C., McGeoch, D.J., Meredith, D.M., Mosson, H.W. and Orr, A.C. (1992) The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinase. Journal of General Virology, 73(2), pp. 303-311. (doi: 10.1099/0022-1317-73-2-303)

1991

Everett, R.D. and Orr, A. (1991) The Vmw175 binding site in the IE-1 promoter has no apparent role in the expression of Vmw110 during herpes simplex virus type 1 infection. Virology, 180(2), pp. 509-517. (doi: 10.1016/0042-6822(91)90064-i)

Everett, R.D., Elliott, M., Hope, G. and Orr, A. (1991) Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site. Nucleic Acids Research, 19(18), pp. 4901-4908. (doi: 10.1093/nar/19.18.4901)

Everett, R.D., Orr, A. and Elliott, M. (1991) High level expression and purification of herpes simplex virus type 1 immediate early polypeptide Vmw110. Nucleic Acids Research, 19(22), pp. 6155-6161. (doi: 10.1093/nar/19.22.6155)

1986

Frame, M.C., McGeoch, D.J., Rixon, F.J., Orr, A.C. and Marsden, H.S. (1986) The 10K virion phosphoprotein encoded by gene US9 from herpes simplex virus type 1. Virology, 150(2), pp. 321-332. (doi: 10.1016/0042-6822(86)90297-7)

This list was generated on Wed Apr 24 10:09:33 2024 BST.

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