Dr Emilie Pondeville

  • Senior Research Fellow (Virology)

telephone: +44 (0) 141 330 5726
email: Emilie.Pondeville@glasgow.ac.uk

Centre for Virus Research, Henry Wellcome Building, 464 Bearsden Road, Glasgow, G61 1qh

Import to contacts

Research interests

CVR logo

I have a long-term research interest in better understanding mosquito biology and physiology. Female anautogenous mosquitoes need a blood meal from a vertebrate host to reproduce. Therefore they can act as vectors for numerous pathogens, e.g. arthropod-borne viruses (arboviruses) or parasites, responsible for both human and animal diseases.

To control the transmission of mosquito-borne diseases, diverse new control strategies such as transgenic mosquitoes are developed, either to reduce mosquito populations, either by rendering them refractory to pathogens. With this aim, a better knowledge of the reproductive biology and of immune responses of mosquito vectors is beneficial, as this could lead to the identification of new target genes for manipulating mosquitoes. It can also inform mosquito control release programs.

Access at the CVR to newly established insectaries, as well as modern transgenic facilities, provide an exciting opportunity to study in vivo mosquito-arbovirus interactions. In collaboration with other CVR groups my group is deciphering the molecular mechanisms involved in vector competence for arboviruses using genetic tools.

Our research aims to better understand the contribution of tissue-specific antiviral strategies in the mosquito, defence pathway crosstalk, as well as the communication between different mosquito tissues during a viral infection that leads to an integrated antiviral response. Moreover, we are focusing our research on vertical transmission of arboviruses and the molecular mechanisms involved as well as the function of this phenomenon in vectorial capacities of mosquitoes. In this context, we are also developing transgenics and genetic tools in Aedes mosquitoes, such as the Gal4/UAS system, to address gene function at the tissue level.

Publications

List by: Type | Date

Jump to: 2025 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2008 | 2005
Number of items: 22.

2025

Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Kerrigan, David, Almire, Floriane, Szemiel, Agnieszka M., Hughes, Joseph ORCID logoORCID: https://orcid.org/0000-0003-2556-2563, Parvy, Jean-Philippe, Palmarini, Massimo ORCID logoORCID: https://orcid.org/0000-0001-7007-4070, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Shi, Xiaohong ORCID logoORCID: https://orcid.org/0000-0002-5289-7222 and Pondeville, Emilie (2025) NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. Nature Communications, 16, 1214. (doi: 10.1038/s41467-024-54809-7) (PMID:39890788) (PMCID:PMC11785797)

2023

Pondeville, E. et al. (2023) Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe. Pathogens and Global Health, 117(3), pp. 293-307. (doi: 10.1080/20477724.2022.2108639) (PMID:35996820) (PMCID:PMC10081053)

2022

Lefteri, D. A. et al. (2022) Mosquito saliva enhances virus infection through sialokinin-dependent vascular leakage. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e211430911. (doi: 10.1073/pnas.2114309119) (PMID:35675424) (PMCID:PMC9214539)

2021

Almire, Floriane, Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Terry, Sandra, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Gestuveo, Rommel J., Szemiel, Agnieszka M., Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, McDonald, Alma, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Laureti, M., Levée, T., Terry, S., Kohl, A. ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. Insect Molecular Biology, 30(3), pp. 355-365. (doi: 10.1111/imb.12700) (PMID:33715239)

Lefteri, D. A. et al. (2021) Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage. bioRxiv, (doi: 10.1101/2021.02.19.431961)

2020

Stokes, Samuel, Almire, Floriane, Tatham, Michael H., McFarlane, Steven, Mertens, Peter, Pondeville, Emilie and Boutell, Chris ORCID logoORCID: https://orcid.org/0000-0002-2970-7785 (2020) The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PLoS Pathogens, 16(12), e1009134. (doi: 10.1371/journal.ppat.1009134) (PMID:33351855) (PMCID:PMC7802965)

Pondeville, Emilie, Puchot, Nicolas, Parvy, Jean-Philippe, Carissimo, Guillaume, Poidevin, Mickael, Waterhouse, Robert M., Marois, Eric and Bourgouin, Catherine (2020) Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila. Insect Biochemistry and Molecular Biology, 120, 103339. (doi: 10.1016/j.ibmb.2020.103339) (PMID:32105779) (PMCID:PMC7181189)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

Ortega-López, Leonardo D. ORCID logoORCID: https://orcid.org/0000-0002-0819-0721, Pondeville, Emilie, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, León, Renato, Pazmino Betancourth, Mauro ORCID logoORCID: https://orcid.org/0000-0003-4259-0611, Almire, Floriane, Torres-Valencia, Sergio, Saldarriaga, Segundo, Mirzai, Nosrat and Ferguson, Heather M. ORCID logoORCID: https://orcid.org/0000-0002-9625-5176 (2020) The mosquito electrocuting trap as an exposure-free method for measuring human-biting rates by Aedes mosquito vectors. Parasites and Vectors, 13, 31. (doi: 10.1186/s13071-020-3887-8) (PMID:31941536) (PMCID:PMC6961254)

2019

Pondeville, Emilie, Puchot, Nicolas, Lang, Michael, Cherrier, Floriane, Schaffner, Francis, Dauphin-Villemant, Chantal, Bischoff, Emmanuel and Bourgouin, Catherine (2019) Evolution of sexually-transferred steroids and mating-induced phenotypes in Anopheles mosquitoes. Scientific Reports, 9, 4669. (doi: 10.1038/s41598-019-41094-4) (PMID:30874601) (PMCID:PMC6420574)

2018

Adolfi, Adriana, Pondeville, Emilie, Lynd, Amy, Lycett, Gareth J. and Bourgouin, Catherine (2018) Multi-tissue GAL4-mediated gene expression in all Anopheles gambiae life stages using an endogenous polyubiquitin promoter. Insect Biochemistry and Molecular Biology, 96, pp. 1-9. (doi: 10.1016/j.ibmb.2018.03.005) (PMID:29578046)

2017

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

2016

Pingen, Marieke ORCID logoORCID: https://orcid.org/0000-0001-5689-9076, Bryden, Steven R. ORCID logoORCID: https://orcid.org/0000-0001-5408-6047, Pondeville, Emilie, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Merits, Andres, Fazakerley, John K., Graham, Gerard J. ORCID logoORCID: https://orcid.org/0000-0002-7801-204X and McKimmie, Clive S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi: 10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, 110(4-5), pp. 164-172. (doi: 10.1080/20477724.2016.1211475) (PMID:27677378) (PMCID:PMC5072118)

2015

Carissimo, G. et al. (2015) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi: 10.1073/pnas.1412984112) (PMID:25548172) (PMCID:PMC4299212)

Kean, Joy, Rainey, Stephanie ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Donald, Claire ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

Pondeville, Emilie, Puchot, Nicolas, Meredith, Janet M., Lynd, Amy, Vernick, Kenneth D., Lycett, Gareth J., Eggleston, Paul and Bourgouin, Catherine (2014) Efficient ΦC31 integrase–mediated site-specific germline transformation of Anopheles gambiae. Nature Protocols, 9(7), pp. 1698-1712. (doi: 10.1038/nprot.2014.117)

2013

Pondeville, Emilie, David, Jean-Philippe, Guittard, Emilie, Maria, Annick, Jacques, Jean-Claude, Ranson, Hilary, Bourgouin, Catherine and Dauphin-Villemant, Chantal (2013) Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. PLoS ONE, 8(12), e79861. (doi: 10.1371/journal.pone.0079861) (PMID:24324583) (PMCID:PMC3851169)

2008

Pondeville, Emilie, Maria, Annick, Jacques, Jean-Claude, Bourgouin, Catherine and Dauphin-Villemant, Chantal (2008) Anopheles gambiae males produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating. Proceedings of the National Academy of Sciences of the United States of America, 105(50), pp. 19631-19636. (doi: 10.1073/pnas.0809264105)

2005

Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C, Antoniewski, C, Carré, C, Noselli, S and Léopold, P (2005) Antagonistic actions of ecdysone and insulins determine final size in drosophila. Science, 310(5748), pp. 667-670. (doi: 10.1126/science.1119432) (PMID:16179433)

This list was generated on Sun Jun 15 11:51:24 2025 BST.
Jump to: Articles
Number of items: 22.

Articles

Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Kerrigan, David, Almire, Floriane, Szemiel, Agnieszka M., Hughes, Joseph ORCID logoORCID: https://orcid.org/0000-0003-2556-2563, Parvy, Jean-Philippe, Palmarini, Massimo ORCID logoORCID: https://orcid.org/0000-0001-7007-4070, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Shi, Xiaohong ORCID logoORCID: https://orcid.org/0000-0002-5289-7222 and Pondeville, Emilie (2025) NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. Nature Communications, 16, 1214. (doi: 10.1038/s41467-024-54809-7) (PMID:39890788) (PMCID:PMC11785797)

Pondeville, E. et al. (2023) Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe. Pathogens and Global Health, 117(3), pp. 293-307. (doi: 10.1080/20477724.2022.2108639) (PMID:35996820) (PMCID:PMC10081053)

Lefteri, D. A. et al. (2022) Mosquito saliva enhances virus infection through sialokinin-dependent vascular leakage. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e211430911. (doi: 10.1073/pnas.2114309119) (PMID:35675424) (PMCID:PMC9214539)

Almire, Floriane, Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Terry, Sandra, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Gestuveo, Rommel J., Szemiel, Agnieszka M., Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, McDonald, Alma, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Laureti, M., Levée, T., Terry, S., Kohl, A. ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. Insect Molecular Biology, 30(3), pp. 355-365. (doi: 10.1111/imb.12700) (PMID:33715239)

Lefteri, D. A. et al. (2021) Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage. bioRxiv, (doi: 10.1101/2021.02.19.431961)

Stokes, Samuel, Almire, Floriane, Tatham, Michael H., McFarlane, Steven, Mertens, Peter, Pondeville, Emilie and Boutell, Chris ORCID logoORCID: https://orcid.org/0000-0002-2970-7785 (2020) The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PLoS Pathogens, 16(12), e1009134. (doi: 10.1371/journal.ppat.1009134) (PMID:33351855) (PMCID:PMC7802965)

Pondeville, Emilie, Puchot, Nicolas, Parvy, Jean-Philippe, Carissimo, Guillaume, Poidevin, Mickael, Waterhouse, Robert M., Marois, Eric and Bourgouin, Catherine (2020) Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila. Insect Biochemistry and Molecular Biology, 120, 103339. (doi: 10.1016/j.ibmb.2020.103339) (PMID:32105779) (PMCID:PMC7181189)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)

Ortega-López, Leonardo D. ORCID logoORCID: https://orcid.org/0000-0002-0819-0721, Pondeville, Emilie, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, León, Renato, Pazmino Betancourth, Mauro ORCID logoORCID: https://orcid.org/0000-0003-4259-0611, Almire, Floriane, Torres-Valencia, Sergio, Saldarriaga, Segundo, Mirzai, Nosrat and Ferguson, Heather M. ORCID logoORCID: https://orcid.org/0000-0002-9625-5176 (2020) The mosquito electrocuting trap as an exposure-free method for measuring human-biting rates by Aedes mosquito vectors. Parasites and Vectors, 13, 31. (doi: 10.1186/s13071-020-3887-8) (PMID:31941536) (PMCID:PMC6961254)

Pondeville, Emilie, Puchot, Nicolas, Lang, Michael, Cherrier, Floriane, Schaffner, Francis, Dauphin-Villemant, Chantal, Bischoff, Emmanuel and Bourgouin, Catherine (2019) Evolution of sexually-transferred steroids and mating-induced phenotypes in Anopheles mosquitoes. Scientific Reports, 9, 4669. (doi: 10.1038/s41598-019-41094-4) (PMID:30874601) (PMCID:PMC6420574)

Adolfi, Adriana, Pondeville, Emilie, Lynd, Amy, Lycett, Gareth J. and Bourgouin, Catherine (2018) Multi-tissue GAL4-mediated gene expression in all Anopheles gambiae life stages using an endogenous polyubiquitin promoter. Insect Biochemistry and Molecular Biology, 96, pp. 1-9. (doi: 10.1016/j.ibmb.2018.03.005) (PMID:29578046)

Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)

Pingen, Marieke ORCID logoORCID: https://orcid.org/0000-0001-5689-9076, Bryden, Steven R. ORCID logoORCID: https://orcid.org/0000-0001-5408-6047, Pondeville, Emilie, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Merits, Andres, Fazakerley, John K., Graham, Gerard J. ORCID logoORCID: https://orcid.org/0000-0002-7801-204X and McKimmie, Clive S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi: 10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, 110(4-5), pp. 164-172. (doi: 10.1080/20477724.2016.1211475) (PMID:27677378) (PMCID:PMC5072118)

Carissimo, G. et al. (2015) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi: 10.1073/pnas.1412984112) (PMID:25548172) (PMCID:PMC4299212)

Kean, Joy, Rainey, Stephanie ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Donald, Claire ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

Pondeville, Emilie, Puchot, Nicolas, Meredith, Janet M., Lynd, Amy, Vernick, Kenneth D., Lycett, Gareth J., Eggleston, Paul and Bourgouin, Catherine (2014) Efficient ΦC31 integrase–mediated site-specific germline transformation of Anopheles gambiae. Nature Protocols, 9(7), pp. 1698-1712. (doi: 10.1038/nprot.2014.117)

Pondeville, Emilie, David, Jean-Philippe, Guittard, Emilie, Maria, Annick, Jacques, Jean-Claude, Ranson, Hilary, Bourgouin, Catherine and Dauphin-Villemant, Chantal (2013) Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. PLoS ONE, 8(12), e79861. (doi: 10.1371/journal.pone.0079861) (PMID:24324583) (PMCID:PMC3851169)

Pondeville, Emilie, Maria, Annick, Jacques, Jean-Claude, Bourgouin, Catherine and Dauphin-Villemant, Chantal (2008) Anopheles gambiae males produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating. Proceedings of the National Academy of Sciences of the United States of America, 105(50), pp. 19631-19636. (doi: 10.1073/pnas.0809264105)

Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C, Antoniewski, C, Carré, C, Noselli, S and Léopold, P (2005) Antagonistic actions of ecdysone and insulins determine final size in drosophila. Science, 310(5748), pp. 667-670. (doi: 10.1126/science.1119432) (PMID:16179433)

This list was generated on Sun Jun 15 11:51:24 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • MosKenya: Assessing mosquito-borne disease risks in Kenya and their response to climate change
    Medical Research Foundation
    2024 - 2027
     
  • Assessing the risk of insect vector-borne diseases in Scotland and their response to environmental change.
    UK Research and Innovation
    2023 - 2026
     
  • MOSAICS - A mosquito arbovirus omics atlas to unravel mosquito-arbovirus interactions
    Biotechnology and Biological Sciences Research Council
    2022 - 2023
     
  • INFRAVEC-2
    European Commission
    2017 - 2021
     
  • Zikalliance
    European Commission
    2016 - 2019
     

Research datasets

Jump to: 2024 | 2021 | 2020
Number of items: 5.

2024

Terhzaz, S. , Kerrigan, D., Almire, F., Szemiel, A. M., Hughes, J. , Parvy, J.-P., Palmarini, M. , Kohl, A. , Shi, X. and Pondeville, E. (2024) NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. [Data Collection]

2021

Almire, F., Terhzaz, S. , Terry, S., McFarlane, M., Gestuveo, R., Sziemel, A. M., Varjak, M. , Mcdonald, A., Kohl, A. and Pondeville, E. (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. [Data Collection]

McFarlane, M. , Laureti, M., Levée, T., Terry, S., Kohl, A. and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. [Data Collection]

2020

Stokes, S., Almire, F., Tatham, M., McFarlane, S., Mertens, P., Pondeville, E. and Boutell, C. (2020) The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. [Data Collection]

Mcdonald, M. , Pondeville, E. and Kohl, A. (2020) The Aedes aegypti Domino ortholog, p400 regulates antiviral exogenous siRNA pathway activity through control of ago-2 levels. [Data Collection]

This list was generated on Sun Jun 15 14:13:18 2025 BST.

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