Dr Matteo Barberis

  • Reader in Systems Biology (University of Surrey)
  • Location: Common room, Sir Graeme Davies Building

Title: Systems Biology strategies to tackle infection and inflammation

Synopsis:

Understanding the dynamics of physiological systems, being these healthy or diseased, and identifying their underlying molecular mechanisms, are overarching aims of Systems Medicine. Indeed, it strives to unravel the differences between health and disease states and rationalise intervention strategies to ideally bring the latter back to health. In this seminar, I will present strategies that my team is developing to investigate molecular mechanisms of inflammation, through integration of computational modelling with experimentation, i.e. Systems Biology. I will also introduce system’s approaches my team employs to reconstruct disease maps from –omics data and to feed these into machine learning algorithms, to predict metabolic switches underlying infection and biomarkers of inflammatory diseases, respectively.

 

Bio:

Matteo Barberis, FRSB, received the PhD in Industrial Biotechnology from the University of Milano-Bicocca, Italy. After postdoctoral training in Systems Biology from the Max Planck Institute for Molecular Genetics and the Humboldt University in Berlin, Germany, he started his independent group at the University of Amsterdam before moving it to the University of Surrey in December 2018. Matteo is Reader in Systems Biology at the School of Biosciences, University of Surrey, and serves as Theme Leader for Infection and Immunity and Coordinator of the Centre for Mathematical and Computational Biology (CMCB) for the Faculty of Health and Medical Science (FHMS).

Matteo's Systems Biology research integrates computational modeling with experimentation to decipher design principles underlying cellular organization, by investigating cell cycle control, metabolism, and the immune system in health and disease. Matteo’s research has resulted in studies published in leading journals such as J Clin Immunol, Clin Transl Med, NAR, and PNAS. Matteo serves the UKRI as member of the BBSRC Pool of Experts and MRC Expert Reviewer, and the scientific community as Executive Director of the International Society for Systems Biology (ISSB) and Associate Editor for Frontiers in Systems and Synthetic Immunology. He served as Coordinator of the Computational Modeling of Biological Systems (SysMod) Community of the International Society for Computational Biology (ISCB) (2018–2025) and Editor-in-Chief of Current Opinion in Systems Biology (2018–2025, boosting its CiteScore from 2.1 to 8.4).

 

First published: 7 December 2025

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