Professor Paul Kalra
- Honorary Clinical Senior Lecturer (School of Health & Wellbeing)
Portsmouth Hospitals University NHS Trust, Queen Alexandra Hospital, Southwick Hill Rd, Cosham, PO6 3LY
Publications
2025
Ahmed, F.Z. et al. (2025) Effects of ferric derisomaltose in heart failure with iron deficiency according to renal function in the IRONMAN randomised controlled trial. American Journal of Nephrology, (Accepted for Publication)
Foley, P.W. et al. (2025) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, 27(1), pp. 166-173. (doi: 10.1002/ejhf.3504) (PMID:39453738) (PMCID:PMC11798631)
2024
Cleland, J. et al. (2024) Adjudication of hospitalizations and deaths in the IRONMAN Trial of intravenous iron for heart failure. Journal of the American College of Cardiology, 84(18), pp. 1704-1717. (doi: 10.1016/j.jacc.2024.08.052) (PMID:39443013) (PMCID:PMC11496827)
Lee, M. et al. (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26(10), pp. 2293-2295. (doi: 10.1002/ejhf.3394) (PMID:39078467)
Graham, Fraser J., Guha, Kaushik, Cleland, John G. ORCID: https://orcid.org/0000-0002-1471-7016 and Kalra, Paul R.
(2024)
Treating iron deficiency in patients with heart failure: what, why, when, how, where and who.
Heart,
(doi: 10.1136/heartjnl-2022-322030)
(PMID:39160066)
(Early Online Publication)
Docherty, Kieran Francis ORCID: https://orcid.org/0000-0002-5446-9969, McMurray, John J.V.
ORCID: https://orcid.org/0000-0002-6317-3975, Kalra, Paul, Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016, Lang, Ninian N.
ORCID: https://orcid.org/0000-0001-8441-6887, Petrie, Mark C.
ORCID: https://orcid.org/0000-0002-6333-9496, Robertson, Michele and Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823
(2024)
Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction.
ESC Heart Failure, 11(4),
pp. 1875-1879.
(doi: 10.1002/ehf2.14742)
(PMID:38549192)
(PMCID:PMC11287326)
Packer, Milton, Anker, Stefan D., Butler, Javed, Cleland, John G.F. ORCID: https://orcid.org/0000-0002-1471-7016, Kalra, Paul R., Mentz, Robert J., Ponikowski, Piotr and Talha, Khawaja M.
(2024)
Critical re‐evaluation of the identification of iron deficiency states and effective iron repletion strategies in patients with chronic heart failure.
European Journal of Heart Failure, 26(6),
pp. 1298-1312.
38727791.
(doi: 10.1002/ejhf.3237)
Ray, R. et al. (2024) The impact of ferric derisomaltose on cardiovascular and non-cardiovascular events in patients with anemia, iron deficiency and heart failure with reduced ejection fraction. Journal of Cardiac Failure, 30(5), pp. 682-690. (doi: 10.1016/j.cardfail.2023.10.006) (PMID:37926238) (PMCID:PMC11096866)
Cleland, J. G.F. et al. (2024) Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European Heart Journal, 45(16), pp. 1410-1426. (doi: 10.1093/eurheartj/ehae086) (PMID:38446126) (PMCID:PMC11032711)
Osmanska, J. et al. (2024) A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 35-44. (doi: 10.1093/ehjcvp/pvad073) (PMID:37804170) (PMCID:PMC10766906)
2023
Yeoh, S. E. et al. (2023) Dapagliflozin versus metolazone in heart failure resistant to loop diuretics. European Heart Journal, 44(31), pp. 2966-2977. (doi: 10.1093/eurheartj/ehad341) (PMID:37210742)
Austin, Rosalynn C., Schoonhoven, Lisette, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2023) Qualitative interviews results from heart failure survey respondents on the interaction between symptoms and burden of self-care work. Journal of Clinical Nursing, 32(15-16), pp. 4649-4662. (doi: 10.1111/jocn.16484) (PMID:35945903)
Ford, Ian ORCID: https://orcid.org/0000-0001-5927-1823 and Kalra, Paul R.
(2023)
Unanswered questions from the IRONMAN trial - authors' reply.
Lancet, 401(10387),
pp. 1495-1496.
(doi: 10.1016/S0140-6736(23)00448-8)
(PMID:37149301)
Graham, Fraser J., Pellicori, Pierpaolo ORCID: https://orcid.org/0000-0001-7175-0464, Kalra, Paul R., Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Bruzzese, Dario and Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016
(2023)
Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis.
European Journal of Heart Failure, 25(4),
pp. 528-537.
(doi: 10.1002/ejhf.2810)
(PMID:36823953)
2022
Kalra, P. R. et al. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10369), pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9) (PMID:36347265)
Kalra, P. R. et al. (2022) Rationale and design of a randomised trial of intravenous iron in patients with heart failure. Heart, 108(24), pp. 1979-1985. (doi: 10.1136/heartjnl-2022-321304) (PMID:35948408) (PMCID:PMC9726969)
Austin, Rosalynn C., Schoonhoven, Lisette, Koutra, Vasiliki, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2022) SYMptoms in chronic heart failure imPACT on burden of treatment (SYMPACT): a cross‐sectional survey. ESC Heart Failure, 9(4), pp. 2279-2290. (doi: 10.1002/ehf2.13904) (PMID:35451208) (PMCID:PMC9288776)
2021
Graham, Fraser J., Pellicori, Pierpaolo ORCID: https://orcid.org/0000-0001-7175-0464, Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Petrie, Mark C.
ORCID: https://orcid.org/0000-0002-6333-9496, Kalra, Paul R. and Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016
(2021)
Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials.
Clinical Research in Cardiology, 110(8),
pp. 1299-1307.
(doi: 10.1007/s00392-021-01837-8)
(PMID:33755777)
Austin, Rosalynn C., Schoonhoven, Lisette, Clancy, Mike, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2021) Do chronic heart failure symptoms interact with burden of treatment? Qualitative literature systematic review. BMJ Open, 11(7), e047060. (doi: 10.1136/bmjopen-2020-047060) (PMID:34330858) (PMCID:PMC8327846)
2020
Austin, Rosalynn C, Schoonhoven, Lisette, Richardson, Alison, Kalra, Paul R. and May, Carl R (2020) How do SYMPtoms and management tasks in chronic heart failure imPACT a person's life (SYMPACT)? Protocol for a mixed-methods study. ESC Heart Failure, 7(6), pp. 4472-4477. (doi: 10.1002/ehf2.13010) (PMID:32940966) (PMCID:PMC7754908)
Sorbets, E. et al. (2020) Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry. European Heart Journal, 41(3), pp. 347-356. (doi: 10.1093/eurheartj/ehz660) (PMID:31504434) (PMCID:PMC6964227)
2019
Vidal-Petiot, E. et al. (2019) Chronic kidney disease has a graded association with death and cardiovascular outcomes in stable coronary artery disease: an analysis of 21,911 patients from the CLARIFY registry. Journal of Clinical Medicine, 9(1), 4. (doi: 10.3390/jcm9010004)
Clark, Andrew L., Kalra, Paul R., Petrie, Mark C. ORCID: https://orcid.org/0000-0002-6333-9496, Mark, Patrick B.
ORCID: https://orcid.org/0000-0003-3387-2123, Tomlinson, Laurie A. and Tomson, Charles R.V.
(2019)
Change in renal function associated with drug treatment in heart failure: national guidance.
Heart, 105(12),
pp. 904-910.
(doi: 10.1136/heartjnl-2018-314158)
(PMID:31118203)
(PMCID:PMC6582720)
2018
Kalra, Paul R., Greenlaw, Nicola ORCID: https://orcid.org/0000-0003-3847-1126, Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Steg, Ph Gabriel and Fox, Kim M.
(2018)
The reply.
American Journal of Medicine, 131(3),
e129.
(doi: 10.1016/j.amjmed.2017.09.019)
(PMID:29454433)
Articles
Ahmed, F.Z. et al. (2025) Effects of ferric derisomaltose in heart failure with iron deficiency according to renal function in the IRONMAN randomised controlled trial. American Journal of Nephrology, (Accepted for Publication)
Foley, P.W. et al. (2025) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, 27(1), pp. 166-173. (doi: 10.1002/ejhf.3504) (PMID:39453738) (PMCID:PMC11798631)
Cleland, J. et al. (2024) Adjudication of hospitalizations and deaths in the IRONMAN Trial of intravenous iron for heart failure. Journal of the American College of Cardiology, 84(18), pp. 1704-1717. (doi: 10.1016/j.jacc.2024.08.052) (PMID:39443013) (PMCID:PMC11496827)
Lee, M. et al. (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26(10), pp. 2293-2295. (doi: 10.1002/ejhf.3394) (PMID:39078467)
Graham, Fraser J., Guha, Kaushik, Cleland, John G. ORCID: https://orcid.org/0000-0002-1471-7016 and Kalra, Paul R.
(2024)
Treating iron deficiency in patients with heart failure: what, why, when, how, where and who.
Heart,
(doi: 10.1136/heartjnl-2022-322030)
(PMID:39160066)
(Early Online Publication)
Docherty, Kieran Francis ORCID: https://orcid.org/0000-0002-5446-9969, McMurray, John J.V.
ORCID: https://orcid.org/0000-0002-6317-3975, Kalra, Paul, Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016, Lang, Ninian N.
ORCID: https://orcid.org/0000-0001-8441-6887, Petrie, Mark C.
ORCID: https://orcid.org/0000-0002-6333-9496, Robertson, Michele and Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823
(2024)
Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction.
ESC Heart Failure, 11(4),
pp. 1875-1879.
(doi: 10.1002/ehf2.14742)
(PMID:38549192)
(PMCID:PMC11287326)
Packer, Milton, Anker, Stefan D., Butler, Javed, Cleland, John G.F. ORCID: https://orcid.org/0000-0002-1471-7016, Kalra, Paul R., Mentz, Robert J., Ponikowski, Piotr and Talha, Khawaja M.
(2024)
Critical re‐evaluation of the identification of iron deficiency states and effective iron repletion strategies in patients with chronic heart failure.
European Journal of Heart Failure, 26(6),
pp. 1298-1312.
38727791.
(doi: 10.1002/ejhf.3237)
Ray, R. et al. (2024) The impact of ferric derisomaltose on cardiovascular and non-cardiovascular events in patients with anemia, iron deficiency and heart failure with reduced ejection fraction. Journal of Cardiac Failure, 30(5), pp. 682-690. (doi: 10.1016/j.cardfail.2023.10.006) (PMID:37926238) (PMCID:PMC11096866)
Cleland, J. G.F. et al. (2024) Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European Heart Journal, 45(16), pp. 1410-1426. (doi: 10.1093/eurheartj/ehae086) (PMID:38446126) (PMCID:PMC11032711)
Osmanska, J. et al. (2024) A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 35-44. (doi: 10.1093/ehjcvp/pvad073) (PMID:37804170) (PMCID:PMC10766906)
Yeoh, S. E. et al. (2023) Dapagliflozin versus metolazone in heart failure resistant to loop diuretics. European Heart Journal, 44(31), pp. 2966-2977. (doi: 10.1093/eurheartj/ehad341) (PMID:37210742)
Austin, Rosalynn C., Schoonhoven, Lisette, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2023) Qualitative interviews results from heart failure survey respondents on the interaction between symptoms and burden of self-care work. Journal of Clinical Nursing, 32(15-16), pp. 4649-4662. (doi: 10.1111/jocn.16484) (PMID:35945903)
Ford, Ian ORCID: https://orcid.org/0000-0001-5927-1823 and Kalra, Paul R.
(2023)
Unanswered questions from the IRONMAN trial - authors' reply.
Lancet, 401(10387),
pp. 1495-1496.
(doi: 10.1016/S0140-6736(23)00448-8)
(PMID:37149301)
Graham, Fraser J., Pellicori, Pierpaolo ORCID: https://orcid.org/0000-0001-7175-0464, Kalra, Paul R., Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Bruzzese, Dario and Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016
(2023)
Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis.
European Journal of Heart Failure, 25(4),
pp. 528-537.
(doi: 10.1002/ejhf.2810)
(PMID:36823953)
Kalra, P. R. et al. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10369), pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9) (PMID:36347265)
Kalra, P. R. et al. (2022) Rationale and design of a randomised trial of intravenous iron in patients with heart failure. Heart, 108(24), pp. 1979-1985. (doi: 10.1136/heartjnl-2022-321304) (PMID:35948408) (PMCID:PMC9726969)
Austin, Rosalynn C., Schoonhoven, Lisette, Koutra, Vasiliki, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2022) SYMptoms in chronic heart failure imPACT on burden of treatment (SYMPACT): a cross‐sectional survey. ESC Heart Failure, 9(4), pp. 2279-2290. (doi: 10.1002/ehf2.13904) (PMID:35451208) (PMCID:PMC9288776)
Graham, Fraser J., Pellicori, Pierpaolo ORCID: https://orcid.org/0000-0001-7175-0464, Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Petrie, Mark C.
ORCID: https://orcid.org/0000-0002-6333-9496, Kalra, Paul R. and Cleland, John G.F.
ORCID: https://orcid.org/0000-0002-1471-7016
(2021)
Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials.
Clinical Research in Cardiology, 110(8),
pp. 1299-1307.
(doi: 10.1007/s00392-021-01837-8)
(PMID:33755777)
Austin, Rosalynn C., Schoonhoven, Lisette, Clancy, Mike, Richardson, Alison, Kalra, Paul R. and May, Carl R. (2021) Do chronic heart failure symptoms interact with burden of treatment? Qualitative literature systematic review. BMJ Open, 11(7), e047060. (doi: 10.1136/bmjopen-2020-047060) (PMID:34330858) (PMCID:PMC8327846)
Austin, Rosalynn C, Schoonhoven, Lisette, Richardson, Alison, Kalra, Paul R. and May, Carl R (2020) How do SYMPtoms and management tasks in chronic heart failure imPACT a person's life (SYMPACT)? Protocol for a mixed-methods study. ESC Heart Failure, 7(6), pp. 4472-4477. (doi: 10.1002/ehf2.13010) (PMID:32940966) (PMCID:PMC7754908)
Sorbets, E. et al. (2020) Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry. European Heart Journal, 41(3), pp. 347-356. (doi: 10.1093/eurheartj/ehz660) (PMID:31504434) (PMCID:PMC6964227)
Vidal-Petiot, E. et al. (2019) Chronic kidney disease has a graded association with death and cardiovascular outcomes in stable coronary artery disease: an analysis of 21,911 patients from the CLARIFY registry. Journal of Clinical Medicine, 9(1), 4. (doi: 10.3390/jcm9010004)
Clark, Andrew L., Kalra, Paul R., Petrie, Mark C. ORCID: https://orcid.org/0000-0002-6333-9496, Mark, Patrick B.
ORCID: https://orcid.org/0000-0003-3387-2123, Tomlinson, Laurie A. and Tomson, Charles R.V.
(2019)
Change in renal function associated with drug treatment in heart failure: national guidance.
Heart, 105(12),
pp. 904-910.
(doi: 10.1136/heartjnl-2018-314158)
(PMID:31118203)
(PMCID:PMC6582720)
Kalra, Paul R., Greenlaw, Nicola ORCID: https://orcid.org/0000-0003-3847-1126, Ford, Ian
ORCID: https://orcid.org/0000-0001-5927-1823, Steg, Ph Gabriel and Fox, Kim M.
(2018)
The reply.
American Journal of Medicine, 131(3),
e129.
(doi: 10.1016/j.amjmed.2017.09.019)
(PMID:29454433)