Dr Lyn Ferguson

Honorary Clinical Senior Lecturer (School of Cardiovascular & Metabolic Health)

Department of Clinical Biochemistry, Queen Elizabeth University Hospital, G51 4TF

Biography

Lyn Ferguson trained in medicine at the University of Glasgow (MBChB Hons. 2010), with an intercalated BSc (MedSci) (first class Hons.) in Anatomy. She undertook academic core medical training in the West of Scotland and obtained membership of the Royal College of Physicians and Surgeons of Glasgow (MRCP(Glasg)), before commencing specialty training in Chemical Pathology and Metabolic Medicine. She is a Fellow of the Royal College of Pathologists (FRCPath).

During her higher specialist training, she undertook a Clinical Research Fellowship, funded by the BHF Centre of Excellence at the University of Glasgow, and is co-investigator of the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) study. She was awarded her PhD in 2020, entitled 'Cardiometabolic comorbidities in psoriatic disease and modulation by phosphodiesterase (PDE) 4 inhibition'. She was awarded the Royal College of Pathologists Research Medal in Chemical Pathology and Metabolic Medicine for work related to this.

She is now a Consultant and Honorary Senior Clinical Lecturer in Metabolic Medicine in the School of Cardiovascular and Metabolic Health, University of Glasgow.

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Research interests

1 - Clinical Studies - IMAPA Study

Psoriasis and psoriatic arthritis are chronic inflammatory diseases of the skin and joints, which are also associated with increased risk of type 2 diabetes and cardiovascular disease. Obesity is a frequent comorbidity in psoriatic disease and is increasingly implicated in its pathogenesis, disease severity, and response to treatment. The medication apremilast, a phosphodiesterase (PDE)4 inhibitor, has been shown to improve psoriatic disease, as well as being associated with weight loss. The Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) study aimed to evaluate the effects of PDE4 inhibition on metabolic, vascular, and immune status in psoriatic disease.

2 - Epidemiological studies - UK Biobank

In collaboration with colleagues from the Institute of Health and Wellbeing, research focuses on the causes, prevention, and management of diabetes, obesity, heart disease, and chronic rheumatic diseases using the UK Biobank. This is a prospective, population cohort study of 500,000 participants designed to determine lifestyle, environmental and genetic factors that predispose to adult chronic diseases.

Publications

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Number of items: 30.

2024

Carrasco-Marín, F. et al. (2024) Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study. Nutrition, Metabolism and Cardiovascular Diseases, (doi: 10.1016/j.numecd.2024.03.010) (In Press)

Ferguson, L. D. , Molenberghs, G., Verbeke, G., Rahimi, K., Rao, S., McInnes, I. B. , McMurray, J. J.V. , Sattar, N. and Conrad, N. (2024) Gout and incidence of 12 cardiovascular diseases: a case–control study including 152 663 individuals with gout and 709 981 matched controls. Lancet Rheumatology, 6(3), e156-e167. (doi: 10.1016/S2665-9913(23)00338-7)

2023

Ferguson, L. , McInnes, I.B., Sattar, N. and Conrad, N. (2023) Gout is Associated with Increased Cardiovascular Risk: Results from Analysis of the CPRD Dataset. ESC Congress 2023, Amsterdam, Netherlands, 25–28 August 2023. (doi: 10.1093/eurheartj/ehad655.2771)

2022

Ho, F. K. et al. (2022) Association of gamma-glutamyltransferase levels with total mortality, liver-related, and cardiovascular outcomes: a prospective cohort study in the UK Biobank. EClinicalMedicine, 48, 101435. (doi: 10.1016/j.eclinm.2022.101435) (PMID:35706481) (PMCID:PMC9112033)

Ferguson, L. D. et al. (2022) Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease – results of the Immune Metabolic Associations in Psoriatic Arthritis study. Rheumatology, 61(3), pp. 1026-1034. (doi: 10.1093/rheumatology/keab474) (PMID:34097014) (PMCID:PMC8889283)

Rodríguez-Gómez, I. et al. (2022) Osteoporosis and its association with cardiovascular disease, respiratory disease, and cancer: findings from the UK Biobank prospective cohort study. Mayo Clinic Proceedings, 97(1), pp. 110-121. (doi: 10.1016/j.mayocp.2021.07.019) (PMID:34996542)

2021

Welsh, P. et al. (2021) Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions. European Journal of Preventive Cardiology, 28(18), pp. 1991-2000. (doi: 10.1093/eurjpc/zwaa063) (PMID:33624048)

Petermann-Rocha, F., Ferguson, L. D. , Gray, S. R. , Rodríguez-Gómez, I., Sattar, N. , Siebert, S. , Ho, F. K., Pell, J. P. and Celis-Morales, C. (2021) Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants. Journal of Cachexia, Sarcopenia and Muscle, 12(5), pp. 1179-1188. (doi: 10.1002/jcsm.12757) (PMID:34264024) (PMCID:PMC8517357)

Ferguson, L. D. , Linge, J., Leinhard, O. D., Woodward, R., Hall Barrientos, P., Roditi, G., Radjenovic, A. , McInnes, I. B. , Siebert, S. and Sattar, N. (2021) Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity – a cross-sectional study. Rheumatology, 60(4), pp. 1858-1862. (doi: 10.1093/rheumatology/keaa604) (PMID:33147607)

Ferguson, L. D. , Sattar, N. and McInnes, I. B. (2021) Managing cardiovascular risk in patients with rheumatic disease. Medical Clinics of North America, 105(2), pp. 247-262. (doi: 10.1016/j.mcna.2020.09.010) (PMID:33589100)

Anderson, J. J. et al. (2021) Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening. BMJ Open Diabetes Research and Care, 9(1), e002176. (doi: 10.1136/bmjdrc-2021-002176) (PMID:34353880) (PMCID:PMC8344314)

2020

Ho, F. K. et al. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, e040402. (doi: 10.1136/bmjopen-2020-040402) (PMID:33444201) (PMCID:PMC7678347)

Hayes, S. et al. (2020) Association between walking pace and stroke incidence: findings from the UK Biobank prospective cohort study. Stroke, 51(5), pp. 1388-1395. (doi: 10.1161/STROKEAHA.119.028064) (PMID:32299326)

Welsh, C. et al. (2020) Association of injury related hospital admissions with commuting by bicycle in the UK: prospective population based study. British Medical Journal, 368, m336. (doi: 10.1136/bmj.m336) (PMID:32161038) (PMCID:PMC7190046)

Welsh, C. et al. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43(2), pp. 440-445. (doi: 10.2337/dc19-1683) (PMID:31852727)

2019

Ferguson, L. D. , Brown, R., Celis-Morales, C. , Welsh, P. , Lyall, D. M. , Pell, J. P. , McInnes, I. B. , Siebert, S. and Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, 58(12), pp. 2137-2142. (doi: 10.1093/rheumatology/kez192) (PMID:31131407) (PMCID:PMC6880847)

Ferguson, L. , Welsh, P. , Brown, R., Tindell, A., Kerrigan, S., Sattar, N. , McInnes, I. and Siebert, S. (2019) Effect of Phosphodiesterase 4 Inhibition with Apremilast on Cardiometabolic Outcomes in Psoriatic Arthritis – Initial Results from the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) Study. In: 2019 ACR/ARP Annual Meeting, Atlanta, GA, 8-13 November 2019,

Sillars, A. et al. (2019) Association of fitness and grip-strength with heart failure: findings from the UK Biobank population-based study. Mayo Clinic Proceedings, 94(11), pp. 2230-2240. (doi: 10.1016/j.mayocp.2019.04.041) (PMID:31685151)

Muilwijk, M. et al. (2019) Contribution of type 2 diabetes to all-cause mortality, cardiovascular disease incidence and cancer incidence in white Europeans and South Asians: findings from the UK Biobank population-based cohort study. BMJ Open Diabetes Research and Care, 7(1), e000765. (doi: 10.1136/bmjdrc-2019-000765) (PMID:31908795) (PMCID:PMC6936483)

Welsh, C. et al. (2019) Comparison of conventional lipoprotein tests and apolipoproteins in the prediction of cardiovascular disease: data from UK Biobank. Circulation, 140(7), pp. 542-552. (doi: 10.1161/CIRCULATIONAHA.119.041149) (PMID:31216866) (PMCID:PMC6693929)

Budu-Aggrey, A. et al. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Medicine, 16(1), e1002739. (doi: 10.1371/journal.pmed.1002739) (PMID:30703100) (PMCID:PMC6354959)

Ferguson, L. D. , Siebert, S. , McInnes, I. B. and Sattar, N. (2019) Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions. Nature Reviews Rheumatology, 15, pp. 461-474. (doi: 10.1038/s41584-019-0256-0) (PMID:31292564)

2018

Ferguson, L.D. , Ntuk, U.E., Celis-Morales, C. , Mackay, D.F. , Pell, J.P. , Gill, J.M.R. and Sattar, N. (2018) Men across a range of ethnicities have a higher prevalence of diabetes: findings from a cross-sectional study of 500000 UK Biobank participants. Diabetic Medicine, 35(2), pp. 270-276. (doi: 10.1111/dme.13551) (PMID:29171078)

2017

Ferguson, L. D. and Sattar, N. (2017) Impact of obesity on cardiovascular disease. In: Sbraccia, P. and Finer, N. (eds.) Obesity: Pathogenesis, Diagnosis, and Treatment. Series: Endocrinology (4). Springer International Publishing, pp. 1-21. ISBN 9783319476858 (doi: 10.1007/978-3-319-47685-8_25-1)

2015

Ferguson, L. and Sattar, N. (2015) Endothelial function measures: not for clinical prime time? International Journal of Clinical Practice, 69(6), pp. 624-625. (doi: 10.1111/ijcp.12642) (PMID:26010940)

Ferguson, L.D. and Logue, J. (2015) Has IMPROVE-IT improved cardiovascular outcome? Journal of the Royal College of Physicians of Edinburgh, 45(3), pp. 215-217. (PMID:26517102)

2013

Ferguson, L. D. , McKay, G. and Fisher, M. (2013) Bendroflumethiazide. Practical Diabetes, 30(8), 340-341a. (doi: 10.1002/pdi.1808)

Ferguson, L.D. and Sattar, N. (2013) Reducing cardiovascular disease risk in type 2 diabetes: is the focus on glycaemia warranted? Diabetes, Obesity and Metabolism, 15(5), pp. 387-391. (doi: 10.1111/dom.12018)

2011

Ferguson, L.D. , Paterson, T., Ramsay, F., Arrol, K., Dabernig, J., Shaw-Dunn, J. and Morley, S. (2011) Applied anatomy of the latissimus dorsi free flap for refinement in one-stage facial reanimation. Journal of Plastic, Reconstructive and Aesthetic Surgery, 64(11), pp. 1417-1423. (doi: 10.1016/j.bjps.2011.06.013)

Higgins, P., Ferguson, L. D. and Walters, M. R. (2011) Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert Review of Cardiovascular Therapy, 9(4), pp. 399-401. (doi: 10.1586/erc.11.29) (PMID:21517722)

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