Dr Kevin Rattigan

  • Research Fellow (Paul O'Gorman Leukaemia Research Centre)

telephone: 01413302679
email: Kevin.Rattigan@glasgow.ac.uk

Cancer Sciences

Import to contacts

Research interests

Research groups

  • Leukaemia

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2020 | 2018
Number of items: 12.

2024

Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)

Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)

Rattigan, K. M. (2024) Mini review of metabolism in leukaemia: from complexity to the clinic. Frontiers in Hematology, 2, 1353994. (doi: 10.3389/frhem.2023.1353994)

2023

Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)

Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)

Rattigan, K. M., Zarou, M.-M. and Helgason, G. V. (2023) Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity. Blood, 141(21), pp. 2553-2565. (doi: 10.1182/blood.2022018258) (PMID:36634302) (PMCID:PMC10646800)

Woodley, K. et al. (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature Communications, 14, 2132. (doi: 10.1038/s41467-023-37652-0) (PMID:37059720) (PMCID:PMC10104861)

2021

Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)

2020

Rodgers, L. C., Cole, J., Rattigan, K. M., Barrett, M. P. , Kurian, N., McInnes, I. B. and Goodyear, C. S. (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)

2018

Ianniciello, A., Rattigan, K. M. and Helgason, G. V. (2018) The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: food for thought. Frontiers in Cell and Developmental Biology, 6, 120. (doi: 10.3389/fcell.2018.00120) (PMID:30320108) (PMCID:PMC6169402)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Rattigan, K. M., Pountain, A. W. , Regnault, C., Achcar, F. , Vincent, I. M. , Goodyear, C. S. and Barrett, M. P. (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

This list was generated on Wed Apr 23 18:44:06 2025 BST.
Jump to: Articles
Number of items: 12.

Articles

Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)

Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)

Rattigan, K. M. (2024) Mini review of metabolism in leukaemia: from complexity to the clinic. Frontiers in Hematology, 2, 1353994. (doi: 10.3389/frhem.2023.1353994)

Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)

Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)

Rattigan, K. M., Zarou, M.-M. and Helgason, G. V. (2023) Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity. Blood, 141(21), pp. 2553-2565. (doi: 10.1182/blood.2022018258) (PMID:36634302) (PMCID:PMC10646800)

Woodley, K. et al. (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature Communications, 14, 2132. (doi: 10.1038/s41467-023-37652-0) (PMID:37059720) (PMCID:PMC10104861)

Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)

Rodgers, L. C., Cole, J., Rattigan, K. M., Barrett, M. P. , Kurian, N., McInnes, I. B. and Goodyear, C. S. (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)

Ianniciello, A., Rattigan, K. M. and Helgason, G. V. (2018) The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: food for thought. Frontiers in Cell and Developmental Biology, 6, 120. (doi: 10.3389/fcell.2018.00120) (PMID:30320108) (PMCID:PMC6169402)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Rattigan, K. M., Pountain, A. W. , Regnault, C., Achcar, F. , Vincent, I. M. , Goodyear, C. S. and Barrett, M. P. (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

This list was generated on Wed Apr 23 18:44:06 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Validation of a therapeutic enzyme to exploit tyrosine dependency in acute myleoid leukaemia
    Leukaemia UK
    2024 - 2026
     
  • Enzyme therapeutic activity to exploit leukaemia tyrosine dependency
    Medical Research Council
    2024 - 2024
     
  • MRC IAA: Therapeutic enzyme to exploit tyrosine dependency in leukaemia
    Medical Research Council
    2023 - 2023
     
  • Validation of a therapeutic enzyme to exploit tyrosine dependency in leukaemia
    Wellcome Trust
    2023 - 2023
     
  • MRC CiC:Therapeutic enzyme to exploit tyrosine dependency in leukaemia
    Medical Research Council
    2023 - 2023
     
  • Validation of a therapeutic enzyme to exploit tyrosine dependency in leukaemia.
    Beatson Cancer Charity
    2023 - 2024
     
  • Development of therapeutic enzyme to targeting tyrosine dependency in leukaemia
    Tenovus Scotland
    2022 - 2023
     
  • Elucidating metabolomics changes in myeloproliferative neoplasms
    Tenovus Scotland
    2019 - 2020