Dr Jodie Hay
- Research Associate (Paul O'Gorman Leukaemia Research Centre)
telephone:
01413017887
email:
Jodie.Hay@glasgow.ac.uk
Paul O'Gorman Leukaemia Res Centre, Gartnavel General Hospital, 21 Shelly Road, G12 0ZD, Glasgow, G12 0XB
Publications
2022
Hay, J. et al. (2022) PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signalling. Cancers, 14(23), 6006. (doi: 10.3390/cancers14236006) (PMID:36497487) (PMCID:PMC9735720)
2021
Walker, A. S. et al. (2021) Tracking the emergence of SARS-CoV-2 alpha variant in the United Kingdom. New England Journal of Medicine, 385(27), pp. 2582-2585. (doi: 10.1056/NEJMc2103227) (PMID:34879193)
Pouwels, K. B. et al. (2021) Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nature Medicine, 27(12), pp. 2127-2135. (doi: 10.1038/s41591-021-01548-7) (PMID:34650248) (PMCID:PMC8674129)
Wei, J. et al. (2021) Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom. Nature Microbiology, 6(9), pp. 1140-1149. (doi: 10.1038/s41564-021-00947-3) (PMID:34290390) (PMCID:PMC8294260)
Walker, A. S. et al. (2021) Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time. eLife, 10, e64683. (doi: 10.7554/elife.64683) (PMID:34250907) (PMCID:PMC8282332)
Conway, D.I. et al. (2021) SARS-CoV-2 positivity in asymptomatic-screened dental patients. Journal of Dental Research, 100(6), pp. 583-590. (doi: 10.1177/00220345211004849) (PMID:33779355) (PMCID:PMC8138329)
Emary, K. R. W. et al. (2021) Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. Lancet, 397(10282), pp. 1351-1362. (doi: 10.1016/S0140-6736(21)00628-0) (PMID:33798499) (PMCID:PMC8009612)
Pouwels, K. B. et al. (2021) Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey. Lancet Public Health, 6(1), e30-e38. (doi: 10.1016/s2468-2667(20)30282-6) (PMID:33308423) (PMCID:PMC7786000)
2019
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
Malik, N. , Dunn, K. M., Cassels, J., Hay, J. , Estell, C., Sansom, O. J. and Michie, A. M. (2019) mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific Reports, 9, 16917. (doi: 10.1038/s41598-019-53141-1) (PMID:31729420) (PMCID:PMC6858379)
Hay, J. , Moles, M. W., Cassels, J. and Michie, A. M. (2019) Subcellular fractionation of primary chronic lymphocytic leukemia cells to monitor nuclear/ cytoplasmic protein trafficking. Journal of Visualized Experiments(152), e60426. (doi: 10.3791/60426) (PMID:31710039)
Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi: 10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)
Cosimo, E. et al. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25(5), pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036) (PMID:30559170) (PMCID:PMC6398589)
2018
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
2017
Hay, J. F. , Lappin, K., Liberante, F., Kettyle, L. M., Matchett, K. B., Thompson, A. and Mills, K. I. (2017) Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy. Oncotarget, 8(40), pp. 67891-67903. (doi: 10.18632/oncotarget.18910) (PMID:28723639) (PMCID:PMC5620222)
Neil, J. C. , Hay, J. and Borland, G. (2017) RUNX oncoproteins and miRNA networks. Oncotarget, 8(38), pp. 62818-62819. (doi: 10.18632/oncotarget.20673) (PMID:28968950) (PMCID:PMC5609882)
Neil, J. C. , Gilroy, K., Borland, G., Hay, J. , Terry, A. and Kilbey, A. (2017) The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology (962). Springer, pp. 247-264. ISBN 9789811032318 (doi: 10.1007/978-981-10-3233-2_16)
2016
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
2013
McLornan, D., Hay, J. , McLaughlin, K., Holohan, C., Burnett, A. K., Hills, R. K., Johnston, P. G., Mills, K. I., McMullin, M. F. and Longley, D. B. (2013) Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia. British Journal of Haematology, 160(2), pp. 188-198. (doi: 10.1111/bjh.12108) (PMID:23167276)
Articles
Hay, J. et al. (2022) PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signalling. Cancers, 14(23), 6006. (doi: 10.3390/cancers14236006) (PMID:36497487) (PMCID:PMC9735720)
Walker, A. S. et al. (2021) Tracking the emergence of SARS-CoV-2 alpha variant in the United Kingdom. New England Journal of Medicine, 385(27), pp. 2582-2585. (doi: 10.1056/NEJMc2103227) (PMID:34879193)
Pouwels, K. B. et al. (2021) Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nature Medicine, 27(12), pp. 2127-2135. (doi: 10.1038/s41591-021-01548-7) (PMID:34650248) (PMCID:PMC8674129)
Wei, J. et al. (2021) Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom. Nature Microbiology, 6(9), pp. 1140-1149. (doi: 10.1038/s41564-021-00947-3) (PMID:34290390) (PMCID:PMC8294260)
Walker, A. S. et al. (2021) Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time. eLife, 10, e64683. (doi: 10.7554/elife.64683) (PMID:34250907) (PMCID:PMC8282332)
Conway, D.I. et al. (2021) SARS-CoV-2 positivity in asymptomatic-screened dental patients. Journal of Dental Research, 100(6), pp. 583-590. (doi: 10.1177/00220345211004849) (PMID:33779355) (PMCID:PMC8138329)
Emary, K. R. W. et al. (2021) Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. Lancet, 397(10282), pp. 1351-1362. (doi: 10.1016/S0140-6736(21)00628-0) (PMID:33798499) (PMCID:PMC8009612)
Pouwels, K. B. et al. (2021) Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey. Lancet Public Health, 6(1), e30-e38. (doi: 10.1016/s2468-2667(20)30282-6) (PMID:33308423) (PMCID:PMC7786000)
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
Malik, N. , Dunn, K. M., Cassels, J., Hay, J. , Estell, C., Sansom, O. J. and Michie, A. M. (2019) mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific Reports, 9, 16917. (doi: 10.1038/s41598-019-53141-1) (PMID:31729420) (PMCID:PMC6858379)
Hay, J. , Moles, M. W., Cassels, J. and Michie, A. M. (2019) Subcellular fractionation of primary chronic lymphocytic leukemia cells to monitor nuclear/ cytoplasmic protein trafficking. Journal of Visualized Experiments(152), e60426. (doi: 10.3791/60426) (PMID:31710039)
Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi: 10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)
Cosimo, E. et al. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25(5), pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036) (PMID:30559170) (PMCID:PMC6398589)
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
Hay, J. F. , Lappin, K., Liberante, F., Kettyle, L. M., Matchett, K. B., Thompson, A. and Mills, K. I. (2017) Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy. Oncotarget, 8(40), pp. 67891-67903. (doi: 10.18632/oncotarget.18910) (PMID:28723639) (PMCID:PMC5620222)
Neil, J. C. , Hay, J. and Borland, G. (2017) RUNX oncoproteins and miRNA networks. Oncotarget, 8(38), pp. 62818-62819. (doi: 10.18632/oncotarget.20673) (PMID:28968950) (PMCID:PMC5609882)
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
McLornan, D., Hay, J. , McLaughlin, K., Holohan, C., Burnett, A. K., Hills, R. K., Johnston, P. G., Mills, K. I., McMullin, M. F. and Longley, D. B. (2013) Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia. British Journal of Haematology, 160(2), pp. 188-198. (doi: 10.1111/bjh.12108) (PMID:23167276)
Book Sections
Neil, J. C. , Gilroy, K., Borland, G., Hay, J. , Terry, A. and Kilbey, A. (2017) The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology (962). Springer, pp. 247-264. ISBN 9789811032318 (doi: 10.1007/978-981-10-3233-2_16)