Dr Joanna Birch

  • Senior Research Fellow (Therapeutic Science Research)

email: Joanna.Birch@glasgow.ac.uk

RI Cancer Sciences, Wolfson Wohl building, Garscube estate, Switchback Road, G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-9522-8435

Research interests

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2019 | 2018 | 2016 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 16.

2024

Pennel, Kathryn, Dutton, Louise ORCID logoORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID logoORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID logoORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID logoORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26(4), pp. 625-639. (doi: 10.1093/neuonc/noad210) (PMID:37936324) (PMCID:PMC10995506)

2023

Koessinger, D. et al. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5(1), vdad067. (doi: 10.1093/noajnl/vdad067) (PMID:37334166) (PMCID:PMC10276538)

2021

Birch, J. et al. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1) (PMID:37936324)

Al-mubarak, H., Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Gallagher, L., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 and Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030) (PMID:34687852)

2019

Al-Mubarak, H., Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Gallagher, L., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Gilmour, L., Foster, J., Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 and Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, 108372. (doi: 10.1016/j.jneumeth.2019.108372) (PMID:31348965)

Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Al-Mubarak, H.F.I., Birch, J.L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X and Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50(2), pp. 529-540. (doi: 10.1002/jmri.26580) (PMID:30569620)

2018

Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)

2016

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

2012

Harwood, Adrian John, Nuñez-Corcuera, Beatriz, Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Yamada, Yoko and Williams, Jeffrey G. (2012) Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation. PLoS ONE, 7(1), e29895. (doi: 10.1371/journal.pone.0029895) (PMID:22253818) (PMCID:PMC3253789)

2011

Nunez-Corcuera, Beatriz, Birch, Joanna ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Williams, Jeffrey G. (2011) A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning. International Journal of Developmental Biology, 55(2), pp. 205-208. (doi: 10.1387/ijdb.113309bn) (PMID:21671223) (PMCID:PMC3586672)

2010

Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Cui, K., White, R.J. and Zhao, K. (2010) Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes. Nature Structural and Molecular Biology, 17(5), pp. 629-634. (doi: 10.1038/nsmb.1806) (PMID:20418881) (PMCID:PMC2917008)

Kantidakis, Theodoros, Ramsbottom, Ben A., Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Dowding, Sarah N. and White, Robert J. (2010) mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proceedings of the National Academy of Sciences of the United States of America, 107(26), pp. 11823-11828. (doi: 10.1073/pnas.1005188107) (PMID:20543138) (PMCID:PMC2900655)

2009

Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Tan, Bertrand C.-M., Panov, Kostya I., Panova, Tatiana B., Andersen, Jens S., Owen-Hughes, Tom A., Russell, Jackie, Lee, Sheng-Chung and Zomerdijk, Joost C. B. M. (2009) FACT facilitates chromatin transcription by RNA polymerases I and III. EMBO Journal, 28(7), pp. 854-865. (doi: 10.1038/emboj.2009.33) (PMID:19214185) (PMCID:PMC2647773)

2008

Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Zomerdijk, Joost C. B. M. (2008) Structure and function of ribosomal RNA gene chromatin. Biochemical Society Transactions, 36(4), pp. 619-624. (doi: 10.1042/BST0360619) (PMID:18631128) (PMCID:PMC3858719)

This list was generated on Fri Jul 18 07:29:37 2025 BST.
Jump to: Articles
Number of items: 16.

Articles

Pennel, Kathryn, Dutton, Louise ORCID logoORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID logoORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID logoORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID logoORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, 26(4), pp. 625-639. (doi: 10.1093/neuonc/noad210) (PMID:37936324) (PMCID:PMC10995506)

Koessinger, D. et al. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5(1), vdad067. (doi: 10.1093/noajnl/vdad067) (PMID:37334166) (PMCID:PMC10276538)

Birch, J. et al. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1) (PMID:37936324)

Al-mubarak, H., Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Gallagher, L., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 and Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030) (PMID:34687852)

Al-Mubarak, H., Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Gallagher, L., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Gilmour, L., Foster, J., Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 and Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, 108372. (doi: 10.1016/j.jneumeth.2019.108372) (PMID:31348965)

Vallatos, A. ORCID logoORCID: https://orcid.org/0000-0002-5202-056X, Al-Mubarak, H.F.I., Birch, J.L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M. ORCID logoORCID: https://orcid.org/0000-0002-0942-215X and Chalmers, A.J. ORCID logoORCID: https://orcid.org/0000-0002-1746-7278 (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50(2), pp. 529-540. (doi: 10.1002/jmri.26580) (PMID:30569620)

Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Harwood, Adrian John, Nuñez-Corcuera, Beatriz, Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Yamada, Yoko and Williams, Jeffrey G. (2012) Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation. PLoS ONE, 7(1), e29895. (doi: 10.1371/journal.pone.0029895) (PMID:22253818) (PMCID:PMC3253789)

Nunez-Corcuera, Beatriz, Birch, Joanna ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Williams, Jeffrey G. (2011) A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning. International Journal of Developmental Biology, 55(2), pp. 205-208. (doi: 10.1387/ijdb.113309bn) (PMID:21671223) (PMCID:PMC3586672)

Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Cui, K., White, R.J. and Zhao, K. (2010) Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes. Nature Structural and Molecular Biology, 17(5), pp. 629-634. (doi: 10.1038/nsmb.1806) (PMID:20418881) (PMCID:PMC2917008)

Kantidakis, Theodoros, Ramsbottom, Ben A., Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Dowding, Sarah N. and White, Robert J. (2010) mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proceedings of the National Academy of Sciences of the United States of America, 107(26), pp. 11823-11828. (doi: 10.1073/pnas.1005188107) (PMID:20543138) (PMCID:PMC2900655)

Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435, Tan, Bertrand C.-M., Panov, Kostya I., Panova, Tatiana B., Andersen, Jens S., Owen-Hughes, Tom A., Russell, Jackie, Lee, Sheng-Chung and Zomerdijk, Joost C. B. M. (2009) FACT facilitates chromatin transcription by RNA polymerases I and III. EMBO Journal, 28(7), pp. 854-865. (doi: 10.1038/emboj.2009.33) (PMID:19214185) (PMCID:PMC2647773)

Birch, Joanna L. ORCID logoORCID: https://orcid.org/0000-0001-9522-8435 and Zomerdijk, Joost C. B. M. (2008) Structure and function of ribosomal RNA gene chromatin. Biochemical Society Transactions, 36(4), pp. 619-624. (doi: 10.1042/BST0360619) (PMID:18631128) (PMCID:PMC3858719)

This list was generated on Fri Jul 18 07:29:37 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Establishing ex vivo pancreatic cancer cultures for preclinical studies
    Beatson Cancer Charity
    2025 - 2026
     
  • Edinburgh-Glasgow Brain Tumour Centre of Excellence: Advanced Therapies for Glioblastoma
    Brain Tumour Research
    2024 - 2029
     
  • IL6/JAK/STAT3 pathway in colorectal cancer
    Office of the Chief Scientific Adviser
    2023 - 2025
     
  • An investigation into the therapeutic potential of combining radiotherapy and IKK inhibition for rectal cancer patients
    Office of the Chief Scientific Adviser
    2023 - 2025
     
  • Investigating the effect of combining the BCL-XL inhibitor, A1331852, with radiotherapy in a preclinical model of GBM on survival
    Beatson Cancer Charity
    2023 - 2023
     
  • Investigating pro-invasive gene signatures arising from acute irradiation of pancreatic cancer cells
    Cancer Research UK
    2022 - 2022
     
  • Investigating BH3 mimetics as radiosensitising agents in glioblastoma and pancreatic ductal adenocarcinoma
    Cancer Research UK
    2022 - 2022
     
  • Combining Radiation with JAK inhibitors as a novel therapeutic strategy
    Cancer Research UK
    2022 - 2022
     
  • Developing better models of the blood-tumour barrier to enhance drug development for glioblastoma
    Office of the Chief Scientific Adviser
    2021 - 2023
     
  • Targeting radiation driven invasion and metastasis in cancers of unmet need
    Medical Research Council
    2021 - 2024
     
  • Probing the ability of a novel MRCK inhibitor, BDP-0009066, to prolong survival in a pre-clinical model of Glioblastoma
    Cancer Research Technology
    2018 - 2019
     
  • ESTABLISHING INTRAVITAL BRAIN IMAGING IN PRE-CLINICAL MOUSE MODELS
    European Society for Radiation Oncology
    2014 - 2014
     
  • Development Award: Measurement of Small Molecule Pharmacokinetics in invasive Regions of Glioblastoma
    Cancer Research UK
    2014 - 2016