Professor Helen Wheadon
- Professor of Stem Cell Regulation (Paul O'Gorman Leukaemia Research Centre)
telephone:
01413017884
email:
Helen.Wheadon@glasgow.ac.uk
R323 Level 3, Leukaemia Research Centre, Gartnavel General Hospital, Glasgow G11 0YN
Research interests
Research groups
- Cancer Hallmarks to Novel Therapies
- Comprehensive Cancer Models
- Leukaemia
Publications
2024
Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)
Busch, C., Nyamondo, K. and Wheadon, H. (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135, 104233. (doi: 10.1016/j.exphem.2024.104233) (PMID:38740324)
Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)
Nyamondo, K. and Wheadon, H. (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181(2), pp. 283-294. (doi: 10.1111/bph.15924) (PMID:35844165)
2023
Busch, C., Mulholland, T., Zagnoni, M., Dalby, M. , Berry, C. and Wheadon, H. (2023) Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Communication and Signaling, 21, 342. (doi: 10.1186/s12964-023-01363-2) (PMID:38031192) (PMCID:PMC10685629)
Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)
2022
Parry, N., Busch, C., Aßmann, V., Cassels, J., Hair, A., Helgason, G. V. , Wheadon, H. and Copland, M. (2022) BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, 457. (doi: 10.1038/s41420-022-01211-1) (PMID:36379918) (PMCID:PMC9666353)
Pancheva, A., Wheadon, H. , Rogers, S. and Otto, T. D. (2022) Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014) (PMCID:PMC9064087)
2021
Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H. and Copland, M. (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)
Parry, N., Wheadon, H. and Copland, M. (2021) The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, 222. (doi: 10.1038/s41419-021-03500-6) (PMID:33637708) (PMCID:PMC7908010)
2020
McAllister, M., Constancio, V., Patek, S., Gan, H., Bailey, P. , Wheadon, H. , Underwood, M., Leung, H. and Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80(15), pp. 1353-1364. (doi: 10.1002/pros.24064) (PMID:32846021)
Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)
2019
Wheadon, H. and Busch, C. (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)
2018
Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H. , Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)
2017
Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)
Lewis, N. S., Lewis, E. E.L., Mullin, M., Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)
2016
Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R., Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)
Lewis, E. E. L., Wheadon, H. , Lewis, N., Yang, J., Mullin, M., Hursthouse, A., Stirling, D., Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)
Middleton, O., Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi: 10.1016/B978-0-12-374279-7.02014-2)
Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)
2015
Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)
Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)
Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)
2014
Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G. , Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)
Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)
2013
Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)
Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.
Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)
Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)
2011
Wheadon, H. , Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)
2010
Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)
2009
Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)
Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)
2008
Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)
2004
Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)
2003
Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)
Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)
2002
Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)
Articles
Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)
Busch, C., Nyamondo, K. and Wheadon, H. (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135, 104233. (doi: 10.1016/j.exphem.2024.104233) (PMID:38740324)
Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)
Nyamondo, K. and Wheadon, H. (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181(2), pp. 283-294. (doi: 10.1111/bph.15924) (PMID:35844165)
Busch, C., Mulholland, T., Zagnoni, M., Dalby, M. , Berry, C. and Wheadon, H. (2023) Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Communication and Signaling, 21, 342. (doi: 10.1186/s12964-023-01363-2) (PMID:38031192) (PMCID:PMC10685629)
Parry, N., Busch, C., Aßmann, V., Cassels, J., Hair, A., Helgason, G. V. , Wheadon, H. and Copland, M. (2022) BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, 457. (doi: 10.1038/s41420-022-01211-1) (PMID:36379918) (PMCID:PMC9666353)
Pancheva, A., Wheadon, H. , Rogers, S. and Otto, T. D. (2022) Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014) (PMCID:PMC9064087)
Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H. and Copland, M. (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)
Parry, N., Wheadon, H. and Copland, M. (2021) The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, 222. (doi: 10.1038/s41419-021-03500-6) (PMID:33637708) (PMCID:PMC7908010)
McAllister, M., Constancio, V., Patek, S., Gan, H., Bailey, P. , Wheadon, H. , Underwood, M., Leung, H. and Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80(15), pp. 1353-1364. (doi: 10.1002/pros.24064) (PMID:32846021)
Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)
Wheadon, H. and Busch, C. (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)
Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H. , Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)
Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)
Lewis, N. S., Lewis, E. E.L., Mullin, M., Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)
Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)
Lewis, E. E. L., Wheadon, H. , Lewis, N., Yang, J., Mullin, M., Hursthouse, A., Stirling, D., Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)
Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)
Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)
Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)
Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)
Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G. , Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)
Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)
Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)
Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)
Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)
Wheadon, H. , Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)
Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)
Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)
Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)
Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)
Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)
Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)
Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)
Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)
Book Sections
Middleton, O., Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi: 10.1016/B978-0-12-374279-7.02014-2)
Conference or Workshop Item
Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)
Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R., Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Conference Proceedings
Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Targeting MDM2 dimerisation as a novel therapeutic approach for acute myeloid leukaemia
2024 - 2025
- Engineering the bone marrow niche to control stem cell regulation, metastaticevolution and cancer dormancy
2023 - 2028
- Mechanobiology-based medicine - Phase 2
2023 - 2028
- Translating the CML-like Ph+ALL population into clinical practice
2023 - 2026
- CRUK Centre Renewal 2021
2022 - 2023
- Mechanobiology-based medicine
2021 - 2022
- Evaluation of key Biomarkers for the prediction of successful treatment-free remission (TFR) in chronic myeloid leukaemia
2021 - 2024
- Validation of an artificial in vitro humanised 3D haemopoietic system to investigate haematological malignancies.
2021 - 2024
- Transcriptomic and proteomic variation of CML blast phase - a step towards novel targeted therapies
2021 - 2024
- Engineered haematopoietic stem cell niches for disease modelling
2020 - 2020
- Exploring gene expression in individual CML stem cells to predict response to therapy in newly diagnosed patients
2016 - 2017
- Single cell RNA sequencing on primative human leukaemic stem cell population to identify novel biomarkers involved in drug resistance and future immunotherapy
2016 - 2018
- Chronic Myeloid Leukaemia tyrosine kinase inhibitor response classification by quantitative RT-PCR
2015 - 2016
- Validating induced pluripotent stem cells (iPSC) as an acceptable model for pre-clinical drug screening in haematological malignancies
2014 - 2017
- Investigation of JAK2 targets is myeloproliferative disorders
2013 - 2016
- Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
2012 - 2016
- Human embryonic stem cells as a model for understanding transcriptional regulation of Myeloproliferative neoplasms
2011 - 2013