Dr David Bryant
- Reader (Therapeutic Science Research)
telephone:
0141330 8597
email:
David.Bryant@glasgow.ac.uk
CRUK Beatson Institute, Garscube Estate, Switchback Road, G61 1BD
Research interests
Link to research page in CRUK Beatson Institute
Publications
2023
Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115)
Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)
2022
Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)
Roman Fernandez, A. , Sandilands, E. and Bryant, D. M. (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, C. and Wang, J. (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)
2021
Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)
Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)
2020
Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)
2019
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
2018
Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)
Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y. , Bryant, D. M. , Shanks, E. and Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)
Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)
Stehbens, S. J., Ju, R. J., Adams, M. N., Perry, S., Haass, N. K., Bryant, D. M. and Pollock, P. M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)
Bryant, D. (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)
2017
Datta, A., Sandilands, E., Mostov, K. E. and Bryant, D. M. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)
Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M. , Luby-Phelps, K. and Marciano, D. K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Bryant, D. and Johnson, A. (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)
Ruch, T. R., Bryant, D. M. , Mostov, K. E., Engel, J. N. and Yap, A. (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)
2016
Bryant, D. M. and Yap, A. S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)
Roman-Fernandez, A. and Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)
Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M. , Cleaver, O., González-Manchón, C. and Marciano, D. K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)
2015
Overeem, A. W., Bryant, D. M. and van IJzendoorn, S. C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)
2014
Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)
Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)
2012
Apodaca, G., Gallo, L. I. and Bryant, D. M. (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)
Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)
2011
Su, T., Chapin, S. J., Bryant, D. M. , Shewan, A. M., Young, K. and Mostov, K. E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)
Lepanto, P., Bryant, D. M. , Rossello, J., Datta, A., Mostov, K. E. and Kierbel, A. (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)
Marciano, D. K., Brakeman, P. R., Lee, C.-Z., Spivak, N., Eastburn, D. J., Bryant, D. M. , Beaudoin, G. M., Hofmann, I., Mostov, K. E. and Reichardt, L. F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)
Roland, J. T., Bryant, D. M. , Datta, A., Itzen, A., Mostov, K. E. and Goldenring, J. R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)
Datta, A., Bryant, D. M. and Mostov, K. E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)
2010
Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)
Bryant, D. M. , Datta, A., Rodríguez-Fraticelli, A. E., Peränen, J., Martín-Belmonte, F. and Mostov, K. E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)
2008
Bryant, D. M. and Mostov, K. E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)
Yu, W., Shewan, A. M., Brakeman, P., Eastburn, D. J., Datta, A., Bryant, D. M. , Fan, Q.-W., Weiss, W. A., Zegers, M. M.P. and Mostov, K. E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)
2007
Bryant, D. and Mostov, K. (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)
Bryant, D. M. , Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/jcs.000653)
2005
Bryant, D. M., and Stow, J. L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)
Bryant, D. M. , Wylie, F. G. and Stow, J. L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)
2004
Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)
Articles
Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115)
Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)
Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)
Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)
Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)
Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)
Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y. , Bryant, D. M. , Shanks, E. and Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)
Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)
Stehbens, S. J., Ju, R. J., Adams, M. N., Perry, S., Haass, N. K., Bryant, D. M. and Pollock, P. M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)
Bryant, D. (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)
Datta, A., Sandilands, E., Mostov, K. E. and Bryant, D. M. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)
Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M. , Luby-Phelps, K. and Marciano, D. K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Bryant, D. and Johnson, A. (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)
Ruch, T. R., Bryant, D. M. , Mostov, K. E., Engel, J. N. and Yap, A. (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)
Bryant, D. M. and Yap, A. S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)
Roman-Fernandez, A. and Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)
Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M. , Cleaver, O., González-Manchón, C. and Marciano, D. K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)
Overeem, A. W., Bryant, D. M. and van IJzendoorn, S. C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)
Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)
Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)
Apodaca, G., Gallo, L. I. and Bryant, D. M. (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)
Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)
Su, T., Chapin, S. J., Bryant, D. M. , Shewan, A. M., Young, K. and Mostov, K. E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)
Lepanto, P., Bryant, D. M. , Rossello, J., Datta, A., Mostov, K. E. and Kierbel, A. (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)
Marciano, D. K., Brakeman, P. R., Lee, C.-Z., Spivak, N., Eastburn, D. J., Bryant, D. M. , Beaudoin, G. M., Hofmann, I., Mostov, K. E. and Reichardt, L. F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)
Roland, J. T., Bryant, D. M. , Datta, A., Itzen, A., Mostov, K. E. and Goldenring, J. R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)
Datta, A., Bryant, D. M. and Mostov, K. E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)
Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)
Bryant, D. M. , Datta, A., Rodríguez-Fraticelli, A. E., Peränen, J., Martín-Belmonte, F. and Mostov, K. E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)
Bryant, D. M. and Mostov, K. E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)
Yu, W., Shewan, A. M., Brakeman, P., Eastburn, D. J., Datta, A., Bryant, D. M. , Fan, Q.-W., Weiss, W. A., Zegers, M. M.P. and Mostov, K. E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)
Bryant, D. and Mostov, K. (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)
Bryant, D. M. , Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/jcs.000653)
Bryant, D. M., and Stow, J. L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)
Bryant, D. M. , Wylie, F. G. and Stow, J. L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)
Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)
Book Sections
Roman Fernandez, A. , Sandilands, E. and Bryant, D. M. (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, C. and Wang, J. (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- OrgTIP: A transplantable organoid-to-in vivo pipeline for targeting phospholipid metabolism to stop colorectal carcinoma
Medical Research Council
2021 - 2025
- Dissecting the role of the metastasis-promoting protein Podocalyxin
The Royal Society
2017 - 2019
Research datasets
2021
Nászai, M., Bellec, K. , Yu, Y., Román-Fernández, Á., Sandilands, E., Johansson, J., Campbell, A., Norman, J. , Sansom, O. , Bryant, D. and Cordero, J. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis. [Data Collection]