2023

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

2022

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Roman Fernandez, A. , Sandilands, E. and Bryant, D. M. (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, C. and Wang, J. (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)

2021

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

2020

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

2019

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

2018

Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y. , Bryant, D. M. , Shanks, E. and Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

Stehbens, S. J., Ju, R. J., Adams, M. N., Perry, S., Haass, N. K., Bryant, D. M. and Pollock, P. M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)

Bryant, D. (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)

2017

Datta, A., Sandilands, E., Mostov, K. E. and Bryant, D. M. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)

Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M. , Luby-Phelps, K. and Marciano, D. K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Bryant, D. and Johnson, A. (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)

Ruch, T. R., Bryant, D. M. , Mostov, K. E., Engel, J. N. and Yap, A. (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)

2016

Bryant, D. M. and Yap, A. S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)

Roman-Fernandez, A. and Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)

Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M. , Cleaver, O., González-Manchón, C. and Marciano, D. K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)

2015

Overeem, A. W., Bryant, D. M. and van IJzendoorn, S. C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)

2014

Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)

Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)

2012

Apodaca, G., Gallo, L. I. and Bryant, D. M. (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)

Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)

2011

Su, T., Chapin, S. J., Bryant, D. M. , Shewan, A. M., Young, K. and Mostov, K. E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)

Lepanto, P., Bryant, D. M. , Rossello, J., Datta, A., Mostov, K. E. and Kierbel, A. (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)

Marciano, D. K., Brakeman, P. R., Lee, C.-Z., Spivak, N., Eastburn, D. J., Bryant, D. M. , Beaudoin, G. M., Hofmann, I., Mostov, K. E. and Reichardt, L. F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)

Roland, J. T., Bryant, D. M. , Datta, A., Itzen, A., Mostov, K. E. and Goldenring, J. R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)

Datta, A., Bryant, D. M. and Mostov, K. E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)

2010

Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)

Bryant, D. M. , Datta, A., Rodríguez-Fraticelli, A. E., Peränen, J., Martín-Belmonte, F. and Mostov, K. E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)

2008

Bryant, D. M. and Mostov, K. E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)

Yu, W., Shewan, A. M., Brakeman, P., Eastburn, D. J., Datta, A., Bryant, D. M. , Fan, Q.-W., Weiss, W. A., Zegers, M. M.P. and Mostov, K. E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)

2007

Bryant, D. and Mostov, K. (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)

Bryant, D. M. , Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/​jcs.000653)

2005

Bryant, D. M., and Stow, J. L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)

Bryant, D. M. , Wylie, F. G. and Stow, J. L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)

2004

Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)

Articles

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Hewit, K., Sandilands, E., Sanchez Martinez, R., James, D., Leung, H. Y. , Bryant, D. M. , Shanks, E. and Markert, E. K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

Stehbens, S. J., Ju, R. J., Adams, M. N., Perry, S., Haass, N. K., Bryant, D. M. and Pollock, P. M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)

Bryant, D. (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)

Datta, A., Sandilands, E., Mostov, K. E. and Bryant, D. M. (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)

Gao, L., Yang, Z., Hiremath, C., Zimmerman, S. E., Long, B., Brakeman, P. R., Mostov, K. E., Bryant, D. M. , Luby-Phelps, K. and Marciano, D. K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Bryant, D. and Johnson, A. (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)

Ruch, T. R., Bryant, D. M. , Mostov, K. E., Engel, J. N. and Yap, A. (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)

Bryant, D. M. and Yap, A. S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)

Roman-Fernandez, A. and Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)

Yang, Z., Zimmerman, S. E., Tsunezumi, J., Braitsch, C., Trent, C., Bryant, D. M. , Cleaver, O., González-Manchón, C. and Marciano, D. K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)

Overeem, A. W., Bryant, D. M. and van IJzendoorn, S. C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)

Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)

Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)

Apodaca, G., Gallo, L. I. and Bryant, D. M. (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)

Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)

Su, T., Chapin, S. J., Bryant, D. M. , Shewan, A. M., Young, K. and Mostov, K. E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)

Lepanto, P., Bryant, D. M. , Rossello, J., Datta, A., Mostov, K. E. and Kierbel, A. (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)

Marciano, D. K., Brakeman, P. R., Lee, C.-Z., Spivak, N., Eastburn, D. J., Bryant, D. M. , Beaudoin, G. M., Hofmann, I., Mostov, K. E. and Reichardt, L. F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)

Roland, J. T., Bryant, D. M. , Datta, A., Itzen, A., Mostov, K. E. and Goldenring, J. R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)

Datta, A., Bryant, D. M. and Mostov, K. E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)

Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)

Bryant, D. M. , Datta, A., Rodríguez-Fraticelli, A. E., Peränen, J., Martín-Belmonte, F. and Mostov, K. E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)

Bryant, D. M. and Mostov, K. E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)

Yu, W., Shewan, A. M., Brakeman, P., Eastburn, D. J., Datta, A., Bryant, D. M. , Fan, Q.-W., Weiss, W. A., Zegers, M. M.P. and Mostov, K. E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)

Bryant, D. and Mostov, K. (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)

Bryant, D. M. , Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/​jcs.000653)

Bryant, D. M., and Stow, J. L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)

Bryant, D. M. , Wylie, F. G. and Stow, J. L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)

Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)

Book Sections

Roman Fernandez, A. , Sandilands, E. and Bryant, D. M. (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, C. and Wang, J. (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)