Professor David Bryant

  • Professor of Cancer Cell Biology (Therapeutic Science Research)

telephone: 0141330 8597
email: David.Bryant@glasgow.ac.uk
pronouns: He/him/his

CRUK Beatson Institute, Garscube Estate, Switchback Road, G61 1BD

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-2721-5012

Research interests

PROFESSOR DAVID BRYANT

Professor of Cancer Cell Biology (Therapeutic Science Research)

telephone: 0141330 8597
email: David.Bryant@glasgow.ac.uk
pronouns: He/him/his

CRUK Scotland Institute, Garscube Estate, Switchback Road, G61 1BD

https://orcid.org/0000-0003-2721-5012

Research Interests:

Research groups

  • Urological (Prostate/Bladder/Kidney)
  • Colorectal/Lower GI/intestinal/gut microbiome

Link to research page in CRUK Scotland Institute

Introduction

Our lab focuses on a fundamental, yet largely unanswered question: How is the normal organisation of tissue disrupted to allow cells to form disarrayed tumours? Cells of many tissues are polarised. That is that cells collectively form configurations tailored to the needs of a tissue. During tumourigenesis this exquisite organisation is lost. Despite the loss of tissue polarity being an obligate event in cancer progression, we know little about this basic process.

We use mini ‘avatars’ of tumours ex vivo to understand how cells collectively organise. Our efforts are focused on colorectal and prostate cancers. We take two approaches to unravel the complexity of this process: 

1) building new tools to analyse tumour avatars ex vivo, and 
2) identifying the signalling processes that drive collective tumour invasion and metastasis. We collaborate extensively for a multi-disciplinary approach to understand tumour metastasis (Sansom, Blyth, Leung, Miller Labs @ CRUK Scotland Institute).

To develop better tools to understand how tumour cells loose polarity, we have developed cutting-edge, high-content microscopy and computational image analysis of tumour spheroids and organoids, live-imaging how normal cells become tumours. Molecularly, we focus on two pathways: phosphoinositide signalling (including the kinases and phosphatases that produce them, and master regulators of their function: the ARF GTPases), and the role of the metastasis-promoting sialomucin, Podocalyxin. We are particularly interested in how these participate in metastasis.

Our ultimate aim is to investigate such changes in cell polarity as potential future biomarkers of cancer in patients, and possible targets for future therapeutic interventions.

Research Highlights

  • Loss of PTEN in High-Grade Serous Ovarian Cancers unleashes a pro-invasive module, consisting of an ARF GTPase module that governs endocytic recycling of pro-invasive integrins (EMBO J, 2023)
  • The modality through which prostate tumours metastasise is regulated by surface levels of the adhesion protein N-cadherin, controlled by the ARF3 GTPase (JCB, 2023)
  • The sialomucin Podocalyxin drives metastasis by acting as a decoy receptor to remove the function of otherwise invasion-inhibiting proteins (Science Advances 2023)
  • Development of a machine-learning and live-imaging based methodology for detecting heterogeneity in 3D culture (Nat Comms, 2022)
  • An ARF GTPase pathway amplified in cancer patients controls key lipid (phosphatidylinositol-phosphate) signalling to drive metastasis (Nat Comms, 2021)
  • Identification of the key lipid (phosphatidylinositol-phosphate) metabolic pathways that control the formation of an apical surface. This defined that PI(3,4)P2 is a determinant of apical identity (Nat Comms, 2018)

 

 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2004
Number of items: 45.

2024

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (Ed.) (2024) Special Issue – Cell and Tissue Polarity. Journal of Cell Science. 137(5) [Edited Journal]

2023

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2023) We are the system. Journal of Cell Science, 136(24), jcs261864. (doi: 10.1242/jcs.261864) (PMID:38158843)

Neilson, L. J. et al. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, 100136. (doi: 10.1016/j.mbplus.2023.100136) (PMID:38223308) (PMCID:PMC10784634)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Nikolatou, Konstantina ORCID logoORCID: https://orcid.org/0000-0002-5626-3390, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Sandilands, Emma (2023) The ARF GTPase regulatory network in collective invasion and metastasis. Biochemical Society Transactions, 51(4), pp. 1559-1569. (doi: 10.1042/BST20221355) (PMID:37622523) (PMCID:PMC10586773)

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115) (PMID:36880595) (PMCID:PMC9997661)

2022

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Roman Fernandez, Alvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460, Sandilands, Emma and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, Chenbei and Wang, Jianbo (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)

2021

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

2020

Millar, Rhona, Kilbey, Anna, Remak, Sarah-Jane, Severson, Tesa M., Dhayade, Sandeep, Sandilands, Emma, Foster, Kyla, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X and Coffelt, Seth B. ORCID logoORCID: https://orcid.org/0000-0003-2257-2862 (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

2019

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

2018

Román-Fernández, Álvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460, Roignot, Julie, Sandilands, Emma, Nacke, Marisa, Mansour, Mohammed A., McGarry, Lynn, Shanks, Emma, Mostov, Keith E. and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Hewit, Kay, Sandilands, Emma, Sanchez Martinez, Rafael, James, Daniel, Leung, Hing Y. ORCID logoORCID: https://orcid.org/0000-0002-3933-3975, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Shanks, Emma and Markert, Elke K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

Stehbens, Samantha J., Ju, Robert J., Adams, Mark N., Perry, Samuel, Haass, Nikolas K., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Pollock, Pamela M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)

2017

Datta, Anirban, Sandilands, Emma, Mostov, Keith E. and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)

Gao, Lei, Yang, Zhufeng, Hiremath, Chitkale, Zimmerman, Susan E., Long, Blake, Brakeman, Paul R., Mostov, Keith E., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Luby-Phelps, Katherine and Marciano, Denise K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Johnson, Aaron (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)

Ruch, Travis R., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Mostov, Keith E., Engel, Joanne N. and Yap, Alpha (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)

2016

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Yap, Alpha S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)

Roman-Fernandez, Alvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460 and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)

Yang, Zhufeng, Zimmerman, Susan E., Tsunezumi, Jun, Braitsch, Caitlin, Trent, Cary, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Cleaver, Ondine, González-Manchón, Consuelo and Marciano, Denise K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)

2015

Overeem, Arend W., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and van IJzendoorn, Sven C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)

2014

Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)

Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)

2012

Apodaca, Gerard, Gallo, Luciana I. and Bryant, David M ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)

Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)

2011

Su, Tao, Chapin, Steven J., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Shewan, Annette M, Young, Kitty and Mostov, Keith E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)

Lepanto, Paola, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Rossello, Jéssica, Datta, Anirban, Mostov, Keith E and Kierbel, Arlinet (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)

Marciano, Denise K., Brakeman, Paul R., Lee, Chao-Zong, Spivak, Natalie, Eastburn, Dennis J., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Beaudoin, Gerard M., Hofmann, Ilse, Mostov, Keith E. and Reichardt, Louis F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)

Roland, Joseph T., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Datta, Anirban, Itzen, Aymelt, Mostov, Keith E. and Goldenring, James R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)

Datta, Anirban, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)

2010

Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Datta, Anirban, Rodríguez-Fraticelli, Alejo E., Peränen, Johan, Martín-Belmonte, Fernando and Mostov, Keith E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)

2008

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)

Yu, Wei, Shewan, Annette M., Brakeman, Paul, Eastburn, Dennis J., Datta, Anirban, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Fan, Qi-Wen, Weiss, William A., Zegers, Mirjam M.P. and Mostov, Keith E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)

2007

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Kerr, Markus C., Hammond, Luke A., Joseph, Shannon R., Mostov, Keith E., Teasdale, Rohan D. and Stow, Jennifer L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/​jcs.000653)

2005

Bryant, David M, ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Stow, Jennifer L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Wylie, Fiona G. and Stow, Jennifer L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)

2004

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Stow, Jennifer L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)

This list was generated on Sun Jun 15 09:53:28 2025 BST.
Jump to: Articles | Book Sections | Edited Journals
Number of items: 45.

Articles

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2023) We are the system. Journal of Cell Science, 136(24), jcs261864. (doi: 10.1242/jcs.261864) (PMID:38158843)

Neilson, L. J. et al. (2023) Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment. Matrix Biology Plus, 19-20, 100136. (doi: 10.1016/j.mbplus.2023.100136) (PMID:38223308) (PMCID:PMC10784634)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Nikolatou, Konstantina ORCID logoORCID: https://orcid.org/0000-0002-5626-3390, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Sandilands, Emma (2023) The ARF GTPase regulatory network in collective invasion and metastasis. Biochemical Society Transactions, 51(4), pp. 1559-1569. (doi: 10.1042/BST20221355) (PMID:37622523) (PMCID:PMC10586773)

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115) (PMID:36880595) (PMCID:PMC9997661)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Millar, Rhona, Kilbey, Anna, Remak, Sarah-Jane, Severson, Tesa M., Dhayade, Sandeep, Sandilands, Emma, Foster, Kyla, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X and Coffelt, Seth B. ORCID logoORCID: https://orcid.org/0000-0003-2257-2862 (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)

Román-Fernández, Álvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460, Roignot, Julie, Sandilands, Emma, Nacke, Marisa, Mansour, Mohammed A., McGarry, Lynn, Shanks, Emma, Mostov, Keith E. and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Hewit, Kay, Sandilands, Emma, Sanchez Martinez, Rafael, James, Daniel, Leung, Hing Y. ORCID logoORCID: https://orcid.org/0000-0002-3933-3975, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Shanks, Emma and Markert, Elke K. (2018) A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death and Disease, 9(11), 1069. (doi: 10.1038/s41419-018-1115-7) (PMID:30341281) (PMCID:PMC6195526)

Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)

Stehbens, Samantha J., Ju, Robert J., Adams, Mark N., Perry, Samuel, Haass, Nikolas K., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Pollock, Pamela M. (2018) FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models. Journal of Cell Science, 131, jcs213678. (doi: 10.1242/jcs.213678) (PMID:30002137)

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2018) Cell scientist to watch−David Bryant. Journal of Cell Science, 131(1), jcs213181. (doi: 10.1242/jcs.213181)

Datta, Anirban, Sandilands, Emma, Mostov, Keith E. and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2017) Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cellular Signalling, 40, pp. 91-98. (doi: 10.1016/j.cellsig.2017.09.001) (PMID:28888686)

Gao, Lei, Yang, Zhufeng, Hiremath, Chitkale, Zimmerman, Susan E., Long, Blake, Brakeman, Paul R., Mostov, Keith E., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Luby-Phelps, Katherine and Marciano, Denise K. (2017) Afadin orients cell division to position the tubule lumen in developing renal tubules. Development, 144(19), pp. 3511-3520. (doi: 10.1242/dev.148908) (PMID:28860115) (PMCID:PMC5665479)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Johnson, Aaron (2017) Meeting report - Intercellular interactions in context: towards a mechanistic understanding of cells in organs. Journal of Cell Science, 130(13), pp. 2083-2085. (doi: 10.1242/jcs.205740) (PMID:28738319)

Ruch, Travis R., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Mostov, Keith E., Engel, Joanne N. and Yap, Alpha (2017) Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Molecular Biology of the Cell, 28(2), pp. 252-260. (doi: 10.1091/mbc.E16-07-0541) (PMID:27881661)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Yap, Alpha S. (2016) Editorial overview: Membrane traffic and cell polarity. Traffic, 17(12), pp. 1231-1232. (doi: 10.1111/tra.12433) (PMID:27885792)

Roman-Fernandez, Alvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460 and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)

Yang, Zhufeng, Zimmerman, Susan E., Tsunezumi, Jun, Braitsch, Caitlin, Trent, Cary, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Cleaver, Ondine, González-Manchón, Consuelo and Marciano, Denise K. (2016) Role of CD34 family members in lumen formation in the developing kidney. Developmental Biology, 418(1), pp. 66-74. (doi: 10.1016/j.ydbio.2016.08.009) (PMID:27542690)

Overeem, Arend W., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and van IJzendoorn, Sven C.D. (2015) Mechanisms of apical–basal axis orientation and epithelial lumen positioning. Trends in Cell Biology, 25(8), pp. 476-485. (doi: 10.1016/j.tcb.2015.04.002) (PMID:25941134)

Bryant, D. M. et al. (2014) A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, 31(2), pp. 171-187. (doi: 10.1016/j.devcel.2014.08.027) (PMID:25307480) (PMCID:PMC4248238)

Tran, C. S. et al. (2014) Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host and Microbe, 15(5), pp. 636-643. (doi: 10.1016/j.chom.2014.04.007) (PMID:24832456) (PMCID:PMC4062193)

Apodaca, Gerard, Gallo, Luciana I. and Bryant, David M ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2012) Role of membrane traffic in the generation of epithelial cell asymmetry. Nature Cell Biology, 14(12), pp. 1235-1243. (doi: 10.1038/ncb2635)

Gálvez-Santisteban, M. et al. (2012) Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nature Cell Biology, 14(8), pp. 838-849. (doi: 10.1038/ncb2541) (PMID:22820376) (PMCID:PMC3433678)

Su, Tao, Chapin, Steven J., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Shewan, Annette M, Young, Kitty and Mostov, Keith E. (2011) Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. Journal of Biological Chemistry, 286(52), pp. 44921-44925. (doi: 10.1074/jbc.M111.296731)

Lepanto, Paola, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Rossello, Jéssica, Datta, Anirban, Mostov, Keith E and Kierbel, Arlinet (2011) Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cellular Microbiology, 13(8), pp. 1212-1222. (doi: 10.1111/j.1462-5822.2011.01611.x)

Marciano, Denise K., Brakeman, Paul R., Lee, Chao-Zong, Spivak, Natalie, Eastburn, Dennis J., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Beaudoin, Gerard M., Hofmann, Ilse, Mostov, Keith E. and Reichardt, Louis F. (2011) p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138(10), pp. 2099-2109. (doi: 10.1242/dev.056564) (PMID:21521738) (PMCID:PMC3082309)

Roland, Joseph T., Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Datta, Anirban, Itzen, Aymelt, Mostov, Keith E. and Goldenring, James R. (2011) Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 2789-2794. (doi: 10.1073/pnas.1010754108)

Datta, Anirban, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith E. (2011) Molecular regulation of lumen morphogenesis. Current Biology, 21(3), R126-R136. (doi: 10.1016/j.cub.2010.12.003)

Su, T. et al. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology, 12(12), pp. 1143-1153. (doi: 10.1038/ncb2118)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Datta, Anirban, Rodríguez-Fraticelli, Alejo E., Peränen, Johan, Martín-Belmonte, Fernando and Mostov, Keith E. (2010) A molecular network for de novo generation of the apical surface and lumen. Nature Cell Biology, 12(11), pp. 1035-1045. (doi: 10.1038/ncb2106)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith E. (2008) From cells to organs: building polarized tissue. Nature Reviews Molecular Cell Biology, 9(11), pp. 887-901. (doi: 10.1038/nrm2523)

Yu, Wei, Shewan, Annette M., Brakeman, Paul, Eastburn, Dennis J., Datta, Anirban, Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Fan, Qi-Wen, Weiss, William A., Zegers, Mirjam M.P. and Mostov, Keith E. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Reports, 9(9), pp. 923-929. (doi: 10.1038/embor.2008.135)

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Mostov, Keith (2007) Development: inflationary pressures. Nature, 449(7162), pp. 549-550. (doi: 10.1038/449549a)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Kerr, Markus C., Hammond, Luke A., Joseph, Shannon R., Mostov, Keith E., Teasdale, Rohan D. and Stow, Jennifer L. (2007) EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120(10), pp. 1818-1828. (doi: 10.1242/​jcs.000653)

Bryant, David M, ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Stow, Jennifer L. (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic, 6(10), pp. 947-953. (doi: 10.1111/j.1600-0854.2005.00332.x)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012, Wylie, Fiona G. and Stow, Jennifer L. (2005) Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of the Cell, 16(1), pp. 14-23. (doi: 10.1091/mbc.E04-09-0845)

Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 and Stow, Jennifer L. (2004) The ins and outs of E-cadherin trafficking. Trends in Cell Biology, 14(8), pp. 427-34. (doi: 10.1016/j.tcb.2004.07.007)

Book Sections

Roman Fernandez, Alvaro ORCID logoORCID: https://orcid.org/0000-0002-5032-3460, Sandilands, Emma and Bryant, David M. ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (2022) The use of three-dimensional cell culture to study apicobasal polarization and lumen formation. In: Chang, Chenbei and Wang, Jianbo (eds.) Cell Polarity Signaling. Series: Methods in Molecular Biology (2438). Springer, pp. 439-454. ISBN 9781071620342 (doi: 10.1007/978-1-0716-2035-9_25)

Edited Journals

Bryant, David ORCID logoORCID: https://orcid.org/0000-0003-2721-5012 (Ed.) (2024) Special Issue – Cell and Tissue Polarity. Journal of Cell Science. 137(5) [Edited Journal]

This list was generated on Sun Jun 15 09:53:28 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • OrgTIP: A transplantable organoid-to-in vivo pipeline for targeting phospholipid metabolism to stop colorectal carcinoma
    Medical Research Council
    2021 - 2025
     
  • Dissecting the role of the metastasis-promoting protein Podocalyxin
    The Royal Society
    2017 - 2019
     

Research datasets

Jump to: 2021
Number of items: 1.

2021

Nászai, M., Bellec, K. , Yu, Y., Román-Fernández, Á., Sandilands, E., Johansson, J., Campbell, A., Norman, J. , Sansom, O. , Bryant, D. and Cordero, J. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis. [Data Collection]

This list was generated on Sun Jun 15 13:05:59 2025 BST.

David Bryant