Professor Daniel Murphy
- Professor of Lung Cancer & Mesothelioma (Therapeutic Science Research)
telephone:
01413308710
email:
Daniel.Murphy@glasgow.ac.uk
Institute of Cancer Sciences, CRUK Beatson Institute, Garscube Estate, Bearsden, G61 1BD
Publications
2023
Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w) (PMID:37100955) (PMCID:PMC10130819)
Whyte, D. et al. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, (doi: 10.1002/1878-0261.13425) (PMID:36975767) (Early Online Publication)
Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)
2022
Yanchus, C. et al. (2022) A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science, 378(6615), pp. 68-78. (doi: 10.1126/science.abj2890) (PMID:36201590) (PMCID:PMC9926876)
Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)
2021
Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, 4920. (doi: 10.1038/s41467-021-25173-7) (PMID:34389715) (PMCID:PMC8363647)
Yun, S. et al. (2021) TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia. Blood Cancer Discovery, 2(2), pp. 162-185. (doi: 10.1158/2643-3230.bcd-20-0029) (PMID:33860275) (PMCID:PMC8043621)
2020
Rodrigues, F. S., Miranda, V. S., Carneiro-Lobo, T. C., Scalabrini, L. C., Kruspig, B., Levantini, E., Murphy, D. J. and Bassères, D. S. (2020) IKKβ kinase promotes stemness, migration, and invasion in KRAS-driven lung adenocarcinoma cells. International Journal of Molecular Sciences, 21(16), 5806. (doi: 10.3390/ijms21165806) (PMID:32823550) (PMCID:PMC7460870)
Muthalagu, N. et al. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10(6), pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620) (PMID:32200350) (PMCID:PMC7611248)
2019
Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29(5), 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056) (PMID:31665640) (PMCID:PMC6886125)
Neidler, S. et al. (2019) Identification of a clinically relevant signature for early progression in KRAS-driven lung adenocarcinoma. Cancers, 11(5), 600. (doi: 10.3390/cancers11050600) (PMID:31032816) (PMCID:PMC6562816)
Scopelliti, A., Bauer, C. , Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J. , Vidal, M., Maddocks, O. D.K. and Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29(2), 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021) (PMID:30344016) (PMCID:PMC6370946)
2018
Muthalagu, N. and Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel? Cell Death and Differentiation, 25(7), pp. 1189-1190. (doi: 10.1038/s41418-018-0117-4) (PMID:29844569) (PMCID:PMC6030217)
Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636) (PMCID:PMC6881183)
Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)
Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J. and Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi: 10.1038/onc.2017.394) (PMID:29106388)
Blyth, K. G. and Murphy, D. J. (2018) Progress and challenges in Mesothelioma: from bench to bedside. Respiratory Medicine, 134, pp. 31-41. (doi: 10.1016/j.rmed.2017.11.015)
2017
Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)
Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, 1728. (doi: 10.1038/s41467-017-01967-6) (PMID:29170413) (PMCID:PMC5701042)
Port, J. and Murphy, D. J. (2017) Mesothelioma: identical routes to malignancy from asbestos and carbon nanotubes. Current Biology, 27(21), R1173-R1176. (doi: 10.1016/j.cub.2017.07.026) (PMID:29112873)
Murphy, D. J. and Blyth, K. G. (2017) Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution'. Cell Death and Differentiation, 24(9), pp. 1473-1474. (doi: 10.1038/cdd.2017.97) (PMID:28622291)
Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)
Sarosiek, K. A. et al. (2017) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell, 31(1), pp. 142-156. (doi: 10.1016/j.ccell.2016.11.011) (PMID:28017613) (PMCID:PMC5363285)
Iltzsche, F. et al. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, 36(1), pp. 110-121. (doi: 10.1038/onc.2016.181) (PMID:27212033)
2015
Bott, A. J. et al. (2015) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism, 22(6), pp. 1068-1077. (doi: 10.1016/j.cmet.2015.09.025) (PMID:26603296) (PMCID:PMC4670565)
Monteverde, T., Muthalagu, N., Port, J. and Murphy, D. (2015) Evidence of cancer-promoting roles for AMPK and related kinases. FEBS Journal, 282(24), pp. 4658-4671. (doi: 10.1111/febs.13534) (PMID:26426570)
Neidler, S. and Murphy, D. J. (2015) Studying lung cancer progression: insights from genetically engineered mouse models of cancer. Lung Cancer Management, 4(4), pp. 155-157. (doi: 10.2217/lmt.15.18)
Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi: 10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)
Leikam, C. et al. (2015) In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells. Cell Death and Disease, 6(4), e1711. (doi: 10.1038/cddis.2015.71) (PMID:25837487)
Murphy, D. J. and Muthalagu, N. (2015) BIM's up first. Molecular and Cellular Oncology, 2(2), e975083. (doi: 10.4161/23723556.2014.975083)
2014
Kamphorst, J. J. and Murphy, D. J. (2014) The 2014 Beatson International Cancer Conference: Powering the Cancer Machine. Cancer and Metabolism, 2(1), 25. (doi: 10.1186/2049-3002-2-25)
Muthalagu, N., Junttila, M. R., Wiese, K. E., Wolf, E., Morton, J. , Bauer, B., Evan, G. I., Eilers, M. and Murphy, D. J. (2014) BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell Reports, 8(5), pp. 1347-1353. (doi: 10.1016/j.celrep.2014.07.057)
2013
Bommert, K.S. et al. (2013) The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. Leukemia, 27(2), pp. 441-450. (doi: 10.1038/leu.2012.185)
2012
Liu, L. et al. (2012) Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature, 483(7391), pp. 608-612. (doi: 10.1038/nature10927)
2009
Khanna, A. et al. (2009) MYC-dependent regulation and prognostic role of cip2a in gastric cancer. Journal of the National Cancer Institute, 101(11), pp. 793-805. (doi: 10.1093/jnci/djp103)
2008
Murphy, D.J. , Junttila, M.R., Pouyet, L., Karnezis, A., Shchors, K., Bui, D.A., Brown-Swigart, L., Johnson, L. and Evan, G.I. (2008) Distinct thresholds govern Myc's biological output In vivo. Cancer Cell, 14(6), pp. 447-457. (doi: 10.1016/j.ccr.2008.10.018)
Soucek, L., Whitfield, J., Martins, C.P., Finch, A.J., Murphy, D.J. , Sodir, N.M., Karnezis, A.N., Swigart, L.B., Nasi, S. and Evan, G.I. (2008) Modelling Myc inhibition as a cancer therapy. Nature, 455(7213), pp. 679-683. (doi: 10.1038/nature07260)
Golipour, A., Myers, D., Seagroves, T., Murphy, D. , Evan, G.I., Donoghue, D.J., Moorehead, R.A. and Porter, L.A. (2008) The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Research, 68(10), pp. 3591-3600. (doi: 10.1158/0008-5472.CAN-07-6453)
Rao, M. et al. (2008) Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle, 7(5), pp. 647-655. (doi: 10.4161/cc.7.5.5446)
2005
Evan, G.I., Christophorou, M., Lawlor, E.A., Ringshausen, I., Prescott, J., Dansen, T., Finch, A., Martins, C. and Murphy, D. (2005) Oncogene-dependent tumor suppression: using the dark side of the force for cancer therapy. Cold Spring Harbor Symposia on Quantitative Biology, 70, pp. 263-273. (doi: 10.1101/sqb.2005.70.054)
2004
Flores, I., Murphy, D.J. , Swigart, L.B., Knies, U. and Evan, G.I. (2004) Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene, 23(35), pp. 5923-5930. (doi: 10.1038/sj.onc.1207796)
Murphy, D.J. , Swigart, L.B., Israel, M.A. and Evan, G.I. (2004) Id2 is dispensable for myc-induced epidermal neoplasia. Molecular and Cellular Biology, 24(5), pp. 2083-2090. (doi: 10.1128/MCB.24.5.2083-2090.2004)
2001
Deeble, P.D., Murphy, D.J. , Parsons, S.J. and Cox, M.E. (2001) Interleukin-6- and cyclic amp-mediated signaling potentiates neuroendocrine differentiation of lncap prostate tumor cells. Molecular and Cellular Biology, 21(24), pp. 8471-8482. (doi: 10.1128/MCB.21.24.8471-8482.2001)
1999
Murphy, D.J. , Hardy, S. and Engel, D.A. (1999) Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Molecular and Cellular Biology, 19(4), pp. 2724-33.
Articles
Vitale, I. et al. (2023) Apoptotic cell death in disease—current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), pp. 1097-1154. (doi: 10.1038/s41418-023-01153-w) (PMID:37100955) (PMCID:PMC10130819)
Whyte, D. et al. (2023) NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. Molecular Oncology, (doi: 10.1002/1878-0261.13425) (PMID:36975767) (Early Online Publication)
Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)
Yanchus, C. et al. (2022) A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science, 378(6615), pp. 68-78. (doi: 10.1126/science.abj2890) (PMID:36201590) (PMCID:PMC9926876)
Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)
Marini, A. et al. (2021) The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature Communications, 12, 4920. (doi: 10.1038/s41467-021-25173-7) (PMID:34389715) (PMCID:PMC8363647)
Yun, S. et al. (2021) TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia. Blood Cancer Discovery, 2(2), pp. 162-185. (doi: 10.1158/2643-3230.bcd-20-0029) (PMID:33860275) (PMCID:PMC8043621)
Rodrigues, F. S., Miranda, V. S., Carneiro-Lobo, T. C., Scalabrini, L. C., Kruspig, B., Levantini, E., Murphy, D. J. and Bassères, D. S. (2020) IKKβ kinase promotes stemness, migration, and invasion in KRAS-driven lung adenocarcinoma cells. International Journal of Molecular Sciences, 21(16), 5806. (doi: 10.3390/ijms21165806) (PMID:32823550) (PMCID:PMC7460870)
Muthalagu, N. et al. (2020) Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma. Cancer Discovery, 10(6), pp. 872-887. (doi: 10.1158/2159-8290.CD-19-0620) (PMID:32200350) (PMCID:PMC7611248)
Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29(5), 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056) (PMID:31665640) (PMCID:PMC6886125)
Neidler, S. et al. (2019) Identification of a clinically relevant signature for early progression in KRAS-driven lung adenocarcinoma. Cancers, 11(5), 600. (doi: 10.3390/cancers11050600) (PMID:31032816) (PMCID:PMC6562816)
Scopelliti, A., Bauer, C. , Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J. , Vidal, M., Maddocks, O. D.K. and Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29(2), 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021) (PMID:30344016) (PMCID:PMC6370946)
Muthalagu, N. and Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel? Cell Death and Differentiation, 25(7), pp. 1189-1190. (doi: 10.1038/s41418-018-0117-4) (PMID:29844569) (PMCID:PMC6030217)
Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636) (PMCID:PMC6881183)
Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)
Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J. and Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi: 10.1038/onc.2017.394) (PMID:29106388)
Blyth, K. G. and Murphy, D. J. (2018) Progress and challenges in Mesothelioma: from bench to bedside. Respiratory Medicine, 134, pp. 31-41. (doi: 10.1016/j.rmed.2017.11.015)
Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)
Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8, 1728. (doi: 10.1038/s41467-017-01967-6) (PMID:29170413) (PMCID:PMC5701042)
Port, J. and Murphy, D. J. (2017) Mesothelioma: identical routes to malignancy from asbestos and carbon nanotubes. Current Biology, 27(21), R1173-R1176. (doi: 10.1016/j.cub.2017.07.026) (PMID:29112873)
Murphy, D. J. and Blyth, K. G. (2017) Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution'. Cell Death and Differentiation, 24(9), pp. 1473-1474. (doi: 10.1038/cdd.2017.97) (PMID:28622291)
Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)
Sarosiek, K. A. et al. (2017) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell, 31(1), pp. 142-156. (doi: 10.1016/j.ccell.2016.11.011) (PMID:28017613) (PMCID:PMC5363285)
Iltzsche, F. et al. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene, 36(1), pp. 110-121. (doi: 10.1038/onc.2016.181) (PMID:27212033)
Bott, A. J. et al. (2015) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism, 22(6), pp. 1068-1077. (doi: 10.1016/j.cmet.2015.09.025) (PMID:26603296) (PMCID:PMC4670565)
Monteverde, T., Muthalagu, N., Port, J. and Murphy, D. (2015) Evidence of cancer-promoting roles for AMPK and related kinases. FEBS Journal, 282(24), pp. 4658-4671. (doi: 10.1111/febs.13534) (PMID:26426570)
Neidler, S. and Murphy, D. J. (2015) Studying lung cancer progression: insights from genetically engineered mouse models of cancer. Lung Cancer Management, 4(4), pp. 155-157. (doi: 10.2217/lmt.15.18)
Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi: 10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)
Leikam, C. et al. (2015) In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells. Cell Death and Disease, 6(4), e1711. (doi: 10.1038/cddis.2015.71) (PMID:25837487)
Murphy, D. J. and Muthalagu, N. (2015) BIM's up first. Molecular and Cellular Oncology, 2(2), e975083. (doi: 10.4161/23723556.2014.975083)
Kamphorst, J. J. and Murphy, D. J. (2014) The 2014 Beatson International Cancer Conference: Powering the Cancer Machine. Cancer and Metabolism, 2(1), 25. (doi: 10.1186/2049-3002-2-25)
Muthalagu, N., Junttila, M. R., Wiese, K. E., Wolf, E., Morton, J. , Bauer, B., Evan, G. I., Eilers, M. and Murphy, D. J. (2014) BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell Reports, 8(5), pp. 1347-1353. (doi: 10.1016/j.celrep.2014.07.057)
Bommert, K.S. et al. (2013) The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. Leukemia, 27(2), pp. 441-450. (doi: 10.1038/leu.2012.185)
Liu, L. et al. (2012) Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature, 483(7391), pp. 608-612. (doi: 10.1038/nature10927)
Khanna, A. et al. (2009) MYC-dependent regulation and prognostic role of cip2a in gastric cancer. Journal of the National Cancer Institute, 101(11), pp. 793-805. (doi: 10.1093/jnci/djp103)
Murphy, D.J. , Junttila, M.R., Pouyet, L., Karnezis, A., Shchors, K., Bui, D.A., Brown-Swigart, L., Johnson, L. and Evan, G.I. (2008) Distinct thresholds govern Myc's biological output In vivo. Cancer Cell, 14(6), pp. 447-457. (doi: 10.1016/j.ccr.2008.10.018)
Soucek, L., Whitfield, J., Martins, C.P., Finch, A.J., Murphy, D.J. , Sodir, N.M., Karnezis, A.N., Swigart, L.B., Nasi, S. and Evan, G.I. (2008) Modelling Myc inhibition as a cancer therapy. Nature, 455(7213), pp. 679-683. (doi: 10.1038/nature07260)
Golipour, A., Myers, D., Seagroves, T., Murphy, D. , Evan, G.I., Donoghue, D.J., Moorehead, R.A. and Porter, L.A. (2008) The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Research, 68(10), pp. 3591-3600. (doi: 10.1158/0008-5472.CAN-07-6453)
Rao, M. et al. (2008) Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle, 7(5), pp. 647-655. (doi: 10.4161/cc.7.5.5446)
Evan, G.I., Christophorou, M., Lawlor, E.A., Ringshausen, I., Prescott, J., Dansen, T., Finch, A., Martins, C. and Murphy, D. (2005) Oncogene-dependent tumor suppression: using the dark side of the force for cancer therapy. Cold Spring Harbor Symposia on Quantitative Biology, 70, pp. 263-273. (doi: 10.1101/sqb.2005.70.054)
Flores, I., Murphy, D.J. , Swigart, L.B., Knies, U. and Evan, G.I. (2004) Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene, 23(35), pp. 5923-5930. (doi: 10.1038/sj.onc.1207796)
Murphy, D.J. , Swigart, L.B., Israel, M.A. and Evan, G.I. (2004) Id2 is dispensable for myc-induced epidermal neoplasia. Molecular and Cellular Biology, 24(5), pp. 2083-2090. (doi: 10.1128/MCB.24.5.2083-2090.2004)
Deeble, P.D., Murphy, D.J. , Parsons, S.J. and Cox, M.E. (2001) Interleukin-6- and cyclic amp-mediated signaling potentiates neuroendocrine differentiation of lncap prostate tumor cells. Molecular and Cellular Biology, 21(24), pp. 8471-8482. (doi: 10.1128/MCB.21.24.8471-8482.2001)
Murphy, D.J. , Hardy, S. and Engel, D.A. (1999) Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Molecular and Cellular Biology, 19(4), pp. 2724-33.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Differential Expression in Bystander Transcriptomes for Mesothelioma Diagnosis: DEBiT-Meso
British Lung Foundation
2022 - 2025
- Using complex state of the art mouse models of cancer to improve the understanding and treatment of human cancer
Medical Research Council
2022 - 2027
- CRUK Centre Renewal 2021
Cancer Research UK
2022 - 2023
- IAMMED-Meso: Integrated analysis in man and mouse for early detection of Mesothelioma
Cancer Research UK
2022 - 2027
- PREDICT-Meso Collaboration on therapeutic intervention in Mesothelioma (QUB-Wilson)
Queen`s University Belfast
2021 - 2022
- Generation of a unique Glasgow RadNet multimodality molecular imaging dataset measuring dynamic immunometabolic phenotypes during radiotherapy in mouse models of lung cancer
Cancer Research UK
2021 - 2022
- Drug repurposing for mesothelioma prevention: assessment of efficacy in a novel asbestos-accelerated mouse model of human disease
British Lung Foundation
2021 - 2023
- PREDICT-Meso Collaboration on therapeutic intervention in Mesothelioma (Imperial-Pardo)
Imperial College London
2021 - 2021
- PREDICT-Meso: PRE-malignant Drivers Combined with Target-Drug validation in Mesothelioma
Cancer Research UK
2020 - 2025
- Pre-clinical in vivo evaluation of immuno-modulatory therapy in MPM
British Lung Foundation (BLF)
2019 - 2022
- heterotypic intercellular ERBB signalling in early progression of KRAS LuAd
Cancer Research UK
2019 - 2022
- Pre-clinical evaluation of pan-ERBB inhibition to treat KRAS mutant NSCLC
British Lung Foundation
2017 - 2020
- NuSiCC
European Commission
2016 - 2018
- SERPLUC: Suppression of Enzymes Required for Progression of Lung Cancer
European Commission
2013 - 2017
- Metabolic vulnerabilities induced by Myc
Cancer Research UK
2012 - 2013
Research datasets
2019
Scopelliti, A., Bauer, C., Yu, Y., Zhang, T., Kruspig, B., Murphy, D. , Vidal, M., Maddocks, O. and Cordero, J. (2019) A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila. [Data Collection]
2018
Krupig, B., Hedley, A. and Murphy, D. (2018) RNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib. [Data Collection]
Krupig, B., Hedley, A. and Murphy, D. (2018) RNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib. [Data Collection]
Krupig, B., Hedley, A. and Murphy, D. (2018) RNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib. [Data Collection]
Neidler, S., Hedley, A. and Murphy, D. (2018) Progression of KRas^G12D;Rosa26-MYC tumours to invasive disease. [Data Collection]
Monteverde, T., Neilson, L., Zanivan, S. R. and Murphy, D. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. [Data Collection]
Port, J., Hedley, A. and Murphy, D. (2018) E-MTAB-6265 - Transcription profiling by RNA-seq of murine colon tumours after in situ depletion of Nuak1. [Data Collection]
Port, J., Muthalagu, N., Hedley, A. and Murphy, D. (2018) Comparison of the transcriptomic impact of NRF2 depletion with that of NUAK1 depletion in SW480 colorectal cancer cells. [Data Collection]
Muthalagu, N., Kalna, G., Hedley, A. and Murphy, D. (2018) RNA-SEQ analysis of human U2OS cells with/without depletion of NUAK1 by shRNA. [Data Collection]
