Schools

Pearson, L.-A., Petit, A.-P., Mendoza-Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P. K., Paul, M., Postis, V., Hu, X., Cowling, V. H., Gray, D. W. (2025) Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach. Biochemical Journal, (doi: 10.1042/bcj20240608)

Williamson, A., Houston, P., Paterson, J., Chalmers, A. J., McLoone, P., Fullerton, N., Foo, S. Y., James, A., Nowicki, S. (2024) Dosimetric comparison of hippocampal sparing technologies in patients with low grade glioma. Neuro-Oncology Advances, 6, (doi: 10.1093/noajnl/vdae131)

Mactier, K., Baxter, M., Peters, A., Fair, K., Hannington, L., Robertson, J., Wood, G., Sarwar, A., Bishr, M., Webb, R., Al-Zubaidi, M., Eastlake, L., Lankester, K., McInerney, S., Creedon, H., Stillie, A., Purshouse, K. (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-094838)

Xavier, V., Martinelli, S., Corbyn, R., Pennie, R., Rakovic, K., Powley, I. R., Officer-Jones, L., Ruscica, V., Galloway, A., Carlin, L. M., Cowling, V. H., Le Quesne, J., Martinou, J.-C., MacVicar, T. (2024) Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Science Alliance, 7, (doi: 10.26508/lsa.202402764)

Jackson, M. R., Richards, A. R., Oladipupo, A.-B. A., Chahal, S. K., Caragher, S., Chalmers, A. J., Gomez-Roman, N. (2024) ClonoScreen3D - a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma. International Journal of Radiation Oncology, Biology, Physics, 120, pp. 162-177. (doi: 10.1016/j.ijrobp.2024.02.046)

Lorimer, C., Mills, S., Chalmers, A., Coombes, I., Thompson, G., Glendenning, J., Radon, M., Jones, C., Williamson, A., Brock, J. (2024) Baseline total brain volume predicts changes in quality of life and overall survival after cranial radiotherapy in older patients with glioblastoma: Results from the prospective BRITER study. Neuro-Oncology Practice, 11, pp. 413-420. (doi: 10.1093/nop/npae019)

Boele, F., Rosenlund, L., Nordentoft, S., Melhuish, S., Nicklin, E., Rydén, I., Williamson, A., Donders-Kamphuis, M., Preusser, M., Le Rhun, E., Kiesel, B., Minniti, G., Furtner, J., Dirven, L., Taphoorn, M., Galldiks, N., Rudà, R., Chalmers, A., Short, S. C., Piil, K., the Nurse and Allied Health Professionals Committee, , the Disparity and Inclusion Committee of EANO, (2024) Inequalities in access to neuro-oncology supportive care and rehabilitation: a survey of healthcare professionals’ perspectives. Neuro-Oncology Practice, 11, pp. 484-493. (doi: 10.1093/nop/npae023)

Lukoszek, R., Inesta-Vaquera, F., Brett, N. J.M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W., Cowling, V. H. (2024) CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.114405)

Werner, J.-M., Petrescu, G. E.D., Boele, F., Preusser, M., Platten, M., Chalmers, A. J., Short, S. C., Piil, K. (2024) Chairing scientific sessions at international Neuro-Oncology meetings: an EANO guide for early-career professionals. Neuro-Oncology Practice, (doi: 10.1093/nop/npae060)

Thapa, A., Cowell, A., Peters, A., Noble, D. J., James, A., Lamb, C., Grose, D., Vohra, S., Schipani, S., Mactier, K., Mackenzie, J., Srinivasan, D., Laws, K., Moleron, R., Niblock, P., Soh, F.-Y., Paterson, C., Wilson, C. (2024) The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pembrolizumab-chemotherapy combination in Scotland. Clinical Oncology, 36, pp. 287-299. (doi: 10.1016/j.clon.2024.02.004)

Vens, C., van Luijk, P., Vogelius, R.I., El Naqa, I., Humbert-Vidan, L., von Neubeck, C., Gomez-Roman, N., Bahn, E., Brualla, L., Böhlen, T.T., Ecker, S., Koch, R., Handeland, A., Pereira, S., Possenti, L., Rancati, T., Todor, D., Vanderstraeten, B., Van Heerden, M., Ullrich, W., Jackson, M., Alber, M., Marignol, L., ESTRO DREAM team, (2024) A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy. Radiotherapy and Oncology, 196, (doi: 10.1016/j.radonc.2024.110277)

Pennel, K., Dutton, L., Melissourgou-Syka, L., Roxburgh, C., Birch, J., Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, (doi: 10.1017/erm.2024.15)

Ahmadian, M., Bodalal, Z., van der Hulst, H. J., Vens, C., Karssemakers, L. H.E., Bogveradze, N., Castagnoli, F., Landolfi, F., Hong, E. K., Gennaro, N., Pizzi, A. D., Beets-Tan, R. G.H., van den Brekel, M. W.M., Castelijns, J. A. (2024) Overcoming data scarcity in radiomics/radiogenomics using synthetic radiomic features. Computers in Biology and Medicine, 174, (doi: 10.1016/j.compbiomed.2024.108389)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Wakeham, K., Cooper, T., Rowbottom, C., Chalmers, A. J., Price, P., Quinlan, S., Spencer, K. (2024) Towards world-class radiotherapy in the UK: time for transformation. Lancet Oncology, 25, pp. 418-419. (doi: 10.1016/S1470-2045(24)00103-7)

Derby, S., Jackson, M. R., Williams, K., Stobo, J., Kelly, C., Sweeting, L., Shad, S., Herbert, C., Short, S. C., Williamson, A., James, A., Nowicki, S., Bulbeck, H., Chalmers, A. J. (2024) Concurrent olaparib and radiation therapy in older patients with newly diagnosed glioblastoma: the phase 1 dose-escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118, pp. 1371-1378. (doi: 10.1016/j.ijrobp.2024.01.011)

Tesson, M., Stevenson, K., Karim, S. A., Nixon, C., Chalmers, A. J., Sansom, O. J., O'Neill, E., Jones, K., Morton, J. P. (2024) Targeted irradiation in an autochthonous mouse model of pancreatic cancer. Disease Models and Mechanisms, 17, (doi: 10.1242/dmm.050463)

Derby, S. et al. (2024) Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis. Neuro-Oncology, (doi: 10.1093/neuonc/noad210)

Knop, K., Gomez-Moreira, C., Galloway, A., Ditsova, D., Cowling, V. H. (2024) RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression. Discovery Immunology, 3, (doi: 10.1093/discim/kyad021)

Van der Hulst, H. J., Jansen, R. W., Vens, C., Bos, P., Schats, W., De Jong, M. C., Martens, R. M., Bodalal, Z., Beets-Tan, R. G. H., Van den Brekel, M. W. M., De Graaf, P., Castelijns, J. A. (2023) The prediction of biological features using magnetic resonance imaging in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Cancers, 15, (doi: 10.3390/cancers15205077)

Kouli, O. O., McLoone, P., Morrison, D., Zaorsky, N. G., Chalmers, A. J. (2023) Risk of stroke-specific mortality after radiotherapy in patients with primary brain tumours. Clinical and Translational Radiation Oncology, 42, (doi: 10.1016/j.ctro.2023.100658)

Liang, S., Almohammed, R., Cowling, V. H. (2023) The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation. Biochemical Society Transactions, 51, pp. 1131-1141. (doi: 10.1042/BST20221154)

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H.J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C.G.G., Staut, N., Subiel, A., Vaes, R. D.W., van Hoof, S. J., Verginadis, I. L., Wilkens, J. J., Williams, K. J., Wilson, G. D., Dubois, L. J. (2023) Roadmap for precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68, (doi: 10.1088/1361-6560/acaf45)

Grocutt, L., Rutherford, A., Caldwell, D., Wilkinson, C., Chalmers, A.J., Dempsey, L., Kelly, C., O'Cathail, S.M. (2023) The impact of COVID-19 on radiotherapy services in Scotland, UK: a population-based study. Clinical Oncology, 35, pp. e227-e234. (doi: 10.1016/j.clon.2022.11.018)

Koessinger, D., Novo, D., Koessinger, A., Campos, A., Peters, J., Dutton, L., Paschke, P., Zerbst, D., Moore, M., Mitchell, L., Neilson, M., Stevenson, K., Chalmers, A., Tait, S., Birch, J., Norman, J. (2023) Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness. Neuro-Oncology Advances, 5, (doi: 10.1093/noajnl/vdad067)

O'Cathail, S.M., Chalmers, A.J. (2022) Integrating novel cancer therapies with radiation - illuminating the tunnel. Clinical Oncology, 35, pp. 38-41. (doi: 10.1016/j.clon.2022.10.010)

Turner, M., Murchie, P., Derby, S., Ong, A. Y., Walji, L., McLernon, D., Macleod, M.-J., Adam, R. (2022) Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis. Journal of Cancer Survivorship, 16, pp. 1414-1448. (doi: 10.1007/s11764-021-01122-7)

Falcone, M., Huerta Uribe, A., Papalazarou, V., Newman, A. C., Athineos, D., Stevenson, K., Sauvé, C.-E. G., Gao, Y., Kim, J. K., Del Latto, M., Kierstead, M., Wu, C., Smith, J. J., Romesser, P. B., Chalmers, A. J., Blyth, K., Maddocks, O. D.K. (2022) Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. British Journal of Cancer, 127, pp. 1773-1786. (doi: 10.1038/s41416-022-01965-6)

Koessinger, A. L. et al. (2022) Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death and Differentiation, 29, pp. 2089-2104. (doi: 10.1038/s41418-022-01001-3)

van der Wiel, A. M. A., Schuitmaker, L., Cong, Y., Theys, J., Van Hoeck, A., Vens, C., Lambin, P., Yaromina, A., Dubois, L. J. (2022) Homologous recombination deficiency scar: mutations and beyond—implications for precision oncology. Cancers, 14, (doi: 10.3390/cancers14174157)

McAleavey, P. G., Walls, G. M., Chalmers, A. J. (2022) Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review. CNS Oncology, 11, (doi: 10.2217/cns-2021-0015)

Zhang, Y., McGowan Holloway, S., Zoë Wilson, M., Alshaikhi, J., Tan, W., Royle, G., Bär, E. (2022) DIR-based models to predict weekly anatomical changes in head and neck cancer proton therapy. Physics in Medicine and Biology, 67, (doi: 10.1088/1361-6560/ac5fe2)

Willers, H., Krause, M., Faivre-Finn, C., Chalmers, A. (2022) Targeting PARP for chemoradiosensitization: opportunities, challenges, and the road ahead. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 265-270. (doi: 10.1016/j.ijrobp.2021.10.142)

Jackson, M. R., Stevenson, K., Chahal, S. K., Curley, E., Finney, G. E., Gutierrez-Quintana, R., Onwubiko, E., Rupp, A., Strathdee, K., Williams, K., MacLeod, M. K.L., McSharry, C., Chalmers, A. J. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112, pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029)

Aiyappa-Maudsley, R., Chalmers, A. J., Parsons, J. L. (2022) Factors affecting the radiation response in glioblastoma. Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdac156)

Gutierrez-Quintana, R., Walker, D. J., Williams, K. J., Forster, D. M., Chalmers, A. J. (2022) Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors? Neuro-Oncology Advances, 4, (doi: 10.1093/noajnl/vdab190)

Derby, S. J., Chalmers, A. J., Carruthers, R. (2022) Radiotherapy-poly(ADP-ribose) polymerase inhibitor combinations: progress to date. Seminars in Radiation Oncology, 32, pp. 15-28. (doi: 10.1016/j.semradonc.2021.09.005)

Birch, J., Strathdee, K., Stevenson, K., Derby, S., Dutton, L., Clough, E., Koessinger, A., Gilmour, L., McGhee, E., McGarrity-Cottrell, C., Dibekeme, A. a., Collis, S., Rominiyi, O., Lembruber Soares, L., Solecki, G., Winkler, F., Carlin, L., Inman, G., Chalmers, A., Norman, J., Carruthers, R. (2021) Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM. Research Square, (doi: 10.21203/rs.3.rs-967109/v1)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16, pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018)

Derby, S., Wallace, J., Venugopal, B., Garcia, A. C. (2021) Advanced penile cancer presenting with renal failure. Oncology, 35, pp. 425-428. (doi: 10.46883/onc.2021.3507.0425)

Koessinger, A. L., Koessinger, D., Kinch, K., Martínez-Escardó, L., Paul, N. R., Elmasry, Y., Malviya, G., Cloix, C., Campbell, K. J., Bock, F. J., O'Prey, J., Stevenson, K., Nixon, C., Jackson, M. R., Ichim, G., Stewart, W., Blyth, K., Ryan, K. M., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2021) Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics. bioRxiv, (doi: 10.1101/2021.06.13.448232)

Nile, D. L., Rae, C., Walker, D. J., Canning Waddington, J., Vincent, I., Burgess, K., Gaze, M. N., Mairs, R. J., Chalmers, A. J. (2021) Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer and Metabolism, 9, (doi: 10.1186/s40170-021-00258-5)

Chalmers, A.J., Carruthers, R.D. (2021) Radiobiology summaries: DNA damage and repair. Clinical Oncology, 33, pp. 275-278. (doi: 10.1016/j.clon.2020.12.006)

Hanna, C. R., Robb, K. A., Blyth, K. G., Jones, R. J., Chalmers, A. J. (2021) Clinician attitudes to using low dose radiotherapy to treat COVID-19 lung disease. International Journal of Radiation Oncology, Biology, Physics, 109, pp. 886-890. (doi: 10.1016/j.ijrobp.2020.12.003)

Rulach, R., Ball, D., Chua, K., Dahele, M., De Ruysscher, D., Franks, K., Gomez, D., Guckenberger, M., Hanna, G., Louie, A., Moghanaki, D., Palma, D., Peedell, C., Salem, A., Silva, S., Videtic, G., Chalmers, A., Harrow, S. (2021) An international expert survey on the indications and practice of radical thoracic reirradiation for non-small cell lung cancer. Advances in Radiation Oncology, 6, (doi: 10.1016/j.adro.2021.100653)

Liu, Q., Palomero, L., Moore, J., Guiz, I., Espín, R., Aytés, A., Mao, J.-H., Paulovich, A. G., Whiteaker, J. R., Ivey, R. G., Iliakis, G., Luo, D., Chalmers, A. J., Murnane, J., Pujana, M. A., Barcellos-Hoff, M. H. (2021) Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Science Translational Medicine, 13, (doi: 10.1126/scitranslmed.abc4465)

Al-mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Chalmers, A.J., Holmes, W.M. (2021) Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of glioblastoma. Magnetic resonance imaging, 85, pp. 121-127. (doi: 10.1016/j.mri.2021.10.030)

Hadjiyiannakis, D., Dimitroyannis, D., Eastlake, L., Peedell, C., Tripathi, L., Simcock, R., Vyas, A., Deutsch, E., Chalmers, A.J. (2021) Personal view: low-dose lung radiotherapy should be evaluated as a treatment for severe COVID-19 lung disease. Clinical Oncology, 33, pp. e64-e68. (doi: 10.1016/j.clon.2020.08.003)

Derby, S., Forshaw, M., Lowrie, C., Grose, D., Marashi, H., McLoone, P., Wilson, C., McIntosh, D. (2021) Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus. BMJ Open Gastroenterology, 8, (doi: 10.1136/bmjgast-2020-000492)

Hanna, C., Kurian, K. M., Williams, K., Watts, C., Jackson, A., Carruthers, R., Strathdee, K., Cruickshank, G., Dunn, L., Erridge, S., Godfrey, L., Jefferies, S., McBain, C., Sleigh, R., McCormick, A., Pittman, M., Halford, S., Chalmers, A. J. (2020) Pharmacokinetics, safety and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial. Neuro-Oncology, 22, pp. 1840-1850. (doi: 10.1093/neuonc/noaa104)

Lee, L. Y. W. et al. (2020) COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study. Lancet Oncology, 21, pp. 1309-1316. (doi: 10.1016/s1470-2045(20)30442-3)

Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., Tait, S. W.G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10, (doi: 10.1038/s41598-020-72322-x)

Rae, C., Fragkoulis, G. I., Chalmers, A. J. (2020) Cytotoxicity and radiosensitizing activity of the fatty acid synthase inhibitor C75 is enhanced by blocking fatty acid uptake in prostate cancer cells. Advances in Radiation Oncology, 5, pp. 944-1005. (doi: 10.1016/j.adro.2020.06.022)

Litchfield, K. et al. (2020) Representative sequencing: unbiased sampling of solid tumor tissue. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107550)

Jackson, M. R., Ashton, M., Koessinger, A. L., Dick, C., Verheij, M., Chalmers, A. J. (2020) Mesothelioma cells depend on the anti-apoptotic protein Bcl-xL for survival and are sensitized to ionizing radiation by BH3-mimetics. International Journal of Radiation Oncology, Biology, Physics, 106, pp. 867-877. (doi: 10.1016/j.ijrobp.2019.11.029)

Gomez-Roman, N., Chong, M. Y., Chahal, S. K., Caragher, S. P., Jackson, M. R., Stevenson, K. H., Dongre, S. A., Chalmers, A. J. (2020) Radiation responses of 2D and 3D glioblastoma cells: a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ. Molecular Cancer Therapeutics, 19, pp. 575-589. (doi: 10.1158/1535-7163.MCT-18-1320)

Chalmers, A.J., Chan, C., Sebag-Montefiore, D. (2020) CTRad 10 years on: from 10-point plan to top 10 achievements. Clinical Oncology, 32, pp. 9-12. (doi: 10.1016/j.clon.2019.09.043)

Chong, M. Y., Lorimer, C. F., Mehta, S., Ibrahim, E., Brock, J., McBain, C., McLoone, P., Chalmers, A. J. (2019) An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncology, 8, (doi: 10.2217/cns-2019-0017)

Beckta, J. M., Bindra, R. S., Chalmers, A. J. (2019) Targeting DNA repair in gliomas. Current Opinion in Neurology, 32, pp. 878-885. (doi: 10.1097/WCO.0000000000000760)

Al-Mubarak, H., Vallatos, A., Gallagher, L., Birch, J., Gilmour, L., Foster, J., Chalmers, A.J., Holmes, W.M. (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: application to an infiltrative brain tumour model. Journal of Neuroscience Methods, 326, (doi: 10.1016/j.jneumeth.2019.108372)

Venkataramani, V. et al. (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, 573, pp. 532-538. (doi: 10.1038/s41586-019-1564-x)

Derby, S., Graham, J., McIntosh, D. (2019) An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancer. BMJ Case Reports, 12, (doi: 10.1136/bcr-2018-225450)

Palma, D. A. et al. (2019) Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial. BMC Cancer, 19, (doi: 10.1186/s12885-019-5977-6)

Vallatos, A., Al-Mubarak, H.F.I., Birch, J.L., Gallagher, L., Mullin, J.M., Gilmour, L., Holmes, W.M., Chalmers, A.J. (2019) Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. Journal of Magnetic Resonance Imaging, 50, pp. 529-540. (doi: 10.1002/jmri.26580)

Kokurewicz, K., Brunetti, E., Welsh, G.H., Wiggins, S.M., Boyd, M., Sorensen, A., Chalmers, A.J., Schettino, G., Subiel, A., DesRosiers, C., Jaroszynski, D.A. (2019) Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Scientific Reports, 9, (doi: 10.1038/s41598-019-46630-w)

Gomez-Roman, N., Chalmers, A. J. (2019) Patient-specific 3D-printed glioblastomas. Nature Biomedical Engineering, 3, pp. 498-499. (doi: 10.1038/s41551-019-0379-2)

Gobin, M., Nazarov, P. V., Warta, R., Timmer, M., Reifenberger, G., Felsberg, J., Vallar, L., Chalmers, A. J., Herold-Mende, C. C., Goldbrunner, R., Niclou, S. P., Van Dyck, E. (2019) A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications. Cancer Research, 79, pp. 1226-1238. (doi: 10.1158/0008-5472.CAN-18-2076)

Caragher, S., Chalmers, A. J., Gomez-Roman, M. (2019) Glioblastoma's next top model: novel culture systems for brain cancer radiotherapy research. Cancers, 11, (doi: 10.3390/cancers11010044)

Rutherford, A., Stevenson, K., Tulk, A., Chalmers, A. J. (2019) Evaluation of four different small animal radiation plans on tumour and normal tissue dosimetry in a glioblastoma mouse model. British Journal of Radiology, 92, (doi: 10.1259/bjr.20180469)

Birch, J. L., Strathdee, K., Gilmour, L., Vallatos, A., McDonald, L., Kouzeli, A., Vasan, R., Qaisi, A. H., Croft, D. R., Crighton, D., Gill, K., Gray, C. H., Konczal, J., Mezna, M., McArthur, D., Schüttelkopf, A. W., McConnell, P., Sime, M., Holmes, W. M., Bower, J., McKinnon, H. J., Drysdale, M., Olson, M. F., Chalmers, A. J. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78, pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697)

Sharma, R. A. et al. (2018) Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology, 13, pp. 627-642. (doi: 10.1038/nrclinonc.2016.79)

Carruthers, R. D., Ahmed, S. U., Ramachandran, S., Strathdee, K., Kurian, K. M., Hedley, A., Gomez-Roman, N., Kalna, G., Neilson, M. P., Gilmour, L., Stevenson, K. H., Hammond, E. M., Chalmers, A. J. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78, pp. 5060-5071. (doi: 10.1158/0008-5472.CAN-18-0569)

Martinez-Zubiaurre, I., Chalmers, A. J., Hellevik, T. (2018) Radiation-induced transformation of immunoregulatory networks in the tumor stroma. Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.01679)

Martin, G. A., Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P., Chalmers, A., Blyth, K. G. (2018) Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion. BMJ Open Respiratory Research, 5, (doi: 10.1136/bmjresp-2018-000293)

Zmuda, F., Blair, A., Liuzzi, M. C., Malviya, G., Chalmers, A. J., Lewis, D., Sutherland, A., Pimlott, S. L. (2018) An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. Journal of Medicinal Chemistry, 61, pp. 4103-4114. (doi: 10.1021/acs.jmedchem.8b00138)

Gray, E., Butler, H. J., Board, R., Brennan, P. M., Chalmers, A. J., Dawson, T., Goodden, J., Hamilton, W., Hegarty, M. G., James, A., Jenkinson, M. D., Kernick, D., Lekka, E., Livermore, L. J., Mills, S. J., O’Neill, K., Palmer, D. S., Vaqas, B., Baker, M. J. (2018) Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios. BMJ Open, 8, (doi: 10.1136/bmjopen-2017-017593)

Holmes, W. M., Vallatos, A., Gilmour, L., Chalmers, A. J. (2018) Multiple boli arterial spin labelling for high signal-to-noise rodent brain perfusion imaging. Magnetic Resonance in Medicine, 79, pp. 1020-1030. (doi: 10.1002/mrm.26706)

Fulton, B., Short, S. C., James, A., Nowicki, S., McBain, C., Jefferies, S., Kelly, C., Stobo, J., Morris, A., Williamson, A., Chalmers, A. (2018) PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status. Clinical and Translational Radiation Oncology, 8, pp. 12-16. (doi: 10.1016/j.ctro.2017.11.003)

Ashton, M., O'Rourke, N., Macleod, N., Laird, B., Stobo, J., Kelly, C., Alexander, L., Franks, K., Moore, K., Currie, S., Valentine, R., Chalmers, A.J. (2018) SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma. Clinical and Translational Radiation Oncology, 8, pp. 45-49. (doi: 10.1016/j.ctro.2017.11.004)

Thompson, M. K., Poortmans, P., Chalmers, A. J., Faivre-Finn, C., Hall, E., Huddart, R. A., Lievens, Y., Sebag-Montefiore, D., Coles, C. E. (2018) Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie? British Journal of Cancer, 119, pp. 389-407. (doi: 10.1038/s41416-018-0201-z)

Lorimer, C.F., Hanna, C., Saran, F., Chalmers, A., Brock, J. (2017) Challenges to treating older glioblastoma patients: the influence of clinical and tumour characteristics on survival outcomes. Clinical Oncology, 29, pp. 739-747. (doi: 10.1016/j.clon.2017.05.010)

Ashton, M., O'Rourke, N., Currie, S., Rimner, A., Chalmers, A. (2017) The role of radical radiotherapy in the management of malignant pleural mesothelioma: a systematic review. Radiotherapy and Oncology, 125, pp. 1-12. (doi: 10.1016/j.radonc.2017.08.003)

Bindra, R. S., Chalmers, A. J., Evans, S., Dewhirst, M. (2017) GBM radiosensitizers: dead in the water…or just the beginning? Journal of Neuro-Oncology, 134, pp. 513-521. (doi: 10.1007/s11060-017-2427-7)

Gomez-Roman, N., Stevenson, K., Gilmour, L., Hamilton, G., Chalmers, A. (2017) A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology, 19, pp. 229-241. (doi: 10.1093/neuonc/now164)

Paterson, C., Allwood-Spiers, S., McCrea, I., Foster, J., McJury, M., Thomson, M., Sankaralingam, M., Grose, D., James, A., Rizwanullah, M., McLoone, P., Chalmers, A., Duffton, A. (2017) Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study. Clinical and Translational Radiation Oncology, 2, pp. 13-18. (doi: 10.1016/j.ctro.2016.12.003)

Carruthers, R., Chalmers, A. J. (2017) Improving the therapeutic ratio of radiotherapy by targeting the DNA damage response. Humana Press

Kaur, A., Denisova, O., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, S. U., Raheem, O., Haapasalo, H. K., Eriksson, J., Chalmers, A. J., Laakkonen, P. M., Westermarck, J. (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research, 76, pp. 7001-7011. (doi: 10.1158/0008-5472.CAN-16-1134)

Tsim, S., Kelly, C., Alexander, L., McCormick, C., Thomson, F., Woodward, R., Foster, J. E., Stobo, D. B., Paul, J., Maskell, N. A., Chalmers, A., Blyth, K. G. (2016) Diagnostic and prognostic biomarkers in the rational assessment of mesothelioma (DIAPHRAGM) study: protocol of a prospective, multi-centre, observational study. BMJ Open, 6, (doi: 10.1136/bmjopen-2016-013324)

Lorimer, C. F., Saran, F., Chalmers, A. J., Brock, J. (2016) Glioblastoma in the elderly - how do we choose who to treat? Journal of Geriatric Oncology, 7, pp. 453-456. (doi: 10.1016/j.jgo.2016.07.005)

Harrow, S., Hanna, G.G., Faivre-Finn, C., McDonald, F., Chalmers, A. (2016) The challenges faced in developing novel drug radiation combinations in non-small cell lung cancer. Clinical Oncology, 28, pp. 720-725. (doi: 10.1016/j.clon.2016.08.004)

Birch, J., Clarke, C., Campbell, A. D., Campbell, K., Mitchell, L., Liko, D., Kalna, G., Strathdee, D., Sansom, O. J., Neilson, M., Blyth, K., Norman, J. C. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5, pp. 1371-1379. (doi: 10.1242/bio.019075)

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M.O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B.P., Theys, J., Short, S. C., Verhaegen, F., Vooijs, M. (2016) NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget, 7, pp. 41251-41264. (doi: 10.18632/oncotarget.9275)

Chalmers, A. J. (2016) Science in focus: combining radiotherapy with inhibitors of the DNA damage response. Clinical Oncology, 28, pp. 279-282. (doi: 10.1016/j.clon.2016.01.035)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26, pp. 755-765. (doi: 10.1016/j.cub.2016.01.045)

Gomez-Roman, N., McGregor, F., Chalmers, A. J., Plumb, J. (2016) Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget, 7, (doi: 10.18632/oncotarget.7998)

Niyazi, M., Brada, M., Chalmers, A. J., Combs, S. E., Erridge, S. C., Fiorentino, A., Grosu, A. L., Lagerwaard, F. J., Minniti, G., Mirimanoff, R.-O., Ricardi, U., Short, S. C., Weber, D. C., Belka, C. (2016) ESTRO-ACROP guideline 'target delineation of glioblastomas' Radiotherapy and Oncology, 118, pp. 35-42. (doi: 10.1016/j.radonc.2015.12.003)