2023

Schell, E. R., McCracken, K. G., Scott, G. R., White, J., Lavretsky, P. and Dawson, N. J. (2023) Consistent changes in muscle metabolism underlie dive performance across multiple lineages of diving ducks. Proceedings of the Royal Society B: Biological Sciences, 290(2007), 20231466. (doi: 10.1098/rspb.2023.1466) (PMID:37752838) (PMCID:PMC10523079)

Metcalfe, N. B. et al. (2023) Solving the conundrum of intra-specific variation in metabolic rate: a multidisciplinary conceptual and methodological toolkit: new technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species. BioEssays, 5(6), 2300026. (doi: 10.1002/bies.202300026) (PMID:37042115)

Salmon, P. , Dawson, N. J. , Millet, C., Selman, C. and Monaghan, P. (2023) Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch. Aging Cell, 22(6), e13822. (doi: 10.1111/acel.13822) (PMID:36938671) (PMCID:PMC10265141)

Salmón, P. , Millet, C., Selman, C. , Monaghan, P. and Dawson, N. J. (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. GeroScience, 45(1), pp. 256-276. (doi: 10.1007/s11357-022-00624-1) (PMID:35986126) (PMCID:PMC9886749)

2022

Dawson, N. J. and Scott, G. R. (2022) Adaptive increases in respiratory capacity and O 2 affinity of subsarcolemmal mitochondria from skeletal muscle of high‐altitude deer mice. FASEB Journal, 36(7), e22391. (doi: 10.1096/fj.202200219r) (PMID:35661419)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2022) Inter-individual variation in mitochondrial phosphorylation efficiency predicts growth rates in ectotherms at high temperatures. FASEB Journal, 36(6), e22333. (doi: 10.1096/fj.202101806RR) (PMID:35486025)

2021

Zavorka, L., Crespel, A., Dawson, N. J. , Papatheodoulou, M., Killen, S. S. and Kainz, M. J. (2021) Climate change induced deprivation of dietary essential fatty acids can reduce growth and mitochondrial efficiency of wild juvenile salmon. Functional Ecology, 35(9), pp. 1960-1971. (doi: 10.1111/1365-2435.13860)

Vandenberg, G. G., Dawson, N. J. , Head, A., Scott, G. R. and Scott, A. L. (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochemistry International, 146, 105036. (doi: 10.1016/j.neuint.2021.105036) (PMID:33785420)

Nord, A., Metcalfe, N. B. , Page, J. L., Huxtable, A., McCafferty, D. J. and Dawson, N. J. (2021) Avian red blood cell mitochondria produce more heat in winter than in autumn. FASEB Journal, 35(5), e21490. (doi: 10.1096/fj.202100107R) (PMID:33829547)

Parr, N., Dawson, N.J. , Ivy, C.M., Morten, J.M., Scott, G.R. and Hawkes, L.A. (2021) Flight muscle and heart phenotypes in the high-flying ruddy shelduck. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 191(3), pp. 563-573. (doi: 10.1007/s00360-020-01326-w) (PMID:33591404)

2020

Dawson, N. J. , Alza, L., Nandal, G., Scott, G. R. and McCracken, K. G. (2020) Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl. eLife, 9, e56259. (doi: 10.7554/elife.56259) (PMID:32729830) (PMCID:PMC7494360)

Dawson, N.J. and Salmón, P. (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Experimental Gerontology, 133, 110883. (doi: 10.1016/j.exger.2020.110883) (PMID:32084534)

Laguë, S. L. et al. (2020) Cardiovascular responses to progressive hypoxia in ducks native to high altitude in the Andes. Journal of Experimental Biology, 223(5), jeb211250. (doi: 10.1242/jeb.211250) (PMID:32041807)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2020) Measurement of mitochondrial respiration in permeabilized fish gills. Journal of Experimental Biology, 223(4), 216762. (doi: 10.1242/jeb.216762) (PMID:31974221) (PMCID:PMC7044462)

2019

Ivy, C. M. et al. (2019) Control of breathing and respiratory gas exchange in high-altitude ducks native to the Andes. Journal of Experimental Biology, 222(7), (doi: 10.1242/jeb.198622) (PMID:30846536)

2018

Dawson, N. J. , Biggar, Y., Malik, A. I. and Storey, K. B. (2018) Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 224, pp. 245-252. (doi: 10.1016/j.cbpb.2018.01.003) (PMID:29331521)

Nikel, K. E., Shanishchara, N. K., Ivy, C. M., Dawson, N. J. and Scott, G. R. (2018) Effects of hypoxia at different life stages on locomotory muscle phenotype in deer mice native to high altitudes. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 224, pp. 98-104. (doi: 10.1016/j.cbpb.2017.11.009)

Scott, G. R., Guo, K. H. and Dawson, N. J. (2018) The mitochondrial basis for adaptive variation in aerobic performance in high-altitude deer mice. Integrative and Comparative Biology, 58(3), pp. 506-518. (doi: 10.1093/icb/icy056) (PMID:29873740)

Dawson, N. J. , Lyons, S. A., Henry, D. A. and Scott, G. R. (2018) Effects of chronic hypoxia on diaphragm function in deer mice native to high altitude. Acta Physiologica, 223(1), e13030. (doi: 10.1111/apha.13030) (PMID:29316265)

2017

Moggridge, J., Biggar, K., Dawson, N. and Storey, K. B. (2017) Sensitive detection of immunoglobulin G stability using in real-time isothermal differential scanning fluorimetry: determinants of protein stability for antibody-based therapeutics. Technology in Cancer Research and Treatment, 16(6), pp. 997-1005. (doi: 10.1177/1533034617714149) (PMID:28602127) (PMCID:PMC5762059)

Dawson, N. J. and Storey, K. B. (2017) Passive regeneration of glutathione: glutathione reductase regulation in the freeze-tolerant North American wood frog, Rana sylvatica. Journal of Experimental Biology, 220(17), pp. 3162-3171. (doi: 10.1242/jeb.159475) (PMID:28659307)

Du, S. N.N., Khajali, F., Dawson, N. J. and Scott, G. R. (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution, 71(6), pp. 1643-1652. (doi: 10.1111/evo.13254) (PMID:28444733)

York, J. M. et al. (2017) Respiratory mechanics of eleven avian species resident at high and low altitude. Journal of Experimental Biology, 220(6), pp. 1079-1089. (doi: 10.1242/jeb.151191) (PMID:28298466)

2016

Dawson, N. J. , Ivy, C. M., Alza, L., Cheek, R., York, J. M., Chua, B., Milsom, W. K., McCracken, K. G. and Scott, G. R. (2016) Mitochondrial physiology in the skeletal and cardiac muscles is altered in torrent ducks, Merganetta armata, from high altitudes in the Andes. Journal of Experimental Biology, 219(23), pp. 3719-3728. (doi: 10.1242/jeb.142711) (PMID:27618861)

Childers, C. L., Green, S. R., Dawson, N. J. and Storey, K. B. (2016) Native denaturation differential scanning fluorimetry: determining the effect of urea using a quantitative real-time thermocycler. Analytical Biochemistry, 508, pp. 114-117. (doi: 10.1016/j.ab.2016.05.019) (PMID:27296634)

Dawson, N. J. and Storey, K. B. (2016) A hydrogen peroxide safety valve: the reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica. Biochimica et Biophysica Acta, 1860(3), pp. 476-485. (doi: 10.1016/j.bbagen.2015.12.007) (PMID:26691137)

2015

Dawson, N. J. , Katzenback, B. A. and Storey, K. B. (2015) Free-radical first responders: the characterization of CuZnSOD and MnSOD regulation during freezing of the freeze-tolerant North American wood frog, Rana sylvatica. Biochimica et Biophysica Acta, 1850(1), pp. 97-106. (doi: 10.1016/j.bbagen.2014.10.003) (PMID:25316288)

2014

Katzenback, B. A., Dawson, N. J. and Storey, K. B. (2014) Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 184(5), pp. 601-611. (doi: 10.1007/s00360-014-0824-1) (PMID:24651940)

2013

Dawson, N. J. , Biggar, K. K. and Storey, K. B. (2013) Characterization of fructose-1,6-bisphosphate aldolase during anoxia in the tolerant turtle, Trachemys scripta elegans: an assessment of enzyme activity, expression and structure. PLoS ONE, 8(7), e68830. (doi: 10.1371/journal.pone.0068830) (PMID:23874782) (PMCID:PMC3715522)

Dawson, N. J. , Bell, R. A.V. and Storey, K. B. (2013) Purification and properties of white muscle lactate dehydrogenase from the anoxia-tolerant turtle, the red-eared slider, Trachemys scripta elegans. Enzyme Research, 2013, 784973. (doi: 10.1155/2013/784973) (PMID:23533717) (PMCID:PMC3594981)

Shahriari, A., Dawson, N. J. , Bell, R. A. V. and Storey, K. B. (2013) Stable suppression of lactate dehydrogenase activity during anoxia in the foot muscle of Littorina littorea and the potential role of acetylation as a novel posttranslational regulatory mechanism. Enzyme Research, 2013, 461374. (doi: 10.1155/2013/461374) (PMID:24233354) (PMCID:PMC3819915)

2012

Biggar, K. K., Dawson, N. J. and Storey, K. B. (2012) Real-time protein unfolding: a method for determining the kinetics of native protein denaturation using a quantitative real-time thermocycler. BioTechniques, 53(4), pp. 231-238. (doi: 10.2144/0000113922) (PMID:23046506)

Dawson, N. J. and Storey, K. B. (2012) An enzymatic bridge between carbohydrate and amino acid metabolism: regulation of glutamate dehydrogenase by reversible phosphorylation in a severe hypoxia-tolerant crayfish. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 182(3), pp. 331-340. (doi: 10.1007/s00360-011-0629-4) (PMID:22076534)

Bell, R. A.V., Dawson, N. J. and Storey, K. B. (2012) Insights into the in vivo regulation of glutamate dehydrogenase from the foot muscle of an estivating land snail. Enzyme Research, 2012, 317314. (doi: 10.1155/2012/317314) (PMID:22536484) (PMCID:PMC3318891)

2011

Dawson, N. J. and Storey, K. B. (2011) Regulation of tail muscle arginine kinase by reversible phosphorylation in an anoxia-tolerant crayfish. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 181(7), pp. 851-859. (doi: 10.1007/s00360-011-0578-y) (PMID:21519878)

Articles

Schell, E. R., McCracken, K. G., Scott, G. R., White, J., Lavretsky, P. and Dawson, N. J. (2023) Consistent changes in muscle metabolism underlie dive performance across multiple lineages of diving ducks. Proceedings of the Royal Society B: Biological Sciences, 290(2007), 20231466. (doi: 10.1098/rspb.2023.1466) (PMID:37752838) (PMCID:PMC10523079)

Metcalfe, N. B. et al. (2023) Solving the conundrum of intra-specific variation in metabolic rate: a multidisciplinary conceptual and methodological toolkit: new technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species. BioEssays, 5(6), 2300026. (doi: 10.1002/bies.202300026) (PMID:37042115)

Salmon, P. , Dawson, N. J. , Millet, C., Selman, C. and Monaghan, P. (2023) Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch. Aging Cell, 22(6), e13822. (doi: 10.1111/acel.13822) (PMID:36938671) (PMCID:PMC10265141)

Salmón, P. , Millet, C., Selman, C. , Monaghan, P. and Dawson, N. J. (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. GeroScience, 45(1), pp. 256-276. (doi: 10.1007/s11357-022-00624-1) (PMID:35986126) (PMCID:PMC9886749)

Dawson, N. J. and Scott, G. R. (2022) Adaptive increases in respiratory capacity and O 2 affinity of subsarcolemmal mitochondria from skeletal muscle of high‐altitude deer mice. FASEB Journal, 36(7), e22391. (doi: 10.1096/fj.202200219r) (PMID:35661419)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2022) Inter-individual variation in mitochondrial phosphorylation efficiency predicts growth rates in ectotherms at high temperatures. FASEB Journal, 36(6), e22333. (doi: 10.1096/fj.202101806RR) (PMID:35486025)

Zavorka, L., Crespel, A., Dawson, N. J. , Papatheodoulou, M., Killen, S. S. and Kainz, M. J. (2021) Climate change induced deprivation of dietary essential fatty acids can reduce growth and mitochondrial efficiency of wild juvenile salmon. Functional Ecology, 35(9), pp. 1960-1971. (doi: 10.1111/1365-2435.13860)

Vandenberg, G. G., Dawson, N. J. , Head, A., Scott, G. R. and Scott, A. L. (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochemistry International, 146, 105036. (doi: 10.1016/j.neuint.2021.105036) (PMID:33785420)

Nord, A., Metcalfe, N. B. , Page, J. L., Huxtable, A., McCafferty, D. J. and Dawson, N. J. (2021) Avian red blood cell mitochondria produce more heat in winter than in autumn. FASEB Journal, 35(5), e21490. (doi: 10.1096/fj.202100107R) (PMID:33829547)

Parr, N., Dawson, N.J. , Ivy, C.M., Morten, J.M., Scott, G.R. and Hawkes, L.A. (2021) Flight muscle and heart phenotypes in the high-flying ruddy shelduck. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 191(3), pp. 563-573. (doi: 10.1007/s00360-020-01326-w) (PMID:33591404)

Dawson, N. J. , Alza, L., Nandal, G., Scott, G. R. and McCracken, K. G. (2020) Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl. eLife, 9, e56259. (doi: 10.7554/elife.56259) (PMID:32729830) (PMCID:PMC7494360)

Dawson, N.J. and Salmón, P. (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Experimental Gerontology, 133, 110883. (doi: 10.1016/j.exger.2020.110883) (PMID:32084534)

Laguë, S. L. et al. (2020) Cardiovascular responses to progressive hypoxia in ducks native to high altitude in the Andes. Journal of Experimental Biology, 223(5), jeb211250. (doi: 10.1242/jeb.211250) (PMID:32041807)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2020) Measurement of mitochondrial respiration in permeabilized fish gills. Journal of Experimental Biology, 223(4), 216762. (doi: 10.1242/jeb.216762) (PMID:31974221) (PMCID:PMC7044462)

Ivy, C. M. et al. (2019) Control of breathing and respiratory gas exchange in high-altitude ducks native to the Andes. Journal of Experimental Biology, 222(7), (doi: 10.1242/jeb.198622) (PMID:30846536)

Dawson, N. J. , Biggar, Y., Malik, A. I. and Storey, K. B. (2018) Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 224, pp. 245-252. (doi: 10.1016/j.cbpb.2018.01.003) (PMID:29331521)

Nikel, K. E., Shanishchara, N. K., Ivy, C. M., Dawson, N. J. and Scott, G. R. (2018) Effects of hypoxia at different life stages on locomotory muscle phenotype in deer mice native to high altitudes. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 224, pp. 98-104. (doi: 10.1016/j.cbpb.2017.11.009)

Scott, G. R., Guo, K. H. and Dawson, N. J. (2018) The mitochondrial basis for adaptive variation in aerobic performance in high-altitude deer mice. Integrative and Comparative Biology, 58(3), pp. 506-518. (doi: 10.1093/icb/icy056) (PMID:29873740)

Dawson, N. J. , Lyons, S. A., Henry, D. A. and Scott, G. R. (2018) Effects of chronic hypoxia on diaphragm function in deer mice native to high altitude. Acta Physiologica, 223(1), e13030. (doi: 10.1111/apha.13030) (PMID:29316265)

Moggridge, J., Biggar, K., Dawson, N. and Storey, K. B. (2017) Sensitive detection of immunoglobulin G stability using in real-time isothermal differential scanning fluorimetry: determinants of protein stability for antibody-based therapeutics. Technology in Cancer Research and Treatment, 16(6), pp. 997-1005. (doi: 10.1177/1533034617714149) (PMID:28602127) (PMCID:PMC5762059)

Dawson, N. J. and Storey, K. B. (2017) Passive regeneration of glutathione: glutathione reductase regulation in the freeze-tolerant North American wood frog, Rana sylvatica. Journal of Experimental Biology, 220(17), pp. 3162-3171. (doi: 10.1242/jeb.159475) (PMID:28659307)

Du, S. N.N., Khajali, F., Dawson, N. J. and Scott, G. R. (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution, 71(6), pp. 1643-1652. (doi: 10.1111/evo.13254) (PMID:28444733)

York, J. M. et al. (2017) Respiratory mechanics of eleven avian species resident at high and low altitude. Journal of Experimental Biology, 220(6), pp. 1079-1089. (doi: 10.1242/jeb.151191) (PMID:28298466)

Dawson, N. J. , Ivy, C. M., Alza, L., Cheek, R., York, J. M., Chua, B., Milsom, W. K., McCracken, K. G. and Scott, G. R. (2016) Mitochondrial physiology in the skeletal and cardiac muscles is altered in torrent ducks, Merganetta armata, from high altitudes in the Andes. Journal of Experimental Biology, 219(23), pp. 3719-3728. (doi: 10.1242/jeb.142711) (PMID:27618861)

Childers, C. L., Green, S. R., Dawson, N. J. and Storey, K. B. (2016) Native denaturation differential scanning fluorimetry: determining the effect of urea using a quantitative real-time thermocycler. Analytical Biochemistry, 508, pp. 114-117. (doi: 10.1016/j.ab.2016.05.019) (PMID:27296634)

Dawson, N. J. and Storey, K. B. (2016) A hydrogen peroxide safety valve: the reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica. Biochimica et Biophysica Acta, 1860(3), pp. 476-485. (doi: 10.1016/j.bbagen.2015.12.007) (PMID:26691137)

Dawson, N. J. , Katzenback, B. A. and Storey, K. B. (2015) Free-radical first responders: the characterization of CuZnSOD and MnSOD regulation during freezing of the freeze-tolerant North American wood frog, Rana sylvatica. Biochimica et Biophysica Acta, 1850(1), pp. 97-106. (doi: 10.1016/j.bbagen.2014.10.003) (PMID:25316288)

Katzenback, B. A., Dawson, N. J. and Storey, K. B. (2014) Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 184(5), pp. 601-611. (doi: 10.1007/s00360-014-0824-1) (PMID:24651940)

Dawson, N. J. , Biggar, K. K. and Storey, K. B. (2013) Characterization of fructose-1,6-bisphosphate aldolase during anoxia in the tolerant turtle, Trachemys scripta elegans: an assessment of enzyme activity, expression and structure. PLoS ONE, 8(7), e68830. (doi: 10.1371/journal.pone.0068830) (PMID:23874782) (PMCID:PMC3715522)

Dawson, N. J. , Bell, R. A.V. and Storey, K. B. (2013) Purification and properties of white muscle lactate dehydrogenase from the anoxia-tolerant turtle, the red-eared slider, Trachemys scripta elegans. Enzyme Research, 2013, 784973. (doi: 10.1155/2013/784973) (PMID:23533717) (PMCID:PMC3594981)

Shahriari, A., Dawson, N. J. , Bell, R. A. V. and Storey, K. B. (2013) Stable suppression of lactate dehydrogenase activity during anoxia in the foot muscle of Littorina littorea and the potential role of acetylation as a novel posttranslational regulatory mechanism. Enzyme Research, 2013, 461374. (doi: 10.1155/2013/461374) (PMID:24233354) (PMCID:PMC3819915)

Biggar, K. K., Dawson, N. J. and Storey, K. B. (2012) Real-time protein unfolding: a method for determining the kinetics of native protein denaturation using a quantitative real-time thermocycler. BioTechniques, 53(4), pp. 231-238. (doi: 10.2144/0000113922) (PMID:23046506)

Dawson, N. J. and Storey, K. B. (2012) An enzymatic bridge between carbohydrate and amino acid metabolism: regulation of glutamate dehydrogenase by reversible phosphorylation in a severe hypoxia-tolerant crayfish. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 182(3), pp. 331-340. (doi: 10.1007/s00360-011-0629-4) (PMID:22076534)

Bell, R. A.V., Dawson, N. J. and Storey, K. B. (2012) Insights into the in vivo regulation of glutamate dehydrogenase from the foot muscle of an estivating land snail. Enzyme Research, 2012, 317314. (doi: 10.1155/2012/317314) (PMID:22536484) (PMCID:PMC3318891)

Dawson, N. J. and Storey, K. B. (2011) Regulation of tail muscle arginine kinase by reversible phosphorylation in an anoxia-tolerant crayfish. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 181(7), pp. 851-859. (doi: 10.1007/s00360-011-0578-y) (PMID:21519878)