Dr Michael Kohl

  • Senior Lecturer (Centre for Neuroscience)

Research interests

My group tries to unravel the neural coding strategies employed in the representation of sensory stimuli and memory storage. We combine electrophysiological recordings with single- and multi-photon imaging and stimulation to monitor and manipulate complex neuronal activity during behaviour in mice.

Our current work focuses on how neural activity in primary sensory cortices integrates with activity in a higher order cortex, such as the retrosplenial cortex. We combine theoretical studies to make quantitative predictions about population codes and their information content to help us guide experiments. We also continue to develop novel experimental tools and analysis approaches.

Our current research is broadly focused on three projects:

Role of interneurons in somatosensory perception: We study how different types of inhibitory interneurons are optimised for controlling neural codes.

Role of hippocampus and retrosplenial cortex in associative memory: We study the interplay of hippocampus and sensory cortices with the retrosplenial cortex during the formation and retrieval of associative memories.

Tool development: We develop novel approaches for recording and manipulating the function of large populations of neurons.

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2014 | 2012 | 2011 | 2010 | 2009
Number of items: 18.

2021

Baruchin, L. J., Ghezzi, F., Kohl, M. M. and Butt, S. J.B. (2021) Contribution of interneuron subtype-specific GABAergic signalling to emergent sensory processing in mouse somatosensory whisker barrel cortex. Cerebral Cortex, (Accepted for Publication)

Prince, L. Y., Tran, M. M., Grey, D., Saad, L., Chasiotis, H., Kwag, J., Kohl, M. M. and Richards, B. A. (2021) Neocortical inhibitory interneuron subtypes are differentially attuned to synchrony- and rate-coded information. Communications Biology, 4, 935. (doi: 10.1038/s42003-021-02437-y)

2020

Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M. and Kwag, J. (2020) Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike-times in the neocortex. Science Advances, 6(17), eaay5333. (doi: 10.1126/sciadv.aay5333) (PMID:32426459) (PMCID:PMC7176419)

Chung, H., Park, K., Jang, H. J., Kohl, M. M. and Kwag, J. (2020) Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo. Brain Structure and Function, 225, pp. 935-954. (doi: 10.1007/s00429-020-02044-3) (PMID:32107637) (PMCID:PMC7166204)

Park, K., Lee, J., Jang, H. J., Richards, B. A., Kohl, M. M. and Kwag, J. (2020) Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers. BMC Biology, 18, 7. (doi: 10.1186/s12915-019-0732-7) (PMID:31937327) (PMCID:PMC6961381)

2019

Chong, E. Z., Panniello, M., Barreiros, I., Kohl, M. M. and Booth, M. J. (2019) Quasi-simultaneous multiplane calcium imaging of neuronal circuits. Biomedical Optics Express, 10(1), pp. 267-282. (doi: 10.1364/BOE.10.000267) (PMID:30775099) (PMCID:PMC6363184)

2018

Khadria, A., Fleischhauer, J., Boczarow, I., Wilkinson, J. D., Kohl, M. M. and Anderson, H. L. (2018) Porphyrin dyes for nonlinear optical imaging of live cells. iScience, 4, pp. 153-163. (doi: 10.1016/j.isci.2018.05.015) (PMID:30240737) (PMCID:PMC6147020)

2017

Kohl, M. M. and Kätzel, D. (2017) Optogenetic mapping of neuronal connections and their plasticity. In: Appasani, K. (ed.) Optogenetics: From Neuronal Function to Mapping and Disease Biology. Cambridge University Press,: Cambridge, pp. 224-238. ISBN 9781107053014 (doi:10.1017/9781107281875.018)

Brown, T. G., Cogswell, C. J., Wilson, T., Chong, E. Z., Barreiros, I., Li, B., Kohl, M. M. and Booth, M. J. (2017) Fast Multiplane Functional Imaging Combining Acousto-optic Switching and Remote Focusing. In: Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV, San Francisco, CA, USA, 30 Jan - 01 Feb 2017, 100700X. ISBN 9781510605817 (doi:10.1117/12.2251476)

El-Gaby, M., Kohl, M. M. and Paulsen, O. (2017) Optogenetic methods to study lateralized synaptic function. In: Rogers, L. J. and Vallortigara, G. (eds.) Lateralized Brain Functions: Methods in Human and Non-Human Species. Series: Neuromethods (122). Humana Press: New York, NY, pp. 331-365. ISBN 9781493967230 (doi:10.1007/978-1-4939-6725-4_11)

2014

Shipton, O. A., El-Gaby, M., Apergis-Schoute, J., Deisseroth, K., Bannerman, D. M., Paulsen, O. and Kohl, M. M. (2014) Left–right dissociation of hippocampal memory processes in mice. Proceedings of the National Academy of Sciences of the United States of America, 111(42), pp. 15238-15243. (doi: 10.1073/pnas.1405648111) (PMID:25246561) (PMCID:PMC4210314)

2012

Botcherby, E. J., Smith, C. W., Kohl, M. M. , Débarre, D., Booth, M. J., Juškaitis, R., Paulsen, O. and Wilson, T. (2012) Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates. Proceedings of the National Academy of Sciences of the United States of America, 109(8), pp. 2919-2924. (doi: 10.1073/pnas.1111662109) (PMID:22315405) (PMCID:PMC3286923)

Reeve, J. E., Kohl, M. M. , Rodríguez-Moreno, A., Paulsen, O. and Anderson, H. L. (2012) Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative and Integrative Biology, 5(3), pp. 240-242. (doi: 10.4161/cib.19400) (PMID:22896783) (PMCID:PMC3419105)

2011

Kohl, M. M. , Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K. and Paulsen, O. (2011) Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. Nature Neuroscience, 14(11), pp. 1413-1415. (doi: 10.1038/nn.2915) (PMID:21946328) (PMCID:PMC3754824)

Rodríguez-Moreno, A., Kohl, M. M. , Reeve, J. E., Eaton, T. R., Collins, H. A., Anderson, H. L. and Paulsen, O. (2011) Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist. Journal of Neuroscience, 31(23), pp. 8564-8569. (doi: 10.1523/JNEUROSCI.0274-11.2011) (PMID:21653860) (PMCID:PMC4299820)

2010

Kohl, M. M. and Paulsen, O. (2010) The roles of GABAB receptors in cortical network activity. Advances in Pharmacology, 58, pp. 205-229. (doi: 10.1016/s1054-3589(10)58009-8) (PMID:20655484)

2009

Mann, E. O., Kohl, M. M. and Paulsen, O. (2009) Distinct roles of GABAA and GABAB receptors in balancing and terminating persistent cortical activity. Journal of Neuroscience, 29(23), pp. 7513-7518. (doi: 10.1523/JNEUROSCI.6162-08.2009) (PMID:19515919) (PMCID:PMC4326656)

Reeve, J. E., Collins, H. A., De Mey, K., Kohl, M. M. , Thorley, K. J., Paulsen, O., Clays, K. and Anderson, H. L. (2009) Amphiphilic porphyrins for second harmonic generation imaging. Journal of the American Chemical Society, 131(8), pp. 2758-2759. (doi: 10.1021/ja8061369) (PMID:19209855)

This list was generated on Thu Oct 21 20:18:23 2021 BST.
Number of items: 18.

Articles

Baruchin, L. J., Ghezzi, F., Kohl, M. M. and Butt, S. J.B. (2021) Contribution of interneuron subtype-specific GABAergic signalling to emergent sensory processing in mouse somatosensory whisker barrel cortex. Cerebral Cortex, (Accepted for Publication)

Prince, L. Y., Tran, M. M., Grey, D., Saad, L., Chasiotis, H., Kwag, J., Kohl, M. M. and Richards, B. A. (2021) Neocortical inhibitory interneuron subtypes are differentially attuned to synchrony- and rate-coded information. Communications Biology, 4, 935. (doi: 10.1038/s42003-021-02437-y)

Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M. and Kwag, J. (2020) Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike-times in the neocortex. Science Advances, 6(17), eaay5333. (doi: 10.1126/sciadv.aay5333) (PMID:32426459) (PMCID:PMC7176419)

Chung, H., Park, K., Jang, H. J., Kohl, M. M. and Kwag, J. (2020) Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo. Brain Structure and Function, 225, pp. 935-954. (doi: 10.1007/s00429-020-02044-3) (PMID:32107637) (PMCID:PMC7166204)

Park, K., Lee, J., Jang, H. J., Richards, B. A., Kohl, M. M. and Kwag, J. (2020) Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers. BMC Biology, 18, 7. (doi: 10.1186/s12915-019-0732-7) (PMID:31937327) (PMCID:PMC6961381)

Chong, E. Z., Panniello, M., Barreiros, I., Kohl, M. M. and Booth, M. J. (2019) Quasi-simultaneous multiplane calcium imaging of neuronal circuits. Biomedical Optics Express, 10(1), pp. 267-282. (doi: 10.1364/BOE.10.000267) (PMID:30775099) (PMCID:PMC6363184)

Khadria, A., Fleischhauer, J., Boczarow, I., Wilkinson, J. D., Kohl, M. M. and Anderson, H. L. (2018) Porphyrin dyes for nonlinear optical imaging of live cells. iScience, 4, pp. 153-163. (doi: 10.1016/j.isci.2018.05.015) (PMID:30240737) (PMCID:PMC6147020)

Shipton, O. A., El-Gaby, M., Apergis-Schoute, J., Deisseroth, K., Bannerman, D. M., Paulsen, O. and Kohl, M. M. (2014) Left–right dissociation of hippocampal memory processes in mice. Proceedings of the National Academy of Sciences of the United States of America, 111(42), pp. 15238-15243. (doi: 10.1073/pnas.1405648111) (PMID:25246561) (PMCID:PMC4210314)

Botcherby, E. J., Smith, C. W., Kohl, M. M. , Débarre, D., Booth, M. J., Juškaitis, R., Paulsen, O. and Wilson, T. (2012) Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates. Proceedings of the National Academy of Sciences of the United States of America, 109(8), pp. 2919-2924. (doi: 10.1073/pnas.1111662109) (PMID:22315405) (PMCID:PMC3286923)

Reeve, J. E., Kohl, M. M. , Rodríguez-Moreno, A., Paulsen, O. and Anderson, H. L. (2012) Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative and Integrative Biology, 5(3), pp. 240-242. (doi: 10.4161/cib.19400) (PMID:22896783) (PMCID:PMC3419105)

Kohl, M. M. , Shipton, O. A., Deacon, R. M., Rawlins, J. N. P., Deisseroth, K. and Paulsen, O. (2011) Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. Nature Neuroscience, 14(11), pp. 1413-1415. (doi: 10.1038/nn.2915) (PMID:21946328) (PMCID:PMC3754824)

Rodríguez-Moreno, A., Kohl, M. M. , Reeve, J. E., Eaton, T. R., Collins, H. A., Anderson, H. L. and Paulsen, O. (2011) Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist. Journal of Neuroscience, 31(23), pp. 8564-8569. (doi: 10.1523/JNEUROSCI.0274-11.2011) (PMID:21653860) (PMCID:PMC4299820)

Kohl, M. M. and Paulsen, O. (2010) The roles of GABAB receptors in cortical network activity. Advances in Pharmacology, 58, pp. 205-229. (doi: 10.1016/s1054-3589(10)58009-8) (PMID:20655484)

Mann, E. O., Kohl, M. M. and Paulsen, O. (2009) Distinct roles of GABAA and GABAB receptors in balancing and terminating persistent cortical activity. Journal of Neuroscience, 29(23), pp. 7513-7518. (doi: 10.1523/JNEUROSCI.6162-08.2009) (PMID:19515919) (PMCID:PMC4326656)

Reeve, J. E., Collins, H. A., De Mey, K., Kohl, M. M. , Thorley, K. J., Paulsen, O., Clays, K. and Anderson, H. L. (2009) Amphiphilic porphyrins for second harmonic generation imaging. Journal of the American Chemical Society, 131(8), pp. 2758-2759. (doi: 10.1021/ja8061369) (PMID:19209855)

Book Sections

Kohl, M. M. and Kätzel, D. (2017) Optogenetic mapping of neuronal connections and their plasticity. In: Appasani, K. (ed.) Optogenetics: From Neuronal Function to Mapping and Disease Biology. Cambridge University Press,: Cambridge, pp. 224-238. ISBN 9781107053014 (doi:10.1017/9781107281875.018)

El-Gaby, M., Kohl, M. M. and Paulsen, O. (2017) Optogenetic methods to study lateralized synaptic function. In: Rogers, L. J. and Vallortigara, G. (eds.) Lateralized Brain Functions: Methods in Human and Non-Human Species. Series: Neuromethods (122). Humana Press: New York, NY, pp. 331-365. ISBN 9781493967230 (doi:10.1007/978-1-4939-6725-4_11)

Conference Proceedings

Brown, T. G., Cogswell, C. J., Wilson, T., Chong, E. Z., Barreiros, I., Li, B., Kohl, M. M. and Booth, M. J. (2017) Fast Multiplane Functional Imaging Combining Acousto-optic Switching and Remote Focusing. In: Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV, San Francisco, CA, USA, 30 Jan - 01 Feb 2017, 100700X. ISBN 9781510605817 (doi:10.1117/12.2251476)

This list was generated on Thu Oct 21 20:18:23 2021 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Restoring hippocampal-cortical memory consolidation in models of Alzheimer's Disease
    Medical Research Council
    2019 - 2022
     

Supervision

Supervised Postgraduate Student

  • Mikel Perez Rodriguez (Visiting Postgraduate)

Research Assistant

Visiting Collaborators