Professor Mariola Kurowska-Stolarska

Professor of Immune Pathology and Homeostasis (Immunology & Infection)

telephone: 01413306085
email: Mariola.Kurowska-Stolarska@glasgow.ac.uk

RB423 Level B4, Iii - Gbrc, University Place, Glasgow G12 8TA

Research interests

TISSUE IMMUNOBIOLOGY LAB

The role of Myeloid cells in tissue homeostasis, inflammation, and disease resolution

The research in our lab aims to dissect the active roles of tissue-resident macrophages and dendritic cells in the joints, skin, and lungs. We focus on (a) their roles in maintaining healthy tissue homeostasis, (b) understanding their involvement in the pathology of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), and (c) reinstating tissue homeostasis during sustained disease remission. While investigating the basic biology of these cells, we seek mechanisms that can be therapeutically harnessed to restore tissue homeostasis or identify biomarkers that can help match patients to the most optimal current treatments targeting inflammatory pathways.

To maximise the impact of human tissue discovery, our lab is guided by the principle of translation—from bedside-to-bench and back in which human and mouse research strategies are interconnected for optimal understanding of novel tissue pathways and clinical innovation. We deconvolute the heterogeneity of myeloid cells in biopsies from patients at various stages of disease trajectories, spanning from the initiation of the disease to drug-free remission. This is achieved through the application of single-cell omics and spatial transcriptomics. The function of identified cell clusters is tested using unique biopsy-derived micro-cocultures and synovial tissue organoid systems. Subsequently, we conduct detailed mechanistic studies in purpose-generated transgenic mice. Collaborating with Prof Alivernini's clinical translational lab and Prof Jaume Bacardit's explainable artificial intelligence (AI) tools; we then assess the biomarker/therapeutic potential of our discoveries in experimental medicine trials (see Figure 1).

A graphic showing the understanding the role of tissue myeloid cells in reinstating and maintaining tissue homeostasis

Our lab functions within FOREUM funded multicentre RA and PsA consortia:

Synovial Tissue Macrophages (STMs) (Figure 2): Our lab has discovered functionally distinct synovial tissue macrophage (STM) populations and highlighted the pivotal role of communication between tissue-resident myeloid cells and fibroblasts in shaping tissue niches that regulate activation of infiltrating inflammatory and autoimmune cells. In health and drug-free RA remission, specific clusters of synovial resident myeloid and stromal cells together maintain homeostasis. For instance, lining-layer MerTK^posTREM2^pos synovial macrophages (STM) with a regulatory phenotype and lubricin-producing (CLIC5^posPRG4^pos) fibroblast-like synoviocytes (FLS) form a barrier against inflammation and aid joint mobility while interstitial MerTK^posLYVE1^posSTMs are located around blood vessels and control the influx of inflammatory cells.

Experimental mouse studies and human studies with early undifferentiated arthritis (UPA) suggest that the disruption of the MerTK^posTREM2^pos STM layer or pathogenic changes in their phenotype to TREM2^low, with decreased expression of the regulatory pathways (e.g., VSIG4 and retinoic acid pathways) and an increase in inflammatory SPP1, may facilitate the onset of arthritis. This phenotypic shift in TREM2^pos STMs creates an inflammation-permissive environment, enabling the initiation of synovitis associated with the influx of neutrophils and monocyte precursors of tissue infiltrating, highly inflammatory macrophages (e.g., MerTK^negSPP1^pos and MerTK^negS100A12^pos). This leads to a change in the lining layer FLS phenotype into MMPs/RANKL-producing joint-destructive phenotype and a selective expansion of CD90^possub-lining FLS clusters (e.g., CXCL12^posMHCII^pos) that drive chronicity of tissue inflammation. The transition from active arthritis to sustained remission that does not flare is associated with the restoration of the regulatory phenotypes in MerTK^posTREM2^posand MerTK^posLYVE1^pos STMs that mediate tissue repair responses in stromal cells.

We are currently studying the origin and niche signals that drive the development of various STM clusters in health, RA, PsA and drug-free remission as well as the role of STM specific pathways (e.g., MerTK and VSIG4) in maintaining and reinstating joint homeostasis in drug free remission with the prospect of pinpointing novel therapeutic targets and/or biomarkers of disease trajectories.

Synovial Tissue Dendritic cells (DC). DC in tissue and draining lymph nodes play a vital role in driving adaptive immune responses against pathogens while balancing immune tolerance versus autoimmunity. Thus, a better understanding the biology of tissue dendritic cells can help to re-instate immune tolerance in autoimmune diseases. We recently established that the synovium contains predominantly myeloid DCs comprising 15 transcriptionally distinct clusters. Their relative proportions, spatial distribution, and functions differ between health, active RA and RA in disease remission (in press). We developed specific methods and tools to investigate how these distinct synovial tissue DC clusters develop and regulate antigen-specific autologous lymphocytes. These include synovial tissue organoid system that enables tracking the developmental trajectories of specific synovial DC clusters from their blood precursors. In addition, autologous blood T-cells (from healthy and RA) CRISPR-Cas9 engineered to express TCR specific for multiple RA citrullinated-autoantigens enables us to assess the T-cell stimulatory versus tolerogenic functions of different autologous synovial tissue DC clusters.

Current RA treatments, while reinstating some of the mechanisms controlling inflammation in drug-free remission, don't reinstate immune tolerance thus we are currently investigating how to harness synovial tissue tolerogenic DC clusters to progress drug-free remission towards reminiscence of cure.

Collaborators

Other projects in the lab

School of Infection & Immunity enters into a research collaboration with Lilly

Lab Group

Find out more about my lab group.

Publications

List by: Type | Date

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Number of items: 109.

2024

MacDonald, L. et al. (2024) Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity, 57(12), 2843-2862.e12. (doi: 10.1016/j.immuni.2024.11.004) (PMID:39609125)

Alivernini, Stefano, Cañete, Juan D., Bacardit, Jaume and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, 30(4), pp. 925-926. (doi: 10.1038/s41591-024-02818-w) (PMID:38361121)

Ng, M. T.H. et al. (2024) A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution. Nature Communications, 15, 1394. (doi: 10.1038/s41467-024-45341-9) (PMID:38374174) (PMCID:PMC10876649)

Paoletti, A. et al. (2024) Liposomal antagomiR-155-5p restores anti-inflammatory macrophages and improves arthritis in preclinical models of rheumatoid arthritis. Arthritis and Rheumatology, 76(1), pp. 18-31. (doi: 10.1002/art.42665) (PMID:37527031)

2023

Johnson, Peter A., Ackerman, Jessica E., Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Coles, Mark, Buckley, Christopher D. and Dakin, Stephanie G. (2023) Three-dimensional, in-vitro approaches for modelling soft-tissue joint diseases. Lancet Rheumatology, 5(9), e553-e563. (doi: 10.1016/S2665-9913(23)00190-X) (PMID:38251499)

2022

van Gijsel-Bonnello, M. et al. (2022) Salt Inducible Kinase 2 regulates fibrosis during bleomycin-induced lung injury. Journal of Biological Chemistry, 298(12), 102644. (doi: 10.1016/j.jbc.2022.102644) (PMID:36309093) (PMCID:PMC9706632)

Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Alivernini, Stefano (2022) Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nature Reviews Rheumatology, 18, pp. 384-397. (doi: 10.1038/s41584-022-00790-8) (PMID:35672464)

Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)

Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)

Micheroli, R. et al. (2022) Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis. RMD Open, 8(1), e001949. (doi: 10.1136/rmdopen-2021-001949) (PMID:34987094) (PMCID:PMC8734041)

2021

Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)

Akbar, Moeed, MacDonald, Lucy ORCID: https://orcid.org/0000-0001-7727-3873, Crowe, Lindsay A.N., Carlberg, Konstantin, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Ståhl, Patrik L., Snelling, Sarah J.B., McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Millar, Neal L. ORCID: https://orcid.org/0000-0001-9251-9907 (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)

MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)

Clayton, Sally A., MacDonald, Lucy ORCID: https://orcid.org/0000-0001-7727-3873, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Clark, Andrew R. (2021) Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis. Frontiers in Immunology, 12, 1488. (doi: 10.3389/fimmu.2021.673916) (PMID:33995417) (PMCID:PMC8118696)

Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)

Rayner, F. et al. (2021) BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5, 22. (doi: 10.1186/s41927-021-00194-3) (PMID:34275488) (PMCID:PMC8286860)

2020

Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)

Ramilowski, J. A. et al. (2020) Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research, 30(7), pp. 1060-1072. (doi: 10.1101/gr.254219.119) (PMID:32718982) (PMCID:PMC7397864)

2019

Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.

McShane, Lucy ORCID: https://orcid.org/0000-0002-6091-9663, Tabas, Ira, Lemke, Greg, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Maffia, Pasquale ORCID: https://orcid.org/0000-0003-3926-4225 (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.

Goncalves-Alves, E. et al. (2019) MicroRNA-155 controls T helper cell activation during viral infection. Frontiers in Immunology, 10, 1367. (doi: 10.3389/fimmu.2019.01367) (PMID:31275315) (PMCID:PMC6593301)

2018

Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280 (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Bui, Laura, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Federico, Francesco, Gremese, Elisa, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Finlay, Samuel, Alivernini, Stefano, Elmesmari, Aziza, Tolusso, Barbara, Ferraccioli, Gianfranco, Gremese, Elisa, Petricca, Luca, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Filer, Andrew (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)

Cooles, Faye A.H., Anderson, Amy E., Skelton, Andrew, Pratt, Arthur G., Kurowska-Stolarska, Mariola S. ORCID: https://orcid.org/0000-0003-2124-7777, McInnes, Iain ORCID: https://orcid.org/0000-0002-6462-4280, Hilkens, Catharien M.U. and Isaacs, John D. (2018) Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology, 9, 755. (doi: 10.3389/fimmu.2018.00755) (PMID:29867920) (PMCID:PMC5968398)

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi: 10.4049/jimmunol.1700325) (PMID:29431694)

Shams, Kave, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Schütte, Fabian, Burden, A. David, McKimmie, Clive S. and Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi: 10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)

Clayton, Sally A., Jones, Simon W., Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Clark, Andrew R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)

Alivernini, Stefano, Gremese, Elisa, McSharry, Charles, Tolusso, Barbara, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Petricca, Luca, Gremese, Elisa, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)

2017

Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and Alivernini, Stefano (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)

Jaigrdar, Shafqat Ahrar, Benson, Robert A. ORCID: https://orcid.org/0000-0003-3687-0481, Elmesmari, Aziza, Kurowska-Stolarska, Mariola Stefania ORCID: https://orcid.org/0000-0003-2124-7777, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280, Garside, Paul ORCID: https://orcid.org/0000-0001-5944-0287 and Macleod, Megan K.L. ORCID: https://orcid.org/0000-0003-1843-8580 (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Saferding, V. et al. (2017) MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Journal of Autoimmunity, 82, pp. 74-84. (doi: 10.1016/j.jaut.2017.05.006) (PMID:28545737)

Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Petricca, Luca, Gremese, Elisa, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)

Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)

Elmesmari, Aziza, Alivernini, Stefano, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Petricca, Luca, Gremese, Elisa, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)

Chen, L. et al. (2017) miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. Annals of the Rheumatic Diseases, 76(3), pp. 620-624. (doi: 10.1136/annrheumdis-2016-210175) (PMID:28039186)

2016

Elmesmari, Aziza, Fraser, Alasdair R., Wood, Claire, Gilchrist, Derek, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Stewart, Lynn, McSharry, Charles, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)

Huesa, C. et al. (2016) Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology. Annals of the Rheumatic Diseases, 75(11), pp. 1989-1997. (doi: 10.1136/annrheumdis-2015-208268) (PMID:26698846) (PMCID:PMC5099200)

Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)

Bolognini, D. et al. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157) (PMID:27385588) (PMCID:PMC5009265)

Lavery, Christopher A., Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Holmes, William ORCID: https://orcid.org/0000-0002-0942-215X, Donnelly, Iona, Caslake, Muriel, Collier, Andrew, Baker, Andrew H. and Miller, Ashley M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Komai-Koma, Mousa, Wang, Eryi, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Li, Dong, McSharry, Charles and Xu, Damo (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

Elmesmari, Aziza, Alivernini, Stefano, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)

2015

Millar, Neal L. ORCID: https://orcid.org/0000-0001-9251-9907, Gilchrist, Derek, Akbar, Moeed, Reilly, James H., Kerr, Shauna C., Campbell, Abigail L., Murrell, George A.C., Liew, Foo Y., Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)

2014

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi: 10.1016/j.jaci.2014.05.011) (PMID:24985397) (PMCID:PMC4258609)

Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)

Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)

Elmesmari, Aziza, Pushparaj, Peter Natesan, Reilly, James, Kerr, Shauna, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2014) Role of SPHKs and S1PRs in Rheumatoid Arthritis. 3rd European Congress of Immunology (ECI 2012), Glasgow, UK, 5-8 Sept 2012. (Unpublished)

Holla, S., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Bayry, J. and Balaji, K. (2014) Selective inhibition of IFNG-induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signaling. Autophagy, 10(2), pp. 311-330. (doi: 10.4161/auto.27225)

2013

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)

Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280 (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.

Millar, N.L. ORCID: https://orcid.org/0000-0001-9251-9907, Gilchrist, D.S., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Murrell, G.A.C. and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.

Millar, Neal L. ORCID: https://orcid.org/0000-0001-9251-9907, Gilchrist, Derek S., Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Murrell, George A.C. and McInnes, Iain ORCID: https://orcid.org/0000-0002-6462-4280 (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.

Miller, Ashley M., Gilchrist, Derek S., Nijjar, Jagtar, Araldi, Elisa, Ramirez, Cristina M., Lavery, Christopher A., Fernández-Hernando, Carlos, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)

Rainey, Ashleigh-Ann, Gilchrist, Derek S., Tange, Clare E., Frleta, Marina, Crawford, Lynn, Baxter, Derek, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.

Tange, Clare E., Alivernini, Stefano, Gilchrist, Derek S., Crawford, Lynn, Rainey, Ashleigh-Ann, Baxter, Derek, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Rainey, A.-A., Pich, D., McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280, Hammerschmidt, W., O'Neill, L.A.J. and Masters, S.L. (2012) Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1 production. Journal of Immunology, 189(8), pp. 3795-3799. (doi: 10.4049/jimmunol.1200312) (PMID:22984081)

Statache, Gianina, Rainey, Ashleigh-Ann, Masters, Seth, Balanescu, Andra, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2012) Regulation of microrna 223 expression in a gouty arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S811. (doi: 10.1002/art.37735)

Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, I. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)

Elmesmari, A., Pushparaj, P., Reilly, J., Kerr, S., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, I. ORCID: https://orcid.org/0000-0002-6462-4280 (2012) The role of SPHKs and SIPRs in rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 260. (doi: 10.1111/imm.12002)

Statache, G., Rainey, A., Crawford, L., Masters, S., Balanescu, A., McInnes, I. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 (2012) Regulation of microRNA 223 expression in a gouty arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, p. 227. (doi: 10.1111/imm.12002)

Ghorpade, Devram Sampat, Leyland, Rebecca, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Patil, Shripad A and Balaji, Kithiganahalli Narayanaswamy (2012) MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Molecular and Cellular Biology, 32(12), pp. 2239-2253. (doi: 10.1128/MCB.06597-11)

Haneklaus, M., Gerlic, M., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Rainey, A., Pitch, D., Hammerschmidt, W., O’Neill, L. and Masters, S. (2012) miR-223 targets IL-1β production and is decreased in synovial fluid monocytes from arthritis patients. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, 12-15 May 2012, pp. 9-10. (doi: 10.1111/j.1445-5994.2012.02761.x)

Baxter, D., McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777 (2012) Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunology and Cell Biology, 90(3), pp. 288-292. (doi: 10.1038/icb.2011.114) (PMID:22249200)

Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair D., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, McQueenie, Ross, Graham, Gerard ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)

Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Hasoo, Manhl, Gilchrist, Derek G., Ruzicska, Eva, Asquith, Darren, Welsh, David, Crawford, Lynn, Hirani, Nik, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and McSharry, Charles (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)

2011

Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)

Zaiss, M. M. et al. (2011) IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-α–mediated bone loss. Journal of Immunology, 186(11), pp. 6097-6105. (doi: 10.4049/jimmunol.1003487) (PMID:21515798)

Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.

2010

Stolarski, Bartosz, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Kewin, Peter, Xu, Damo and Liew, Foo Y. (2010) IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation. Journal of Immunology, 185(6), pp. 3472-3480. (doi: 10.4049/jimmunol.1000730)

Xu, D. et al. (2010) IL-33 exacerbates autoantibody-induced arthritis. Journal of Immunology, 184(5), pp. 2620-2626. (doi: 10.4049/jimmunol.0902685) (PMID:20139274)

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Hueber, A., Stolarski, B. and McInnes, I. B. ORCID: https://orcid.org/0000-0002-6462-4280 (2010) Interleukin-33: a novel mediator with a role in distinct disease pathologies. Journal of Internal Medicine, 269(1), pp. 29-35. (doi: 10.1111/j.1365-2796.2010.02316.x) (PMID:21158975)

Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Ballantine, L., Stolarski, B., Hunter, J., Hueber, Axel, Gracie, J.A., Liew, Foo Y. and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 (2010) miR-155 and miR-34a regulate proinflammatory cytokine production by human monocytes. In: European Workshop for Rheumatology Research, Bamberg, Germany, 4-7 Mar 2010, A30-A30. (doi: 10.1136/ard.2010.129619g)

2009

Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)

Kurowska-Stolarska, M. et al. (2009) Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis. Arthritis and Rheumatism, 60(12), pp. 3663-3675. (doi: 10.1002/art.25001)

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Kewin, P., Xu, D., McSharry, Charles, Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

2008

Kurowska-Stolarska, M. et al. (2008) IL-33 induces antigen-specific IL-5⁺ T cells and promotes allergic-induced airway inflammation independent of IL-4. Journal of Immunology, 181(7), pp. 4780-4790.

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Kurowska-Stolarska, Mariola S. ORCID: https://orcid.org/0000-0003-2124-7777, Kewin, Peter, Stolarski, Bartosz, Fraser, Alisdair, Xu, Damo, McInnes, Iain ORCID: https://orcid.org/0000-0002-6462-4280 and Liew, Foo Y. (2008) A role of IL-33 in bone turnover. In: 72nd Annual Scientific Meeting of the American College of Rheumatology and the 43rd Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Francisco CA, USA, 24-29 Oct 2008, S895.

Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)

Kewin, P., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2008) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased local Th2 cytokine and chemokine production. In: Scottish Thoracic Society Meeting, Stirling, UK, 26 Oct 2007, p. 50. (doi: 10.1258/rsmsmj.53.2.48)

2007

Ospelt, C, Kurowska-Stolarska, M ORCID: https://orcid.org/0000-0003-2124-7777, Neidhart, M, Michel, B A, Gay, R E, Laufer, S and Gay, S (2007) The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the Rheumatic Diseases, 67(4), pp. 524-529. (doi: 10.1136/ard.2007.071589)

Kewin, P., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Murphy, G., Pitman, N., ChooKang, B., Patel, M., Xu, D., Liew, F.Y. and Thomson, N. (2007) IL-33 is sufficient to induce eosinophilic airway inflammation, and exacerbates established inflammation, through increased ST2 dependent local Th2 cytokine and chemokine production. In: Winter Meeting of the British-Thoracic-Society, London, UK, 05-07 Dec 2007, A1.

2005

Distler, Jörg H.W., Jüngel, Astrid, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Michel, Beat A., Gay, Renate E., Gay, Steffen and Distler, Oliver (2005) Nucleofection: a new, highly efficient transfection method for primary human keratinocytes. Experimental Dermatology, 14(4), pp. 315-20. (doi: 10.1111/j.0906-6705.2005.00276.x)

Kurowska-Stolarska, M. et al. (2005) The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis. In: 25th European Workshop for Rheumatology Research, Glasgow, UK, 24-27 Feb 2005, P48. (doi: 10.1186/ar1569)

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Neidhart, M., Michel, B.A., Simmen, B.R. and Gay, R.E. (2005) Licofelone, a COX/5-LOX inhibitor blocks chemoattraction of Th1 cells by down regulation of CXCR3 ligands in synovial fibroblasts. In: 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, USA, 12-17 Nov 2005, S568.

2004

Ospelt, C. et al. (2004) Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways. In: Sixth International Symposium on Advances in Targeted Therapies, Venice, Italy, 28 Apr - 2 May 2004, ii90-ii91. (doi: 10.1136/ard.2004.028324)

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Distler, J., Pap, T., Jungel, A., Michel, B.A., Simmen, B.R., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of differentiation-2 (Id-2) induced by hypoxia promotes bone de radation in rheumatoid arthritis (RA). In: 68th Annual Scientific Meeting of the American College of Rheumatology/39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S655.

Jüngel, A. et al. (2004) Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis and Rheumatism, 50(5), pp. 1468-1476. (doi: 10.1002/art.20218)

Distler, Jörg H.W., Wenger, Roland H., Gassmann, Max, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Hirth, Astrid, Gay, Steffen and Distler, Oliver (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis and Rheumatism, 50(1), pp. 10-23. (doi: 10.1002/art.11425)

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Distler, J., Pap, T., Hirth, A., Moritz, W., Michel, B.A., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2004) The inhibitor of helix-loop-helix transcription factor ID-2 triggered by hypoxia and proinflammatory cytokines promotes the activated phenotype of synovial fibroblasts facilitating bone degradation. In: 5th Annual Congress of the European League Against Rheumatism (EULAR 2004), Berlin, Germany, 9-12 June 2004, p. 79.

Ospelt, C., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Neidhart, M., Michel, B.A., Simmen, B.R., Gay, R.E and Gay, S. (2004) Licofelone, a cylooxygenase/5-lipoxygenase inhibitor reduces expression of IP-10 in rheumatoid arthritis synovial fibroblasts. In: 68th Annual Scientific Meeting of the American College of Rheumatology / 39th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Antonio, TX, USA, 16-21 Oct 2004, S570.

2003

Distler, J. H. W., Hirth, A., Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Gay, R. E., Gay, S. and Distler, O. (2003) Angiogenic and angiostatic factors in the molecular control of angiogenesis. Quarterly Journal of Nuclear Medicine, 47(3), pp. 149-61.

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Distler, J., Moritz, W., Marti, H., Gay, R.E., Maslinski, W., Gay, S. and Distler, O. (2003) The expression of inhibitor of differentiation-2 (Id-2) is induced by hypoxia in synovial fibroblasts independently of HIF-1a. In: 67th Annual Scientific Meeting of the American College of Rheumatology/38th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Orlando, FL, USA, 23-28 Oct 2003, S146.

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Distler, O., Rudnicka, W., Distler, J., Gay, R.E., Maslinski, W. and Gay, S. (2003) IL-15 and its role in rheumatoid arthritis. In: 3rd World Congress of the Global Arthritis Research Network (GARN): International Arthritis Summit, Miyakazi, Japan, 14-17 Sept 2003, p. 139. (doi: 10.1186/ar940)

2002

Kurowska-Stolarska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Rudnicka, W., Janicka, I., Chorazy, M., Kowalczewski, J., Ziolkowska, M., Ferrari-Lacraz, S., Ferrari-Lacraz, S., Strom, T.B. and Maslinski, W. (2002) Endogenous IL-15 in autocrine fashion enhances rheumatoid arthritis fibroblast-like synoviocytes proliferation and resistance to apoptosis. In: 66th Annual Scientific Meeting of the American College of Rheumatology/37th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, New Orleans, LA, USA, 24-29 Oct 2002, S554.

Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Rudnicka, Weronika, Kontny, Ewa, Janicka, Iwona, Chorazy, Magdalena, Kowalczewski, Jacek, Ziółkowska, Maria, Ferrari-Lacraz, Sylvie, Strom, Terry B and Maśliński, Włodzimierz (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. Journal of Immunology, 169(4), pp. 1760-7. (doi: 10.4049/jimmunol.169.4.1760)

Ziolkowska, M. et al. (2002) High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis and Rheumatism, 46(7), pp. 1744-1753. (doi: 10.1002/art.10388)

Kurowska, M. ORCID: https://orcid.org/0000-0003-2124-7777, Rudnicka, W., Maślińska, D. and Maśliński, W. (2002) Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Annals of the New York Academy of Sciences, 966, pp. 441-445. (doi: 10.1111/j.1749-6632.2002.tb04245.x)

2000

Kontny, E, Szczepańska, K, Kowalczewski, J, Kurowska, M ORCID: https://orcid.org/0000-0003-2124-7777, Janicka, I, Marcinkiewicz, J and Maśliński, W (2000) The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 43(10), pp. 2169-2177.

Kontny, Ewa, Kurowska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Szczepańska, Katarzyna and Maśliński, Włodzimierz (2000) Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. Journal of Leukocyte Biology, 67(2), pp. 249-258.

1999

Kontny, Ewa, Grabowska, Agnieszka, Kowalczewski, Jacek, Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777, Janicka, Iwona, Marcinkiewicz, Janusz and Maśliński, Wlodzimierz (1999) Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis and Rheumatism, 42(12), pp. 2552-60. (doi: 10.1002/1529-0131(199912)42:12<2552::AID-ANR7>3.0.CO;2-V)

This list was generated on Sun Jun 15 10:55:20 2025 BST.

Jump to: Articles | Conference or Workshop Item | Conference Proceedings

Number of items: 109.

Articles

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi: 10.4049/jimmunol.1700325) (PMID:29431694)

Saferding, V. et al. (2017) MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. Journal of Autoimmunity, 82, pp. 74-84. (doi: 10.1016/j.jaut.2017.05.006) (PMID:28545737)

Xu, D. et al. (2010) IL-33 exacerbates autoantibody-induced arthritis. Journal of Immunology, 184(5), pp. 2620-2626. (doi: 10.4049/jimmunol.0902685) (PMID:20139274)

Conference or Workshop Item

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Petricca, Luca, Gremese, Elisa, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)

Elmesmari, Aziza, Alivernini, Stefano, Tolusso, Barbara, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Petricca, Luca, Gremese, Elisa, Ferraccioli, Gianfranco, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola ORCID: https://orcid.org/0000-0003-2124-7777 (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)

Conference Proceedings

This list was generated on Sun Jun 15 10:55:20 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Identifying synovial and tenosynovial cellular and molecular mechanisms and biomarkers of transition from pre-clinical RA to RA
Versus Arthritis
2024 - 2028
Human 3D synovial tissue organoids as a versatile tool to facilitate anti-rheumatic drug development for rheumatoid arthritis (3D4RA)
ZonMw
2024 - 2024
Quality not quantity: evaluating the role of immune mRNA isoforms at single-cell level in inflammatory arthritis
Tenovus Scotland
2024 - 2024
Dissecting the cellular and molecular atlas of Rheumatoid Arthritis (RA) in sustained remission to identify pathways maintaining remission and triggering flares.
Foundation for Research in Rheumatology
2023 - 2025
Identifying therapeutic targets to treat and prevent disease flare in rheumatoid arthritis
Medical Research Council
2022 - 2024
Identifying the mechanisms and biomarkers of transition from Psoriasis (PsO) to Psoriatic Arthritis (PsA)
Foundation for Research in Rheumatology
2022 - 2024
Defining AXL Role in Atherosclerosis
British Heart Foundation
2021 - 2023
Dissecting innate immune determinants of severity and resolution in a longitudinal study of COVID-19
UK Research and Innovation
2020 - 2022
The mechanisms by which JAK inhibition fosters disease remission in Psoriatic Arthritis and Rheumatoid Arthritis treated with Tofacitinib.
Pfizer
2020 - 2023
Dissecting the role of distinct phenotypic clusters of synovial tissue macrophages in the regulation of joint homeostasis and the resolution of joint inflammation in Rheumatoid Arthritis
Versus Arthritis
2020 - 2024
The double life of platelets: Do platelets provide fuel or foam for inflammatory arthritis?
Versus Arthritis
2020 - 2022
The double life of platelets: Do platelets provide fuel or foam for inflammatory arthritis?
Versus Arthritis
2020 - 2024
ArthritisHeal
European Commission
2019 - 2023
Joint enterprise: the collaboration of synovial fibroblasts and macrophages to sustain inflammation
Arthritis Research UK
2018 - 2019
BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (BIO-FLARE study)
Medical Research Council
2017 - 2021
ISSF Catalyst@ The Glasgow ??? FANTOM6 consortium investigation of the role of LncRNAs in specifying tissue macrophage phenotypes
Wellcome Trust
2015 - 2016
MIR-34a AS POSSIBLE EPIGENETIC REGULATOR OF INFLAMMATION DRIVEN FIBROSIS IN SYSTEMIC SCLEROSIS
British Society for Rheumatology
2015 - 2015
Designer Receptor Exclusively Activated by Designer Drug' to define the role of short chain fatty acids in metabolic disease and inflammation (Fatty acid DREADD)
Biotechnology and Biological Sciences Research Council
2014 - 2014
Microparticles as carriers of genetic material - a new mechanism of intercellular communication that underlies the pathogenesis of rheumatoid arthritis
Tenovus Scotland
2014 - 2015
Identification of disease-associated pathways induced in Psoriatic Arthritis synovial fibroblasts by biomechanical stress (ISSF Catalyst)
Wellcome Trust
2014 - 2015
GPR120: a G protein-coupled receptor with the potential to regulate insulin secretion and inflammation
Biotechnology and Biological Sciences Research Council
2013 - 2017
Expression of SYK in skin and Synovial tissues and identity of cell type.
Astrazeneca (SE)
2012 - 2013
Does a micro-RNA network regulate BMP-7 in different phases of osteoarthritis of the knee?
Tenovus Scotland
2012 - 2013
MicroRNA in monocytes: its contribution to the pathogenesis of arthritis and cardiovascular co-morbidity
Arthritis Research UK
2009 - 2014

Supervision

Jack Frew: 2320454F@student.gla.ac.uk

Luxin Yang: 2285540Y@student.gla.ac.uk

Marcus Doohan: 2439044D@student.gla.ac.uk

Dr Dario Bruno: 2624949B@student.gla.ac.uk

Olympia Hardy: 2505621H@student.gla.ac.uk

Caglar Cil (PGR): 2492741C@student.gla.ac.uk

Cil, Caglar
Investigation of Glycosylation Changes on Synovial Fibroblas
Frew, Jack

Professional activities & recognition

Prizes, awards & distinctions

2018: Award for the best science abstract at European League Against Rheumatism Conference (European Society of Rheumatology) EULAR (Amsterdam, Netherlands)
2017: Award for the best science abstract at European League Against Rheumatism Conference (European Society of Rheumatology) EULAR (Madrid, Spain)
2009: Arthritis Research UK Career Development Fellowship (Glasgow, UK)
2005: Young Investigator Award, European Workshop for Rheumatology Research (Glasgow, UK)
2002: Polish Rheumatology Society Award for the best scientific paper (Warsaw, Poland)
2002: Harmann-Muller Fellowship (Zurich, Switzerland)

Selected international presentations

2024: The European Alliance of Associations for Rheumatology (EULAR), (Vienna, Austria)
2024: The 9th Conference on Osteoimmunology (Loutraki, Greece,)
2023: The 18th International Congress of Immunology – IUIS 2023 (Cape Town, SA)
2023: The European Alliance of Associations for Rheumatology (EULAR) (Milan, Italy)
2023: Advanced in Targeted Therapies (ATT) meeting (Niece, France)
2022: 5th International Therapeutic Tolerance workshop (Newcastle, UK)
2022: The European Alliance of Associations for Rheumatology (EULAR) (Copenhagen , Denmark)
2022: The British Society of Immunology meeting (Liverpool, UK)
2022: The British Society of Rheumatology Meeting (Glasgow, UK)
2022: The Japanese College Rheumatology Meeting (JRM) (Japan)
2021: Biomarkers in Rheumatic Diseases, 12th International Meeting (Rome, Italy)
2021: European Congress of Immunology (ECI) (online)
2020: European Workshop for Rheumatology Research (EWRR) (Gent, Brussels)
2019: Forum on Rheumatoid Arthritis (Washington, USA)

A head and shoulders profile shot of Professor Mariola Kurowska-Stolarska

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