2022

Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809)

Lachaud, Q., Aziz, M. H. N., Burton, F. L., MacQuaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, (doi: 10.1093/cvr/cvab375) (PMID:35020837) (Early Online Publication)

2021

Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)

Burton, R. F. and Burton, F. L. (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)

Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)

2020

Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

2018

Henry, A. D., MacQuaide, N. , Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)

van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)

Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)

Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)

2016

Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)

Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)

2015

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)

2014

Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)

2013

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

2012

Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)

2011

Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

2010

Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)

Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca²⁺. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)

Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)

2008

Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)

Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

2007

Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)

Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)

2005

Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)

2004

Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)

Articles

Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809)

Lachaud, Q., Aziz, M. H. N., Burton, F. L., MacQuaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, (doi: 10.1093/cvr/cvab375) (PMID:35020837) (Early Online Publication)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)

Burton, R. F. and Burton, F. L. (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)

Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)

Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Henry, A. D., MacQuaide, N. , Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)

van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)

Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)

Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)

Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)

Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)

Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)

Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)

Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca²⁺. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)

Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)

Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)

Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)

Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)

Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)

Book Sections

Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)

Conference Proceedings

Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.