2025

Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789, Gilchrist, Rebecca J. ORCID: https://orcid.org/0000-0001-5003-4362, Yang, Zhechao, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, Francis L. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2025) A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. Royal Society Open Science, 12(3), 241539. (doi: 10.1098/rsos.241539) (PMID:29515888) (PMCID:PMC5830777)

Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Bishop, Martin J., Burton, Francis L., Denning, Chris, Gadegaard, Nikolaj ORCID: https://orcid.org/0000-0002-3396-846X, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (doi: 10.1093/cvr/cvaf034) (PMID:40036828) (Early Online Publication)

2024

Shead, Kyle D., Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Burton, Francis, Lang, Ninian ORCID: https://orcid.org/0000-0001-8441-6887, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)

Freeman, Michael, Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Boland, Erin, Dunne, Michael, Burton, Francis, Denning, Chris, Myles, Rachel ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

Nyman, Mathias, Stølen, Tomas O., Johnsen, Anne Berit, Garten, Karin, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Loennechen, Jan Pål (2024) A comprehensive protocol combining in vivo and ex vivo electrophysiological experiments in an arrhythmogenic animal model. American Journal of Physiology - Heart and Circulatory Physiology, 326(1), H203-H215. (doi: 10.1152/ajpheart.00358.2023) (PMID:37975708)

2023

Selli, Anders Lund, Ghasemi, Mohammadreza, Watters, Taylor, Burton, Francis, Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 and Dietrichs, Erik Sveberg (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)

Lu, Hua Rong, Van de Sande, Dieter, Mohammadreza, Ghasemi, Watters, Taylor, Burton, Francis, Pham, Ly, Altrocchi, Cristina, Gallacher, David J. and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)

Alexander, Cherry, Bishop, Martin J., Gilchrist, Rebecca J. ORCID: https://orcid.org/0000-0001-5003-4362, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

2022

Lachaud, Quentin, Aziz, Muhamad Hifzhudin Noor, Burton, Francis L., Macquaide, Niall ORCID: https://orcid.org/0000-0001-9026-0073, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)

Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Mortensen, Peter, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789, Gao, Hao ORCID: https://orcid.org/0000-0001-6852-9435, Pohjolainen, Lotta, Talman, Virpi, Ruskoaho, Heikki, Burton, Francis L., Gadegaard, Nikolaj ORCID: https://orcid.org/0000-0002-3396-846X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)

2021

Hortigon-Vinagre, M.P., Zamora, V., Burton, Francis L. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)

Burton, Richard Francis and Burton, Francis Lindley (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)

Da Silva Costa, Ana ORCID: https://orcid.org/0000-0003-3229-5424, Mortensen, Peter, Hortigon-Vinagre, Maria P., van der Heyden, Marcel A. G., Burton, Francis L., Gao, Hao ORCID: https://orcid.org/0000-0001-6852-9435, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)

2020

Dietrichs, Erik S., McGlynn, Karen, Allan, Andrew, Connolly, Adam, Bishop, Martin, Burton, Francis, Kettlewell, Sarah, Myles, Rachel ORCID: https://orcid.org/0000-0003-4670-361X, Tveita, Torkjel and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

2018

Henry, Alasdair D., MacQuaide, N. ORCID: https://orcid.org/0000-0001-9026-0073, Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)

van Meer, Berend J., Sala, Luca, Tertoolen, Leon G.J., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741, Burton, Francis L. and Mummery, Christine L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)

Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)

Lachaud, Q., MacQuaide, Niall ORCID: https://orcid.org/0000-0001-9026-0073, Burton, Francis and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)

2016

Huethorst, E., Hortigon, M. ORCID: https://orcid.org/0000-0001-5531-1779, Zamora-Rodriguez, V., Reynolds, P.M. ORCID: https://orcid.org/0000-0001-7614-0008, Burton, F., Smith, G. ORCID: https://orcid.org/0000-0003-4821-9741 and Gadegaard, N. ORCID: https://orcid.org/0000-0002-3396-846X (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)

Nisbet, Ashley M., Camelliti, Patrizia, Walker, Nicola L., Burton, Francis L., Cobbe, Stuart M., Kohl, Peter and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)

2015

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Ghouri, Iffath A., Kelly, Allen, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Kemi, Ole Johan ORCID: https://orcid.org/0000-0003-1344-9512 (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)

2014

Campbell, Annabel S., Burton, Francis L., Baillie, George ORCID: https://orcid.org/0000-0003-2469-6316 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

Nisbet, Ashley M., Burton, Francis L., Walker, Nicola L., Craig, Margaret A., Cheng, Hongwei, Hancox, Jules C., Orchard, Clive H. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)

2013

Kettlewell, Sarah, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID: https://orcid.org/0000-0002-5429-8303 (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

Di Diego, J.M., Sicouri, S., Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, FL., Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J. ORCID: https://orcid.org/0000-0003-1344-9512, Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

2012

Cheng, H., Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741, Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)

2011

Myles, R. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

2010

Burton, F.L., Malkova, D. ORCID: https://orcid.org/0000-0002-8085-0528, Caslake, M.J. and Gill, J.M.R. ORCID: https://orcid.org/0000-0003-3615-0986 (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)

Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Smith, G. ORCID: https://orcid.org/0000-0003-4821-9741, Reynolds, M., Burton, F.L. and Kemi, O.J. ORCID: https://orcid.org/0000-0003-1344-9512 (2010) Confocal and multiphoton imaging of intracellular Ca²⁺. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)

Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741, Reynolds, Martin, Burton, Francis and Kemi, Ole Johan ORCID: https://orcid.org/0000-0003-1344-9512 (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, Michael (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)

2008

Burton, F.L., Malkova, D. ORCID: https://orcid.org/0000-0002-8085-0528, Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)

Lang, N.N. ORCID: https://orcid.org/0000-0001-8441-6887, Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

2007

Caldwell, J, Burton, FL, Smith, GL and Cobbe, SM (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)

Walker, NL, Burton, FL, Kettlewell, S, Smith, GL and Cobbe, SM (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)

2005

Kohl, P, Camelliti, P, Burton, FL and Smith, GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)

2004

Kettlewell, S, Walker, NL, Cobbe, SM, Burton, FL and Smith, GL (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)

Articles

Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789, Gilchrist, Rebecca J. ORCID: https://orcid.org/0000-0001-5003-4362, Yang, Zhechao, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, Francis L. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2025) A large population of cell-specific action potential models replicating fluorescence recordings of voltage in rabbit ventricular myocytes. Royal Society Open Science, 12(3), 241539. (doi: 10.1098/rsos.241539) (PMID:29515888) (PMCID:PMC5830777)

Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Bishop, Martin J., Burton, Francis L., Denning, Chris, Gadegaard, Nikolaj ORCID: https://orcid.org/0000-0002-3396-846X, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (doi: 10.1093/cvr/cvaf034) (PMID:40036828) (Early Online Publication)

Shead, Kyle D., Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Burton, Francis, Lang, Ninian ORCID: https://orcid.org/0000-0001-8441-6887, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)

Freeman, Michael, Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Boland, Erin, Dunne, Michael, Burton, Francis, Denning, Chris, Myles, Rachel ORCID: https://orcid.org/0000-0003-4670-361X and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

Nyman, Mathias, Stølen, Tomas O., Johnsen, Anne Berit, Garten, Karin, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Loennechen, Jan Pål (2024) A comprehensive protocol combining in vivo and ex vivo electrophysiological experiments in an arrhythmogenic animal model. American Journal of Physiology - Heart and Circulatory Physiology, 326(1), H203-H215. (doi: 10.1152/ajpheart.00358.2023) (PMID:37975708)

Selli, Anders Lund, Ghasemi, Mohammadreza, Watters, Taylor, Burton, Francis, Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 and Dietrichs, Erik Sveberg (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)

Lu, Hua Rong, Van de Sande, Dieter, Mohammadreza, Ghasemi, Watters, Taylor, Burton, Francis, Pham, Ly, Altrocchi, Cristina, Gallacher, David J. and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)

Alexander, Cherry, Bishop, Martin J., Gilchrist, Rebecca J. ORCID: https://orcid.org/0000-0001-5003-4362, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

Lachaud, Quentin, Aziz, Muhamad Hifzhudin Noor, Burton, Francis L., Macquaide, Niall ORCID: https://orcid.org/0000-0001-9026-0073, Myles, Rachel C. ORCID: https://orcid.org/0000-0003-4670-361X, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)

Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Mortensen, Peter, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789, Gao, Hao ORCID: https://orcid.org/0000-0001-6852-9435, Pohjolainen, Lotta, Talman, Virpi, Ruskoaho, Heikki, Burton, Francis L., Gadegaard, Nikolaj ORCID: https://orcid.org/0000-0002-3396-846X and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)

Hortigon-Vinagre, M.P., Zamora, V., Burton, Francis L. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)

Burton, Richard Francis and Burton, Francis Lindley (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)

Da Silva Costa, Ana ORCID: https://orcid.org/0000-0003-3229-5424, Mortensen, Peter, Hortigon-Vinagre, Maria P., van der Heyden, Marcel A. G., Burton, Francis L., Gao, Hao ORCID: https://orcid.org/0000-0001-6852-9435, Simitev, Radostin D. ORCID: https://orcid.org/0000-0002-2207-5789 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)

Dietrichs, Erik S., McGlynn, Karen, Allan, Andrew, Connolly, Adam, Bishop, Martin, Burton, Francis, Kettlewell, Sarah, Myles, Rachel ORCID: https://orcid.org/0000-0003-4670-361X, Tveita, Torkjel and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Henry, Alasdair D., MacQuaide, N. ORCID: https://orcid.org/0000-0001-9026-0073, Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)

van Meer, Berend J., Sala, Luca, Tertoolen, Leon G.J., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741, Burton, Francis L. and Mummery, Christine L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)

Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)

Lachaud, Q., MacQuaide, Niall ORCID: https://orcid.org/0000-0001-9026-0073, Burton, Francis and Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)

Huethorst, E., Hortigon, M. ORCID: https://orcid.org/0000-0001-5531-1779, Zamora-Rodriguez, V., Reynolds, P.M. ORCID: https://orcid.org/0000-0001-7614-0008, Burton, F., Smith, G. ORCID: https://orcid.org/0000-0003-4821-9741 and Gadegaard, N. ORCID: https://orcid.org/0000-0002-3396-846X (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)

Nisbet, Ashley M., Camelliti, Patrizia, Walker, Nicola L., Burton, Francis L., Cobbe, Stuart M., Kohl, Peter and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Ghouri, Iffath A., Kelly, Allen, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Kemi, Ole Johan ORCID: https://orcid.org/0000-0003-1344-9512 (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)

Nisbet, Ashley M., Burton, Francis L., Walker, Nicola L., Craig, Margaret A., Cheng, Hongwei, Hancox, Jules C., Orchard, Clive H. and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)

Kettlewell, Sarah, Burton, Francis L., Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 and Workman, Antony J. ORCID: https://orcid.org/0000-0002-5429-8303 (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)

Di Diego, J.M., Sicouri, S., Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, FL., Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J. ORCID: https://orcid.org/0000-0003-1344-9512, Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

Cheng, H., Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741, Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)

Myles, R. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

Burton, F.L., Malkova, D. ORCID: https://orcid.org/0000-0002-8085-0528, Caslake, M.J. and Gill, J.M.R. ORCID: https://orcid.org/0000-0003-3615-0986 (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)

Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Smith, G. ORCID: https://orcid.org/0000-0003-4821-9741, Reynolds, M., Burton, F.L. and Kemi, O.J. ORCID: https://orcid.org/0000-0003-1344-9512 (2010) Confocal and multiphoton imaging of intracellular Ca²⁺. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)

Burton, F.L., Malkova, D. ORCID: https://orcid.org/0000-0002-8085-0528, Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)

Lang, N.N. ORCID: https://orcid.org/0000-0001-8441-6887, Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. ORCID: https://orcid.org/0000-0003-4670-361X, Burton, F.L., Cobbe, S.M. and Smith, G.L. ORCID: https://orcid.org/0000-0003-4821-9741 (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

Caldwell, J, Burton, FL, Smith, GL and Cobbe, SM (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)

Walker, NL, Burton, FL, Kettlewell, S, Smith, GL and Cobbe, SM (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)

Kohl, P, Camelliti, P, Burton, FL and Smith, GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)

Kettlewell, S, Walker, NL, Cobbe, SM, Burton, FL and Smith, GL (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)

Book Sections

Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741, Reynolds, Martin, Burton, Francis and Kemi, Ole Johan ORCID: https://orcid.org/0000-0003-1344-9512 (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, Michael (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)

Conference Proceedings

Campbell, Annabel S., Burton, Francis L., Baillie, George ORCID: https://orcid.org/0000-0003-2469-6316 and Smith, Godfrey L. ORCID: https://orcid.org/0000-0003-4821-9741 (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.