Professor Eleanor Davies

  • Professor of Molecular Endocrinology (Cardiovascular & Metabolic Health)

telephone: 01413302376
email: Eleanor.Davies@glasgow.ac.uk

RC431 Level C4, Institute of C&MS, Bhf Gcrc, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-8128-5404

Biography

I am Professor of Molecular Endocrinology at the BHF Glasgow Cardiovascular Research Institute.  I graduated from the University of Glasgow with a BSc (Hons) Biochemistry and then from Edinburgh University with a PhD.  After a 3-year INSERM post-doctoral Fellowship in Paris, I returned to Glasgow in 1994. I am co-director of the University MSc Cardiovascular Sciences programme and the Institute Post-Graduate Director. I am a member council for the Society for Endocrinology and co-lead the Society’s adrenal/ cardiovascular network, I am also a member of the nominations and publications committee.   I am a reviewer for multiple national and international funding organisations and journals and I sit on the Chief Scientist Office committee for experimental and translational medicine.   I am the UK lead of an EU-COST network (ADMIRE)  and WP co-lead of an H2020 programme.  I have served as an Editorial board member for Endocrinology and been Chairman of the International Aldosterone conference.  

I am the UK lead of an EU-COST network (ADMIRE) and WP co-lead of an EU H2020 programme  (ens@t-ht).  I have served as an Editorial board member for Endocrinology and been Chairman of the International Aldosterone conference.  

 

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Research interests

Research Theme: Vascular Diseases and Comorbidities

I lead a translational research group investigating the role of the mineralocorticoid aldosterone in cardiovascular disease, in particular hypertension and stroke.   Our research focuses on the regulation of aldosterone production by the adrenal gland and its action via the mineralocorticoid receptor and we have active collaborations with groups in Europe and the USA.  Our studies integrate basic molecular biology, cell biology and human clinical studies and utilise a wide range of transferrable techniques including cell culture, RT-PCR, Immunochemistry, DNA sequencing, miRNA arrays, RNAseq, reporter gene studies and bioinformatics.  Our work is currently funded by studentships and grants and from the EU (H2020), CSO, BHF and Governments of Malaysia and Saudi Arabia.   

Research:

 

Our work is currently funded by studentships and grants and from the EU (H2020) (ens@t-ht), CSO, BHF and Governments of Malaysia and Saudi Arabia.

Research groups

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2019 | 2017 | 2016 | 2015 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 58.

2023

Murphy, C. N., Delles, C. , Davies, E. and Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, 117282. (doi: 10.1016/j.atherosclerosis.2023.117282) (PMID:37821271)

MacKenzie, S. M. , Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C. and Davies, E. (2023) MicroRNAs in aldosterone production and action. In: Vitamins and Hormones. Series: Vitamins and hormones. Elsevier. (doi: 10.1016/bs.vh.2023.07.001) (In Press)

2022

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, 104276. (doi: 10.1016/j.ebiom.2022.104276) (PMID:36179553) (PMCID:PMC9520210)

Pommer, G. et al. (2022) Preanalytical considerations and out-patient vs in-patient tests of plasma metanephrines to diagnose pheochromocytoma. Journal of Clinical Endocrinology and Metabolism, 107(9), e3689-e3698. (doi: 10.1210/clinem/dgac390) (PMID:35767279)

Bliziotis, N. G. et al. (2022) Preanalytical pitfalls in untargeted plasma nuclear magnetic resonance metabolomics of endocrine hypertension. Metabolites, 12(8), e679. (doi: 10.3390/metabo12080679) (PMID:35893246) (PMCID:PMC9394285)

Reel, S. et al. (2022) Predicting hypertension subtypes with machine learning using targeted metabolites and their ratios. Metabolites, 12(8), 755. (doi: 10.3390/metabo12080755) (PMID:36005627) (PMCID:PMC9416693)

Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, 142. (doi: 10.1186/s13148-022-01347-y) (PMID:36329530) (PMCID:PMC9635165)

2021

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

2019

MacKenzie, S. M. , Nguyen Dinh Cat, A., van Kralingen, J. and Davies, E. (2019) Aldosterone. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 103-115. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_10)

MacKenzie, S. M. , Van Kralingen, J. C. and Davies, E. (2019) Regulation of aldosterone secretion. In: Litwack, G. (ed.) Aldosterone. Series: Vitamins and Hormones (109). Elsevier, pp. 241-263. ISBN 9780128177822 (doi: 10.1016/bs.vh.2018.07.001)

2017

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

MacKenzie, S. M. , Freel, M., Connell, J. M., Fraser, R. and Davies, E. (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. International Journal of Molecular Sciences, 18(3), 579. (doi: 10.3390/ijms18030579) (PMID:28272372) (PMCID:PMC5372595)

MacKenzie, S. M. , Davies, E. and Alvarez-Madrazo, S. (2017) Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 139-150. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_11)

2016

Diver, L. A. et al. (2016) Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: support for blood pressure genome-wide association study signals at this locus. Hypertension, 67(4), pp. 724-732. (doi: 10.1161/HYPERTENSIONAHA.115.06925) (PMID:26902494) (PMCID:PMC4789491)

Horikoshi, M. et al. (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), pp. 248-252. (doi: 10.1038/nature19806) (PMID:27680694) (PMCID:PMC5164934)

2015

McManus, F., Fraser, R., Davies, E. , Connell, J.M.C. and Freel, E.M. (2015) Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics. Journal of Endocrinology, 224, pp. 149-157. (doi: 10.1530/JOE-14-0561)

2013

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi: 10.1161/HYPERTENSIONAHA.112.200741)

2012

Freel, E. M., Mark, P. B. , Weir, R. A.P., McQuarrie, E. P., Allan, K., Dargie, H. J., McClure, J. D. , Jardine, A. G. , Davies, E. and Connell, J. M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5(6), pp. 740-747. (doi: 10.1161/CIRCIMAGING.112.974576)

McManus, F., Sands, W., Diver, L., MacKenzie, S. M. , Fraser, R., Davies, E. and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111(2), pp. 212-219. (doi: 10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M. , Connell, J. M.C. and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350(2), pp. 163-167. (doi: 10.1016/j.mce.2011.06.026)

2010

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52(5), pp. 705-711. (doi: 10.1016/j.jhep.2009.10.037)

2009

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi: 10.1210/jc.2009-1406)

Reynolds, R. M., Walker, B. R., Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E. and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53(6), pp. 932-936. (doi: 10.1161/​HYPERTENSIONAHA.109.129320)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70(3), pp. 363-371. (doi: 10.1111/j.1365-2265.2008.03383.x)

Davies, E., Davies, E., Ainsworth, R., Aitken, C., Carman, W. and Kroes, A. (2009) Viral myocarditis. Journal of Clinical Virology, 45(3), VII-VIX.

2008

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C. and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69(6), pp. 848-854. (doi: 10.1111/j.1365-2265.2008.03262.x)

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E. and Connell, J.M.C. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68(5), pp. 700-706. (doi: 10.1111/j.1365-2265.2007.03116.x)

Connell, J. M.C., MacKenzie, S. M. , Freel, E. M., Fraser, R. and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29(2), pp. 133-154. (doi: 10.1210/er.2007-0030)

Ye, P., Kenyon, C. J., MacKenzie, S. M. , Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C. and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196(2), pp. 305-311. (doi: 10.1677/JOE-07-0439)

MacKenzie, S. M. , Dewar, D. , Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi: 10.1677/JOE-07-0427)

2007

Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67(6), pp. 832-838. (doi: 10.1111/j.1365-2265.2007.02971.x)

Freel, E.M., Bernhardt, M., Ingram, R., Wallace, A.M., Fraser, R., Davies, E. and Connell, J.M.C. (2007) Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy. Clinical Endocrinology, 66(5), pp. 659-665. (doi: 10.1111/j.1365-2265.2007.02791.x)

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49(1), pp. 113-119. (doi: 10.1161/01.HYP.0000249904.93940.7a)

2006

Barr, M., MacKenzie, S. , Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J. and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65, pp. 816-825. (doi: 10.1111/j.1365-2265.2006.02673.x)

Imrie, H. et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91(12), pp. 5051-5056. (doi: 10.1210/jc.2006-1481)

2005

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12), pp. 5287-5293. (doi: 10.1210/en.2005-0370) (PMID:16179417)

Connell, J. and Davies, E. (2005) The new biology of aldosterone. Journal of Endocrinology, 186, pp. 1-20. (doi: 10.1677/joe.1.06017)

Imrie, H., Mayosi, B., Baker, M., Fraser, R., Davies, E. , Ingram, M., Watkins, H., Farrall, M., Connell, J. and Keavney, B. (2005) Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Journal of Clinical Endocrinology and Metabolism, 90, pp. 1072-1077. (doi: 10.1210/jc.2004-0870)

2004

Freel, E., Shakerdi, L.A., Friel, E., Wallace, A.M., Davies, E., Fraser, R. and Connell, J.M.C. (2004) Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89(9), pp. 4628-4633. (doi: 10.1210/jc.2004-0379)

Freel, E.M., Shakerdi, L., Friel, E., Wallace, A.M., Davies, E. , Fraser, R. and Connell, J.M.C. (2004) The origin of circulating 18-oxo and 18-hydroxycortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89(9), pp. 4628-4633. (doi: 10.1210/jc.2004-0379)

Connell, J. M.C., Fraser, R., MacKenzie, S. M. , Friel, E. C., Ingram, M. C., Holloway, C. D. and Davies, E. (2004) The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology, 217(1-2), pp. 243-247. (doi: 10.1016/j.mce.2003.10.025) (PMID:15134824)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S. , Davies, E. , Shakerdi, L., Wallace, A., Fraser, R. and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61, pp. 174-181. (doi: 10.1111/j.1365-2265.2004.02073.x)

2003

Davies, E. and MacKenzie, S. M. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30(7), pp. 437-445. (doi: 10.1046/j.1440-1681.2003.03867.x) (PMID:12823256)

Connell, J., Fraser, R., MacKenzie, S. and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41, pp. 993-999. (doi: 10.1161/01.HYP.0000064344.00173.44)

Davies, E. and Kenyon, C. (2003) CYP11B2 polymorphisms and cardiovascular risk factors. [Editorial]. Journal of Hypertension, 21(7), pp. 1249-1253.

Ye, P., Kenyon, C., MacKenzie, S. , Seckl, J., Fraser, R., Connell, J. and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144, pp. 3321-3328. (doi: 10.1210/en.2003-0109)

2002

MacKenzie, S. M. , Fraser, R., Connell, J. M.C. and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3(4), pp. 214-221. (doi: 10.3317/jraas.2002.043) (PMID:12584665)

Draper, N. et al. (2002) Association Studies between Microsatellite Markers within the Gene Encoding Human 11{beta}-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism. Journal of Clinical Endocrinology and Metabolism, 87(11), pp. 4984-4990. (doi: 10.1210/jc.2001-011375)

Lim, P., MacDonald, T., Holloway, C., Friel, E., Anderson, N., Dow, E., Jung, R., Davies, E. , Fraser, R. and Connell, J. (2002) Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. Journal of Clinical Endocrinology and Metabolism, 87(9), pp. 4398-4402.

MacKenzie, S. , Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J. and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29(3), pp. 319-325. (doi: 10.1677/jme.0.0290319)

2001

Connell, J.M.C., Fraser, R. and Davies, E. (2001) Disorders of mineralocorticoid synthesis. Best Practice and Research: Clinical Endocrinology and Metabolism, 15, pp. 43-60. (doi: 10.1053/beem.2000.0118)

Davies, E. , Holloway, C., Ingram, M., Friel, E., Inglis, G., Swan, L., Hillis, W., Fraser, R. and Connell, J. (2001) An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Clinical Endocrinology, 54, pp. 813-817.

Fisher, A., Friel, E., Bernhardt, R., Gomez-Sanchez, C., Connell, J., Fraser, R. and Davies, E. (2001) Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11 beta-hydroxylase. Journal of Clinical Endocrinology and Metabolism, 86, pp. 4326-4329.

Inglis, G., Plouin, P., Friel, E., Davies, E. , Fraser, R. and Connell, J. (2001) Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). Clinical Endocrinology, 54, pp. 725-730.

2000

MacKenzie, S.M. , Clark, C.J., Fraser, R., Gomez-Sanchez, C.E., Connell, J. and Davies, E. (2000) Expression of 11 beta-hydroxylase and aldosterone synthase genes in the rat brain. Journal of Molecular Endocrinology, 24(3), pp. 321-328. (doi: 10.1677/jme.0.0240321) (PMID:10828825)

Clark, C.J., Davies, E. , Anderson, N.H., Farmer, R., Friel, E.C., Fraser, R. and Connell, J.M.C. (2000) alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. Hypertension, 36(6), pp. 990-994.

MacKenzie, S.M. , Clark, C.J., Ingram, M.C., Lai, M., Seckl, J., Gomez-Sanchez, C.E., Fraser, R., Connell, J.M.C. and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26(4), pp. 531-535. (doi: 10.3109/07435800009048566) (PMID:11196425)

This list was generated on Thu Apr 25 08:56:46 2024 BST.
Jump to: Articles | Book Sections
Number of items: 58.

Articles

Murphy, C. N., Delles, C. , Davies, E. and Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, 117282. (doi: 10.1016/j.atherosclerosis.2023.117282) (PMID:37821271)

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, 104276. (doi: 10.1016/j.ebiom.2022.104276) (PMID:36179553) (PMCID:PMC9520210)

Pommer, G. et al. (2022) Preanalytical considerations and out-patient vs in-patient tests of plasma metanephrines to diagnose pheochromocytoma. Journal of Clinical Endocrinology and Metabolism, 107(9), e3689-e3698. (doi: 10.1210/clinem/dgac390) (PMID:35767279)

Bliziotis, N. G. et al. (2022) Preanalytical pitfalls in untargeted plasma nuclear magnetic resonance metabolomics of endocrine hypertension. Metabolites, 12(8), e679. (doi: 10.3390/metabo12080679) (PMID:35893246) (PMCID:PMC9394285)

Reel, S. et al. (2022) Predicting hypertension subtypes with machine learning using targeted metabolites and their ratios. Metabolites, 12(8), 755. (doi: 10.3390/metabo12080755) (PMID:36005627) (PMCID:PMC9416693)

Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, 142. (doi: 10.1186/s13148-022-01347-y) (PMID:36329530) (PMCID:PMC9635165)

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

MacKenzie, S. M. , Freel, M., Connell, J. M., Fraser, R. and Davies, E. (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. International Journal of Molecular Sciences, 18(3), 579. (doi: 10.3390/ijms18030579) (PMID:28272372) (PMCID:PMC5372595)

Diver, L. A. et al. (2016) Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: support for blood pressure genome-wide association study signals at this locus. Hypertension, 67(4), pp. 724-732. (doi: 10.1161/HYPERTENSIONAHA.115.06925) (PMID:26902494) (PMCID:PMC4789491)

Horikoshi, M. et al. (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), pp. 248-252. (doi: 10.1038/nature19806) (PMID:27680694) (PMCID:PMC5164934)

McManus, F., Fraser, R., Davies, E. , Connell, J.M.C. and Freel, E.M. (2015) Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics. Journal of Endocrinology, 224, pp. 149-157. (doi: 10.1530/JOE-14-0561)

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi: 10.1161/HYPERTENSIONAHA.112.200741)

Freel, E. M., Mark, P. B. , Weir, R. A.P., McQuarrie, E. P., Allan, K., Dargie, H. J., McClure, J. D. , Jardine, A. G. , Davies, E. and Connell, J. M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5(6), pp. 740-747. (doi: 10.1161/CIRCIMAGING.112.974576)

McManus, F., Sands, W., Diver, L., MacKenzie, S. M. , Fraser, R., Davies, E. and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111(2), pp. 212-219. (doi: 10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M. , Connell, J. M.C. and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350(2), pp. 163-167. (doi: 10.1016/j.mce.2011.06.026)

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52(5), pp. 705-711. (doi: 10.1016/j.jhep.2009.10.037)

Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B. M., Watkins, H., Avery, P., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. and Keavney, B. (2009) Familial and phenotypic associations of the aldosterone renin ratio. Journal of Clinical Endocrinology and Metabolism, 94(11), pp. 4324-4333. (doi: 10.1210/jc.2009-1406)

Reynolds, R. M., Walker, B. R., Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E. and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53(6), pp. 932-936. (doi: 10.1161/​HYPERTENSIONAHA.109.129320)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70(3), pp. 363-371. (doi: 10.1111/j.1365-2265.2008.03383.x)

Davies, E., Davies, E., Ainsworth, R., Aitken, C., Carman, W. and Kroes, A. (2009) Viral myocarditis. Journal of Clinical Virology, 45(3), VII-VIX.

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C. and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69(6), pp. 848-854. (doi: 10.1111/j.1365-2265.2008.03262.x)

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E. and Connell, J.M.C. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68(5), pp. 700-706. (doi: 10.1111/j.1365-2265.2007.03116.x)

Connell, J. M.C., MacKenzie, S. M. , Freel, E. M., Fraser, R. and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29(2), pp. 133-154. (doi: 10.1210/er.2007-0030)

Ye, P., Kenyon, C. J., MacKenzie, S. M. , Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C. and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196(2), pp. 305-311. (doi: 10.1677/JOE-07-0439)

MacKenzie, S. M. , Dewar, D. , Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi: 10.1677/JOE-07-0427)

Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67(6), pp. 832-838. (doi: 10.1111/j.1365-2265.2007.02971.x)

Freel, E.M., Bernhardt, M., Ingram, R., Wallace, A.M., Fraser, R., Davies, E. and Connell, J.M.C. (2007) Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy. Clinical Endocrinology, 66(5), pp. 659-665. (doi: 10.1111/j.1365-2265.2007.02791.x)

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49(1), pp. 113-119. (doi: 10.1161/01.HYP.0000249904.93940.7a)

Barr, M., MacKenzie, S. , Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J. and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65, pp. 816-825. (doi: 10.1111/j.1365-2265.2006.02673.x)

Imrie, H. et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91(12), pp. 5051-5056. (doi: 10.1210/jc.2006-1481)

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12), pp. 5287-5293. (doi: 10.1210/en.2005-0370) (PMID:16179417)

Connell, J. and Davies, E. (2005) The new biology of aldosterone. Journal of Endocrinology, 186, pp. 1-20. (doi: 10.1677/joe.1.06017)

Imrie, H., Mayosi, B., Baker, M., Fraser, R., Davies, E. , Ingram, M., Watkins, H., Farrall, M., Connell, J. and Keavney, B. (2005) Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Journal of Clinical Endocrinology and Metabolism, 90, pp. 1072-1077. (doi: 10.1210/jc.2004-0870)

Freel, E., Shakerdi, L.A., Friel, E., Wallace, A.M., Davies, E., Fraser, R. and Connell, J.M.C. (2004) Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89(9), pp. 4628-4633. (doi: 10.1210/jc.2004-0379)

Freel, E.M., Shakerdi, L., Friel, E., Wallace, A.M., Davies, E. , Fraser, R. and Connell, J.M.C. (2004) The origin of circulating 18-oxo and 18-hydroxycortisol in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 89(9), pp. 4628-4633. (doi: 10.1210/jc.2004-0379)

Connell, J. M.C., Fraser, R., MacKenzie, S. M. , Friel, E. C., Ingram, M. C., Holloway, C. D. and Davies, E. (2004) The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology, 217(1-2), pp. 243-247. (doi: 10.1016/j.mce.2003.10.025) (PMID:15134824)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S. , Davies, E. , Shakerdi, L., Wallace, A., Fraser, R. and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61, pp. 174-181. (doi: 10.1111/j.1365-2265.2004.02073.x)

Davies, E. and MacKenzie, S. M. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30(7), pp. 437-445. (doi: 10.1046/j.1440-1681.2003.03867.x) (PMID:12823256)

Connell, J., Fraser, R., MacKenzie, S. and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41, pp. 993-999. (doi: 10.1161/01.HYP.0000064344.00173.44)

Davies, E. and Kenyon, C. (2003) CYP11B2 polymorphisms and cardiovascular risk factors. [Editorial]. Journal of Hypertension, 21(7), pp. 1249-1253.

Ye, P., Kenyon, C., MacKenzie, S. , Seckl, J., Fraser, R., Connell, J. and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144, pp. 3321-3328. (doi: 10.1210/en.2003-0109)

MacKenzie, S. M. , Fraser, R., Connell, J. M.C. and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3(4), pp. 214-221. (doi: 10.3317/jraas.2002.043) (PMID:12584665)

Draper, N. et al. (2002) Association Studies between Microsatellite Markers within the Gene Encoding Human 11{beta}-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism. Journal of Clinical Endocrinology and Metabolism, 87(11), pp. 4984-4990. (doi: 10.1210/jc.2001-011375)

Lim, P., MacDonald, T., Holloway, C., Friel, E., Anderson, N., Dow, E., Jung, R., Davies, E. , Fraser, R. and Connell, J. (2002) Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. Journal of Clinical Endocrinology and Metabolism, 87(9), pp. 4398-4402.

MacKenzie, S. , Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J. and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29(3), pp. 319-325. (doi: 10.1677/jme.0.0290319)

Connell, J.M.C., Fraser, R. and Davies, E. (2001) Disorders of mineralocorticoid synthesis. Best Practice and Research: Clinical Endocrinology and Metabolism, 15, pp. 43-60. (doi: 10.1053/beem.2000.0118)

Davies, E. , Holloway, C., Ingram, M., Friel, E., Inglis, G., Swan, L., Hillis, W., Fraser, R. and Connell, J. (2001) An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Clinical Endocrinology, 54, pp. 813-817.

Fisher, A., Friel, E., Bernhardt, R., Gomez-Sanchez, C., Connell, J., Fraser, R. and Davies, E. (2001) Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11 beta-hydroxylase. Journal of Clinical Endocrinology and Metabolism, 86, pp. 4326-4329.

Inglis, G., Plouin, P., Friel, E., Davies, E. , Fraser, R. and Connell, J. (2001) Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). Clinical Endocrinology, 54, pp. 725-730.

MacKenzie, S.M. , Clark, C.J., Fraser, R., Gomez-Sanchez, C.E., Connell, J. and Davies, E. (2000) Expression of 11 beta-hydroxylase and aldosterone synthase genes in the rat brain. Journal of Molecular Endocrinology, 24(3), pp. 321-328. (doi: 10.1677/jme.0.0240321) (PMID:10828825)

Clark, C.J., Davies, E. , Anderson, N.H., Farmer, R., Friel, E.C., Fraser, R. and Connell, J.M.C. (2000) alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. Hypertension, 36(6), pp. 990-994.

MacKenzie, S.M. , Clark, C.J., Ingram, M.C., Lai, M., Seckl, J., Gomez-Sanchez, C.E., Fraser, R., Connell, J.M.C. and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26(4), pp. 531-535. (doi: 10.3109/07435800009048566) (PMID:11196425)

Book Sections

MacKenzie, S. M. , Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C. and Davies, E. (2023) MicroRNAs in aldosterone production and action. In: Vitamins and Hormones. Series: Vitamins and hormones. Elsevier. (doi: 10.1016/bs.vh.2023.07.001) (In Press)

MacKenzie, S. M. , Nguyen Dinh Cat, A., van Kralingen, J. and Davies, E. (2019) Aldosterone. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 103-115. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_10)

MacKenzie, S. M. , Van Kralingen, J. C. and Davies, E. (2019) Regulation of aldosterone secretion. In: Litwack, G. (ed.) Aldosterone. Series: Vitamins and Hormones (109). Elsevier, pp. 241-263. ISBN 9780128177822 (doi: 10.1016/bs.vh.2018.07.001)

MacKenzie, S. M. , Davies, E. and Alvarez-Madrazo, S. (2017) Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 139-150. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_11)

This list was generated on Thu Apr 25 08:56:46 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • HT-Advance
    Innovate EU Guarantee
    2022 - 2028
     
  • MINDSHIFT
    European Commission
    2021 - 2025
     
  • ENSAT-HF - Omic-based strategies for improved diagnosis and treatment of endocrine hypertension.
    European Commission
    2015 - 2020
     
  • ENSAT-HF
    European Commission
    2015 - 2020
     
  • Understanding the genetic regulation of adrenal steroid hormones in cardiovascular disease - Developing a stratified approach to cardiovascular care
    Chief Scientist Office
    2014 - 2016
     
  • Analysis of the Adrenodoxin and Adrenodoxin Reductase Genes in Cardiovascular Diseases
    Medical Research Foundation
    2011 - 2013
     
  • Regulation of aldosterone synthase (CYP11B2) and 11b-Hydroxylase gene expression by novel micro RNAs
    British Heart Foundation
    2010 - 2013
     
  • Regulation of aldosterone and cortisol synthesis in hypertension and cardiovascular disease
    Medical Research Council
    2009 - 2011
     
  • Variation in promoter function in CYP11B2 and regulation of aldosterone secretion in cardiovascular disease
    Medical Research Council
    2007 - 2010
     
  • Functional analysis of polymorphisms/mutations in steroidogenic genes and their implications for human cardiovascular homeostasis
    British Heart Foundation
    2005 - 2007
     
  • Quantification of 11 beta-hydroxylase (CYP11B1) gene expression in adipose tissue from normal and obese human subjects
    Tenovus Scotland
    2004 - 2005
     
  • Expression of 11 beta-hydroxylase and aldosterone synthase in the human central nervous system
    North Glasgow University Hospitals NHS Trust
    2003 - 2005
     
  • The Role of Corticosteroids in Cardiovascular Regulation - Studies of the Molecular Basis for Altered Steroid Synthesis
    Medical Research Council
    2000 - 2005
     

Supervision

Additional information

Editorial Board

  • 2009 - present: Endocrinology USA - Editorial Board Member
  • 2003 - 2007: Endocrinology - Member

Grant Advisory Board

  • - present: Medical Research Council - Grant reviewer
  • - present: Wellcome Trust - Grant reviewer
  • - present: British Heart Foundation - Grant reviewer
  • - present: BBSRC - Grant reviewer
  • - present: Royal Society - Grant reviewer

Professional Learned Society

  • 2012: Society for Endocrinology - Programme Co-ordinator for BES 2012
  • 2011 - 2015: Chief Scientist Office - Member of Experimental and Translational Medical Research Committee
  • 2010 - 2014: Society for Endocrinology - Member of Programme Committee
  • 2009 - 2010: International Aldosterone Conference (USA) - Chairman
  • 2008 - 2009: International Aldosterone Conference (USA) - Co-Chairman
  • 2005 - 2008: Society for Endocrinology - Member of Science Committee
  • 2005 - 2009: Society for Endocrinology - Member of Science Committee
  • 2005 - present: Faculty of Medicine 1000 - Faculty Member of Diabetes and Endocrinology

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