Professor Robert Insall

  • Professor (Beatson Institute for Cancer Research)
  • Associate Academic (Institute of Molecular Cell and Systems Biology)

Research interests

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancer
    Engineering & Physical Sciences Research Council
    2016 - 2020
     
  • Chemotaxis in melanoma metastasis.
    Wellcome Trust
    2011 - 2013
     
  • Computational modelling of cell movement and chemotaxis
    MRC
    2009 - 2010
     

Publications

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Number of items: 146.

2017

Susanto, O. et al. (2017) LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells. Journal of Cell Science, (doi:10.1242/jcs.207514) (PMID:28871044) (Early Online Publication)

Husmeier, D. , Ferguson, E., Matthiopoulos, J. and Insall, R. (2017) Statistical Inference of the Drivers of Collective Cell Movement. RSS 2017 Annual Conference, Glasgow, Scotland, 04-07 Sep 2017.

Ferguson, E. A., Matthiopoulos, J. , Insall, R. H. and Husmeier, D. (2017) Statistical inference of the mechanisms driving collective cell movement. Journal of the Royal Statistical Society: Series C (Applied Statistics), 66(4), pp. 869-890. (doi:10.1111/rssc.12203)

Periz, J. et al. (2017) Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. eLife, 6, e24119. (doi:10.7554/eLife.24119) (PMID:28322189) (PMCID:PMC5375643)

Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi:10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)

2016

Veltman, D. M., Williams, T. D., Bloomfield, G., Chen, B.-C., Betzig, E., Insall, R. and Kay, R. R. (2016) A plasma membrane template for macropinocytic cups. eLife, 5, e20085. (doi:10.7554/eLife.20085) (PMID:27960076) (PMCID:PMC5154761)

Mackenzie, J.A., Nolan, M. and Insall, R.H. (2016) Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model. Interface Focus, 6(5), 20160036. (doi:10.1098/rsfs.2016.0036) (PMID:27708760) (PMCID:PMC4992739)

Buckley, C. M., Gopaldass, N., Bosmani, C., Johnston, S. A., Soldati, T., Insall, R. and King, J. S. (2016) WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors. Proceedings of the National Academy of Sciences of the United States of America, 113(40), E5906-E5915. (doi:10.1073/pnas.1524532113) (PMID:27647881) (PMCID:PMC5056073)

Ferguson, E. A., Matthiopoulos, J. , Insall, R. H. and Husmeier, D. (2016) Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma. Journal of the Royal Society: Interface, 13(123), 20160695. (doi:10.1098/rsif.2016.0695) (PMID:27798280)

Tweedy, L., Susanto, O. and Insall, R. H. (2016) Self-generated chemotactic gradients—cells steering themselves. Current Opinion in Cell Biology, 42, pp. 46-51. (doi:10.1016/j.ceb.2016.04.003) (PMID:27105308)

Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H. and Machesky, L. M. (2016) Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell and Melanoma Research, 29(5), pp. 559-571. (doi:10.1111/pcmr.12506) (PMID:27390154) (PMCID:PMC5082549)

Susanto, O., Muinonen-Martin, A. J., Nobis, M. and Insall, R. H. (2016) Visualizing cancer cell chemotaxis and invasion in 2D and 3D. In: Jin, T. and Hereld, D. (eds.) Chemotaxis. Series: Methods in molecular biology, 1407 (1407). Springer, pp. 217-228. ISBN 9781493934782 (doi:10.1007/978-1-4939-3480-5_17)

Frej, A. D. et al. (2016) The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles. Molecular and Cellular Biology, 36(10), pp. 1464-1479. (doi:10.1128/mcb.00039-16) (PMID:26951199) (PMCID:PMC4859692)

Tweedy, L., Knecht, D. A., Mackay, G. N. and Insall, R. H. (2016) Self-generated chemoattractant gradients: attractant depletion extends the range and robustness of chemotaxis. PLoS Biology, 14(3), e1002404. (doi:10.1371/journal.pbio.1002404) (PMID:26981861) (PMCID:PMC4794234)

MacDonald, G., Mackenzie, J.A., Nolan, M. and Insall, R.H. (2016) A computational method for the coupled solution of reaction–diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis. Journal of Computational Physics, 309, pp. 207-226. (doi:10.1016/j.jcp.2015.12.038) (PMID:27330221) (PMCID:PMC4896117)

2015

Siebert, S., Machesky, L. M. and Insall, R. H. (2015) Overflow in science and its implications for trust. eLife, 4, e10825. (doi:10.7554/eLife.10825)

Muinonen-Martin, A. J. and Insall, R. H. (2015) Melanomas’ fatal attraction to lysophosphatidic acid trails: a new prognostic and therapeutic approach? Melanoma Management, 2(2), pp. 97-100. (doi:10.2217/mmt.15.11)

Roberts, H. M., Ling, M. R., Insall, R. , Kalna, G., Spengler, J., Grant, M. M. and Chapple, I. L.C. (2015) Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients. Journal of Clinical Periodontology, 42(1), pp. 1-11. (doi:10.1111/jcpe.12326) (PMID:25360483) (PMCID:PMC4340045)

Urushihara, H. et al. (2015) Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation. BMC Genomics, 16, 80. (doi:10.1186/s12864-015-1278-x) (PMID:25758444) (PMCID:PMC4334915)

2014

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

Veltman, D.M., Lemieux, M.G., Knecht, D.A. and Insall, R.H. (2014) PIP3-dependent macropinocytosis is incompatible with chemotaxis. Journal of Cell Biology, 204(4), pp. 497-505. (doi:10.1083/jcb.201309081)

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R.H. , Stockley, R.A. and Lord, J.M. (2014) Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood, 123(2), pp. 239-248. (doi:10.1182/blood-2013-08-519520)

Tyrrell, B. J., Neilson, M., Insall, R. H. and Machesky, L. M. (2014) Predicting cell shapes in melanomas. Pigment Cell and Melanoma Research, 27(1), pp. 5-6. (doi:10.1111/pcmr.12176) (PMID:24118871)

2013

Davidson, A.J., Ura, S., Thomason, P.A., Kalna, G. and Insall, R.H. (2013) Abi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex. Eukaryotic Cell, 12(11), pp. 1509-1516. (doi:10.1128/EC.00116-13) (PMID:24036345) (PMCID:PMC3837927)

Insall, R.H. (2013) WASH complex conservation: don’t WASH away the family! Trends in Cell Biology, 23(11), pp. 519-520. (doi:10.1016/j.tcb.2013.07.009)

Insall, R. (2013) The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration. Current Opinion in Cell Biology, 25(5), pp. 526-531. (doi:10.1016/j.ceb.2013.04.009)

King, J.S., Gueho, A., Hagedorn, M., Gopaldass, N., Leuba, F., Soldati, T. and Insall, R.H. (2013) WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion. Molecular Biology of the Cell, 24(17), pp. 2714-2726. (doi:10.1091/mbc.E13-02-0092)

Davidson, A.J., King, J.S. and Insall, R.H. (2013) The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum. BioTechniques, 55(1), pp. 39-41. (doi:10.2144/000114054)

Park, L., Thomason, P.A., Zech, T., King, J.S., Veltman, D.M., Carnell, M., Ura, S., Machesky, L.M. and Insall, R.H. (2013) Cyclical Action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell, 24(2), pp. 169-181. (doi:10.1016/j.devcel.2012.12.014)

Choi, C.-H., Thomason, P.A., Zaki, M., Insall, R.H. and Barber, D.D.L. (2013) Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in dictyostelium. Journal of Biological Chemistry, 288(4), pp. 2464-2474. (doi:10.1074/jbc.M112.435313)

Tang, H. et al. (2013) Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology, 23(2), pp. 107-117. (doi:10.1016/j.cub.2012.11.059)

Davidson, A. J. and Insall, R. H. (2013) SCAR/WAVE. Communicative and Integrative Biology, 6(6), e27033. (doi:10.4161/cib.27033) (PMID:24753786) (PMCID:PMC3984289)

Itakura, A., Aslan, J.E., Kusanto, B.T., Phillips, K.G., Porter, J.E., Newton, P.K., Nan, X., Insall, R.H. , Chernoff, J. and McCarty, O.J.T. (2013) p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE, 8(9), e73063. (doi:10.1371/journal.pone.0073063)

Muinonen-Martin, A.J., Knecht, D.A., Veltman, D.M., Thomason, P.A., Kalna, G. and Insall, R.H. (2013) Measuring chemotaxis using direct visualization microscope chambers. Methods in Molecular Biology, 1046, pp. 307-321. (doi:10.1007/978-1-62703-538-5_18)

2012

Shirazi, M. H., Marsh, P., Keane, M. G., Khushal, A. and Insall, R. (2012) Laparoscopic total extra-peritoneal inguinal hernia repairs by a surgeon experienced at laparoscopic cholecystectomy. Journal of the Pakistan Medical Association, 62(12), pp. 1301-1304. (PMID:23866478)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Veltman, D. M., King, J. S., Machesky, L. M. and Insall, R. H. (2012) SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods. Journal of Cell Biology, 198(4), pp. 501-508. (doi:10.1083/jcb.201205058) (PMID:22891261) (PMCID:PMC3514037)

Pakes, N.K., Veltman, D.M., Rivero, F., Nasir, J., Insall, R. and Williams, R.S.B. (2012) The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. Journal of Cell Science, 125(10), pp. 2457-2465. (doi:10.1242/jcs.100966)

Ura, S., Pollitt, A.Y., Veltman, D.M., Morrice, N.A., Machesky, L.M. and Insall, R.H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22(7), pp. 553-561. (doi:10.1016/j.cub.2012.02.020)

Insall, R. (2012) How a paper on RAC set the standard. Nature Reviews Molecular Cell Biology, 13(2), p. 66. (doi:10.1038/nrm3277)

Spence, H.J., Timpson, P., Tang, H.R., Insall, R.H. and Machesky, L.M. (2012) Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. Biochemical Journal, 448(1), pp. 35-42. (doi:10.1042/BJ20112206)

2011

King, J.S., Veltman, D.M. and Insall, R.H. (2011) The induction of autophagy by mechanical stress. Autophagy, 7(12), pp. 1490-1499. (doi:10.4161/auto.7.12.17924)

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Neilson, M. P., Veltman, D. M., van Haastert, P. J. M., Webb, S. D., Mackenzie, J. A. and Insall, R. H. (2011) Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. PLoS Biology, 9(5), e1000618. (doi:10.1371/journal.pbio.1000618)

Sapey, E., Stockley, J. A., Greenwood, H., Ahmad, A., Bayley, D., Lord, J. M., Insall, R. H. and Stockley, R. A. (2011) Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 183(9), pp. 1176-1186. (doi:10.1164/rccm.201008-1285OC)

Shirazi, M. H., Tennant, W. G. and Insall, R. (2011) Novel carotid surgery in an asymptomatic totally occluded common carotid artery. Journal of the Pakistan Medical Association, 61(2), pp. 187-189. (PMID:21375176)

Carnell, M., Zech, T., Calaminus, S.D., Ura, S., Hagedorn, M., Johnston, S.A., May, R.C., Soldati, T., Machesky, L.M. and Insall, R.H. (2011) Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), pp. 831-839. (doi:10.1083/jcb.201009119)

Carnell, M.J. and Insall, R.H. (2011) Actin on disease – Studying the pathobiology of cell motility using Dictyostelium discoideum. Seminars in Cell and Developmental Biology, 22(1), pp. 82-88. (doi:10.1016/j.semcdb.2010.12.003)

Davidson, A. and Insall, R.H. (2011) Actin-Based Motility: WAVE Regulatory Complex Structure Reopens Old SCARs. Current Biology, 21(2), R66-R68. (doi:10.1016/j.cub.2010.12.001)

Insall, R. (2011) Career postdocs increase scrap heap. Nature, 471(7340), p. 578. (doi:10.1038/471578e)

Insall, R.H. (2011) Dogma bites back – the evidence for branched actin. Trends in Cell Biology, 21(1), p. 2. (doi:10.1016/j.tcb.2010.11.002)

Itakura, A., Verbout, N. G., Phillips, K. G., Insall, R.H., Gailani, D., Tucker, E. I., Gruber, A. and McCarty, O. J. T. (2011) Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. Journal of Leukocyte Biology, 90(5), pp. 923-927. (doi:10.1189/jlb.0411182)

Neilson, M.P., Mackenzie, J.A., Webb, S.D. and Insall, R.H. (2011) Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback. SIAM Journal on Scientific Computing, 33(3), pp. 1035-1057. (doi:10.1137/100788938)

Veltman, D.W., Auciello, G., Spence, H.J., Machesky, L.M., Rappoport, J.Z. and Insall, R.H. (2011) Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Biochemical Journal, 436(1), pp. 45-52. (doi:10.1042/BJ20101684)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H., Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

2010

Neilson, M. P., Mackenzie, J. A., Webb, S. D. and Insall, R. H. (2010) Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell. Integrative Biology, 2(11-12), pp. 687-695. (doi:10.1039/c0ib00047g)

Insall, R. H. (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nature Reviews Molecular Cell Biology, 11(6), pp. 453-458. (doi:10.1038/nrm2905)

Gullberg, D., Muinonen-Martin, A.J., Veltman, D.M., Kalna, G. and Insall, R. (2010) An improved chamber for direct visualisation of chemotaxis. PLoS ONE, 5(12), e15309. (doi:10.1371/journal.pone.0015309)

King, J. S., Veltman, D. M., Georgiou, M., Baum, B. and Insall, R. H. (2010) SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis. Journal of Cell Science, 123(13), pp. 2246-2255. (doi:10.1242/jcs.063735)

Veltman, D.M. and Insall, R. H. (2010) WASP Family Proteins: Their Evolution and Its Physiological Implications. Molecular Biology of the Cell, 21(16), pp. 2880-2893. (doi:10.1091/mbc.E10-04-0372)

2009

Kim, J. and Insall, R. (2009) Position and velocity estimation of cell boundary. In: International Conference on Systems Biology, Palo Alto, USA, 30 Aug - 4 Sep 2009,

Insall, R. and Machesky, L.M. (2009) Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks. Developmental Cell, 17(3), pp. 310-322. (doi:10.1016/j.devcel.2009.08.012)

King, J.S. and Insall, R.H. (2009) Chemotaxis: finding the way forward with Dictyostelium. Trends in Cell Biology, 19(10), pp. 523-530. (doi:10.1016/j.tcb.2009.07.004)

Pollitt, A. Y. and Insall, R. H. (2009) WASP and SCAR/WAVE proteins: the drivers of actin assembly. Journal of Cell Science, 122(15), pp. 2575-2578. (doi:10.1242/jcs.023879)

Pollitt, A.Y. and Insall, R.H. (2009) Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein. BMC Cell Biology, 10(1), p. 13. (doi:10.1186/1471-2121-10-13)

2008

Heath, R. J. W. and Insall, R. H. (2008) Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles. Journal of Cell Science, 121(7), pp. 1054-1064. (doi:10.1242/jcs.021113)

Heath, R. J. W. and Insall, R. H. (2008) F-BAR domains: multifunctional regulators of membrane curvature. Journal of Cell Science, 121(12), pp. 1951-1954. (doi:10.1242/jcs.023895)

King, J.S. and Insall, R.H. (2008) Chemotaxis: TorC before You Akt…. Current Biology, 18(18), R864-R866. (doi:10.1016/j.cub.2008.07.051)

Pollitt, A.Y. and Insall, R.H. (2008) Abi Mutants in Dictyostelium Reveal Specific Roles for the SCAR/WAVE Complex in Cytokinesis. Current Biology, 18(3), pp. 203-210. (doi:10.1016/j.cub.2008.01.026)

2007

Zaki, M., King, J., Fütterer, K. and Insall, R. H. (2007) Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics. BMC Genetics, 8(1), 28. (doi:10.1186/1471-2156-8-28) (PMID:17553170) (PMCID:PMC1904233)

Kae, H., Kortholt, A., Rehmann, H., Insall, R. H. , Van Haastert, P. J.M., Spiegelman, G. B. and Weeks, G. (2007) Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. EMBO Reports, 8(5), pp. 477-482. (doi:10.1038/sj.embor.7400936) (PMID:17380187) (PMCID:PMC1866193)

Andrew, N. and Insall, R. H. (2007) Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nature Cell Biology, 9(2), pp. 193-200. (doi:10.1038/ncb1536) (PMID:17220879)

Insall, R. and Andrew, N. (2007) Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. Current Opinion in Microbiology, 10(6), pp. 578-581. (doi:10.1016/j.mib.2007.10.004)

2006

Zaki, M., Andrew, N. and Insall, R. H. (2006) Entamoeba histolytica cell movement: a central role for self-generated chemokines and chemorepellents. Proceedings of the National Academy of Sciences of the United States of America, 103(49), pp. 18751-18756. (doi:10.1073/pnas.0605437103) (PMID:17132728) (PMCID:PMC1693734)

Somesh, B. P., Vlahou, G., Iijima, M., Insall, R. H. , Devreotes, P. and Rivero, F. (2006) RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell, 5(10), pp. 1648-1663. (doi:10.1128/EC.00221-06) (PMID:16950926) (PMCID:PMC1595345)

Pollitt, A. Y., Blagg, S. L., Ibarra, N. and Insall, R. H. (2006) Cell motility and SCAR localisation in axenically growing Dictyostelium cells. European Journal of Cell Biology, 85(9-10), pp. 1091-1098. (doi:10.1016/j.ejcb.2006.05.014) (PMID:16822579)

Insall, R. H. and Jones, G. E. (2006) Moving matters: signals and mechanisms in directed cell migration. Nature Cell Biology, 8(8), pp. 776-779. (doi:10.1038/ncb0806-776) (PMID:16880806)

Ibarra, N., Blagg, S. L., Vazquez, F. and Insall, R. H. (2006) Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways. Current Biology, 16(7), pp. 717-722. (doi:10.1016/j.cub.2006.02.068) (PMID:16581519)

King, J. and Insall, R. (2006) Parasexual genetics using axenic cells. Methods in Molecular Biology, 346, pp. 125-136. (doi:10.1385/1-59745-144-4:125) (PMID:16957288)

2005

Ibarra, N., Pollitt, A. and Insall, R.H. (2005) Regulation of actin assembly by SCAR/WAVE proteins. Biochemical Society Transactions, 33(6), pp. 1243-1246. (doi:10.1042/BST0331243) (PMID:16246088)

Wilkins, A., Szafranski, K., Fraser, D. J., Bakthavatsalam, D., Müller, R., Fisher, P. R., Glöckner, G., Eichinger, L., Noegel, A. A. and Insall, R. H. (2005) The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles. Genome Biology, 6(8), R68. (doi:10.1186/gb-2005-6-8-r68) (PMID:16086850) (PMCID:PMC1273635)

Zouwail, S., Pettit, T. R., Dove, S. K., Chibalina, M. V., Powner, D. J., Haynes, L., Wakelam, M. J.O. and Insall, R. H. (2005) Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium. Biochemical Journal, 389(1), pp. 207-214. (doi:10.1042/BJ20050085) (PMID:15769249)

Insall, R. (2005) The Dictyostelium genome: the private life of a social model revealed? Genome Biology, 6(6), 222. (doi:10.1186/gb-2005-6-6-222) (PMID:15960812) (PMCID:PMC1175964)

2004

Blagg, S.L. and Insall, R.H. (2004) Control of SCAR activity in Dictyostelium discoideum. Biochemical Society Transactions, 32(6), pp. 1113-1114. (doi:10.1042/BST0321113) (PMID:15506982)

Insall, R. (2004) Presidential candidates failed peer-review test. Nature, 432(7016), p. 439. (doi:10.1038/432439c) (PMID:15565125)

Morgan, C. P., Insall, R. , Haynes, L. and Cockcroft, S. (2004) Identification of phospholipase B from Dictyostelium discoideumreveals a new lipase family present in mammals, flies and nematodes, but not yeast. Biochemical Journal, 382(2), pp. 441-449. (doi:10.1042/BJ20040110)

Secko, D. M., Insall, R. H. , Spiegelman, G. B. and Weeks, G. (2004) The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG. Proteomics, 4(9), pp. 2629-2639. (doi:10.1002/pmic.200300788) (PMID:15352238)

Chibalina, M. V., Anjard, C. and Insall, R. H. (2004) Gdt2 regulates the transition of Dictyosteliumcells from growth to differentiation. BMC Developmental Biology, 4(1), 8. (doi:10.1186/1471-213X-4-8)

Insall, R. H. and Machesky, L. M. (2004) Regulation of WASP: PIP2 pipped By Toca-1? Cell, 118(2), pp. 140-141. (doi:10.1016/j.cell.2004.07.005) (PMID:15260983)

Blagg, S. L. and Insall, R. H. (2004) Solving the WAVE function. Nature Cell Biology, 6(4), pp. 279-281. (doi:10.1038/ncb0404-279) (PMID:15057236)

Insall, R. H. (2004) PI3K and chemotaxis: localized patches make the cell’s eyes... Drug Discovery Today, 9(2), p. 97. (doi:10.1016/S1359-6446(03)02923-4)

Blagg, S. and Insall, R. (2004) Scar, WASp and the Arp2/3 complex in Dictyostelium migration. In: Ridley, A., Peckham, M. and Clark, P. (eds.) Cell Motility: From Molecules to Organisms. Wiley: Chichester, pp. 247-260. ISBN 9780470848722 (doi:10.1002/0470011742.ch16)

2003

Blagg, S. L., Stewart, M., Sambles, C. and Insall, R. H. (2003) PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Current Biology, 13(17), pp. 1480-1487. (doi:10.1016/S0960-9822(03)00580-3) (PMID:12956949)

King, J. and Insall, R. H. (2003) Parasexual genetics of Dictyostelium gene disruptions: identification of a ras pathway using diploids. BMC Genetics, 4(1), 12. (doi:10.1186/1471-2156-4-12) (PMID:12854977) (PMCID:PMC183827)

Insall, R. (2003) Impact factors: target the funding bodies. Nature, 423(6940), p. 585. (doi:10.1038/423585b) (PMID:12789312)

Insall, R. (2003) Protein conformation: through a lens, darkly. Biochemical Journal, 372(1), e1-e2. (doi:10.1042/bj20030358COM) (PMID:12939165)

Insall, R. (2003) Dictyostelium chemotaxis: fascism through the back door? Current Biology, 13(9), R353-R354. (doi:10.1016/S0960-9822(03)00274-4) (PMID:12725750)

Insall, R. (2003) Robert Insall. Current Biology, 13(5), R167-R168. (doi:10.1016/s0960-9822(03)00112-x) (PMID:12620201)

Anderson, S. I., Behrendt, B., Machesky, L. M., Insall, R. H. and Nash, G. B. (2003) Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton, 54(2), pp. 135-146. (doi:10.1002/cm.10091) (PMID:12529859)

2002

Chubb, J. R., Wilkins, A., Wessels, D. J., Soll, D. R. and Insall, R. H. (2002) Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants. Cell Motility and the Cytoskeleton, 53(2), pp. 150-162. (doi:10.1002/cm.10064) (PMID:12211111)

Garcia, M. X. U., Roberts, C., Alexander, H., Stewart, A. M., Harwood, A., Alexander, S. and Insall, R. H. (2002) Methanol and acriflavine resistance in Dictyostelium are caused by loss of catalase. Microbiology, 148(1), pp. 333-340. (doi:10.1099/00221287-148-1-333) (PMID:11782526)

2001

Insall, R. H. and Weiner, O. D. (2001) PIP3, PIP2, and cell movement—similar messages, different meanings? Developmental Cell, 1(6), pp. 743-747. (doi:10.1016/S1534-5807(01)00086-7) (PMID:11740936) (PMCID:PMC2819114)

Insall, R. , Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S. J., Weber, I. and Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton, 50(3), pp. 115-128. (doi:10.1002/cm.10005) (PMID:11807934)

Insall, R. H. (2001) The whole organism, and nothing but the organism. Cell, 107(3), pp. 279-281. (doi:10.1016/S0092-8674(01)00558-X) [Book Review]

Machesky, L. M., Insall, R. H. and Volkman, L. E. (2001) WASP homology sequences in baculoviruses. Trends in Cell Biology, 11(7), pp. 286-287. (doi:10.1016/S0962-8924(01)02009-8) (PMID:11434350)

Chubb, J. R. and Insall, R. H. (2001) Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks. Biochimica et Biophysica Acta: General Subjects, 1525(3), pp. 262-271. (doi:10.1016/S0304-4165(01)00111-8) (PMID:11257439)

Wilkins, A. and Insall, R. H. (2001) Small GTPases in Dictyostelium: lessons from a social amoeba. Trends in Genetics, 17(1), pp. 41-48. (doi:10.1016/S0168-9525(00)02181-8) (PMID:11163921)

Insall, R. and Machesky, L. (2001) Cytoskeleton. Encyclopedia of Life Sciences, (doi:10.1038/npg.els.0001252)

2000

Wilkins, A., Chubb, J. R. and Insall, R. H. (2000) A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development. Current Biology, 10(22), pp. 1427-1437. (doi:10.1016/S0960-9822(00)00797-1) (PMID:11102804)

Insall, R. (2000) The PKB that doesn’t need to jump. Trends in Genetics, 16(10), p. 441. (doi:10.1016/S0168-9525(00)02130-2) (PMID:11050328)

Traynor, D., Milne, J. L.S., Insall, R. H. and Kay, R. R. (2000) Ca2+ signalling is not required for chemotaxis in Dictyostelium. EMBO Journal, 19(17), pp. 4846-4854. (doi:10.1093/emboj/19.17.4846) (PMID:10970875) (PMCID:PMC302083)

Wilkins, A., Khosla, M., Fraser, D. J., Spiegelman, G. B., Fisher, P. R., Weeks, G. and Insall, R. H. (2000) Dictyostelium RasD is required for normal phototaxis, but not differentiation. Genes and Development, 14(11), pp. 1407-1413. (doi:10.1101/gad.14.11.1407) (PMID:10837033) (PMCID:PMC316659)

Swigart, P., Insall, R. , Wilkins, A. and Cockroft, S. (2000) Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae Sec14p are found in the same cell. Biochemical Journal, 347(3), pp. 837-843. (doi:10.1042/bj3470837) (PMID:10769190)

Insall, R. (2000) Too much of a good thing? Current Biology, 10(7), R253. (doi:10.1016/S0960-9822(00)00409-7) (PMID:10753757)

Khosla, M., Spiegelman, G. B., Insall, R. and Weeks, G. (2000) Functional overlap of the dictyostelium RasG, RasD and RasB proteins. Journal of Cell Science, 113(8), pp. 1427-1434. (PMID:10725225)

Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H. , Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A. and Yin, H.L. (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology, 10(6), pp. 311-320. (doi:10.1016/S0960-9822(00)00384-5) (PMID:10744973)

Chubb, J. R., Wilkins, A., Thomas, G. M. and Insall, R. H. (2000) The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement. Journal of Cell Science, 113(4), pp. 709-719. (PMID:10652263)

1999

Loomis, W. F. and Insall, R. H. (1999) A cell for all reasons. Nature, 401(6752), pp. 440-441. (doi:10.1038/46713) (PMID:10519543)

Lee, S., Parent, C. A., Insall, R. and Firtel, R. A. (1999) A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Molecular Biology of the Cell, 10(9), pp. 2829-2845. (doi:10.1091/mbc.10.9.2829) (PMID:10473630) (PMCID:PMC25521)

Machesky, L. M. and Insall, R. H. (1999) Signaling to actin dynamics. Journal of Cell Biology, 146(2), pp. 267-272. (doi:10.1083/jcb.146.2.267) (PMID:10427083) (PMCID:PMC2156183)

Insall, R. (1999) PKB starts to jump. Trends in Genetics, 15(7), p. 260. (doi:10.1016/S0168-9525(99)01802-8)

Insall, R. and Machesky, L. (1999) PH domains in WASP – a bug in the system? Trends in Cell Biology, 9(6), p. 211. (doi:10.1016/S0962-8924(99)01569-X) (PMID:10354565)

Insall, R. (1999) Cynicism and credulity. Current Biology, 9(7), R231. (doi:10.1016/S0960-9822(99)80147-X) (PMID:10209127)

1998

Machesky, L. M. and Insall, R. H. (1998) Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Current Biology, 8(25), pp. 1347-1356. (doi:10.1016/S0960-9822(98)00015-3) (PMID:9889097)

Insall, R. (1998) Keeping it in the family. Current Biology, 8(12), R401. (doi:10.1016/S0960-9822(98)70258-1)

Machesky, L. M., Insall, R. H. and Kay, R. R. (1998) The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Current Biology, 8(10), 607-S4. (doi:10.1016/S0960-9822(98)70233-7) (PMID:9601648)

1997

Insall, R. (1997) The right stuff. Current Biology, 7(11), R665. (doi:10.1016/S0960-9822(06)00345-9) (PMID:9382817)

Tuxworth, R. I., Cheetham, J. L., Machesky, L. M., Spiegelmann, G. B., Weeks, G. and Insall, R. H. (1997) Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. Journal of Cell Biology, 138(3), pp. 605-614. (doi:10.1083/jcb.138.3.605) (PMID:9245789) (PMCID:PMC2141629)

Insall, R. (1997) The talk's the thing. Current Biology, 7(6), R331. (doi:10.1016/S0960-9822(06)00161-8)

Aubry, L., Maeda, M., Insall, R. , Devreotes, P. N. and Firtel, R. A. (1997) The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. Journal of Biological Chemistry, 272(7), pp. 3883-3886. (doi:10.1074/jbc.272.7.3883) (PMID:9020088)

Insall, R. (1997) The enemy within. Current Biology, 7(2), R59. (doi:10.1016/S0960-9822(06)00032-7) (PMID:9081661)

1996

Insall, R. (1996) The art of MBoC by B.A. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J. Watson. Trends in Genetics, 12(10), p. 430. (doi:10.1016/0168-9525(96)81491-0) [Book Review]

Insall, R. H. , Borleis, J. and Devreotes, P. N. (1996) The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology, 6(6), pp. 719-729. (doi:10.1016/S0960-9822(09)00453-9) (PMID:8793298)

Insall, R. H. (1996) Osmoregulation: cyclic GMP and the big squeeze. Current Biology, 6(5), pp. 516-518. (doi:10.1016/S0960-9822(02)00530-4) (PMID:8805270)

Maeda, M., Aubry, L., Insall, R. , Gaskins, C., Devreotes, P. N. and Firtel, R. A. (1996) Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Journal of Biological Chemistry, 271(7), pp. 3351-3354. (doi:10.1074/jbc.271.7.3351) (PMID:8631932)

Chen, M.-Y., Insall, R. H. and Devreotes, P. N. (1996) Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics, 12(2), pp. 52-57. (doi:10.1016/0168-9525(96)81400-4) (PMID:8851971)

Insall, R. (1996) And now it's time for tea. Current Biology, 6(2), p. 99. (doi:10.1016/S0960-9822(02)00427-X) (PMID:8859322)

1995

Insall, R. (1995) Glycogen synthase kinase and Dictyostelium development: old pathways pointing in new directions? Trends in Genetics, 11(2), pp. 37-39. (doi:10.1016/S0168-9525(00)88989-1) (PMID:7716803)

1994

Insall, R. , Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F. and Devreotes, P. (1994) CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. Journal of Cell Biology, 126(6), pp. 1537-1545. (doi:10.1083/jcb.126.6.1537) (PMID:8089184) (PMCID:PMC2290948)

Soede, R. D.M., Insall, R. H. , Devreotes, P. N. and Schaap, P. (1994) Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression. Development, 120(7), pp. 1997-2002. (PMID:7925004)

Insall, R. H. , Soede, R. D.M., Schaap, P. and Devreotes, P. N. (1994) Two cAMP receptors activate common signaling pathways in Dictyostelium. Molecular Biology of the Cell, 5(6), pp. 703-711. (doi:10.1091/mbc.5.6.703) (PMID:7949426) (PMCID:PMC301085)

1992

Pupillo, M., Insall, R. , Pitt, G. S. and Devreotes, P. N. (1992) Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molecular Biology of the Cell, 3(11), pp. 1229-1234. (doi:10.1091/mbc.3.11.1229) (PMID:1333842) (PMCID:PMC275689)

Insall, R. , Nayler, O. and Kay, R. R. (1992) DIF-1 induces its own breakdown in Dictyostelium. EMBO Journal, 11(8), pp. 2849-2854. (PMID:1322291) (PMCID:PMC556764)

Ceccarelli, A., Mahbubani, H. J., Insall, R. , Schnitzler, G., Firtel, R. A. and Williams, J. G. (1992) A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression. Developmental Biology, 152(1), pp. 188-193. (doi:10.1016/0012-1606(92)90169-H) (PMID:1321061)

1991

Berks, M., Traynor, D., Carrin, I., Insall, R. H. and Kay, R. R. (1991) Diffusible signal molecules controlling cell differentiation and patterning in Dictyostelium. Development, 113(S1), pp. 131-139. (PMID:1660326)

1990

Insall, R. and Kay, R. R. (1990) A specific DIF binding protein in Dictyostelium. EMBO Journal, 9(10), pp. 3323-3328. (PMID:2170113) (PMCID:PMC552069)

This list was generated on Fri Oct 20 00:54:56 2017 BST.
Number of items: 146.

Articles

Susanto, O. et al. (2017) LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells. Journal of Cell Science, (doi:10.1242/jcs.207514) (PMID:28871044) (Early Online Publication)

Ferguson, E. A., Matthiopoulos, J. , Insall, R. H. and Husmeier, D. (2017) Statistical inference of the mechanisms driving collective cell movement. Journal of the Royal Statistical Society: Series C (Applied Statistics), 66(4), pp. 869-890. (doi:10.1111/rssc.12203)

Periz, J. et al. (2017) Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. eLife, 6, e24119. (doi:10.7554/eLife.24119) (PMID:28322189) (PMCID:PMC5375643)

Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi:10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)

Veltman, D. M., Williams, T. D., Bloomfield, G., Chen, B.-C., Betzig, E., Insall, R. and Kay, R. R. (2016) A plasma membrane template for macropinocytic cups. eLife, 5, e20085. (doi:10.7554/eLife.20085) (PMID:27960076) (PMCID:PMC5154761)

Mackenzie, J.A., Nolan, M. and Insall, R.H. (2016) Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model. Interface Focus, 6(5), 20160036. (doi:10.1098/rsfs.2016.0036) (PMID:27708760) (PMCID:PMC4992739)

Buckley, C. M., Gopaldass, N., Bosmani, C., Johnston, S. A., Soldati, T., Insall, R. and King, J. S. (2016) WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors. Proceedings of the National Academy of Sciences of the United States of America, 113(40), E5906-E5915. (doi:10.1073/pnas.1524532113) (PMID:27647881) (PMCID:PMC5056073)

Ferguson, E. A., Matthiopoulos, J. , Insall, R. H. and Husmeier, D. (2016) Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma. Journal of the Royal Society: Interface, 13(123), 20160695. (doi:10.1098/rsif.2016.0695) (PMID:27798280)

Tweedy, L., Susanto, O. and Insall, R. H. (2016) Self-generated chemotactic gradients—cells steering themselves. Current Opinion in Cell Biology, 42, pp. 46-51. (doi:10.1016/j.ceb.2016.04.003) (PMID:27105308)

Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H. and Machesky, L. M. (2016) Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell and Melanoma Research, 29(5), pp. 559-571. (doi:10.1111/pcmr.12506) (PMID:27390154) (PMCID:PMC5082549)

Frej, A. D. et al. (2016) The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles. Molecular and Cellular Biology, 36(10), pp. 1464-1479. (doi:10.1128/mcb.00039-16) (PMID:26951199) (PMCID:PMC4859692)

Tweedy, L., Knecht, D. A., Mackay, G. N. and Insall, R. H. (2016) Self-generated chemoattractant gradients: attractant depletion extends the range and robustness of chemotaxis. PLoS Biology, 14(3), e1002404. (doi:10.1371/journal.pbio.1002404) (PMID:26981861) (PMCID:PMC4794234)

MacDonald, G., Mackenzie, J.A., Nolan, M. and Insall, R.H. (2016) A computational method for the coupled solution of reaction–diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis. Journal of Computational Physics, 309, pp. 207-226. (doi:10.1016/j.jcp.2015.12.038) (PMID:27330221) (PMCID:PMC4896117)

Siebert, S., Machesky, L. M. and Insall, R. H. (2015) Overflow in science and its implications for trust. eLife, 4, e10825. (doi:10.7554/eLife.10825)

Muinonen-Martin, A. J. and Insall, R. H. (2015) Melanomas’ fatal attraction to lysophosphatidic acid trails: a new prognostic and therapeutic approach? Melanoma Management, 2(2), pp. 97-100. (doi:10.2217/mmt.15.11)

Roberts, H. M., Ling, M. R., Insall, R. , Kalna, G., Spengler, J., Grant, M. M. and Chapple, I. L.C. (2015) Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients. Journal of Clinical Periodontology, 42(1), pp. 1-11. (doi:10.1111/jcpe.12326) (PMID:25360483) (PMCID:PMC4340045)

Urushihara, H. et al. (2015) Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation. BMC Genomics, 16, 80. (doi:10.1186/s12864-015-1278-x) (PMID:25758444) (PMCID:PMC4334915)

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

Veltman, D.M., Lemieux, M.G., Knecht, D.A. and Insall, R.H. (2014) PIP3-dependent macropinocytosis is incompatible with chemotaxis. Journal of Cell Biology, 204(4), pp. 497-505. (doi:10.1083/jcb.201309081)

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R.H. , Stockley, R.A. and Lord, J.M. (2014) Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood, 123(2), pp. 239-248. (doi:10.1182/blood-2013-08-519520)

Tyrrell, B. J., Neilson, M., Insall, R. H. and Machesky, L. M. (2014) Predicting cell shapes in melanomas. Pigment Cell and Melanoma Research, 27(1), pp. 5-6. (doi:10.1111/pcmr.12176) (PMID:24118871)

Davidson, A.J., Ura, S., Thomason, P.A., Kalna, G. and Insall, R.H. (2013) Abi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex. Eukaryotic Cell, 12(11), pp. 1509-1516. (doi:10.1128/EC.00116-13) (PMID:24036345) (PMCID:PMC3837927)

Insall, R.H. (2013) WASH complex conservation: don’t WASH away the family! Trends in Cell Biology, 23(11), pp. 519-520. (doi:10.1016/j.tcb.2013.07.009)

Insall, R. (2013) The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration. Current Opinion in Cell Biology, 25(5), pp. 526-531. (doi:10.1016/j.ceb.2013.04.009)

King, J.S., Gueho, A., Hagedorn, M., Gopaldass, N., Leuba, F., Soldati, T. and Insall, R.H. (2013) WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion. Molecular Biology of the Cell, 24(17), pp. 2714-2726. (doi:10.1091/mbc.E13-02-0092)

Davidson, A.J., King, J.S. and Insall, R.H. (2013) The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum. BioTechniques, 55(1), pp. 39-41. (doi:10.2144/000114054)

Park, L., Thomason, P.A., Zech, T., King, J.S., Veltman, D.M., Carnell, M., Ura, S., Machesky, L.M. and Insall, R.H. (2013) Cyclical Action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. Developmental Cell, 24(2), pp. 169-181. (doi:10.1016/j.devcel.2012.12.014)

Choi, C.-H., Thomason, P.A., Zaki, M., Insall, R.H. and Barber, D.D.L. (2013) Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in dictyostelium. Journal of Biological Chemistry, 288(4), pp. 2464-2474. (doi:10.1074/jbc.M112.435313)

Tang, H. et al. (2013) Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Current Biology, 23(2), pp. 107-117. (doi:10.1016/j.cub.2012.11.059)

Davidson, A. J. and Insall, R. H. (2013) SCAR/WAVE. Communicative and Integrative Biology, 6(6), e27033. (doi:10.4161/cib.27033) (PMID:24753786) (PMCID:PMC3984289)

Itakura, A., Aslan, J.E., Kusanto, B.T., Phillips, K.G., Porter, J.E., Newton, P.K., Nan, X., Insall, R.H. , Chernoff, J. and McCarty, O.J.T. (2013) p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE, 8(9), e73063. (doi:10.1371/journal.pone.0073063)

Muinonen-Martin, A.J., Knecht, D.A., Veltman, D.M., Thomason, P.A., Kalna, G. and Insall, R.H. (2013) Measuring chemotaxis using direct visualization microscope chambers. Methods in Molecular Biology, 1046, pp. 307-321. (doi:10.1007/978-1-62703-538-5_18)

Shirazi, M. H., Marsh, P., Keane, M. G., Khushal, A. and Insall, R. (2012) Laparoscopic total extra-peritoneal inguinal hernia repairs by a surgeon experienced at laparoscopic cholecystectomy. Journal of the Pakistan Medical Association, 62(12), pp. 1301-1304. (PMID:23866478)

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi:10.1083/jcb.201203025)

Veltman, D. M., King, J. S., Machesky, L. M. and Insall, R. H. (2012) SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods. Journal of Cell Biology, 198(4), pp. 501-508. (doi:10.1083/jcb.201205058) (PMID:22891261) (PMCID:PMC3514037)

Pakes, N.K., Veltman, D.M., Rivero, F., Nasir, J., Insall, R. and Williams, R.S.B. (2012) The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. Journal of Cell Science, 125(10), pp. 2457-2465. (doi:10.1242/jcs.100966)

Ura, S., Pollitt, A.Y., Veltman, D.M., Morrice, N.A., Machesky, L.M. and Insall, R.H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22(7), pp. 553-561. (doi:10.1016/j.cub.2012.02.020)

Insall, R. (2012) How a paper on RAC set the standard. Nature Reviews Molecular Cell Biology, 13(2), p. 66. (doi:10.1038/nrm3277)

Spence, H.J., Timpson, P., Tang, H.R., Insall, R.H. and Machesky, L.M. (2012) Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. Biochemical Journal, 448(1), pp. 35-42. (doi:10.1042/BJ20112206)

King, J.S., Veltman, D.M. and Insall, R.H. (2011) The induction of autophagy by mechanical stress. Autophagy, 7(12), pp. 1490-1499. (doi:10.4161/auto.7.12.17924)

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Neilson, M. P., Veltman, D. M., van Haastert, P. J. M., Webb, S. D., Mackenzie, J. A. and Insall, R. H. (2011) Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. PLoS Biology, 9(5), e1000618. (doi:10.1371/journal.pbio.1000618)

Sapey, E., Stockley, J. A., Greenwood, H., Ahmad, A., Bayley, D., Lord, J. M., Insall, R. H. and Stockley, R. A. (2011) Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 183(9), pp. 1176-1186. (doi:10.1164/rccm.201008-1285OC)

Shirazi, M. H., Tennant, W. G. and Insall, R. (2011) Novel carotid surgery in an asymptomatic totally occluded common carotid artery. Journal of the Pakistan Medical Association, 61(2), pp. 187-189. (PMID:21375176)

Carnell, M., Zech, T., Calaminus, S.D., Ura, S., Hagedorn, M., Johnston, S.A., May, R.C., Soldati, T., Machesky, L.M. and Insall, R.H. (2011) Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), pp. 831-839. (doi:10.1083/jcb.201009119)

Carnell, M.J. and Insall, R.H. (2011) Actin on disease – Studying the pathobiology of cell motility using Dictyostelium discoideum. Seminars in Cell and Developmental Biology, 22(1), pp. 82-88. (doi:10.1016/j.semcdb.2010.12.003)

Davidson, A. and Insall, R.H. (2011) Actin-Based Motility: WAVE Regulatory Complex Structure Reopens Old SCARs. Current Biology, 21(2), R66-R68. (doi:10.1016/j.cub.2010.12.001)

Insall, R. (2011) Career postdocs increase scrap heap. Nature, 471(7340), p. 578. (doi:10.1038/471578e)

Insall, R.H. (2011) Dogma bites back – the evidence for branched actin. Trends in Cell Biology, 21(1), p. 2. (doi:10.1016/j.tcb.2010.11.002)

Itakura, A., Verbout, N. G., Phillips, K. G., Insall, R.H., Gailani, D., Tucker, E. I., Gruber, A. and McCarty, O. J. T. (2011) Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. Journal of Leukocyte Biology, 90(5), pp. 923-927. (doi:10.1189/jlb.0411182)

Neilson, M.P., Mackenzie, J.A., Webb, S.D. and Insall, R.H. (2011) Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback. SIAM Journal on Scientific Computing, 33(3), pp. 1035-1057. (doi:10.1137/100788938)

Veltman, D.W., Auciello, G., Spence, H.J., Machesky, L.M., Rappoport, J.Z. and Insall, R.H. (2011) Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Biochemical Journal, 436(1), pp. 45-52. (doi:10.1042/BJ20101684)

Zech, T., Calaminus, S.D.J., Caswell, P., Spence, H.J., Carnell, M., Insall, R.H., Norman, J. and Machesky, L.M. (2011) The Arp2/3 activator WASH regulates 5 1-integrin-mediated invasive migration. Journal of Cell Science, 124(22), pp. 3753-3759. (doi:10.1242/jcs.080986)

Neilson, M. P., Mackenzie, J. A., Webb, S. D. and Insall, R. H. (2010) Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell. Integrative Biology, 2(11-12), pp. 687-695. (doi:10.1039/c0ib00047g)

Insall, R. H. (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nature Reviews Molecular Cell Biology, 11(6), pp. 453-458. (doi:10.1038/nrm2905)

Gullberg, D., Muinonen-Martin, A.J., Veltman, D.M., Kalna, G. and Insall, R. (2010) An improved chamber for direct visualisation of chemotaxis. PLoS ONE, 5(12), e15309. (doi:10.1371/journal.pone.0015309)

King, J. S., Veltman, D. M., Georgiou, M., Baum, B. and Insall, R. H. (2010) SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis. Journal of Cell Science, 123(13), pp. 2246-2255. (doi:10.1242/jcs.063735)

Veltman, D.M. and Insall, R. H. (2010) WASP Family Proteins: Their Evolution and Its Physiological Implications. Molecular Biology of the Cell, 21(16), pp. 2880-2893. (doi:10.1091/mbc.E10-04-0372)

Insall, R. and Machesky, L.M. (2009) Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks. Developmental Cell, 17(3), pp. 310-322. (doi:10.1016/j.devcel.2009.08.012)

King, J.S. and Insall, R.H. (2009) Chemotaxis: finding the way forward with Dictyostelium. Trends in Cell Biology, 19(10), pp. 523-530. (doi:10.1016/j.tcb.2009.07.004)

Pollitt, A. Y. and Insall, R. H. (2009) WASP and SCAR/WAVE proteins: the drivers of actin assembly. Journal of Cell Science, 122(15), pp. 2575-2578. (doi:10.1242/jcs.023879)

Pollitt, A.Y. and Insall, R.H. (2009) Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein. BMC Cell Biology, 10(1), p. 13. (doi:10.1186/1471-2121-10-13)

Heath, R. J. W. and Insall, R. H. (2008) Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles. Journal of Cell Science, 121(7), pp. 1054-1064. (doi:10.1242/jcs.021113)

Heath, R. J. W. and Insall, R. H. (2008) F-BAR domains: multifunctional regulators of membrane curvature. Journal of Cell Science, 121(12), pp. 1951-1954. (doi:10.1242/jcs.023895)

King, J.S. and Insall, R.H. (2008) Chemotaxis: TorC before You Akt…. Current Biology, 18(18), R864-R866. (doi:10.1016/j.cub.2008.07.051)

Pollitt, A.Y. and Insall, R.H. (2008) Abi Mutants in Dictyostelium Reveal Specific Roles for the SCAR/WAVE Complex in Cytokinesis. Current Biology, 18(3), pp. 203-210. (doi:10.1016/j.cub.2008.01.026)

Zaki, M., King, J., Fütterer, K. and Insall, R. H. (2007) Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics. BMC Genetics, 8(1), 28. (doi:10.1186/1471-2156-8-28) (PMID:17553170) (PMCID:PMC1904233)

Kae, H., Kortholt, A., Rehmann, H., Insall, R. H. , Van Haastert, P. J.M., Spiegelman, G. B. and Weeks, G. (2007) Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. EMBO Reports, 8(5), pp. 477-482. (doi:10.1038/sj.embor.7400936) (PMID:17380187) (PMCID:PMC1866193)

Andrew, N. and Insall, R. H. (2007) Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nature Cell Biology, 9(2), pp. 193-200. (doi:10.1038/ncb1536) (PMID:17220879)

Insall, R. and Andrew, N. (2007) Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. Current Opinion in Microbiology, 10(6), pp. 578-581. (doi:10.1016/j.mib.2007.10.004)

Zaki, M., Andrew, N. and Insall, R. H. (2006) Entamoeba histolytica cell movement: a central role for self-generated chemokines and chemorepellents. Proceedings of the National Academy of Sciences of the United States of America, 103(49), pp. 18751-18756. (doi:10.1073/pnas.0605437103) (PMID:17132728) (PMCID:PMC1693734)

Somesh, B. P., Vlahou, G., Iijima, M., Insall, R. H. , Devreotes, P. and Rivero, F. (2006) RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell, 5(10), pp. 1648-1663. (doi:10.1128/EC.00221-06) (PMID:16950926) (PMCID:PMC1595345)

Pollitt, A. Y., Blagg, S. L., Ibarra, N. and Insall, R. H. (2006) Cell motility and SCAR localisation in axenically growing Dictyostelium cells. European Journal of Cell Biology, 85(9-10), pp. 1091-1098. (doi:10.1016/j.ejcb.2006.05.014) (PMID:16822579)

Insall, R. H. and Jones, G. E. (2006) Moving matters: signals and mechanisms in directed cell migration. Nature Cell Biology, 8(8), pp. 776-779. (doi:10.1038/ncb0806-776) (PMID:16880806)

Ibarra, N., Blagg, S. L., Vazquez, F. and Insall, R. H. (2006) Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways. Current Biology, 16(7), pp. 717-722. (doi:10.1016/j.cub.2006.02.068) (PMID:16581519)

King, J. and Insall, R. (2006) Parasexual genetics using axenic cells. Methods in Molecular Biology, 346, pp. 125-136. (doi:10.1385/1-59745-144-4:125) (PMID:16957288)

Ibarra, N., Pollitt, A. and Insall, R.H. (2005) Regulation of actin assembly by SCAR/WAVE proteins. Biochemical Society Transactions, 33(6), pp. 1243-1246. (doi:10.1042/BST0331243) (PMID:16246088)

Wilkins, A., Szafranski, K., Fraser, D. J., Bakthavatsalam, D., Müller, R., Fisher, P. R., Glöckner, G., Eichinger, L., Noegel, A. A. and Insall, R. H. (2005) The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles. Genome Biology, 6(8), R68. (doi:10.1186/gb-2005-6-8-r68) (PMID:16086850) (PMCID:PMC1273635)

Zouwail, S., Pettit, T. R., Dove, S. K., Chibalina, M. V., Powner, D. J., Haynes, L., Wakelam, M. J.O. and Insall, R. H. (2005) Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium. Biochemical Journal, 389(1), pp. 207-214. (doi:10.1042/BJ20050085) (PMID:15769249)

Insall, R. (2005) The Dictyostelium genome: the private life of a social model revealed? Genome Biology, 6(6), 222. (doi:10.1186/gb-2005-6-6-222) (PMID:15960812) (PMCID:PMC1175964)

Blagg, S.L. and Insall, R.H. (2004) Control of SCAR activity in Dictyostelium discoideum. Biochemical Society Transactions, 32(6), pp. 1113-1114. (doi:10.1042/BST0321113) (PMID:15506982)

Insall, R. (2004) Presidential candidates failed peer-review test. Nature, 432(7016), p. 439. (doi:10.1038/432439c) (PMID:15565125)

Morgan, C. P., Insall, R. , Haynes, L. and Cockcroft, S. (2004) Identification of phospholipase B from Dictyostelium discoideumreveals a new lipase family present in mammals, flies and nematodes, but not yeast. Biochemical Journal, 382(2), pp. 441-449. (doi:10.1042/BJ20040110)

Secko, D. M., Insall, R. H. , Spiegelman, G. B. and Weeks, G. (2004) The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG. Proteomics, 4(9), pp. 2629-2639. (doi:10.1002/pmic.200300788) (PMID:15352238)

Chibalina, M. V., Anjard, C. and Insall, R. H. (2004) Gdt2 regulates the transition of Dictyosteliumcells from growth to differentiation. BMC Developmental Biology, 4(1), 8. (doi:10.1186/1471-213X-4-8)

Insall, R. H. and Machesky, L. M. (2004) Regulation of WASP: PIP2 pipped By Toca-1? Cell, 118(2), pp. 140-141. (doi:10.1016/j.cell.2004.07.005) (PMID:15260983)

Blagg, S. L. and Insall, R. H. (2004) Solving the WAVE function. Nature Cell Biology, 6(4), pp. 279-281. (doi:10.1038/ncb0404-279) (PMID:15057236)

Insall, R. H. (2004) PI3K and chemotaxis: localized patches make the cell’s eyes... Drug Discovery Today, 9(2), p. 97. (doi:10.1016/S1359-6446(03)02923-4)

Blagg, S. L., Stewart, M., Sambles, C. and Insall, R. H. (2003) PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Current Biology, 13(17), pp. 1480-1487. (doi:10.1016/S0960-9822(03)00580-3) (PMID:12956949)

King, J. and Insall, R. H. (2003) Parasexual genetics of Dictyostelium gene disruptions: identification of a ras pathway using diploids. BMC Genetics, 4(1), 12. (doi:10.1186/1471-2156-4-12) (PMID:12854977) (PMCID:PMC183827)

Insall, R. (2003) Impact factors: target the funding bodies. Nature, 423(6940), p. 585. (doi:10.1038/423585b) (PMID:12789312)

Insall, R. (2003) Protein conformation: through a lens, darkly. Biochemical Journal, 372(1), e1-e2. (doi:10.1042/bj20030358COM) (PMID:12939165)

Insall, R. (2003) Dictyostelium chemotaxis: fascism through the back door? Current Biology, 13(9), R353-R354. (doi:10.1016/S0960-9822(03)00274-4) (PMID:12725750)

Insall, R. (2003) Robert Insall. Current Biology, 13(5), R167-R168. (doi:10.1016/s0960-9822(03)00112-x) (PMID:12620201)

Anderson, S. I., Behrendt, B., Machesky, L. M., Insall, R. H. and Nash, G. B. (2003) Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motility and the Cytoskeleton, 54(2), pp. 135-146. (doi:10.1002/cm.10091) (PMID:12529859)

Chubb, J. R., Wilkins, A., Wessels, D. J., Soll, D. R. and Insall, R. H. (2002) Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants. Cell Motility and the Cytoskeleton, 53(2), pp. 150-162. (doi:10.1002/cm.10064) (PMID:12211111)

Garcia, M. X. U., Roberts, C., Alexander, H., Stewart, A. M., Harwood, A., Alexander, S. and Insall, R. H. (2002) Methanol and acriflavine resistance in Dictyostelium are caused by loss of catalase. Microbiology, 148(1), pp. 333-340. (doi:10.1099/00221287-148-1-333) (PMID:11782526)

Insall, R. H. and Weiner, O. D. (2001) PIP3, PIP2, and cell movement—similar messages, different meanings? Developmental Cell, 1(6), pp. 743-747. (doi:10.1016/S1534-5807(01)00086-7) (PMID:11740936) (PMCID:PMC2819114)

Insall, R. , Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S. J., Weber, I. and Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton, 50(3), pp. 115-128. (doi:10.1002/cm.10005) (PMID:11807934)

Machesky, L. M., Insall, R. H. and Volkman, L. E. (2001) WASP homology sequences in baculoviruses. Trends in Cell Biology, 11(7), pp. 286-287. (doi:10.1016/S0962-8924(01)02009-8) (PMID:11434350)

Chubb, J. R. and Insall, R. H. (2001) Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks. Biochimica et Biophysica Acta: General Subjects, 1525(3), pp. 262-271. (doi:10.1016/S0304-4165(01)00111-8) (PMID:11257439)

Wilkins, A. and Insall, R. H. (2001) Small GTPases in Dictyostelium: lessons from a social amoeba. Trends in Genetics, 17(1), pp. 41-48. (doi:10.1016/S0168-9525(00)02181-8) (PMID:11163921)

Insall, R. and Machesky, L. (2001) Cytoskeleton. Encyclopedia of Life Sciences, (doi:10.1038/npg.els.0001252)

Wilkins, A., Chubb, J. R. and Insall, R. H. (2000) A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development. Current Biology, 10(22), pp. 1427-1437. (doi:10.1016/S0960-9822(00)00797-1) (PMID:11102804)

Insall, R. (2000) The PKB that doesn’t need to jump. Trends in Genetics, 16(10), p. 441. (doi:10.1016/S0168-9525(00)02130-2) (PMID:11050328)

Traynor, D., Milne, J. L.S., Insall, R. H. and Kay, R. R. (2000) Ca2+ signalling is not required for chemotaxis in Dictyostelium. EMBO Journal, 19(17), pp. 4846-4854. (doi:10.1093/emboj/19.17.4846) (PMID:10970875) (PMCID:PMC302083)

Wilkins, A., Khosla, M., Fraser, D. J., Spiegelman, G. B., Fisher, P. R., Weeks, G. and Insall, R. H. (2000) Dictyostelium RasD is required for normal phototaxis, but not differentiation. Genes and Development, 14(11), pp. 1407-1413. (doi:10.1101/gad.14.11.1407) (PMID:10837033) (PMCID:PMC316659)

Swigart, P., Insall, R. , Wilkins, A. and Cockroft, S. (2000) Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae Sec14p are found in the same cell. Biochemical Journal, 347(3), pp. 837-843. (doi:10.1042/bj3470837) (PMID:10769190)

Insall, R. (2000) Too much of a good thing? Current Biology, 10(7), R253. (doi:10.1016/S0960-9822(00)00409-7) (PMID:10753757)

Khosla, M., Spiegelman, G. B., Insall, R. and Weeks, G. (2000) Functional overlap of the dictyostelium RasG, RasD and RasB proteins. Journal of Cell Science, 113(8), pp. 1427-1434. (PMID:10725225)

Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H. , Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A. and Yin, H.L. (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology, 10(6), pp. 311-320. (doi:10.1016/S0960-9822(00)00384-5) (PMID:10744973)

Chubb, J. R., Wilkins, A., Thomas, G. M. and Insall, R. H. (2000) The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement. Journal of Cell Science, 113(4), pp. 709-719. (PMID:10652263)

Loomis, W. F. and Insall, R. H. (1999) A cell for all reasons. Nature, 401(6752), pp. 440-441. (doi:10.1038/46713) (PMID:10519543)

Lee, S., Parent, C. A., Insall, R. and Firtel, R. A. (1999) A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Molecular Biology of the Cell, 10(9), pp. 2829-2845. (doi:10.1091/mbc.10.9.2829) (PMID:10473630) (PMCID:PMC25521)

Machesky, L. M. and Insall, R. H. (1999) Signaling to actin dynamics. Journal of Cell Biology, 146(2), pp. 267-272. (doi:10.1083/jcb.146.2.267) (PMID:10427083) (PMCID:PMC2156183)

Insall, R. (1999) PKB starts to jump. Trends in Genetics, 15(7), p. 260. (doi:10.1016/S0168-9525(99)01802-8)

Insall, R. and Machesky, L. (1999) PH domains in WASP – a bug in the system? Trends in Cell Biology, 9(6), p. 211. (doi:10.1016/S0962-8924(99)01569-X) (PMID:10354565)

Insall, R. (1999) Cynicism and credulity. Current Biology, 9(7), R231. (doi:10.1016/S0960-9822(99)80147-X) (PMID:10209127)

Machesky, L. M. and Insall, R. H. (1998) Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Current Biology, 8(25), pp. 1347-1356. (doi:10.1016/S0960-9822(98)00015-3) (PMID:9889097)

Insall, R. (1998) Keeping it in the family. Current Biology, 8(12), R401. (doi:10.1016/S0960-9822(98)70258-1)

Machesky, L. M., Insall, R. H. and Kay, R. R. (1998) The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Current Biology, 8(10), 607-S4. (doi:10.1016/S0960-9822(98)70233-7) (PMID:9601648)

Insall, R. (1997) The right stuff. Current Biology, 7(11), R665. (doi:10.1016/S0960-9822(06)00345-9) (PMID:9382817)

Tuxworth, R. I., Cheetham, J. L., Machesky, L. M., Spiegelmann, G. B., Weeks, G. and Insall, R. H. (1997) Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. Journal of Cell Biology, 138(3), pp. 605-614. (doi:10.1083/jcb.138.3.605) (PMID:9245789) (PMCID:PMC2141629)

Insall, R. (1997) The talk's the thing. Current Biology, 7(6), R331. (doi:10.1016/S0960-9822(06)00161-8)

Aubry, L., Maeda, M., Insall, R. , Devreotes, P. N. and Firtel, R. A. (1997) The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. Journal of Biological Chemistry, 272(7), pp. 3883-3886. (doi:10.1074/jbc.272.7.3883) (PMID:9020088)

Insall, R. (1997) The enemy within. Current Biology, 7(2), R59. (doi:10.1016/S0960-9822(06)00032-7) (PMID:9081661)

Insall, R. H. , Borleis, J. and Devreotes, P. N. (1996) The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology, 6(6), pp. 719-729. (doi:10.1016/S0960-9822(09)00453-9) (PMID:8793298)

Insall, R. H. (1996) Osmoregulation: cyclic GMP and the big squeeze. Current Biology, 6(5), pp. 516-518. (doi:10.1016/S0960-9822(02)00530-4) (PMID:8805270)

Maeda, M., Aubry, L., Insall, R. , Gaskins, C., Devreotes, P. N. and Firtel, R. A. (1996) Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Journal of Biological Chemistry, 271(7), pp. 3351-3354. (doi:10.1074/jbc.271.7.3351) (PMID:8631932)

Chen, M.-Y., Insall, R. H. and Devreotes, P. N. (1996) Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics, 12(2), pp. 52-57. (doi:10.1016/0168-9525(96)81400-4) (PMID:8851971)

Insall, R. (1996) And now it's time for tea. Current Biology, 6(2), p. 99. (doi:10.1016/S0960-9822(02)00427-X) (PMID:8859322)

Insall, R. (1995) Glycogen synthase kinase and Dictyostelium development: old pathways pointing in new directions? Trends in Genetics, 11(2), pp. 37-39. (doi:10.1016/S0168-9525(00)88989-1) (PMID:7716803)

Insall, R. , Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F. and Devreotes, P. (1994) CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. Journal of Cell Biology, 126(6), pp. 1537-1545. (doi:10.1083/jcb.126.6.1537) (PMID:8089184) (PMCID:PMC2290948)

Soede, R. D.M., Insall, R. H. , Devreotes, P. N. and Schaap, P. (1994) Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression. Development, 120(7), pp. 1997-2002. (PMID:7925004)

Insall, R. H. , Soede, R. D.M., Schaap, P. and Devreotes, P. N. (1994) Two cAMP receptors activate common signaling pathways in Dictyostelium. Molecular Biology of the Cell, 5(6), pp. 703-711. (doi:10.1091/mbc.5.6.703) (PMID:7949426) (PMCID:PMC301085)

Pupillo, M., Insall, R. , Pitt, G. S. and Devreotes, P. N. (1992) Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molecular Biology of the Cell, 3(11), pp. 1229-1234. (doi:10.1091/mbc.3.11.1229) (PMID:1333842) (PMCID:PMC275689)

Insall, R. , Nayler, O. and Kay, R. R. (1992) DIF-1 induces its own breakdown in Dictyostelium. EMBO Journal, 11(8), pp. 2849-2854. (PMID:1322291) (PMCID:PMC556764)

Ceccarelli, A., Mahbubani, H. J., Insall, R. , Schnitzler, G., Firtel, R. A. and Williams, J. G. (1992) A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression. Developmental Biology, 152(1), pp. 188-193. (doi:10.1016/0012-1606(92)90169-H) (PMID:1321061)

Berks, M., Traynor, D., Carrin, I., Insall, R. H. and Kay, R. R. (1991) Diffusible signal molecules controlling cell differentiation and patterning in Dictyostelium. Development, 113(S1), pp. 131-139. (PMID:1660326)

Insall, R. and Kay, R. R. (1990) A specific DIF binding protein in Dictyostelium. EMBO Journal, 9(10), pp. 3323-3328. (PMID:2170113) (PMCID:PMC552069)

Book Sections

Susanto, O., Muinonen-Martin, A. J., Nobis, M. and Insall, R. H. (2016) Visualizing cancer cell chemotaxis and invasion in 2D and 3D. In: Jin, T. and Hereld, D. (eds.) Chemotaxis. Series: Methods in molecular biology, 1407 (1407). Springer, pp. 217-228. ISBN 9781493934782 (doi:10.1007/978-1-4939-3480-5_17)

Blagg, S. and Insall, R. (2004) Scar, WASp and the Arp2/3 complex in Dictyostelium migration. In: Ridley, A., Peckham, M. and Clark, P. (eds.) Cell Motility: From Molecules to Organisms. Wiley: Chichester, pp. 247-260. ISBN 9780470848722 (doi:10.1002/0470011742.ch16)

Book Reviews

Insall, R. H. (2001) The whole organism, and nothing but the organism. Cell, 107(3), pp. 279-281. (doi:10.1016/S0092-8674(01)00558-X) [Book Review]

Insall, R. (1996) The art of MBoC by B.A. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J. Watson. Trends in Genetics, 12(10), p. 430. (doi:10.1016/0168-9525(96)81491-0) [Book Review]

Conference or Workshop Item

Husmeier, D. , Ferguson, E., Matthiopoulos, J. and Insall, R. (2017) Statistical Inference of the Drivers of Collective Cell Movement. RSS 2017 Annual Conference, Glasgow, Scotland, 04-07 Sep 2017.

Conference Proceedings

Kim, J. and Insall, R. (2009) Position and velocity estimation of cell boundary. In: International Conference on Systems Biology, Palo Alto, USA, 30 Aug - 4 Sep 2009,

This list was generated on Fri Oct 20 00:54:56 2017 BST.