Professor Owen Sansom

  • Director of Institute/ Professor (Beatson Institute for Cancer Research)

Research interests

Colorectal Cancer is the third most common cancer in the western world. The focus of the colorectal cancer and Wnt signalling group is to try to understand the early changes associated with intestinal neoplasia to identify novel markers of disease and new targets for therapy. The key intestinal tumour suppressor is the Apc gene which is mutated in approximately 80% of sporadic cancer. Germline heterozygosity of Apc leads to Familial Adenomatous Polyposis. Central to our work is the use of novel inducible models of intestinal tumourigenesis which allow us to study the functions of specific tumour suppressor genes.

Link to Colorectal Cancer and Wnt Signalling website


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Are CXCR2 positive cells important in generating an immunosuppressive metastatic niche for colorectal metastatic disease in the liver?
    Cancer Research UK
    2018 - 2020
     
  • Characterising CXCR2 expressing neutrophils in colorectal liver metastases.
    Academy of Medical Sciences
    2018 - 2020
     
  • ACRClerate: Colorectal Cancer Stratified Medicine Network
    Cancer Research UK
    2017 - 2018
     
  • Clinical Training Award Cycle 3 2017
    Cancer Research UK
    2017 - 2020
     
  • CRUK Centre Renewal
    Cancer Research UK
    2017 - 2019
     
  • Developing new clinically relevant positron emission tomography (PET) probes in Glasgow
    Beatson Cancer Charity
    2017 - 2022
     
  • Glasgow ECMC
    Cancer Research UK
    2017 - 2019
     
  • Glasgow ECMC
    Chief Scientist Office
    2017 - 2018
     
  • Precision Medicine Laboratory sequencing of patient tumour samples
    Beatson Cancer Charity
    2017 - 2022
     
  • Precision-Panc: a dynamic therapeutic development platform for pancreatic cancer
    Cancer Research UK
    2017 - 2018
     
  • Examining the relationship between KRAS mutation and immunotherapy resistance in colorectal cancer
    Medical Research Council
    2016 - 2019
     
  • Elucidating the role of individual mTor complexes in the development and progression of chronic lymphocytic leukaemia
    Bloodwise
    2016 - 2019
     
  • Optimising the use of chemotherapy in prostate cancer
    Prostate Cancer Research Foundation
    2015 - 2018
     
  • CR-UK Centre renewal
    Cancer Research UK
    2014 - 2017
     
  • In Vivo Optimization of Therapy in Pancreatic Ductal Adenocarcinoma.
    Beatson West of Scotland Cancer Centre
    2013 - 2014
     
  • The relationship between genetic aberrations and CpG Island Methylator Phenotype in colorectal cancer
    Cancer Research UK
    2012 - 2013
     
  • Investigating the role of CXCR2 in pancreatic inflammation and cancer.
    Wellcome Trust
    2011 - 2014
     
  • In vivo Evaluation of Src Kinase Inhibition as Adjuvant Therapy following Pancreatic Cancer Resection
    Pancreatic Cancer Research Fund
    2011 - 2013
     
  • Using the Drosophila fly intestine to investigate Wnt targets in vivo.
    National Centre for the Replacement of Animals Research
    2010 - 2013
     
  • Investigating the use of an EUS core biopsy needle versus a traditional FNA cytology aspiration technique in obtaining tumour tissue for diagnostic, IHC and kinome-signature analysis
    Cancer Research UK
    2010 - 2012
     
  • Investigating personalised therapy in mouse models of pancreatic cancer.
    Medical Research Council
    2010 - 2013
     
  • An investigation of the pro-tumorigenic activity of the chemokine receptor CXCR2 using models of de novo tumorigenesis.
    Medical Research Council
    2010 - 2012
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 222.

2018

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J. and Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, (doi:10.1002/path.5143) (PMID:30043421) (Early Online Publication)

Malik, N., Sansom, O. J. and Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, (Accepted for Publication)

Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23(11), pp. 3312-3326. (doi:10.1016/j.celrep.2018.05.038) (PMID:29898401) (PMCID:PMC6019737)

Hodder, M. C., Flanagan, D. J. and Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22(6), pp. 785-787. (doi:10.1016/j.stem.2018.05.005) (PMID:29859166)

Godfrey, J. D., Morton, J. P. , Wilczynska, A., Sansom, O. J. and Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9(6), 644. (doi:10.1038/s41419-018-0628-4) (PMID:29844410) (PMCID:PMC5973943)

Woroniuk, A. et al. (2018) STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9, 2124. (doi:10.1038/s41467-018-04404-4) (PMID:29844364) (PMCID:PMC5974301)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi:10.1016/j.celrep.2018.03.131) (PMID:29719257)

Ahmad, I. and Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi:10.1002/path.5029) (PMID:29314004)

Morris, H. T., Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H. , Snapper, S. B., Carey, F. A., Sansom, O. J. and Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, (doi:10.1002/path.5086) (PMID:29672847) (Early Online Publication)

Pearson, H. B. et al. (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery, (doi:10.1158/2159-8290.CD-17-0867) (PMID:29581176) (Early Online Publication)

Huels, D.J. et al. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, 1132. (doi:10.1038/s41467-018-03426-2)

Patel, R. et al. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10(4), e8347. (doi:10.15252/emmm.201708347) (PMID:29540470)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, (doi:10.1158/2159-8290.CD-17-0533) (PMID:29500295) (Early Online Publication)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J. and Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi:10.1038/onc.2017.394) (PMID:29106388)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J. and Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13(1), e0183585. (doi:10.1371/journal.pone.0183585) (PMID:29293509) (PMCID:PMC5749721)

Leach, J., Morton, J. P. and Sansom, O. J. (2018) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, (doi:10.1016/j.molimm.2017.12.013) (PMID:29269005) (In Press)

2017

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8(1), 1728. (doi:10.1038/s41467-017-01967-6) (PMID:29170413) (PMCID:PMC5701042)

D'Costa, Z. et al. (2017) Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research, 77(21), pp. 5952-5962. (doi:10.1158/0008-5472.CAN-16-2833) (PMID:28765154)

Chou, A. et al. (2017) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, (doi:10.1136/gutjnl-2017-315144) (PMID:29080858) (Early Online Publication)

Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi:10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)

Cammareri, P. et al. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24(10), pp. 1681-1693. (doi:10.1038/cdd.2017.92) (PMID:28622298)

Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4(2), pp. 263-282. (doi:10.1016/j.jcmgh.2017.05.005) (PMID:28752115) (PMCID:PMC5524227)

Tian, A. et al. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13(7), e1006870. (doi:10.1371/journal.pgen.1006870) (PMID:28708826) (PMCID:PMC5510812)

Phesse, T. J. and Sansom, O. J. (2017) Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology, 19(7), pp. 752-754. (doi:10.1038/ncb3567) (PMID:28659641)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi:10.1038/cdd.2016.120) (PMID:28106883)

Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi:10.1158/0008-5472.CAN-16-2565) (PMID:28515147)

Diamantopoulou, Z. et al. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31(5), pp. 621-634. (doi:10.1016/j.ccell.2017.03.007) (PMID:28416184)

Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi:10.1038/nature22056) (PMID:28425994)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi:10.1126/scitranslmed.aai8504) (PMID:28381539)

Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi:10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)

Fumagalli, A. et al. (2017) Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357-E2364. (doi:10.1073/pnas.1701219114) (PMID:28270604) (PMCID:PMC5410814)

Azad, A. et al. (2017) PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine, 9(2), pp. 167-180. (doi:10.15252/emmm.201606674) (PMID:27932443) (PMCID:PMC5286375)

Myant, K. B. et al. (2017) HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. EMBO Molecular Medicine, 9(2), pp. 181-197. (doi:10.15252/emmm.201606684) (PMID:28003334) (PMCID:PMC5286368)

van der Weyden, L. et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541(7636), pp. 233-236. (doi:10.1038/nature20792) (PMID:28052056)

Jackstadt, R. and Sansom, O. J. (2017) The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. EMBO Journal, 36(1), pp. 3-4. (doi:10.15252/embj.201695973) (PMID:27932445) (PMCID:PMC5210127)

Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152(1), 68-74.e2. (doi:10.1053/j.gastro.2016.09.060) (PMID:27856273)

Morton, J. P. and Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9(1), pp. 9-12. (doi:10.2217/imt-2016-0115) (PMID:28000523)

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P. , Sansom, O. J. , Zender, L. and Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31(2), pp. 172-183. (doi:10.1101/gad.290635.116) (PMID:28143833)

Rose, A. M., Sansom, O. J. and Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16(5), pp. 386-387. (doi:10.1080/15384101.2016.1259892) (PMID:27860538)

Wildenberg, M.E. et al. (2017) The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, 10(2), pp. 352-360. (doi:10.1038/mi.2016.65)

2016

Spender, L. C. et al. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget, 7(50), pp. 81995-82012. (doi:10.18632/oncotarget.13226) (PMID:27835901)

Driscoll, D. R. et al. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76(23), pp. 6911-6923. (doi:10.1158/0008-5472.CAN-16-0810) (PMID:27758884)

Guest, R. V. et al. (2016) Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 113(43), pp. 12250-12255. (doi:10.1073/pnas.1600067113) (PMID:27791012) (PMCID:PMC5086988)

Koppens, M. A.J., Bounova, G., Cornelissen-Steijger, P., de Vries, N., Sansom, O. J. , Wessels, L. F.A. and van Lohuizen, M. (2016) Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget, 7(43), pp. 69816-69828. (doi:10.18632/oncotarget.12002) (PMID:27634879) (PMCID:PMC5342517)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi:10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Kumar, N. et al. (2016) A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development, 143(20), pp. 3711-3722. (doi:10.1242/dev.137992) (PMID:27802136)

Cammareri, P. et al. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications, 7, 12493. (doi:10.1038/ncomms12493) (PMID:27558455) (PMCID:PMC5007296)

Lesina, M. et al. (2016) RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. Journal of Clinical Investigation, 126(8), pp. 2919-2932. (doi:10.1172/jci86477) (PMID:27454298)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi:10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

Ahmad, I. et al. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113(29), pp. 8290-8295. (doi:10.1073/pnas.1601571113) (PMID:27357679) (PMCID:PMC4961202)

Gao, Y., Vincent, D., Davis, A. J., Sansom, O. , Bartholin, L. and Li, Q. (2016) Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget, 7(27), pp. 40904-40918. (doi:10.18632/oncotarget.10149) (PMID:27344183)

Wörmann, S. M. et al. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151(1), 180-193.e12. (doi:10.1053/j.gastro.2016.03.010) (PMID:27003603)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi:10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi:10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Matzke-Ogi, A. et al. (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology, 150(2), 513-525.e10. (doi:10.1053/j.gastro.2015.10.020) (PMID:26597578)

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi:10.1016/j.celrep.2015.12.020) (PMID:26725115)

Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K., Sansom, O. and Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30(1), pp. 52-63. (doi:10.1101/gad.271130.115) (PMID:26679840) (PMCID:PMC4701978)

Jackstadt, R. and Sansom, O. (2016) Mouse models of intestinal cancer. Journal of Pathology, 238(2), pp. 141-151. (doi:10.1002/path.4645) (PMID:26414675) (PMCID:PMC4832380)

Carotenuto, P. et al. (2016) Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut, 66(7), pp. 1268-1277. (doi:10.1136/gutjnl-2016-312278) (PMID:27618837) (PMCID:PMC5530482)

Elbediwy, A. et al. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. (doi:10.1242/dev.133728) (PMID:26989177) (PMCID:PMC4874484)

2015

Fordham, R. P. and Sansom, O. (2015) Colon contradictions: NF-κB signaling in intestinal tumorigenesis. Journal of Experimental Medicine, 212(13), pp. 2184-2188. (doi:10.1084/jem.21213insight2) (PMID:26666752)

Ladang, A. et al. (2015) Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212(12), pp. 2057-2075. (doi:10.1084/jem.20142288) (PMID:26527802)

Gopinathan, A., Morton, J. P. , Jodrell, D. I. and Sansom, O. J. (2015) GEMMs as preclinical models for testing pancreatic cancer therapies. Disease Models and Mechanisms, 8(10), pp. 1185-1200. (doi:10.1242/dmm.021055) (PMID:26438692) (PMCID:PMC4610236)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi:10.1002/path.4555) (PMID:25950520)

Myant, K. et al. (2015) Serine 62-phosphorylated MYC associates with nuclear lamins and its regulation by CIP2A is essential for regenerative proliferation. Cell Reports, 12(6), pp. 1019-1031. (doi:10.1016/j.celrep.2015.07.003) (PMID:26235622)

Topham, C. et al. (2015) MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), pp. 129-140. (doi:10.1016/j.ccell.2015.06.001) (PMID:26175417) (PMCID:PMC4518499)

Méniel, V., Megges, M., Young, M.A., Cole, A., Sansom, O.J. and Clarke, A.R. (2015) Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene, 34(31), pp. 4118-4129. (doi:10.1038/onc.2014.342) (PMID:25347740)

von Karstedt, S. et al. (2015) Cancer cell-autonomous trail-r signaling promotes kras-driven cancer progression, invasion, and metastasis. Cancer Cell, 27(4), pp. 561-573. (doi:10.1016/j.ccell.2015.02.014) (PMID:25843002)

Kundu, P. et al. (2015) An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine, 7(281), 281ra44. (doi:10.1126/scitranslmed.3010567) (PMID:25834110)

Loveridge, C., Mui, E., Ahmad, I. , Welsh, M., Tan, E., Fleming, J., Sansom, O. and Leung, H. (2015) The Role of Erk5 in Prostate Carcinogenesis. In: 11th World Congress on Urological Research, Nijmegen, The Nertherlands, September 2015, (Unpublished)

Boulter, L. et al. (2015) WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Journal of Clinical Investigation, 125(3), pp. 1269-1285. (doi:10.1172/JCI76452) (PMID:25689248)

Ueberham, E. et al. (2015) Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors. Molecular Cancer Research, 13(2), pp. 239-249. (doi:10.1158/1541-7786.MCR-14-0278-T) (PMID:25270420)

Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi:10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)

Davis, H. et al. (2015) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nature Medicine, 21(1), pp. 62-70. (doi:10.1038/nm.3750)

Conde-Perez, A. et al. (2015) A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nature Communications, 6, 8093. (doi:10.1038/ncomms9093) (PMID:26307673) (PMCID:PMC4560817)

Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi:10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)

Huels, D.J. and Sansom, O.J. (2015) Stem vs non-stem cell origin of colorectal cancer. British Journal of Cancer, 113(1), pp. 1-5. (doi:10.1038/bjc.2015.214) (PMID:26110974)

Lindsay, C. R., Li, A., Faller, W., Ozanne, B., Welch, H., Machesky, L. M. and Sansom, O. (2015) A Rac1-independent role for P-Rex1 in melanoblasts. Journal of Investigative Dermatology, 135(1), pp. 314-318. (doi:10.1038/jid.2014.323)

Lindström, N. O. et al. (2015) Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron. eLife, 4, e04000. (doi:10.7554/eLife.04000) (PMID:25647637) (PMCID:4337611)

Lu, W.-Y. et al. (2015) Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nature Cell Biology, 17(8), pp. 971-983. (doi:10.1038/ncb3203) (PMID:26192438)

Ma, Y., Faller, W., Sansom, O. , Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi:10.1097/CMR.0000000000000135) (PMID:25535872)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi:10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

Mills, J.C. and Sansom, O.J. (2015) Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Science Signaling, 8(385), re8. (doi:10.1126/scisignal.aaa7540) (PMID:26175494)

2014

Lunardi, S. et al. (2014) IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget, 5(22), pp. 11064-11080.

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

Morran, D. C. et al. (2014) Targeting mTOR dependency in pancreatic cancer. Gut, 63(9), pp. 1481-1489. (doi:10.1136/gutjnl-2013-306202) (PMID:24717934) (PMCID:PMC4145424)

Hamilton, G. et al. (2014) AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget, 5(15), pp. 6142-6167.

Rajan, P. et al. (2014) Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. European Urology, 66(1), pp. 32-39. (doi:10.1016/j.eururo.2013.08.011) (PMID:24054872) (PMCID:PMC4062940)

Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi:10.1016/j.cub.2014.04.007)

Foth, M. et al. (2014) Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. Journal of Pathology, 233(2), pp. 148-158. (doi:10.1002/path.4334)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi:10.1053/j.gastro.2014.01.046)

Valeri, N. et al. (2014) microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi:10.1016/j.ccr.2014.03.006)

Song, J.-H., Huels, D. J., Ridgway, R. A., Sansom, O. J. , Kholodenko, B. N., Kolch, W. and Cho, K.-H. (2014) The APC network regulates the removal of mutated cells from colonic crypts. Cell Reports, 7(1), pp. 94-103. (doi:10.1016/j.celrep.2014.02.043)

Johnsson, A.-K. E. et al. (2014) The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Reports, 6(6), pp. 1153-1164. (doi:10.1016/j.celrep.2014.02.024)

Arjonen, A. et al. (2014) Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis. Journal of Clinical Investigation, 124(3), pp. 1069-1082. (doi:10.1172/JCI67280)

Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi:10.1136/gutjnl-2012-303883)

Guest, R. V., Boulter, L., Kendall, T. J., Minnis-Lyons, S. E., Walker, R., Wigmore, S. J., Sansom, O. and Forbes, S. J. (2014) Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Research, 74(4), pp. 1005-1010. (doi:10.1158/0008-5472.CAN-13-1911)

Ali, A. et al. (2014) Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel. BMC Clinical Pathology, 14, p. 35. (doi:10.1186/1472-6890-14-35)

Belmont, P. J. et al. (2014) Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. Disease Models and Mechanisms, 7(6), pp. 613-623. (doi:10.1242/dmm.013904)

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M., Muller, W. J., Vidal, M. and Sansom, O. J. (2014) c-Src drives intestinal regeneration and transformation. EMBO Journal, 33(3), pp. 1474-1491. (doi:10.1002/embj.201387454)

Dhillon, A. and Sansom, O. (2014) Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom. Disease Models and Mechanisms, 7(8), pp. 937-940. (doi:10.1242/dmm.017350)

Myant, K. and Sansom, O. J. (2014) Wnt signaling and colorectal cancer. In: Hoppler, S. and Moon, R. (eds.) Wnt Signaling in Development and Disease. John Wiley & Sons, pp. 357-367. ISBN 9781118444122 (doi:10.1002/9781118444122.ch27)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi:10.1101/gad.247528.114)

2013

Phesse, T. J. and Sansom, O. J. (2013) Responding to R-Spondin: Slit2 potentiates intestinal regeneration. Cell Stem Cell, 13(5), pp. 512-514. (doi:10.1016/j.stem.2013.10.006)

Nobis, M., Carragher, N.O., McGhee, E.J., Morton, J.P. , Sansom, O.J. , Anderson, K.I. and Timpson, P. (2013) Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS Journal, 280(21), pp. 5177-5197. (doi:10.1111/febs.12348)

Cheung, E.C., Athineos, D., Lee, P., Ridgway, R.A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K., Sansom, O.J. and Vousden, K.H. (2013) TIGAR is required for efficient intestinal regeneration and tumorigenesis. Developmental Cell, 25(5), pp. 463-477. (doi:10.1016/j.devcel.2013.05.001)

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi:10.1016/j.stem.2013.04.006)

Ma, Y., Li, A., Faller, W.J., Libertini, S., Fiorito, F., Gillespie, D.A., Sansom, O.J. , Yamashiro, S. and Machesky, L.M. (2013) Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development, 140(10), pp. 2203-2211. (doi:10.1242/dev.089789)

Bird, T.G. et al. (2013) Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proceedings of the National Academy of Sciences of the United States of America, 110(16), pp. 6542-6547. (doi:10.1073/pnas.1302168110)

Morton, J. and Sansom, O.J. (2013) MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC. Molecular Oncology, 7(2), pp. 248-258. (doi:10.1016/j.molonc.2013.02.015)

Radulescu, S. et al. (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene, 32(16), pp. 2048-2057. (doi:10.1038/onc.2012.224)

Steele, C.W., Jamieson, N.B., Evans, T.R.J. , McKay, C.J., Sansom, O.J. , Morton, J. and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108(5), pp. 997-1003. (doi:10.1038/bjc.2013.24)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi:10.1038/onc.2012.148)

Patel, R. et al. (2013) Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Journal of Clinical Investigation, 123(3), pp. 1157-1175. (doi:10.1172/JCI63672)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi:10.1158/2159-8290.CD-12-0292)

Schwitalla, S. et al. (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell, 152(1-2), pp. 25-38. (doi:10.1016/j.cell.2012.12.012)

Acosta, J.C. et al. (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15, pp. 978-990. (doi:10.1038/ncb2784)

Huels, D.J., Cammareri, P., Ridgway, R.A., Medema, J.P. and Sansom, O.J. (2013) Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis. Methods in Molecular Biology, 1012, pp. 237-248. (doi:10.1007/978-1-62703-429-6_16)

Karim, S.A., Creedon, H., Patel, H., Carragher, N.O., Morton, J.P. , Muller, W.J., Evans, T.R.J. , Gusterson, B., Sansom, O.J. and Brunton, V.G. (2013) Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. Journal of Pathology, 230(4), pp. 430-440. (doi:10.1002/path.4202)

Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi:10.4161/cc.26031)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi:10.1158/0008-5472.CAN-12-4545)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

Wiese, K. E., Walz, S., von Eyss, B., Wolf, E., Athineos, D., Sansom, O. and Eilers, M. (2013) The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harbor Perspectives in Medicine, 3(12), a014290. (doi:10.1101/cshperspect.a014290)

2012

Cordero, J. B., Stefanatos, R. K., Myant, K., Vidal, M. and Sansom, O. J. (2012) Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development, 139(24), pp. 4524-4535. (doi:10.1242/dev.078261)

Machesky, L.M. and Sansom, O.J. (2012) Rac1 in the driver’s seat for melanoma. Pigment Cell and Melanoma Research, 25(6), pp. 762-764. (doi:10.1111/pcmr.12004)

Radulescu, S. et al. (2012) Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports, 2(2), pp. 270-282. (doi:10.1016/j.celrep.2012.07.003)

Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi:10.1172/JCI61067)

Gao, M. et al. (2012) SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. EMBO Molecular Medicine, 4(8), pp. 776-790. (doi:10.1002/emmm.201100944)

Ahmad, I., Sansom, O.J. and Leung, H.Y. (2012) Exploring molecular genetics of bladder cancer: lessons learned from mouse models. Disease Models and Mechanisms, 5(3), pp. 323-332. (doi:10.1242/dmm.008888)

Boulter, L. et al. (2012) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature Medicine, 18(4), pp. 572-579. (doi:10.1038/nm.2667)

Blyth, K., Morton, J.P. and Sansom, O.J. (2012) The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? Current Opinion in Genetics and Development, 22(1), pp. 28-35. (doi:10.1016/j.gde.2012.02.009)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi:10.1016/j.devcel.2011.11.008)

Jamieson, N. B., Morran, D. C., Morton, J. P. , Ali, A., Dickson, E. J., Carter, C. R., Sansom, O. J. , Evans, T. R. J. , McKay, C. J. and Oien, K. A. (2012) MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clinical Cancer Research, 18(2), pp. 534-545. (doi:10.1158/1078-0432.CCR-11-0679)

Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi:10.1111/j.1748-1716.2011.02288.x)

Sandilands, E. et al. (2012) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nature Cell Biology, 14(1), pp. 51-60. (doi:10.1038/ncb2386)

Cordero, J. B., Stefanatos, R. K., Scopelliti, A., Vidal, M. and Sansom, O. J. (2012) Inducible progenitor-derived wingless regulates adult midgut regeneration in drosophila. EMBO Journal, 31(19), pp. 3901-3917. (doi:10.1038/emboj.2012.248)

Klotz, D.M., Nelson, S.A., Kroboth, K., Newton, I.P., Radulescu, S., Ridgway, R.A., Sansom, O.J. , Appleton, P.L. and Nathke, I.S. (2012) The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. Journal of Cell Science, 125(4), pp. 887-895. (doi:10.1242/jcs.091843)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K., Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi:10.1038/jid.2012.186)

McCall, P. et al. (2012) NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. British Journal of Cancer, 107(9), pp. 1554-1563. (doi:10.1038/bjc.2012.372)

Tho, L.M., Libertini, S., Rampling, R., Sansom, O. and Gillespie, D.A. (2012) Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene, 31(11), pp. 1366-1375. (doi:10.1038/onc.2011.326)

2011

Myant, K. and Sansom, O.J. (2011) Wnt/Myc interactions in intestinal cancer: partners in crime. Experimental Cell Research, 317(19), pp. 2725-2731. (doi:10.1016/j.yexcr.2011.08.001)

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi:10.1242/dmm.006874)

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi:10.1038/cr.2010.154)

Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42(1), pp. 36-49. (doi:10.1016/j.molcel.2011.02.020)

Ahmad, I. , Patel, R., Liu, Y., Singh, L.B., Taketo, M.M., Wu, X.-R., Leung, H.Y. and Sansom, O.J. (2011) Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death and Disease, 2, e124. (doi:10.1038/cddis.2011.7)

Subauste, M.C., Ventura-Holman, T., Lu, D., Du, L., Sansom, O.J. and Maher, J.F. (2011) Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia. Cancer Epidemiology, 35(1), pp. 97-100. (doi:10.1016/j.canep.2010.09.007)

Ahmad, I. et al. (2011) β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene, 30(2), pp. 178-189. (doi:10.1038/onc.2010.399)

Ahmad, I. et al. (2011) HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 108(39), pp. 16392-16397. (doi:10.1073/pnas.1101263108)

Graham, K., Moran-Jones, K., Sansom, O.J. , Brunton, V.G. and Frame, M.C. (2011) FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS ONE, 6(12), e27806. (doi:10.1371/journal.pone.0027806)

Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2(Art 55), pp. 1-9. (doi:10.1038/ncomms1560)

Matallanas, D. et al. (2011) Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular Cell, 44(6), pp. 893-906. (doi:10.1016/j.molcel.2011.10.016)

Matthews, J.R., Sansom, O.J. and Clarke, A.R. (2011) Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death and Differentiation, 18(12), pp. 1934-1943. (doi:10.1038/cdd.2011.77)

Morton, J.P. , Myant, K.B. and Sansom, O.J. (2011) A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis. Cell Cycle, 10(2), pp. 173-175. (doi:10.4161/cc.10.2.14350)

Morton, J.P. , Steele, C.W. and Sansom, O.J. (2011) Timing Is Everything: Brca2 and p53 Mutations in Pancreatic Cancer. Gastroenterology, 140(4), pp. 1143-1146. (doi:10.1053/j.gastro.2011.02.026)

Myant, K. and Sansom, O. (2011) Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex. Cell Division, 6(3), pp. 1-4. (doi:10.1186/1747-1028-6-3)

Myant, K. and Sansom, O.J. (2011) More, More, More: Downregulation of a MK5-FoxO3a-mir34b/c Pathway Further Increases c-Myc Levels in Colorectal Cancer. Molecular Cell, 41(4), pp. 369-370. (doi:10.1016/j.molcel.2011.01.028)

Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi:10.1016/j.ccr.2011.05.008)

Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi:10.1158/0008-5472.CAN-10-2267)

2010

Morton, J.P. et al. (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 107(1), pp. 246-251. (doi:10.1073/pnas.0908428107)

Ashton, G. et al. (2010) Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling. Developmental Cell, 19(2), pp. 259-269. (doi:10.1016/j.devcel.2010.07.015)

Athineos, D. and Sansom, O. (2010) Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. Oncogene, 29(17), pp. 2585-2590. (doi:10.1038/onc.2010.5)

Cole, A.M., Ridgway, R.A., Derkits, S.E., Parry, L., Barker, N., Clevers, H., Clarke, A.R. and Sansom, O.J. (2010) p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine, 2(11), pp. 472-486. (doi:10.1002/emmm.201000101)

Morton, J. et al. (2010) LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology, 139(2), 586-597.e6. (doi:10.1053/j.gastro.2010.04.055)

Morton, J. et al. (2010) Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma. Gastroenterology, 139(1), pp. 292-303. (doi:10.1053/j.gastro.2010.03.034)

Nusse, R. et al. (2010) Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo. PLoS Genetics, 6(1), e1000816. (doi:10.1371/journal.pgen.1000816)

Quyn, A., Appleton, P., Carey, F., Steele, R., Barker, N., Clevers, H., Ridgway, R., Sansom, O. and Näthke, I. (2010) Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue. Cell Stem Cell, 6(2), p. 175. (doi:10.1016/j.stem.2009.12.007)

Radulescu, S., Ridgway, R.A., Appleton, P., Kroboth, K., Patel, S., Woodgett, J., Taylor, S., Nathke, I.S. and Sansom, O.J. (2010) Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene, 29(49), pp. 6418-6427. (doi:10.1038/onc.2010.373)

Woodcock, S., Rushton, H., Castañeda-Saucedo, E., Myant, K., White, G., Blyth, K., Sansom, O. and Malliri, A. (2010) Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Current Biology, 20(7), pp. 669-675. (doi:10.1016/j.cub.2010.02.033)

2009

Cordero, J. B., Vidal, M. and Sansom, O. J. (2009) APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. Cell Cycle, 8(18), pp. 2927-2931. (doi:10.4161/cc.8.18.9472)

Serrels, B. et al. (2009) A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model. Carcinogenesis, 30(2), pp. 249-257. (doi:10.1093/carcin/bgn278)

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2009) The role of murine models of prostate cancer in drug target discovery and validation. Expert Opinion on Drug Discovery, 4(8), pp. 879-888. (doi:10.1517/17460440903049308)

Barker, N., Ridgway, R., van Es, J., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A., Sansom, O. and Clevers, H. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457(7229), pp. 608-611. (doi:10.1038/nature07602)

Burke, Z., Reed, K., Phesse, T., Sansom, O. , Clarke, A. and Tosh, D. (2009) Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism. Gastroenterology, 136(7), pp. 2316-2324. (doi:10.1053/j.gastro.2009.02.063)

Chong, J. et al. (2009) E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells. Nature, 462(7275), pp. 930-934. (doi:10.1038/nature08677)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi:10.1016/j.cell.2009.11.026)

Ritchie, K. J., Walsh, S., Sansom, O. J. , Henderson, C. J. and Wolf, C. R. (2009) Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi. Proceedings of the National Academy of Sciences of the United States of America, 106(49), pp. 20859-20864. (doi:10.1073/pnas.0911351106)

Subauste, M., Sansom, O. , Porecha, N., Raich, N., Du, L. and Maher, J. (2009) Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Molecular Carcinogenesis, 49(2), pp. 105-113. (doi:10.1002/mc.20594)

Wellner, U. et al. (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology, 11(12), 1487-U236. (doi:10.1038/ncb1998)

2008

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2008) Advances in mouse models of prostate cancer. Expert Reviews in Molecular Medicine, 10, e16. (doi:10.1017/S1462399408000689)

Marsh, V., Winton, D., Williams, G., Dubois, N., Trumpp, A., Sansom, O. and Clarke, A. (2008) Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics, 40(12), pp. 1436-1444. (doi:10.1038/ng.256)

Patek, C. et al. (2008) Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Experimental Cell Research, 314(5), pp. 1105-1114. (doi:10.1016/j.yexcr.2007.11.004)

Patek, C. et al. (2008) The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterology, 8, p. 24. (doi:10.1186/1471-230X-8-24)

Phesse, T. J., Parry, L., Reed, K. R., Ewan, K. B., Dale, T. C., Sansom, O. J. and Clarke, A. R. (2008) Deficiency of Mbd2 Attenuates Wnt Signaling. Molecular and Cellular Biology, 28(19), pp. 6094-6103. (doi:10.1128/MCB.00539-08)

Reed, K. R., Athineos, D., Meniel, V. S., Wilkins, J. A., Ridgway, .A., Burke, Z. D., Muncan, V., Clarke, A. R. and Sansom, O.J. (2008) B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America, 105(48), pp. 18919-18923. (doi:10.1073/pnas.0805778105)

Reed, K., Meniel, V., Marsh, V., Cole, A., Sansom, O. and Clarke, A. (2008) A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer, 8, p. 162. (doi:10.1186/1471-2407-8-162)

Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. and Hupp, T. (2008) Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284(1), pp. 334-344. (doi:10.1074/jbc.M805165200)

Wilkins, J. A. and Sansom, O. J. (2008) C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine. Cancer Research, 68(13), pp. 4963-4966. (doi:10.1158/0008-5472.CAN-07-5558)

2007

Berger, J., Sansom, O. , Clarke, A. and Bird, A. (2007) MBD2 is required for correct spatial gene expression in the gut. Molecular and Cellular Biology, 27(11), pp. 4049-4057. (doi:10.1158/1535-7163.MCT-06-0382)

Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi:10.1038/sj.onc.1210457)

Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi:10.1038/sj.onc.1210457)

Dikovskaya, D., Schiffmann, D., Newton, I., Oakley, A., Kroboth, K., Sansom, O. , Jamieson, T., Meniel, V., Clarke, A. and Nathke, I. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of Cell Biology, 176(2), pp. 183-195. (doi:10.1083/jcb.200610099)

Sansom, O. , Maddison, K. and Clarke, A. (2007) Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nature Clinical Practice Oncology, 4(5), pp. 305-315. (doi:10.1038/ncponc0812)

Sansom, O. , Mansergh, F., Evans, M., Wilkins, J. and Clarke, A. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APC(Min/+) mice. Gut, 56(10), pp. 1410-1414. (doi:10.1136/gut.2006.116921)

Sansom, O. , Meniel, V., Muncan, V., Phesse, T., Wilkins, J., Reed, K., Vass, J., Athineos, D., Clevers, H. and Clarke, A. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature, 446(7136), pp. 676-679. (doi:10.1038/nature05674)

Stark, L., Reid, K., Sansom, O. , Din, F., Guichard, S., Mayer, I., Jodrell, D., Clarke, A. and Dunlop, M. (2007) Aspirin activates the NF-kappa B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis, 28(5), pp. 968-976. (doi:10.1093/carcin/bgl220)

2006

Serrels, A., MacPherson, I.R.J. , Evans, T.R.J. , Lee, F.Y., Clark, E.A., Sansom, O.J. , Ashton, G.H., Frame, M.C. and Brunton, V.G. (2006) Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Molecular Cancer Therapeutics, 5(12), pp. 3014-3022. (doi:10.1158/1535-7163.MCT-06-0382)

Muncan, V. et al. (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology, 26(22), pp. 8418-8426. (doi:10.1125/MCB.00821-06)

Prokhortchouk, A. et al. (2006) Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology, 26(1), pp. 199-208.

Reed, K., Sansom, O. , Hayes, A., Gescher, A., Peters, J. and Clarke, A. (2006) PPAR delta status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer, 6, p. 113. (doi:10.1186/1471-2407-6-113)

Sansom, O. et al. (2006) Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103(38), pp. 14122-14127. (doi:10.1073/pnas.0604130103)

2005

Hay, T., Jenkins, H., Sansom, O. , Martin, N., Smith, G. and Clarke, A. (2005) Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Research, 65(22), pp. 10145-10148. (doi:10.1158/0008-5472.CAN-05-1186)

Hay, T., Patrick, T., Winton, D., Sansom, O. and Clarke, A. (2005) Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene, 24(23), pp. 3842-3846. (doi:10.1038/sj.onc.1208533)

Meniel, V., Hay, T., Douglas-Jones, A., Sansom, O. and Clarke, A. (2005) Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research, 65(2), pp. 410-416.

Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2005) MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene, 24(14), pp. 2430-2432. (doi:10.1038/sj.onc.1208166)

Sansom, O. , Reed, K., van de Wetering, M., Muncan, V., Winton, D., Clevers, H. and Clarke, A. (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. Journal of Biological Chemistry, 280(31), pp. 28463-28467. (doi:10.1074/jbc.M500191200)

2004

Ireland, H., Kemp, R., Houghton, C., Howard, L., Clarke, A., Sansom, O. and Winton, D. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin. Gastroenterology, 126(5), pp. 1236-1246. (doi:10.1053/j.gastro.2004.03.020)

Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Teesdale-Spittle, P., Errington, R. and Smith, P. (2004) Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle, 3(5), pp. 662-671.

Reed, K., Sansom, O. , Hayes, A., Gescher, A., Winton, D., Peters, J. and Clarke, A. (2004) PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene, 23, pp. 8992-8996. (doi:10.1038/sj.onc.1208143)

Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2004) MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene, 23(33), pp. 5693-5696. (doi:10.1038/sj.onc.1207767)

2003

Clarke, A. and Sansom, O. (2003) Analyzing tumor suppressor activities in the murine small intestine. Oncology Research, 13(06-Oct), pp. 333-337.

Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Court, J., Errington, R. and Smith, P. (2003) Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene, 22(48), pp. 7642-7648. (doi:10.1038/sj.onc.1206876)

Sansom, O. , Berger, J., Bishop, S., Hendrich, B., Bird, A. and Clarke, A. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics, 34(2), pp. 145-147. (doi:10.1038/ng1155)

Sansom, O. , Bishop, S., Court, H., Dudley, S., Liskay, R. and Clarke, A. (2003) Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair, 2(9), pp. 1029-1039. (doi:10.1016/S1568-7864(03)00111-3)

Sansom, O. , Zabkiewicz, J., Bishop, S., Guy, J., Bird, A. and Clarke, A. (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene, 22(46), pp. 7130-7136. (doi:10.1038/sj.onc.1206850)

Screaton, R., Kiessling, S., Sansom, O. , Millar, C., Maddison, K., Bird, A., Clarke, A. and Frisch, S. (2003) Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 100(9), pp. 5211-5216. (doi:10.1073/pnas.0431215100)

2002

Gallagher, R. et al. (2002) Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene, 21(42), pp. 6446-6457. (doi:10.1038/sj.onc.1205892)

Millar, C., Guy, J., Sansom, O. , Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P., Bishop, S., Clarke, A. and Bird, A. (2002) Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science, 297(5580), pp. 403-405. (doi:10.1126/science.1073354)

Sansom, O. and Clarke, A. (2002) The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. Oncogene, 21(38), pp. 5934-5939. (doi:10.1038/sj.onc.1205760)

Toft, N., Curtis, L., Sansom, O. , Leitch, A., Wyllie, A., Riele, H., Arends, M. and Clarke, A. (2002) Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene, 21(15), pp. 6299-6306. (doi:10.1038/sj.onc.1205727)

2001

Sansom, O. (2001) A role for mismatch repair in control of DNA ploidy following DNA damage. Oncogene, 20(15), pp. 1923-1927. (doi:10.1038/sj.onc.1204276)

Sansom, O. , Stark, L., Dunlop, M. and Clarke, A. (2001) Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Research, 61(19), pp. 7060-7064.

This list was generated on Thu Sep 20 16:52:00 2018 BST.
Number of items: 222.

Articles

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J. and Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, (doi:10.1002/path.5143) (PMID:30043421) (Early Online Publication)

Malik, N., Sansom, O. J. and Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, (Accepted for Publication)

Conway, J. R.W. et al. (2018) Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer. Cell Reports, 23(11), pp. 3312-3326. (doi:10.1016/j.celrep.2018.05.038) (PMID:29898401) (PMCID:PMC6019737)

Hodder, M. C., Flanagan, D. J. and Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22(6), pp. 785-787. (doi:10.1016/j.stem.2018.05.005) (PMID:29859166)

Godfrey, J. D., Morton, J. P. , Wilczynska, A., Sansom, O. J. and Bushell, M. D. (2018) MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. Cell Death and Disease, 9(6), 644. (doi:10.1038/s41419-018-0628-4) (PMID:29844410) (PMCID:PMC5973943)

Woroniuk, A. et al. (2018) STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. Nature Communications, 9, 2124. (doi:10.1038/s41467-018-04404-4) (PMID:29844364) (PMCID:PMC5974301)

Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi:10.1016/j.celrep.2018.03.131) (PMID:29719257)

Ahmad, I. and Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi:10.1002/path.5029) (PMID:29314004)

Morris, H. T., Fort, L., Spence, H. J., Patel, R., Vincent, D. F., Park, J. H. , Snapper, S. B., Carey, F. A., Sansom, O. J. and Machesky, L. M. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. Journal of Pathology, (doi:10.1002/path.5086) (PMID:29672847) (Early Online Publication)

Pearson, H. B. et al. (2018) Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery, (doi:10.1158/2159-8290.CD-17-0867) (PMID:29581176) (Early Online Publication)

Huels, D.J. et al. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, 1132. (doi:10.1038/s41467-018-03426-2)

Patel, R. et al. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10(4), e8347. (doi:10.15252/emmm.201708347) (PMID:29540470)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, (doi:10.1158/2159-8290.CD-17-0533) (PMID:29500295) (Early Online Publication)

Monteverde, T., Tait-Mulder, J., Hedley, A.,, Knight, J.R., Sansom, O.J. and Murphy, D.J. (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi:10.1038/onc.2017.394) (PMID:29106388)

Martin, K. J., McGhee, E. J., Schwarz, J. P., Drysdale, M., Brachmann, S. M., Stucke, V., Sansom, O. J. and Anderson, K. I. (2018) Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments. PLoS ONE, 13(1), e0183585. (doi:10.1371/journal.pone.0183585) (PMID:29293509) (PMCID:PMC5749721)

Leach, J., Morton, J. P. and Sansom, O. J. (2018) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, (doi:10.1016/j.molimm.2017.12.013) (PMID:29269005) (In Press)

Farrell, A. S. et al. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nature Communications, 8(1), 1728. (doi:10.1038/s41467-017-01967-6) (PMID:29170413) (PMCID:PMC5701042)

D'Costa, Z. et al. (2017) Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research, 77(21), pp. 5952-5962. (doi:10.1158/0008-5472.CAN-16-2833) (PMID:28765154)

Chou, A. et al. (2017) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut, (doi:10.1136/gutjnl-2017-315144) (PMID:29080858) (Early Online Publication)

Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi:10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)

Cammareri, P. et al. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24(10), pp. 1681-1693. (doi:10.1038/cdd.2017.92) (PMID:28622298)

Chuvin, N. et al. (2017) Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS(G12D)-driven pancreatic tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 4(2), pp. 263-282. (doi:10.1016/j.jcmgh.2017.05.005) (PMID:28752115) (PMCID:PMC5524227)

Tian, A. et al. (2017) Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genetics, 13(7), e1006870. (doi:10.1371/journal.pgen.1006870) (PMID:28708826) (PMCID:PMC5510812)

Phesse, T. J. and Sansom, O. J. (2017) Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology, 19(7), pp. 752-754. (doi:10.1038/ncb3567) (PMID:28659641)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi:10.1038/cdd.2016.120) (PMID:28106883)

Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi:10.1158/0008-5472.CAN-16-2565) (PMID:28515147)

Diamantopoulou, Z. et al. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31(5), pp. 621-634. (doi:10.1016/j.ccell.2017.03.007) (PMID:28416184)

Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi:10.1038/nature22056) (PMID:28425994)

Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi:10.1126/scitranslmed.aai8504) (PMID:28381539)

Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi:10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)

Fumagalli, A. et al. (2017) Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2357-E2364. (doi:10.1073/pnas.1701219114) (PMID:28270604) (PMCID:PMC5410814)

Azad, A. et al. (2017) PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Molecular Medicine, 9(2), pp. 167-180. (doi:10.15252/emmm.201606674) (PMID:27932443) (PMCID:PMC5286375)

Myant, K. B. et al. (2017) HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. EMBO Molecular Medicine, 9(2), pp. 181-197. (doi:10.15252/emmm.201606684) (PMID:28003334) (PMCID:PMC5286368)

van der Weyden, L. et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541(7636), pp. 233-236. (doi:10.1038/nature20792) (PMID:28052056)

Jackstadt, R. and Sansom, O. J. (2017) The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. EMBO Journal, 36(1), pp. 3-4. (doi:10.15252/embj.201695973) (PMID:27932445) (PMCID:PMC5210127)

Humphris, J. L. et al. (2017) Hypermutation in pancreatic cancer. Gastroenterology, 152(1), 68-74.e2. (doi:10.1053/j.gastro.2016.09.060) (PMID:27856273)

Morton, J. P. and Sansom, O. J. (2017) CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy? Immunotherapy, 9(1), pp. 9-12. (doi:10.2217/imt-2016-0115) (PMID:28000523)

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P. , Sansom, O. J. , Zender, L. and Keyes, W. M. (2017) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes and Development, 31(2), pp. 172-183. (doi:10.1101/gad.290635.116) (PMID:28143833)

Rose, A. M., Sansom, O. J. and Inman, G. J. (2017) Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence. Cell Cycle, 16(5), pp. 386-387. (doi:10.1080/15384101.2016.1259892) (PMID:27860538)

Wildenberg, M.E. et al. (2017) The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, 10(2), pp. 352-360. (doi:10.1038/mi.2016.65)

Spender, L. C. et al. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget, 7(50), pp. 81995-82012. (doi:10.18632/oncotarget.13226) (PMID:27835901)

Driscoll, D. R. et al. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76(23), pp. 6911-6923. (doi:10.1158/0008-5472.CAN-16-0810) (PMID:27758884)

Guest, R. V. et al. (2016) Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 113(43), pp. 12250-12255. (doi:10.1073/pnas.1600067113) (PMID:27791012) (PMCID:PMC5086988)

Koppens, M. A.J., Bounova, G., Cornelissen-Steijger, P., de Vries, N., Sansom, O. J. , Wessels, L. F.A. and van Lohuizen, M. (2016) Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget, 7(43), pp. 69816-69828. (doi:10.18632/oncotarget.12002) (PMID:27634879) (PMCID:PMC5342517)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi:10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Kumar, N. et al. (2016) A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development, 143(20), pp. 3711-3722. (doi:10.1242/dev.137992) (PMID:27802136)

Cammareri, P. et al. (2016) Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications, 7, 12493. (doi:10.1038/ncomms12493) (PMID:27558455) (PMCID:PMC5007296)

Lesina, M. et al. (2016) RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. Journal of Clinical Investigation, 126(8), pp. 2919-2932. (doi:10.1172/jci86477) (PMID:27454298)

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi:10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

Ahmad, I. et al. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113(29), pp. 8290-8295. (doi:10.1073/pnas.1601571113) (PMID:27357679) (PMCID:PMC4961202)

Gao, Y., Vincent, D., Davis, A. J., Sansom, O. , Bartholin, L. and Li, Q. (2016) Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. Oncotarget, 7(27), pp. 40904-40918. (doi:10.18632/oncotarget.10149) (PMID:27344183)

Wörmann, S. M. et al. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151(1), 180-193.e12. (doi:10.1053/j.gastro.2016.03.010) (PMID:27003603)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi:10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi:10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Matzke-Ogi, A. et al. (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology, 150(2), 513-525.e10. (doi:10.1053/j.gastro.2015.10.020) (PMID:26597578)

Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi:10.1016/j.celrep.2015.12.020) (PMID:26725115)

Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K., Sansom, O. and Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30(1), pp. 52-63. (doi:10.1101/gad.271130.115) (PMID:26679840) (PMCID:PMC4701978)

Jackstadt, R. and Sansom, O. (2016) Mouse models of intestinal cancer. Journal of Pathology, 238(2), pp. 141-151. (doi:10.1002/path.4645) (PMID:26414675) (PMCID:PMC4832380)

Carotenuto, P. et al. (2016) Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut, 66(7), pp. 1268-1277. (doi:10.1136/gutjnl-2016-312278) (PMID:27618837) (PMCID:PMC5530482)

Elbediwy, A. et al. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. (doi:10.1242/dev.133728) (PMID:26989177) (PMCID:PMC4874484)

Fordham, R. P. and Sansom, O. (2015) Colon contradictions: NF-κB signaling in intestinal tumorigenesis. Journal of Experimental Medicine, 212(13), pp. 2184-2188. (doi:10.1084/jem.21213insight2) (PMID:26666752)

Ladang, A. et al. (2015) Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212(12), pp. 2057-2075. (doi:10.1084/jem.20142288) (PMID:26527802)

Gopinathan, A., Morton, J. P. , Jodrell, D. I. and Sansom, O. J. (2015) GEMMs as preclinical models for testing pancreatic cancer therapies. Disease Models and Mechanisms, 8(10), pp. 1185-1200. (doi:10.1242/dmm.021055) (PMID:26438692) (PMCID:PMC4610236)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi:10.1002/path.4555) (PMID:25950520)

Myant, K. et al. (2015) Serine 62-phosphorylated MYC associates with nuclear lamins and its regulation by CIP2A is essential for regenerative proliferation. Cell Reports, 12(6), pp. 1019-1031. (doi:10.1016/j.celrep.2015.07.003) (PMID:26235622)

Topham, C. et al. (2015) MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), pp. 129-140. (doi:10.1016/j.ccell.2015.06.001) (PMID:26175417) (PMCID:PMC4518499)

Méniel, V., Megges, M., Young, M.A., Cole, A., Sansom, O.J. and Clarke, A.R. (2015) Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene, 34(31), pp. 4118-4129. (doi:10.1038/onc.2014.342) (PMID:25347740)

von Karstedt, S. et al. (2015) Cancer cell-autonomous trail-r signaling promotes kras-driven cancer progression, invasion, and metastasis. Cancer Cell, 27(4), pp. 561-573. (doi:10.1016/j.ccell.2015.02.014) (PMID:25843002)

Kundu, P. et al. (2015) An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine, 7(281), 281ra44. (doi:10.1126/scitranslmed.3010567) (PMID:25834110)

Boulter, L. et al. (2015) WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Journal of Clinical Investigation, 125(3), pp. 1269-1285. (doi:10.1172/JCI76452) (PMID:25689248)

Ueberham, E. et al. (2015) Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors. Molecular Cancer Research, 13(2), pp. 239-249. (doi:10.1158/1541-7786.MCR-14-0278-T) (PMID:25270420)

Faller, W. et al. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature, 517(7535), pp. 497-500. (doi:10.1038/nature13896) (PMID:25383520) (PMCID:PMC4304784)

Davis, H. et al. (2015) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nature Medicine, 21(1), pp. 62-70. (doi:10.1038/nm.3750)

Conde-Perez, A. et al. (2015) A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nature Communications, 6, 8093. (doi:10.1038/ncomms9093) (PMID:26307673) (PMCID:PMC4560817)

Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi:10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)

Huels, D.J. and Sansom, O.J. (2015) Stem vs non-stem cell origin of colorectal cancer. British Journal of Cancer, 113(1), pp. 1-5. (doi:10.1038/bjc.2015.214) (PMID:26110974)

Lindsay, C. R., Li, A., Faller, W., Ozanne, B., Welch, H., Machesky, L. M. and Sansom, O. (2015) A Rac1-independent role for P-Rex1 in melanoblasts. Journal of Investigative Dermatology, 135(1), pp. 314-318. (doi:10.1038/jid.2014.323)

Lindström, N. O. et al. (2015) Integrated β-catenin, BMP, PTEN, and notch signalling patterns the nephron. eLife, 4, e04000. (doi:10.7554/eLife.04000) (PMID:25647637) (PMCID:4337611)

Lu, W.-Y. et al. (2015) Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nature Cell Biology, 17(8), pp. 971-983. (doi:10.1038/ncb3203) (PMID:26192438)

Ma, Y., Faller, W., Sansom, O. , Brown, E. R., Doig, T. N., Melton, D. W. and Machesky, L. (2015) Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma. Melanoma Research, 25(2), pp. 169-172. (doi:10.1097/CMR.0000000000000135) (PMID:25535872)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi:10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

Mills, J.C. and Sansom, O.J. (2015) Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Science Signaling, 8(385), re8. (doi:10.1126/scisignal.aaa7540) (PMID:26175494)

Lunardi, S. et al. (2014) IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget, 5(22), pp. 11064-11080.

Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (PMID:25313567) (PMCID:PMC4196730)

Morran, D. C. et al. (2014) Targeting mTOR dependency in pancreatic cancer. Gut, 63(9), pp. 1481-1489. (doi:10.1136/gutjnl-2013-306202) (PMID:24717934) (PMCID:PMC4145424)

Hamilton, G. et al. (2014) AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget, 5(15), pp. 6142-6167.

Rajan, P. et al. (2014) Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. European Urology, 66(1), pp. 32-39. (doi:10.1016/j.eururo.2013.08.011) (PMID:24054872) (PMCID:PMC4062940)

Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi:10.1016/j.cub.2014.04.007)

Foth, M. et al. (2014) Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. Journal of Pathology, 233(2), pp. 148-158. (doi:10.1002/path.4334)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi:10.1053/j.gastro.2014.01.046)

Valeri, N. et al. (2014) microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi:10.1016/j.ccr.2014.03.006)

Song, J.-H., Huels, D. J., Ridgway, R. A., Sansom, O. J. , Kholodenko, B. N., Kolch, W. and Cho, K.-H. (2014) The APC network regulates the removal of mutated cells from colonic crypts. Cell Reports, 7(1), pp. 94-103. (doi:10.1016/j.celrep.2014.02.043)

Johnsson, A.-K. E. et al. (2014) The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Reports, 6(6), pp. 1153-1164. (doi:10.1016/j.celrep.2014.02.024)

Arjonen, A. et al. (2014) Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis. Journal of Clinical Investigation, 124(3), pp. 1069-1082. (doi:10.1172/JCI67280)

Lourenco, F.C. et al. (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. Gut, 63(3), pp. 480-493. (doi:10.1136/gutjnl-2012-303883)

Guest, R. V., Boulter, L., Kendall, T. J., Minnis-Lyons, S. E., Walker, R., Wigmore, S. J., Sansom, O. and Forbes, S. J. (2014) Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Research, 74(4), pp. 1005-1010. (doi:10.1158/0008-5472.CAN-13-1911)

Ali, A. et al. (2014) Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel. BMC Clinical Pathology, 14, p. 35. (doi:10.1186/1472-6890-14-35)

Belmont, P. J. et al. (2014) Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. Disease Models and Mechanisms, 7(6), pp. 613-623. (doi:10.1242/dmm.013904)

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M., Muller, W. J., Vidal, M. and Sansom, O. J. (2014) c-Src drives intestinal regeneration and transformation. EMBO Journal, 33(3), pp. 1474-1491. (doi:10.1002/embj.201387454)

Dhillon, A. and Sansom, O. (2014) Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom. Disease Models and Mechanisms, 7(8), pp. 937-940. (doi:10.1242/dmm.017350)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi:10.1101/gad.247528.114)

Phesse, T. J. and Sansom, O. J. (2013) Responding to R-Spondin: Slit2 potentiates intestinal regeneration. Cell Stem Cell, 13(5), pp. 512-514. (doi:10.1016/j.stem.2013.10.006)

Nobis, M., Carragher, N.O., McGhee, E.J., Morton, J.P. , Sansom, O.J. , Anderson, K.I. and Timpson, P. (2013) Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS Journal, 280(21), pp. 5177-5197. (doi:10.1111/febs.12348)

Cheung, E.C., Athineos, D., Lee, P., Ridgway, R.A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K., Sansom, O.J. and Vousden, K.H. (2013) TIGAR is required for efficient intestinal regeneration and tumorigenesis. Developmental Cell, 25(5), pp. 463-477. (doi:10.1016/j.devcel.2013.05.001)

Myant, K.B. et al. (2013) ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell, 12(6), pp. 761-773. (doi:10.1016/j.stem.2013.04.006)

Ma, Y., Li, A., Faller, W.J., Libertini, S., Fiorito, F., Gillespie, D.A., Sansom, O.J. , Yamashiro, S. and Machesky, L.M. (2013) Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. Development, 140(10), pp. 2203-2211. (doi:10.1242/dev.089789)

Bird, T.G. et al. (2013) Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proceedings of the National Academy of Sciences of the United States of America, 110(16), pp. 6542-6547. (doi:10.1073/pnas.1302168110)

Morton, J. and Sansom, O.J. (2013) MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC. Molecular Oncology, 7(2), pp. 248-258. (doi:10.1016/j.molonc.2013.02.015)

Radulescu, S. et al. (2013) Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene, 32(16), pp. 2048-2057. (doi:10.1038/onc.2012.224)

Steele, C.W., Jamieson, N.B., Evans, T.R.J. , McKay, C.J., Sansom, O.J. , Morton, J. and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108(5), pp. 997-1003. (doi:10.1038/bjc.2013.24)

Muller, P.A.J. et al. (2013) Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), pp. 1252-1265. (doi:10.1038/onc.2012.148)

Patel, R. et al. (2013) Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Journal of Clinical Investigation, 123(3), pp. 1157-1175. (doi:10.1172/JCI63672)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi:10.1158/2159-8290.CD-12-0292)

Schwitalla, S. et al. (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell, 152(1-2), pp. 25-38. (doi:10.1016/j.cell.2012.12.012)

Acosta, J.C. et al. (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15, pp. 978-990. (doi:10.1038/ncb2784)

Huels, D.J., Cammareri, P., Ridgway, R.A., Medema, J.P. and Sansom, O.J. (2013) Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis. Methods in Molecular Biology, 1012, pp. 237-248. (doi:10.1007/978-1-62703-429-6_16)

Karim, S.A., Creedon, H., Patel, H., Carragher, N.O., Morton, J.P. , Muller, W.J., Evans, T.R.J. , Gusterson, B., Sansom, O.J. and Brunton, V.G. (2013) Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. Journal of Pathology, 230(4), pp. 430-440. (doi:10.1002/path.4202)

Myant, K.B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O.J. and Cordero, J.B. (2013) Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle, 12(18), pp. 2973-2977. (doi:10.4161/cc.26031)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi:10.1158/0008-5472.CAN-12-4545)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

Wiese, K. E., Walz, S., von Eyss, B., Wolf, E., Athineos, D., Sansom, O. and Eilers, M. (2013) The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harbor Perspectives in Medicine, 3(12), a014290. (doi:10.1101/cshperspect.a014290)

Cordero, J. B., Stefanatos, R. K., Myant, K., Vidal, M. and Sansom, O. J. (2012) Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development, 139(24), pp. 4524-4535. (doi:10.1242/dev.078261)

Machesky, L.M. and Sansom, O.J. (2012) Rac1 in the driver’s seat for melanoma. Pigment Cell and Melanoma Research, 25(6), pp. 762-764. (doi:10.1111/pcmr.12004)

Radulescu, S. et al. (2012) Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports, 2(2), pp. 270-282. (doi:10.1016/j.celrep.2012.07.003)

Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi:10.1172/JCI61067)

Gao, M. et al. (2012) SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. EMBO Molecular Medicine, 4(8), pp. 776-790. (doi:10.1002/emmm.201100944)

Ahmad, I., Sansom, O.J. and Leung, H.Y. (2012) Exploring molecular genetics of bladder cancer: lessons learned from mouse models. Disease Models and Mechanisms, 5(3), pp. 323-332. (doi:10.1242/dmm.008888)

Boulter, L. et al. (2012) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature Medicine, 18(4), pp. 572-579. (doi:10.1038/nm.2667)

Blyth, K., Morton, J.P. and Sansom, O.J. (2012) The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? Current Opinion in Genetics and Development, 22(1), pp. 28-35. (doi:10.1016/j.gde.2012.02.009)

Dozynkiewicz, M.A. et al. (2012) Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Developmental Cell, 22(1), pp. 131-145. (doi:10.1016/j.devcel.2011.11.008)

Jamieson, N. B., Morran, D. C., Morton, J. P. , Ali, A., Dickson, E. J., Carter, C. R., Sansom, O. J. , Evans, T. R. J. , McKay, C. J. and Oien, K. A. (2012) MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clinical Cancer Research, 18(2), pp. 534-545. (doi:10.1158/1078-0432.CCR-11-0679)

Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi:10.1111/j.1748-1716.2011.02288.x)

Sandilands, E. et al. (2012) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nature Cell Biology, 14(1), pp. 51-60. (doi:10.1038/ncb2386)

Cordero, J. B., Stefanatos, R. K., Scopelliti, A., Vidal, M. and Sansom, O. J. (2012) Inducible progenitor-derived wingless regulates adult midgut regeneration in drosophila. EMBO Journal, 31(19), pp. 3901-3917. (doi:10.1038/emboj.2012.248)

Klotz, D.M., Nelson, S.A., Kroboth, K., Newton, I.P., Radulescu, S., Ridgway, R.A., Sansom, O.J. , Appleton, P.L. and Nathke, I.S. (2012) The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. Journal of Cell Science, 125(4), pp. 887-895. (doi:10.1242/jcs.091843)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K., Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi:10.1038/jid.2012.186)

McCall, P. et al. (2012) NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. British Journal of Cancer, 107(9), pp. 1554-1563. (doi:10.1038/bjc.2012.372)

Tho, L.M., Libertini, S., Rampling, R., Sansom, O. and Gillespie, D.A. (2012) Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene, 31(11), pp. 1366-1375. (doi:10.1038/onc.2011.326)

Myant, K. and Sansom, O.J. (2011) Wnt/Myc interactions in intestinal cancer: partners in crime. Experimental Cell Research, 317(19), pp. 2725-2731. (doi:10.1016/j.yexcr.2011.08.001)

Li, A. et al. (2011) Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell, 21(4), pp. 722-734. (doi:10.1016/j.devcel.2011.07.008)

Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi:10.1242/dmm.006874)

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi:10.1038/cr.2010.154)

Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42(1), pp. 36-49. (doi:10.1016/j.molcel.2011.02.020)

Ahmad, I. , Patel, R., Liu, Y., Singh, L.B., Taketo, M.M., Wu, X.-R., Leung, H.Y. and Sansom, O.J. (2011) Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death and Disease, 2, e124. (doi:10.1038/cddis.2011.7)

Subauste, M.C., Ventura-Holman, T., Lu, D., Du, L., Sansom, O.J. and Maher, J.F. (2011) Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia. Cancer Epidemiology, 35(1), pp. 97-100. (doi:10.1016/j.canep.2010.09.007)

Ahmad, I. et al. (2011) β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene, 30(2), pp. 178-189. (doi:10.1038/onc.2010.399)

Ahmad, I. et al. (2011) HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 108(39), pp. 16392-16397. (doi:10.1073/pnas.1101263108)

Graham, K., Moran-Jones, K., Sansom, O.J. , Brunton, V.G. and Frame, M.C. (2011) FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS ONE, 6(12), e27806. (doi:10.1371/journal.pone.0027806)

Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2(Art 55), pp. 1-9. (doi:10.1038/ncomms1560)

Matallanas, D. et al. (2011) Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular Cell, 44(6), pp. 893-906. (doi:10.1016/j.molcel.2011.10.016)

Matthews, J.R., Sansom, O.J. and Clarke, A.R. (2011) Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death and Differentiation, 18(12), pp. 1934-1943. (doi:10.1038/cdd.2011.77)

Morton, J.P. , Myant, K.B. and Sansom, O.J. (2011) A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis. Cell Cycle, 10(2), pp. 173-175. (doi:10.4161/cc.10.2.14350)

Morton, J.P. , Steele, C.W. and Sansom, O.J. (2011) Timing Is Everything: Brca2 and p53 Mutations in Pancreatic Cancer. Gastroenterology, 140(4), pp. 1143-1146. (doi:10.1053/j.gastro.2011.02.026)

Myant, K. and Sansom, O. (2011) Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex. Cell Division, 6(3), pp. 1-4. (doi:10.1186/1747-1028-6-3)

Myant, K. and Sansom, O.J. (2011) More, More, More: Downregulation of a MK5-FoxO3a-mir34b/c Pathway Further Increases c-Myc Levels in Colorectal Cancer. Molecular Cell, 41(4), pp. 369-370. (doi:10.1016/j.molcel.2011.01.028)

Samuel, M.S. et al. (2011) Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell, 19(6), pp. 776-791. (doi:10.1016/j.ccr.2011.05.008)

Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi:10.1158/0008-5472.CAN-10-2267)

Morton, J.P. et al. (2010) Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 107(1), pp. 246-251. (doi:10.1073/pnas.0908428107)

Ashton, G. et al. (2010) Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling. Developmental Cell, 19(2), pp. 259-269. (doi:10.1016/j.devcel.2010.07.015)

Athineos, D. and Sansom, O. (2010) Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine. Oncogene, 29(17), pp. 2585-2590. (doi:10.1038/onc.2010.5)

Cole, A.M., Ridgway, R.A., Derkits, S.E., Parry, L., Barker, N., Clevers, H., Clarke, A.R. and Sansom, O.J. (2010) p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine, 2(11), pp. 472-486. (doi:10.1002/emmm.201000101)

Morton, J. et al. (2010) LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology, 139(2), 586-597.e6. (doi:10.1053/j.gastro.2010.04.055)

Morton, J. et al. (2010) Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma. Gastroenterology, 139(1), pp. 292-303. (doi:10.1053/j.gastro.2010.03.034)

Nusse, R. et al. (2010) Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo. PLoS Genetics, 6(1), e1000816. (doi:10.1371/journal.pgen.1000816)

Quyn, A., Appleton, P., Carey, F., Steele, R., Barker, N., Clevers, H., Ridgway, R., Sansom, O. and Näthke, I. (2010) Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue. Cell Stem Cell, 6(2), p. 175. (doi:10.1016/j.stem.2009.12.007)

Radulescu, S., Ridgway, R.A., Appleton, P., Kroboth, K., Patel, S., Woodgett, J., Taylor, S., Nathke, I.S. and Sansom, O.J. (2010) Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene, 29(49), pp. 6418-6427. (doi:10.1038/onc.2010.373)

Woodcock, S., Rushton, H., Castañeda-Saucedo, E., Myant, K., White, G., Blyth, K., Sansom, O. and Malliri, A. (2010) Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Current Biology, 20(7), pp. 669-675. (doi:10.1016/j.cub.2010.02.033)

Cordero, J. B., Vidal, M. and Sansom, O. J. (2009) APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. Cell Cycle, 8(18), pp. 2927-2931. (doi:10.4161/cc.8.18.9472)

Serrels, B. et al. (2009) A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model. Carcinogenesis, 30(2), pp. 249-257. (doi:10.1093/carcin/bgn278)

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2009) The role of murine models of prostate cancer in drug target discovery and validation. Expert Opinion on Drug Discovery, 4(8), pp. 879-888. (doi:10.1517/17460440903049308)

Barker, N., Ridgway, R., van Es, J., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A., Sansom, O. and Clevers, H. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457(7229), pp. 608-611. (doi:10.1038/nature07602)

Burke, Z., Reed, K., Phesse, T., Sansom, O. , Clarke, A. and Tosh, D. (2009) Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism. Gastroenterology, 136(7), pp. 2316-2324. (doi:10.1053/j.gastro.2009.02.063)

Chong, J. et al. (2009) E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells. Nature, 462(7275), pp. 930-934. (doi:10.1038/nature08677)

Muller, P. et al. (2009) Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), pp. 1327-1341. (doi:10.1016/j.cell.2009.11.026)

Ritchie, K. J., Walsh, S., Sansom, O. J. , Henderson, C. J. and Wolf, C. R. (2009) Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi. Proceedings of the National Academy of Sciences of the United States of America, 106(49), pp. 20859-20864. (doi:10.1073/pnas.0911351106)

Subauste, M., Sansom, O. , Porecha, N., Raich, N., Du, L. and Maher, J. (2009) Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Molecular Carcinogenesis, 49(2), pp. 105-113. (doi:10.1002/mc.20594)

Wellner, U. et al. (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology, 11(12), 1487-U236. (doi:10.1038/ncb1998)

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2008) Advances in mouse models of prostate cancer. Expert Reviews in Molecular Medicine, 10, e16. (doi:10.1017/S1462399408000689)

Marsh, V., Winton, D., Williams, G., Dubois, N., Trumpp, A., Sansom, O. and Clarke, A. (2008) Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics, 40(12), pp. 1436-1444. (doi:10.1038/ng.256)

Patek, C. et al. (2008) Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Experimental Cell Research, 314(5), pp. 1105-1114. (doi:10.1016/j.yexcr.2007.11.004)

Patek, C. et al. (2008) The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterology, 8, p. 24. (doi:10.1186/1471-230X-8-24)

Phesse, T. J., Parry, L., Reed, K. R., Ewan, K. B., Dale, T. C., Sansom, O. J. and Clarke, A. R. (2008) Deficiency of Mbd2 Attenuates Wnt Signaling. Molecular and Cellular Biology, 28(19), pp. 6094-6103. (doi:10.1128/MCB.00539-08)

Reed, K. R., Athineos, D., Meniel, V. S., Wilkins, J. A., Ridgway, .A., Burke, Z. D., Muncan, V., Clarke, A. R. and Sansom, O.J. (2008) B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America, 105(48), pp. 18919-18923. (doi:10.1073/pnas.0805778105)

Reed, K., Meniel, V., Marsh, V., Cole, A., Sansom, O. and Clarke, A. (2008) A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer, 8, p. 162. (doi:10.1186/1471-2407-8-162)

Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A., Sansom, O. and Hupp, T. (2008) Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling. Journal of Biological Chemistry, 284(1), pp. 334-344. (doi:10.1074/jbc.M805165200)

Wilkins, J. A. and Sansom, O. J. (2008) C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine. Cancer Research, 68(13), pp. 4963-4966. (doi:10.1158/0008-5472.CAN-07-5558)

Berger, J., Sansom, O. , Clarke, A. and Bird, A. (2007) MBD2 is required for correct spatial gene expression in the gut. Molecular and Cellular Biology, 27(11), pp. 4049-4057. (doi:10.1158/1535-7163.MCT-06-0382)

Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi:10.1038/sj.onc.1210457)

Clarke, A., Jones, N., Pryde, F., Adachi, Y. and Sansom, O. (2007) 53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. Oncogene, 26(43), pp. 6349-6355. (doi:10.1038/sj.onc.1210457)

Dikovskaya, D., Schiffmann, D., Newton, I., Oakley, A., Kroboth, K., Sansom, O. , Jamieson, T., Meniel, V., Clarke, A. and Nathke, I. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of Cell Biology, 176(2), pp. 183-195. (doi:10.1083/jcb.200610099)

Sansom, O. , Maddison, K. and Clarke, A. (2007) Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer. Nature Clinical Practice Oncology, 4(5), pp. 305-315. (doi:10.1038/ncponc0812)

Sansom, O. , Mansergh, F., Evans, M., Wilkins, J. and Clarke, A. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APC(Min/+) mice. Gut, 56(10), pp. 1410-1414. (doi:10.1136/gut.2006.116921)

Sansom, O. , Meniel, V., Muncan, V., Phesse, T., Wilkins, J., Reed, K., Vass, J., Athineos, D., Clevers, H. and Clarke, A. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature, 446(7136), pp. 676-679. (doi:10.1038/nature05674)

Stark, L., Reid, K., Sansom, O. , Din, F., Guichard, S., Mayer, I., Jodrell, D., Clarke, A. and Dunlop, M. (2007) Aspirin activates the NF-kappa B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis, 28(5), pp. 968-976. (doi:10.1093/carcin/bgl220)

Serrels, A., MacPherson, I.R.J. , Evans, T.R.J. , Lee, F.Y., Clark, E.A., Sansom, O.J. , Ashton, G.H., Frame, M.C. and Brunton, V.G. (2006) Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Molecular Cancer Therapeutics, 5(12), pp. 3014-3022. (doi:10.1158/1535-7163.MCT-06-0382)

Muncan, V. et al. (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology, 26(22), pp. 8418-8426. (doi:10.1125/MCB.00821-06)

Prokhortchouk, A. et al. (2006) Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology, 26(1), pp. 199-208.

Reed, K., Sansom, O. , Hayes, A., Gescher, A., Peters, J. and Clarke, A. (2006) PPAR delta status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer, 6, p. 113. (doi:10.1186/1471-2407-6-113)

Sansom, O. et al. (2006) Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103(38), pp. 14122-14127. (doi:10.1073/pnas.0604130103)

Hay, T., Jenkins, H., Sansom, O. , Martin, N., Smith, G. and Clarke, A. (2005) Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Research, 65(22), pp. 10145-10148. (doi:10.1158/0008-5472.CAN-05-1186)

Hay, T., Patrick, T., Winton, D., Sansom, O. and Clarke, A. (2005) Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene, 24(23), pp. 3842-3846. (doi:10.1038/sj.onc.1208533)

Meniel, V., Hay, T., Douglas-Jones, A., Sansom, O. and Clarke, A. (2005) Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research, 65(2), pp. 410-416.

Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2005) MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene, 24(14), pp. 2430-2432. (doi:10.1038/sj.onc.1208166)

Sansom, O. , Reed, K., van de Wetering, M., Muncan, V., Winton, D., Clevers, H. and Clarke, A. (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. Journal of Biological Chemistry, 280(31), pp. 28463-28467. (doi:10.1074/jbc.M500191200)

Ireland, H., Kemp, R., Houghton, C., Howard, L., Clarke, A., Sansom, O. and Winton, D. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin. Gastroenterology, 126(5), pp. 1236-1246. (doi:10.1053/j.gastro.2004.03.020)

Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Teesdale-Spittle, P., Errington, R. and Smith, P. (2004) Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle, 3(5), pp. 662-671.

Reed, K., Sansom, O. , Hayes, A., Gescher, A., Winton, D., Peters, J. and Clarke, A. (2004) PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene, 23, pp. 8992-8996. (doi:10.1038/sj.onc.1208143)

Sansom, O. , Bishop, S., Bird, A. and Clarke, A. (2004) MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene, 23(33), pp. 5693-5696. (doi:10.1038/sj.onc.1207767)

Clarke, A. and Sansom, O. (2003) Analyzing tumor suppressor activities in the murine small intestine. Oncology Research, 13(06-Oct), pp. 333-337.

Marquez, N., Chappell, S., Sansom, O. , Clarke, A., Court, J., Errington, R. and Smith, P. (2003) Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene, 22(48), pp. 7642-7648. (doi:10.1038/sj.onc.1206876)

Sansom, O. , Berger, J., Bishop, S., Hendrich, B., Bird, A. and Clarke, A. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics, 34(2), pp. 145-147. (doi:10.1038/ng1155)

Sansom, O. , Bishop, S., Court, H., Dudley, S., Liskay, R. and Clarke, A. (2003) Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair, 2(9), pp. 1029-1039. (doi:10.1016/S1568-7864(03)00111-3)

Sansom, O. , Zabkiewicz, J., Bishop, S., Guy, J., Bird, A. and Clarke, A. (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene, 22(46), pp. 7130-7136. (doi:10.1038/sj.onc.1206850)

Screaton, R., Kiessling, S., Sansom, O. , Millar, C., Maddison, K., Bird, A., Clarke, A. and Frisch, S. (2003) Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 100(9), pp. 5211-5216. (doi:10.1073/pnas.0431215100)

Gallagher, R. et al. (2002) Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene, 21(42), pp. 6446-6457. (doi:10.1038/sj.onc.1205892)

Millar, C., Guy, J., Sansom, O. , Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P., Bishop, S., Clarke, A. and Bird, A. (2002) Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science, 297(5580), pp. 403-405. (doi:10.1126/science.1073354)

Sansom, O. and Clarke, A. (2002) The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. Oncogene, 21(38), pp. 5934-5939. (doi:10.1038/sj.onc.1205760)

Toft, N., Curtis, L., Sansom, O. , Leitch, A., Wyllie, A., Riele, H., Arends, M. and Clarke, A. (2002) Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene, 21(15), pp. 6299-6306. (doi:10.1038/sj.onc.1205727)

Sansom, O. (2001) A role for mismatch repair in control of DNA ploidy following DNA damage. Oncogene, 20(15), pp. 1923-1927. (doi:10.1038/sj.onc.1204276)

Sansom, O. , Stark, L., Dunlop, M. and Clarke, A. (2001) Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Research, 61(19), pp. 7060-7064.

Book Sections

Myant, K. and Sansom, O. J. (2014) Wnt signaling and colorectal cancer. In: Hoppler, S. and Moon, R. (eds.) Wnt Signaling in Development and Disease. John Wiley & Sons, pp. 357-367. ISBN 9781118444122 (doi:10.1002/9781118444122.ch27)

Conference Proceedings

Loveridge, C., Mui, E., Ahmad, I. , Welsh, M., Tan, E., Fleming, J., Sansom, O. and Leung, H. (2015) The Role of Erk5 in Prostate Carcinogenesis. In: 11th World Congress on Urological Research, Nijmegen, The Nertherlands, September 2015, (Unpublished)

This list was generated on Thu Sep 20 16:52:00 2018 BST.