Professor John Le Quesne

  • Professor in Molecular Pathology (Institute of Cancer Sciences)

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2014
Number of items: 21.

2020

López, S. et al. (2020) Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nature Genetics, 52(3), pp. 283-293. (doi: 10.1038/s41588-020-0584-7) (PMID:32139907)

2019

Waldron, J. A., Tack, D. C., Ritchey, L. E., Gillen, S. L., Wilczynska, A., Turro, E., Bevilacqua, P. C., Assmann, S. M., Bushell, M. and Le Quesne, J. (2019) mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biology, 20(1), 300. (doi: 10.1186/s13059-019-1901-2) (PMID:31888698) (PMCID:PMC6936103)

Le Quesne, J., Pritchard, C., Officer, L., Kamata, T., Smith, C., Sereno, M., Das, M., Baena, J. and Al Dujaily, E. (2019) Reduced protumorigenic tumor-associated macrophages with statin use in premalignant human lung adenocarcinoma. JNCI Cancer Spectrum, 4(2), pkz101. (doi: 10.1093/jncics/pkz101) (PMID:32190817) (PMCID:PMC7068793)

Fercoq, F., Remion, E., Frohberger, S. J., Vallarino-Lhermitte, N., Hoerauf, A., Le Quesne, J., Landmann, F., Hübner, M. P., Carlin, L. M. and Martin, C. (2019) IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Neglected Tropical Diseases, 13(8), e0007691. (doi: 10.1371/journal.pntd.0007691) (PMID:31469835) (PMCID:PMC6742411)

Moore, D. A. et al. (2019) In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth—a clinically relevant distinction. Modern Pathology, 32(8), pp. 1095-1105. (doi: 10.1038/s41379-019-0257-1) (PMID:30932019)

Rosenthal, R. et al. (2019) Neoantigen-directed immune escape in lung cancer evolution. Nature, 567(7749), pp. 479-485. (doi: 10.1038/s41586-019-1032-7) (PMID:30894752) (PMCID:PMC6954100)

Rakhit, C. P., Trigg, R. M., Le Quesne, J., Kelly, M., Shaw, J. A., Pritchard, C. and Martins, L. M. (2019) Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA. Disease Models and Mechanisms, 12(2), dmm036863. (doi: 10.1242/dmm.036863) (PMID:30760495) (PMCID:PMC6398498)

2018

Amelio, I. et al. (2018) p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Proceedings of the National Academy of Sciences, 115(46), E10869-E10878. (doi: 10.1073/pnas.1808314115) (PMID:30381462) (PMCID:PMC6243248)

Lazarus, K. A. et al. (2018) BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma. Nature Communications, 9(1), 3327. (doi: 10.1038/s41467-018-05790-5) (PMID:30127402) (PMCID:PMC6102279)

Mackay, H. L. et al. (2018) Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9(1), 3070. (doi: 10.1038/s41467-018-05368-1) (PMID:30076358) (PMCID:PMC6076230)

Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636)

Arce Vargas, F. et al. (2018) Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell, 33(4), 649-663.e4. (doi: 10.1016/j.ccell.2018.02.010) (PMID:29576375) (PMCID:PMC5904288)

Waldron, J. A., Raza, F. and Le Quesne, J. (2018) eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes. Nucleic Acids Research, 46(6), pp. 3075-3087. (doi: 10.1093/nar/gky108) (PMID:29471358) (PMCID:PMC5888628)

Kolluri, K. K. et al. (2018) Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. eLife, 7, e30224. (doi: 10.7554/eLife.30224) (PMID:29345617) (PMCID:PMC5773178)

2017

Chernova, T. et al. (2017) Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a ( Ink4a/Arf ). Current Biology, 27(21), 3302-3314.e6. (doi: 10.1016/j.cub.2017.09.007) (PMID:29112861) (PMCID:PMC5681354)

Jamal-Hanjani, M. et al. (2017) Tracking the evolution of non–small-cell lung cancer. New England Journal of Medicine, 376(22), pp. 2109-2121. (doi: 10.1056/NEJMoa1616288) (PMID:28445112)

Abbosh, C. et al. (2017) Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature, 545(7655), pp. 446-451. (doi: 10.1038/nature22364) (PMID:28445469) (PMCID:PMC5812436)

Arce Vargas, F. et al. (2017) Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors. Immunity, 46(4), pp. 577-586. (doi: 10.1016/j.immuni.2017.03.013) (PMID:28410988) (PMCID:PMC5437702)

Karekla, E., Liao, W.-J., Sharp, B., Pugh, J., Reid, H., Le Quesne, J., Moore, D., Pritchard, C., MacFarlane, M. and Pringle, J. H. (2017) Ex vivo explant cultures of non–small cell lung carcinoma enable evaluation of primary tumor responses to anticancer therapy. Cancer Research, 77(8), pp. 2029-2039. (doi: 10.1158/0008-5472.CAN-16-1121) (PMID:28202521)

2014

Jamal-Hanjani, M. et al. (2014) Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study. PLoS Biology, 12(7), e1001906. (doi: 10.1371/journal.pbio.1001906) (PMID:25003521) (PMCID:PMC4086714)

Turnock-Jones, J. J. and Le Quesne, J. P.C. (2014) MicroRNA in situ hybridization in tissue microarrays. In: Nielsen, B. S. (ed.) In Situ Hybridization Protocols. Series: Methods in molecular biology, 1211 (1211). Humana Press, pp. 85-93. ISBN 9781493914586 (doi:10.1007/978-1-4939-1459-3_8)

This list was generated on Thu Jul 2 14:33:57 2020 BST.
Number of items: 21.

Articles

López, S. et al. (2020) Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nature Genetics, 52(3), pp. 283-293. (doi: 10.1038/s41588-020-0584-7) (PMID:32139907)

Waldron, J. A., Tack, D. C., Ritchey, L. E., Gillen, S. L., Wilczynska, A., Turro, E., Bevilacqua, P. C., Assmann, S. M., Bushell, M. and Le Quesne, J. (2019) mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biology, 20(1), 300. (doi: 10.1186/s13059-019-1901-2) (PMID:31888698) (PMCID:PMC6936103)

Le Quesne, J., Pritchard, C., Officer, L., Kamata, T., Smith, C., Sereno, M., Das, M., Baena, J. and Al Dujaily, E. (2019) Reduced protumorigenic tumor-associated macrophages with statin use in premalignant human lung adenocarcinoma. JNCI Cancer Spectrum, 4(2), pkz101. (doi: 10.1093/jncics/pkz101) (PMID:32190817) (PMCID:PMC7068793)

Fercoq, F., Remion, E., Frohberger, S. J., Vallarino-Lhermitte, N., Hoerauf, A., Le Quesne, J., Landmann, F., Hübner, M. P., Carlin, L. M. and Martin, C. (2019) IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Neglected Tropical Diseases, 13(8), e0007691. (doi: 10.1371/journal.pntd.0007691) (PMID:31469835) (PMCID:PMC6742411)

Moore, D. A. et al. (2019) In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth—a clinically relevant distinction. Modern Pathology, 32(8), pp. 1095-1105. (doi: 10.1038/s41379-019-0257-1) (PMID:30932019)

Rosenthal, R. et al. (2019) Neoantigen-directed immune escape in lung cancer evolution. Nature, 567(7749), pp. 479-485. (doi: 10.1038/s41586-019-1032-7) (PMID:30894752) (PMCID:PMC6954100)

Rakhit, C. P., Trigg, R. M., Le Quesne, J., Kelly, M., Shaw, J. A., Pritchard, C. and Martins, L. M. (2019) Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA. Disease Models and Mechanisms, 12(2), dmm036863. (doi: 10.1242/dmm.036863) (PMID:30760495) (PMCID:PMC6398498)

Amelio, I. et al. (2018) p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Proceedings of the National Academy of Sciences, 115(46), E10869-E10878. (doi: 10.1073/pnas.1808314115) (PMID:30381462) (PMCID:PMC6243248)

Lazarus, K. A. et al. (2018) BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma. Nature Communications, 9(1), 3327. (doi: 10.1038/s41467-018-05790-5) (PMID:30127402) (PMCID:PMC6102279)

Mackay, H. L. et al. (2018) Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9(1), 3070. (doi: 10.1038/s41467-018-05368-1) (PMID:30076358) (PMCID:PMC6076230)

Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636)

Arce Vargas, F. et al. (2018) Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell, 33(4), 649-663.e4. (doi: 10.1016/j.ccell.2018.02.010) (PMID:29576375) (PMCID:PMC5904288)

Waldron, J. A., Raza, F. and Le Quesne, J. (2018) eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes. Nucleic Acids Research, 46(6), pp. 3075-3087. (doi: 10.1093/nar/gky108) (PMID:29471358) (PMCID:PMC5888628)

Kolluri, K. K. et al. (2018) Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. eLife, 7, e30224. (doi: 10.7554/eLife.30224) (PMID:29345617) (PMCID:PMC5773178)

Chernova, T. et al. (2017) Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a ( Ink4a/Arf ). Current Biology, 27(21), 3302-3314.e6. (doi: 10.1016/j.cub.2017.09.007) (PMID:29112861) (PMCID:PMC5681354)

Jamal-Hanjani, M. et al. (2017) Tracking the evolution of non–small-cell lung cancer. New England Journal of Medicine, 376(22), pp. 2109-2121. (doi: 10.1056/NEJMoa1616288) (PMID:28445112)

Abbosh, C. et al. (2017) Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature, 545(7655), pp. 446-451. (doi: 10.1038/nature22364) (PMID:28445469) (PMCID:PMC5812436)

Arce Vargas, F. et al. (2017) Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors. Immunity, 46(4), pp. 577-586. (doi: 10.1016/j.immuni.2017.03.013) (PMID:28410988) (PMCID:PMC5437702)

Karekla, E., Liao, W.-J., Sharp, B., Pugh, J., Reid, H., Le Quesne, J., Moore, D., Pritchard, C., MacFarlane, M. and Pringle, J. H. (2017) Ex vivo explant cultures of non–small cell lung carcinoma enable evaluation of primary tumor responses to anticancer therapy. Cancer Research, 77(8), pp. 2029-2039. (doi: 10.1158/0008-5472.CAN-16-1121) (PMID:28202521)

Jamal-Hanjani, M. et al. (2014) Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study. PLoS Biology, 12(7), e1001906. (doi: 10.1371/journal.pbio.1001906) (PMID:25003521) (PMCID:PMC4086714)

Book Sections

Turnock-Jones, J. J. and Le Quesne, J. P.C. (2014) MicroRNA in situ hybridization in tissue microarrays. In: Nielsen, B. S. (ed.) In Situ Hybridization Protocols. Series: Methods in molecular biology, 1211 (1211). Humana Press, pp. 85-93. ISBN 9781493914586 (doi:10.1007/978-1-4939-1459-3_8)

This list was generated on Thu Jul 2 14:33:57 2020 BST.