2025

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z) (PMID:39972137) (Early Online Publication)

2024

Liu, Dan, Young, Francesca, Lamb, Kieran D., Claudio Quiros, Adalberto, Pancheva, Alexandrina, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Macdonald, Craig ORCID: https://orcid.org/0000-0003-3143-279X, Robertson, David L. ORCID: https://orcid.org/0000-0001-6338-0221 and Yuan, Ke ORCID: https://orcid.org/0000-0002-2318-1460 (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(6), 1321. (doi: 10.1038/s41588-024-01809-4) (PMID:38831011)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1) (PMID:38816652) (PMCID:PMC11251046) (Early Online Publication)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(3), pp. 458-472. (doi: 10.1038/s41588-024-01654-5) (PMID:38351382)

2023

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

2022

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Edwards, S. C. et al. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220(2), e20211431. (doi: 10.1084/jem.20211431) (PMID:36480166) (PMCID:PMC9732671)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

2021

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16(10), pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018) (PMID:34116230) (PMCID:PMC8514249)

2020

Mohan, S. et al. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15(2), pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007) (PMID:31629061) (PMCID:PMC7001105)

2019

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25(10), pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1) (PMID:31591595) (PMCID:PMC6986897)

Memon, Danish, Bi, Jing and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, 7372. (doi: 10.1038/s41598-019-43758-7) (PMID:31089191) (PMCID:PMC6517443)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25(5), pp. 738-743. (doi: 10.1038/s41591-019-0380-z) (PMID:31011204)

Parry, M. A. et al. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2(1), pp. 1-11. (doi: 10.1016/j.euo.2018.08.005) (PMID:30929837) (PMCID:PMC6472613)

Lallo, A. et al. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176(3), pp. 436-450. (doi: 10.1111/bph.14542) (PMID:30427531) (PMCID:PMC6329630)

2018

Kim, Chang Sik, Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G, Dive, Caroline, Brady, Ged and Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35(14), pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004) (PMID:30520956) (PMCID:PMC6612818)

Lallo, A. et al. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24(20), pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805) (PMID:29941481)

Torres-Ayuso, P. et al. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, 15. (doi: 10.1038/s41525-018-0055-6) (PMID:29951225) (PMCID:PMC6010465)

Hudson, A. M. et al. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11(526), eaan6776. (doi: 10.1126/scisignal.aan6776) (PMID:29666306)

Bennett, Laura, Howell, Matthew, Memon, Danish, Smowton, Chris, Zhou, Cong and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, 14830. (doi: 10.1038/s41598-018-33276-3) (PMID:30287876) (PMCID:PMC6172282)

2017

Chiu, Anthony, Ayub, Mahmood, Dive, Caroline, Brady, Ged, Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 and Hancock, John (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33(17), pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308) (PMID:28475662) (PMCID:PMC5860069)

Khandelwal, G. et al. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15(8), pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431) (PMID:28442585)

Smowton, Christopher, Balla, Andoena, Antoniades, Demetris, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Pallis, George, Dikaiakos, Marios D. and Xing, Wei (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

Carter, L. et al. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23(1), pp. 114-119. (doi: 10.1038/nm.4239) (PMID:27869802)

Draper, Julia E., Sroczynska, Patrycja, Leong, Hui Sun, Fadlullah, Muhammad Z. H., Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Kouskoff, Valerie and Lacaud, Georges (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130(3), pp. 271-284. (doi: 10.1182/blood-2016-06-723635) (PMID:28490570) (PMCID:PMC5833261)

2016

Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, 13322. (doi: 10.1038/ncomms13322) (PMID:27827359) (PMCID:PMC5105195)

Memon, Danish, Dawson, Keren, Smowton, Christopher SF, Xing, Wei, Dive, Caroline and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, 16020. (doi: 10.1038/npjgenmed.2016.20) (PMID:28480052) (PMCID:PMC5417364)

Carter, L. R. et al. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. 107th Annual Meeting of the American Association for Cancer Research - Proceedings, New Orleans, LA. Philadelphia (PA), 16-20 Apr 2016. p. 3155. (doi: 10.1158/1538-7445.AM2016-3155)

Morrow, C.J. et al. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27(6), pp. 1155-1160. (doi: 10.1093/annonc/mdw122) (PMID:27013395) (PMCID:PMC4880063)

Tape, C. J. et al. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165(4), pp. 910-920. (doi: 10.1016/j.cell.2016.03.029) (PMID:27087446) (PMCID:PMC4868820)

Rothwell, D. G. et al. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10(4), pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006) (PMID:26639657) (PMCID:PMC4834815)

Marusiak, A. A. et al. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76(3), pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t) (PMID:26637668) (PMCID:PMC4740929)

Grimes, H. Leighton, Draper, Julia E., Sroczynska, Patrycja, Tsoulaki, Olga, Leong, Hui Sun, Fadlullah, Muhammad Z. H., Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Kouskoff, Valerie and Lacaud, Georges (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12(1), e1005814. (doi: 10.1371/journal.pgen.1005814) (PMID:26808730) (PMCID:PMC4726605)

Thambyrajah, R. et al. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18(1), pp. 21-32. (doi: 10.1038/ncb3276) (PMID:26619147)

2015

Liu, J. et al. (2015) Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia. Oncotarget, 6(40), pp. 43048-43064. (doi: 10.18632/oncotarget.5528) (PMID:26474278) (PMCID:PMC4767490)

Antal, C. E. et al. (2015) Cancer-associated protein kinase C mutations reveal kinase’s role as tumor suppressor. Cell, 160(3), pp. 489-502. (doi: 10.1016/j.cell.2015.01.001) (PMID:25619690) (PMCID:PMC4313737)

Hudson, Andrew M, Wirth, Christopher, Stephenson, Natalie L, Fawdar, Shameem, Brognard, John and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2015) Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges. Pharmacogenomics, 16(10), pp. 1149-1160. (doi: 10.2217/pgs.15.60) (PMID:26230733)

Smowton, Christopher, Copil, Georgiana, Truong, Hong-Linh, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 and Xing, Wei (2015) Genome Analysis in a Dynamically Scaled Hybrid Cloud. In: 2015 IEEE 11th International Conference on e-Science, Munich, Germany, 31 Aug - 4 Sept 2015, pp. 391-400. ISBN 9781467393256 (doi: 10.1109/eScience.2015.17)

Smowton, Christopher, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Xing, Wei, Balla, Andoena, Antoniades, Demetris, Pallis, George and Dikaiakos, Marios D. (2015) Analysing Cancer Genomics in the Elastic Cloud. In: 2015 15th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing, Shenzhen, China, 4-7 May 2015, pp. 835-844. (doi: 10.1109/CCGrid.2015.176)

Xing, Wei, Jie, Wei and Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 (2015) SCAN: A Smart Application Platform for Empowering Parallelizations of Big Genomic Data Analysis in Clouds. In: 2015 44th International Conference on Parallel Processing, Beijing, China, 1-4 Sept 2015, pp. 290-299. ISBN 9781467375870 (doi: 10.1109/ICPP.2015.38)

2014

Rothwell, D. G. et al. (2014) Evaluation and validation of a robust single cell RNA-amplification protocol through transcriptional profiling of enriched lung cancer initiating cells. BMC Genomics, 15, 1129. (doi: 10.1186/1471-2164-15-1129) (PMID:25519510) (PMCID:PMC4320548)

Hudson, Andrew M., Yates, Tim, Li, Yaoyong, Trotter, Eleanor W., Fawdar, Shameem, Chapman, Phil, Lorigan, Paul, Biankin, Andrew ORCID: https://orcid.org/0000-0002-0362-5597, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 and Brognard, John (2014) Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery. Cancer Research, 74(22), pp. 6390-6396. (doi: 10.1158/0008-5472.CAN-14-1020) (PMID:25256751)

Lie-A-Ling, Michael, Marinopoulou, Elli, Li, Yaoyong, Patel, Rahima, Stefanska, Monika, Bonifer, Constanze, Miller, Crispin, Kouskoff, Valerie and Lacaud, Georges (2014) RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence. Blood, 124(11), e11-e20. (doi: 10.1182/blood-2014-04-572958) (PMID:25082880)

Aboussekhra, A. et al. (2014) Epithelial and stromal MicroRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation. PLoS ONE, 9(8), e105099. (doi: 10.1371/journal.pone.0105099) (PMID:25122196) (PMCID:PMC4133372)

Hodgkinson, C. L. et al. (2014) Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nature Medicine, 20(8), pp. 897-903. (doi: 10.1038/nm.3600) (PMID:24880617)

Leong, Hui Sun, Dawson, Keren, Wirth, Chris, Li, Yaoyong, Connolly, Yvonne, Smith, Duncan L., Wilkinson, Caroline R. M. and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2014) A global non-coding RNA system modulates fission yeast protein levels in response to stress. Nature Communications, 5, 3947. (doi: 10.1038/ncomms4947) (PMID:24853205) (PMCID:PMC4050258)

Gires, O. et al. (2014) Investigation of radiosensitivity gene signatures in cancer cell lines. PLoS ONE, 9(1), e86329. (doi: 10.1371/journal.pone.0086329) (PMID:24466029) (PMCID:PMC3899227)

Articles

Müller, M. et al. (2025) Human-correlated genetic models identify precision therapy for liver cancer. Nature, (doi: 10.1038/s41586-025-08585-z) (PMID:39972137) (Early Online Publication)

Liu, Dan, Young, Francesca, Lamb, Kieran D., Claudio Quiros, Adalberto, Pancheva, Alexandrina, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Macdonald, Craig ORCID: https://orcid.org/0000-0003-3143-279X, Robertson, David L. ORCID: https://orcid.org/0000-0001-6338-0221 and Yuan, Ke ORCID: https://orcid.org/0000-0002-2318-1460 (2024) PLM-interact: extending protein language models to predict protein-protein interactions. bioRxiv, (doi: 10.1101/2024.11.05.622169)

Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(6), 1321. (doi: 10.1038/s41588-024-01809-4) (PMID:38831011)

Wiesheu, R. et al. (2024) IL-27 maintains cytotoxic Ly6C+ T cells that arise from immature precursors. EMBO Journal, (doi: 10.1038/s44318-024-00133-1) (PMID:38816652) (PMCID:PMC11251046) (Early Online Publication)

Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(3), pp. 458-472. (doi: 10.1038/s41588-024-01654-5) (PMID:38351382)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Román-Fernández, A. et al. (2022) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Edwards, S. C. et al. (2022) PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells. Journal of Experimental Medicine, 220(2), e20211431. (doi: 10.1084/jem.20211431) (PMID:36480166) (PMCID:PMC9732671)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Kay, E. J. et al. (2022) Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism, 4(6), pp. 693-710. (doi: 10.1038/s42255-022-00582-0) (PMID:35760868) (PMCID:PMC9236907)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Tsim, S. et al. (2021) Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases. Journal of Thoracic Oncology, 16(10), pp. 1705-1717. (doi: 10.1016/j.jtho.2021.05.018) (PMID:34116230) (PMCID:PMC8514249)

Mohan, S. et al. (2020) Profiling of circulating free DNA using targeted and genome-wide sequencing in patients with SCLC. Journal of Thoracic Oncology, 15(2), pp. 216-230. (doi: 10.1016/j.jtho.2019.10.007) (PMID:31629061) (PMCID:PMC7001105)

Chemi, F. et al. (2019) Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 25(10), pp. 1534-1539. (doi: 10.1038/s41591-019-0593-1) (PMID:31591595) (PMCID:PMC6986897)

Memon, Danish, Bi, Jing and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2019) In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. Scientific Reports, 9, 7372. (doi: 10.1038/s41598-019-43758-7) (PMID:31089191) (PMCID:PMC6517443)

Rothwell, D. G. et al. (2019) Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. Nature Medicine, 25(5), pp. 738-743. (doi: 10.1038/s41591-019-0380-z) (PMID:31011204)

Parry, M. A. et al. (2019) Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer. European Urology Oncology, 2(1), pp. 1-11. (doi: 10.1016/j.euo.2018.08.005) (PMID:30929837) (PMCID:PMC6472613)

Lallo, A. et al. (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176(3), pp. 436-450. (doi: 10.1111/bph.14542) (PMID:30427531) (PMCID:PMC6329630)

Kim, Chang Sik, Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G, Dive, Caroline, Brady, Ged and Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 (2018) In silico error correction improves cfDNA mutation calling. Bioinformatics, 35(14), pp. 2380-2385. (doi: 10.1093/bioinformatics/bty1004) (PMID:30520956) (PMCID:PMC6612818)

Lallo, A. et al. (2018) The combination of the PARP inhibitor Olaparib and the WEE1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer. Clinical Cancer Research, 24(20), pp. 5153-5164. (doi: 10.1158/1078-0432.CCR-17-2805) (PMID:29941481)

Torres-Ayuso, P. et al. (2018) Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin. npj Genomic Medicine, 3, 15. (doi: 10.1038/s41525-018-0055-6) (PMID:29951225) (PMCID:PMC6010465)

Hudson, A. M. et al. (2018) Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. Science Signaling, 11(526), eaan6776. (doi: 10.1126/scisignal.aan6776) (PMID:29666306)

Bennett, Laura, Howell, Matthew, Memon, Danish, Smowton, Chris, Zhou, Cong and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2018) Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. Scientific Reports, 8, 14830. (doi: 10.1038/s41598-018-33276-3) (PMID:30287876) (PMCID:PMC6172282)

Chiu, Anthony, Ayub, Mahmood, Dive, Caroline, Brady, Ged, Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 and Hancock, John (2017) twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis. Bioinformatics, 33(17), pp. 2743-2745. (doi: 10.1093/bioinformatics/btx308) (PMID:28475662) (PMCID:PMC5860069)

Khandelwal, G. et al. (2017) Next-generation sequencing analysis and algorithms for PDX and CDX models. Molecular Cancer Research, 15(8), pp. 1012-1016. (doi: 10.1158/1541-7786.MCR-16-0431) (PMID:28442585)

Smowton, Christopher, Balla, Andoena, Antoniades, Demetris, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Pallis, George, Dikaiakos, Marios D. and Xing, Wei (2017) A cost-effective approach to improving performance of big genomic data analyses in clouds. Future Generation Computer Systems, 67, pp. 368-381. (doi: 10.1016/j.future.2015.11.011)

Carter, L. et al. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine, 23(1), pp. 114-119. (doi: 10.1038/nm.4239) (PMID:27869802)

Draper, Julia E., Sroczynska, Patrycja, Leong, Hui Sun, Fadlullah, Muhammad Z. H., Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Kouskoff, Valerie and Lacaud, Georges (2017) Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130(3), pp. 271-284. (doi: 10.1182/blood-2016-06-723635) (PMID:28490570) (PMCID:PMC5833261)

Williamson, S. C. et al. (2016) Vasculogenic mimicry in small cell lung cancer. Nature Communications, 7, 13322. (doi: 10.1038/ncomms13322) (PMID:27827359) (PMCID:PMC5105195)

Memon, Danish, Dawson, Keren, Smowton, Christopher SF, Xing, Wei, Dive, Caroline and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2016) Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response. npj Genomic Medicine, 1, 16020. (doi: 10.1038/npjgenmed.2016.20) (PMID:28480052) (PMCID:PMC5417364)

Morrow, C.J. et al. (2016) Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Annals of Oncology, 27(6), pp. 1155-1160. (doi: 10.1093/annonc/mdw122) (PMID:27013395) (PMCID:PMC4880063)

Tape, C. J. et al. (2016) Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell, 165(4), pp. 910-920. (doi: 10.1016/j.cell.2016.03.029) (PMID:27087446) (PMCID:PMC4868820)

Rothwell, D. G. et al. (2016) Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample. Molecular Oncology, 10(4), pp. 566-574. (doi: 10.1016/j.molonc.2015.11.006) (PMID:26639657) (PMCID:PMC4834815)

Marusiak, A. A. et al. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76(3), pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t) (PMID:26637668) (PMCID:PMC4740929)

Grimes, H. Leighton, Draper, Julia E., Sroczynska, Patrycja, Tsoulaki, Olga, Leong, Hui Sun, Fadlullah, Muhammad Z. H., Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Kouskoff, Valerie and Lacaud, Georges (2016) RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis. PLoS Genetics, 12(1), e1005814. (doi: 10.1371/journal.pgen.1005814) (PMID:26808730) (PMCID:PMC4726605)

Thambyrajah, R. et al. (2016) GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology, 18(1), pp. 21-32. (doi: 10.1038/ncb3276) (PMID:26619147)

Liu, J. et al. (2015) Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia. Oncotarget, 6(40), pp. 43048-43064. (doi: 10.18632/oncotarget.5528) (PMID:26474278) (PMCID:PMC4767490)

Antal, C. E. et al. (2015) Cancer-associated protein kinase C mutations reveal kinase’s role as tumor suppressor. Cell, 160(3), pp. 489-502. (doi: 10.1016/j.cell.2015.01.001) (PMID:25619690) (PMCID:PMC4313737)

Hudson, Andrew M, Wirth, Christopher, Stephenson, Natalie L, Fawdar, Shameem, Brognard, John and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2015) Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges. Pharmacogenomics, 16(10), pp. 1149-1160. (doi: 10.2217/pgs.15.60) (PMID:26230733)

Rothwell, D. G. et al. (2014) Evaluation and validation of a robust single cell RNA-amplification protocol through transcriptional profiling of enriched lung cancer initiating cells. BMC Genomics, 15, 1129. (doi: 10.1186/1471-2164-15-1129) (PMID:25519510) (PMCID:PMC4320548)

Hudson, Andrew M., Yates, Tim, Li, Yaoyong, Trotter, Eleanor W., Fawdar, Shameem, Chapman, Phil, Lorigan, Paul, Biankin, Andrew ORCID: https://orcid.org/0000-0002-0362-5597, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 and Brognard, John (2014) Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery. Cancer Research, 74(22), pp. 6390-6396. (doi: 10.1158/0008-5472.CAN-14-1020) (PMID:25256751)

Lie-A-Ling, Michael, Marinopoulou, Elli, Li, Yaoyong, Patel, Rahima, Stefanska, Monika, Bonifer, Constanze, Miller, Crispin, Kouskoff, Valerie and Lacaud, Georges (2014) RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence. Blood, 124(11), e11-e20. (doi: 10.1182/blood-2014-04-572958) (PMID:25082880)

Aboussekhra, A. et al. (2014) Epithelial and stromal MicroRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation. PLoS ONE, 9(8), e105099. (doi: 10.1371/journal.pone.0105099) (PMID:25122196) (PMCID:PMC4133372)

Hodgkinson, C. L. et al. (2014) Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nature Medicine, 20(8), pp. 897-903. (doi: 10.1038/nm.3600) (PMID:24880617)

Leong, Hui Sun, Dawson, Keren, Wirth, Chris, Li, Yaoyong, Connolly, Yvonne, Smith, Duncan L., Wilkinson, Caroline R. M. and Miller, Crispin J. ORCID: https://orcid.org/0000-0003-4341-1283 (2014) A global non-coding RNA system modulates fission yeast protein levels in response to stress. Nature Communications, 5, 3947. (doi: 10.1038/ncomms4947) (PMID:24853205) (PMCID:PMC4050258)

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Conference or Workshop Item

Carter, L. R. et al. (2016) Abstract 3155: Investigating chemoresistance in small cell lung cancer through the molecular profiling of single circulating tumour cells. 107th Annual Meeting of the American Association for Cancer Research - Proceedings, New Orleans, LA. Philadelphia (PA), 16-20 Apr 2016. p. 3155. (doi: 10.1158/1538-7445.AM2016-3155)

Conference Proceedings

Smowton, Christopher, Copil, Georgiana, Truong, Hong-Linh, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 and Xing, Wei (2015) Genome Analysis in a Dynamically Scaled Hybrid Cloud. In: 2015 IEEE 11th International Conference on e-Science, Munich, Germany, 31 Aug - 4 Sept 2015, pp. 391-400. ISBN 9781467393256 (doi: 10.1109/eScience.2015.17)

Smowton, Christopher, Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283, Xing, Wei, Balla, Andoena, Antoniades, Demetris, Pallis, George and Dikaiakos, Marios D. (2015) Analysing Cancer Genomics in the Elastic Cloud. In: 2015 15th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing, Shenzhen, China, 4-7 May 2015, pp. 835-844. (doi: 10.1109/CCGrid.2015.176)

Xing, Wei, Jie, Wei and Miller, Crispin ORCID: https://orcid.org/0000-0003-4341-1283 (2015) SCAN: A Smart Application Platform for Empowering Parallelizations of Big Genomic Data Analysis in Clouds. In: 2015 44th International Conference on Parallel Processing, Beijing, China, 1-4 Sept 2015, pp. 290-299. ISBN 9781467375870 (doi: 10.1109/ICPP.2015.38)