Professor Kostas Tokatlidis

  • Cathcart Chair (Institute of Molecular Cell & Systems Biology)

Research interests

'Mitochondria biogenesis (protein targeting/folding/assembly) in health and disease' 


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Mitochondria salvage via a novel antioxidant protein import pathway
    Biotechnology and Biological Sciences Research Council
    2018 - 2021
     
  • Analysis of a novel protein translocation pathway of the mitchondrial intermembrane space
    Lister Institute of Preventive Medicine
    2018 - 2018
     
  • Thiol Modification and Redox Signalling
    Medical Research Council
    2016 - 2018
     
  • Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.
    The Royal Society
    2013 - 2018
     

Teaching

Coordinator - Level 4 (Final year) Biochemistry degree

Coordinator - Level 4 Advanced Studies in Biochemistry option course

Coordinator - Level 4 Mitochondrial Biology option course

Lectures in three L4 courses: Central Approaches in Biochemistry, Cell compartmentalisation, Mitochondrial Biology

Tutorials in L3 Biochemistry


Additional information

Editorial Board

  • 2013 - present: Biochemical Journal - Editor
  • 2012 - present: FEBS Journal - Editor
  • 2011 - present: ISRN Structural Biology - Editor
  • 2010 - present: Life Sciences Encyclopedia (Wiley) - Editor, Structural Biology Section

Grant Advisory Board

  • 2013: EU Expert for Marie Curie proposals
  • 2010 - 2011: Deutsche Forschungsgemeinschaft - International Expert in review panel for Centres of Excellence and Graduate Schools
  • 2004 - 2006: EU expert for ITN and RTN grant applications

Invited International Presentations

  • 2013: USA - FASEB Meeting om Mitochondria Assembly
  • 2012: Manchester, England, UK - Faculty of Life Sciences, University of Manchester
  • 2012: Newcastle upon Tyne, England, UK - Institute for Cell and Molecular Biosciences, Medical School, Newcastle University
  • 2012: USA - GRC Gordon Research Conference Meeting on Thiol-Based Redox Regulation and Signalling
  • 2012: Warwick, England, UK - School of Biological Sciences, Warwick University
  • 2011: Florence, Italy - CERM, University of Florence
  • 2011: Sardinia, Italy - EMBO-FEBS Conference 'Protein Transport Systems'
  • 2010: Brussels, Belgium - Universite Catholique de Louvain, de Duve Institute
  • 2010: Berlin, Germany - 1st World Congress on Targeting Mitochondria: Strategies, Innovations & Clinical Applications, International Society of Antioxidants in Nutrition and Health
  • 2010: Dortmund, Germany - Leibniz Institute for Analytical Sciences (ISAS)
  • 2010: Berlin, Germany - Institute of Chemistry and Biochemistry, Free University Berlin
  • 2009: Thessaloniki, Greece - Symposium on New Frontiers in Chemical and Biochemical Engineering, CERTH
  • 2009: Thessaloniki, Greece - 3rd Innovation and Entrepreneurship Symposium, Centre for Research and Technology
  • 2009: Aussois, France - FEBS Advanced Lecture Course Mitochondria in Life, Death and Disease
  • 2009: Prague, Czech Republic - 2nd EU-NMR Meeting (Satellite Meeting to 34th FEBS Congress)
  • 2009: Lisbon, Portugal - 2nd ESF/UB European Summer School in Nanomedicine
  • 2009: Munich, Germany - Institute of Physiological Chemistry, LMU-Munich
  • 2009: Freiburg, Germany - Institute of Molecular Biology and Biochemistry, University of Freiburg
  • 2008: Munich, Germany - SFB Meeting on ‘Endosymbiosis: From Prokaryotes to Eukaryotic Organelles’, LMU-Munich
  • 2008: Athens, Greece - 33rd FEBS & 11th IUBMB Congress
  • 2008: Il Ciocco, Lucca, Italy - GRC Gordon Research Conference 'Thiol redox processes'
  • 2007: Il Ciocco, Lucca, Italy - Gordon Research Conference 'Protein Transport Across Cell Membranes'
  • 2006: Gdansk, Poland - EMBO-FEBS Conference, 'Protein Targeting and Translocation'
  • 2006: Mumbai, India - International Symposium on Emerging Trends in Genomic and Proteomic Sciences, Indian Council of Medical Research
  • 2005: Munich, Germany - Institute of Physiological Chemistry, LMU-Munich
  • 2003: Glasgow, Scotland, UK - Institute of Biomedical and Life Sciences, University of Glasgow
  • 2003: Spa, Belgium - ESF European Research Conference 'Protein Targeting'
  • 2003: Cambridge, England, UK - Lister Institute Fellows meeting, Cambridge University, King’s College
  • 2003: Crete, Greece - The 2003 ONASSIS Lectures in Biology, FORTH-Crete
  • 2002: Cambridge, England, UK - MRC-Dunn Human Nutrition Unit
  • 2002: Manchester, England, UK - NESBIC UK-Japan Structural Biology Meeting
  • 2002: Bordeaux, France - Institut de Biochimie et Genetique Cellulaire, CNRS-Bordeaux
  • 2002: Crete, Greece - IESL and IMBB, FORTH
  • 2002: Crete, Greece - Department of Chemistry, University of Crete
  • 2001: Leeds, England, UK - Department of Biochemistry and Molecular Biology, University of Leeds
  • 2001: Acquafredda di Maratea, Italy - ESF European Research Conference 'Protein Targeting'
  • 2001: Leeds, England, UK - NESBIC, Structural Biology Meeting
  • 2000: Leeds, England, UK - Biochemical Society Meeting, 'Moving signals and molecules through membranes'
  • 1999: Obernai, France - ESF European Research Conference 'Protein Targeting'
  • 1998: Cambridge, England, UK - MRC-LMB
  • 1998: Crete, Greece - Department of Chemistry, University of Crete, and IMBB-FORTH
  • 1998: Manchester, England, UK - School of Biological Sciences, University of Manchester
  • 1998: Charmey, Switzerland - Workshop on Mitochondrial RNA Import
  • 1998: Glasgow, Scotland, UK - Institute of Biomedical and Life Sciences, University of Glasgow
  • 1997: Grenoble, France - EMBL-Outstation
  • 1997: Albufeira, Portugal - 1st European Research Conference 'Protein Targeting: Protein Translocation Across Cellular Membranes'
  • 1997: Marseille, France - LIDSM-CNRS
  • 1997: Grenoble, France - Centre d'Etudes Atomiques
  • 1997: Crete, Greece - Department of Biology, University of Crete, and IMBB-FORTH
  • 1997: Albufeira, Portugal - 4th European Research Conference 'Molecular Basis of Biological Membrane Protein Structure and Function'
  • 1997: Heidelberg, Germany - Heidelberg Cell Biology Symposium
  • 1997: Paris, France - Institut Pasteur
  • 1997: Freiburg, Germany - Institüt für Biochemie & Molekularbiologie, Universität Freiburg
  • 1996: Munich, Germany - Institut für Physiologische Chemie, LMU-München
  • 1996: Berlin, Germany - Max Delbrück Center Symposium on Protein Transport and Stability
  • 1992: San Francisco, California, USA - ACS National Meeting and Symposium on Protein Folding and Recovery
  • 1990: Boston, Massachusetts, USA - American Chemical Society National Meeting and Symposium on Protein Refolding

Prizes, Awards and Distinctions

  • 2013: Elected Member, EMBO
  • 2013: Wolfson-Royal Society Research Merit Award
  • 2012: Research Excellence Award, Greek Ministry of Education
  • 2011: Visiting Professor, University of Florence, Italy
  • 2001: MRC Career Establishment Award
  • 2001: Lister Institute Research Fellow

Professional Learned Society

  • 2012 - 2015: EU-ROS - Management Committee Member, EU COST Action on Reactive Oxygen Species
  • 2005 - present: Lister Institute - Member
  • 1998 - present: Biochemical Society - Member
  • 1998 - present: American Society for Biochemistry and Molecular Biology - Member

Research Fellowship

  • 2001 - 2006: Lister Fellow
  • 1995 - 1996: Roche Postdoctoral Fellow
  • 1993 - 1995: EMBO Postdoctoral Fellow
  • 1993 - 1995: HFSP Postdoctoral Fellow
  • 1992 - 1993: EU Research Fellow
  • 1988 - 1989: Fulbright Fellow

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999
Number of items: 52.

2018

Tokatlidis, K. (2018) Shaping the import system of mitochondria. eLife, 7, e38209. (doi:10.7554/elife.38209) (PMID:29923828) (PMCID:PMC6010340)

Cardenas-Rodriguez, M., Chatzi, A. and Tokatlidis, K. (2018) Iron–sulfur clusters: from metals through mitochondria biogenesis to disease. Journal of Biological Inorganic Chemistry, 23(4), pp. 509-520. (doi:10.1007/s00775-018-1548-6) (PMID:29511832) (PMCID:PMC6006200)

Egea, J. et al. (2018) Corrigendum to “European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162]. Redox Biology, 14, pp. 694-696. (doi:10.1016/j.redox.2017.10.001) (PMID:29107648)

2017

Egea, J. et al. (2017) European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, 13, pp. 94-162. (doi:10.1016/j.redox.2017.05.007) (PMID:28577489)

Cardenas-Rodriguez, M. and Tokatlidis, K. (2017) Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space. FEBS Letters, 591(17), pp. 2661-2670. (doi:10.1002/1873-3468.12766) (PMID:28746987) (PMCID:PMC5601281)

MacPherson, L. and Tokatlidis, K. (2017) Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease. Biochemical Journal, 474(15), pp. 2533-2545. (doi:10.1042/BCJ20160627) (PMID:28701417) (PMCID:PMC5509380)

Kritsiligkou, P., Chatzi, A., Charalampous, G., Mironov, A., Grant, C. M. and Tokatlidis, K. (2017) Unconventional targeting of a thiol peroxidase to the mitochondrial intermembrane space facilitates oxidative protein folding. Cell Reports, 18(11), pp. 2729-2741. (doi:10.1016/j.celrep.2017.02.053) (PMID:28297675) (PMCID:PMC5368413)

Manganas, P., MacPherson, L. and Tokatlidis, K. (2017) Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space. Cell and Tissue Research, 367(1), pp. 43-57. (doi:10.1007/s00441-016-2488-5) (PMID:27632163) (PMCID:PMC5203823)

2016

Nuebel, E., Manganas, P. and Tokatlidis, K. (2016) Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: new pathways and metabolic cross-talk. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(11), pp. 2613-2623. (doi:10.1016/j.bbamcr.2016.07.004) (PMID:27425144) (PMCID:PMC5404111)

Kalef-Ezra, E., Kotzamani, D., Zaganas, I., Katrakili, N., Plaitakis, A. and Tokatlidis, K. (2016) Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence. Biochemical Journal, 473(18), pp. 2813-2829. (doi:10.1042/BCJ20160535) (PMID:27422783) (PMCID:PMC5095901)

Chatzi, A., Manganas, P. and Tokatlidis, K. (2016) Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(6 Pt.A), pp. 1298-1306. (doi:10.1016/j.bbamcr.2016.03.023) (PMID:27033519)

Modjtahedi, N., Tokatlidis, K. , Dessen, P. and Kroemer, G. (2016) Mitochondrial proteins containing coiled-coil-helix-coiled-coil-helix (CHCH) domains in health and disease. Trends in Biochemical Sciences, 41(3), pp. 245-260. (doi:10.1016/j.tibs.2015.12.004) (PMID:26782138)

2015

Hangen, E. et al. (2015) Interaction between AIF and CHCHD4 regulates respiratory chain biogenesis. Molecular Cell, 58(6), pp. 1001-1014. (doi:10.1016/j.molcel.2015.04.020) (PMID:26004228)

Mordas, A. and Tokatlidis, K. (2015) The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Accounts of Chemical Research, 48(8), pp. 2191-2199. (doi:10.1021/acs.accounts.5b00150) (PMID:26214018) (PMCID:PMC4551283)

2013

Chatzi, A., Sideris, D.P., Katrakili, N., Pozidis, C. and Tokatlidis, K. (2013) Biogenesis of yeast Mia40 - uncoupling folding from import and atypical recognition features. FEBS Journal, 280(20), pp. 4960-4969. (doi:10.1111/febs.12482)

Tokatlidis, K. and Brown, G.C. (2013) Introduction: focus on mitochondria. FEBS Journal, 280(20), p. 4932. (doi:10.1111/febs.12504)

Chatzi, A. and Tokatlidis, K. (2013) The mitochondrial intermembrane space: a hub for oxidative folding linked to protein biogenesis. Antioxidants and Redox Signaling, 19(1), pp. 54-62. (doi:10.1089/ars.2012.4855) (PMID:22901034)

Kallergi, E., Kalef-Ezra, E., Karagouni-Dalakoura, K. and Tokatlidis, K. (2013) Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis. Neurochemical Research, 39(3), pp. 546-555. (doi:10.1007/s11064-013-1109-x)

Banci, L. et al. (2013) An intrinsically disordered domain has a dual function coupled to compartment-dependent redox control. Journal of Molecular Biology, 425(3), pp. 594-608. (doi:10.1016/j.jmb.2012.11.032)

2012

Banci, L., Bertini, I., Calderone, V., Cefaro, C., Ciofi-Baffoni, S., Gallo, A. and Tokatlidis, K. (2012) An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR. Journal of the American Chemical Society, 134(3), pp. 1442-1445. (doi:10.1021/ja209881f)

Kallergi, E. et al. (2012) Targeting and maturation of Erv1/ALR in the mitochondrial intermembrane space. ACS Chemical Biology, 7(4), pp. 707-714. (doi:10.1021/cb200485b)

2011

Banci, L., Bertini, I., Ciofi-Baffoni, S., Boscaro, F., Chatzi, A., Mikolajczyk, M., Tokatlidis, K. and Winkelmann, J. (2011) Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery. Chemistry and Biology, 18(6), pp. 794-804. (doi:10.1016/j.chembiol.2011.03.015) (PMID:21700214)

Banci, L., Bertini, I., Calderone, V., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Kallergi, E., Lionaki, E., Pozidis, C. and Tokatlidis, K. (2011) Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proceedings of the National Academy of Sciences of the United States of America, 108(12), pp. 4811-4816. (doi:10.1073/pnas.1014542108)

2010

Banci, L. et al. (2010) Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import. Proceedings of the National Academy of Sciences of the United States of America, 107(47), pp. 20190-20195. (doi:10.1073/pnas.1010095107)

Lionaki, E., Aivaliotis, M., Pozidis, C. and Tokatlidis, K. (2010) The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria. Antioxidants and Redox Signaling, 13(9), pp. 1327-1339. (doi:10.1089/ars.2010.3200)

Sideris, D.P. and Tokatlidis, K. (2010) Oxidative protein folding in the mitochondrial intermembrane space. Antioxidants and Redox Signaling, 13(8), pp. 1189-1204. (doi:10.1089/ars.2010.3157)

Sideris, D.P. and Tokatlidis, K. (2010) Trapping oxidative folding intermediates during translocation to the intermembrane space of mitochondria: in vivo and in vitro studies. In: Economou, A. (ed.) Protein Secretion. Series: Methods in molecular biology (619). Humana Press: New York, NY, USA, pp. 411-423. ISBN 9781603271677 (doi:10.1007/978-1-60327-412-8_25)

2009

Sideris, D.P., Petrakis, N., Katrakili, N., Mikropoulou, D., Gallo, A., Ciofi-Baffoni, S., Banci, L., Bertini, I. and Tokatlidis, K. (2009) A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. Journal of Cell Biology, 187(7), pp. 1007-1022. (doi:10.1083/jcb.200905134)

Petrakis, N., Alcock, F. and Tokatlidis, K. (2009) Mitochondrial ATP-independent chaperones. IUBMB Life, 61(9), pp. 909-914. (doi:10.1002/iub.235)

Banci, L., Bertini, I., Ciofi-Baffoni, S. and Tokatlidis, K. (2009) The coiled coil-helix-coiled coil-helix proteins may be redox proteins. FEBS Letters, 583(11), pp. 1699-1702. (doi:10.1016/j.febslet.2009.03.061)

Banci, L., Bertini, I., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Martinelli, M., Sideris, D.P., Katrakili, N. and Tokatlidis, K. (2009) MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nature Structural and Molecular Biology, 16(2), pp. 198-206. (doi:10.1038/nsmb.1553)

2008

Roussakis, E., Voutsadaki, S., Pinakoulaki, E., Sideris, D.P., Tokatlidis, K. and Katerinopoulos, H.E. (2008) ICPBCZin: a red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions. Cell Calcium, 44(3), pp. 270-275. (doi:10.1016/j.ceca.2007.12.008)

Grossmann, J.G., Callaghan, A.J., Marcaida, M.J., Luisi, B.F., Alcock, F.H. and Tokatlidis, K. (2008) Complementing structural information of modular proteins with small angle neutron scattering and contrast variation. European Biophysics Journal with Biophysics Letters, 37(5), pp. 603-611. (doi:10.1007/s00249-008-0278-z)

Alcock, F.H., Grossmann, J.G., Gentle, I.E., Likić, V.A., Lithgow, T. and Tokatlidis, K. (2008) Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space. Biochemical Journal, 409(2), pp. 377-387. (doi:10.1042/BJ20070877)

Lionaki, E., de Marcos Lousa, C., Baud, C., Vougioukalaki, M., Panayotou, G. and Tokatlidis, K. (2008) The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain. Journal of Biological Chemistry, 283(23), pp. 15747-15753. (doi:10.1074/jbc.M800350200)

2007

Sideris, D.P. and Tokatlidis, K. (2007) Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space. Molecular Microbiology, 65(5), pp. 1360-1373. (doi:10.1111/j.1365-2958.2007.05880.x)

Vergnolle, M.A.S., Alcock, F.H., Petrakis, N. and Tokatlidis, K. (2007) Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells. Journal of Molecular Biology, 371(5), pp. 1315-1324. (doi:10.1016/j.jmb.2007.06.025)

Gentle, I.E. et al. (2007) Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space. Molecular Biology and Evolution, 24(5), pp. 1149-1160. (doi:10.1093/molbev/msm031)

Baud, C., de Marcos-Lousa, C. and Tokatlidis, K. (2007) Molecular interactions of the mitochondrial Tim12 translocase subunit. Protein and Peptide Letters, 14(6), pp. 597-600. (doi:10.2174/092986607780990019)

2006

de Marcos-Lousa, C., P Sideris, D. and Tokatlidis, K. (2006) Translocation of mitochondrial inner-membrane proteins: conformation matters. Trends in Biochemical Sciences, 31(5), pp. 259-267. (doi:10.1016/j.tibs.2006.03.006)

2005

Allen, S., Balabanidou, V., Sideris, D.P., Lisowsky, T. and Tokatlidis, K. (2005) Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c. Journal of Molecular Biology, 353(5), pp. 937-944. (doi:10.1016/j.jmb.2005.08.049)

Vergnolle, M.A.S., Baud, C., Golovanov, A.P., Alcock, F., Luciano, P., Lian, L.-Y. and Tokatlidis, K. (2005) Distinct domains of small tims involved in subunit interaction and substrate recognition. Journal of Molecular Biology, 351(4), pp. 839-849. (doi:10.1016/j.jmb.2005.06.010)

Tokatlidis, K. (2005) A disulfide relay system in mitochondria. Cell, 121(7), pp. 965-967. (doi:10.1016/j.cell.2005.06.019)

Sawney, H., Vergnolle, M.A.S., Junne, T., Dolfini, L. and Tokatlidis, K. (2005) A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Biochemical Journal, 385(1), pp. 173-180. (doi:10.1042/BJ20040650)

2004

Lu, H., Allen, S., Wardleworth, L., Savory, P. and Tokatlidis, K. (2004) Functional TIM10 chaperone assembly is redox-regulated in vivo. Journal of Biological Chemistry, 279(18), pp. 18952-18958. (doi:10.1074/jbc.M313045200)

2003

Allen, S., Lu, H., Thornton, D. and Tokatlidis, K. (2003) Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. Journal of Biological Chemistry, 278(40), pp. 38505-38513. (doi:10.1074/jbc.M306027200)

Dyall, S.D., Agius, S.C., De Marcos Lousa, C., Trézéguet, V. and Tokatlidis, K. (2003) The dynamic dimerization of the yeast ADP/ATP carrier in the iunner mitochondrial membrane is affected by conserved cysteine residues. Journal of Biological Chemistry, 278(29), pp. 26757-26764. (doi:10.1074/jbc.M302700200)

2002

Minczuk, M. et al. (2002) Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. Nucleic Acids Research, 30(23), pp. 5074-5086. (doi:10.1093/nar/gkf647)

Vial, S., Lu, H., Allen, S., Savory, P., Thornton, D., Sheerhan, J. and Tokatlidis, K. (2002) Assembly of Tim9 and Tim10 into a functional chaperone. Journal of Biological Chemistry, 277(39), pp. 36100-36108. (doi:10.1074/jbc.M202310200)

2001

Luciano, P., Vial, S., Vegnolle, M.A.S., Dyall, S.D., Robinson, D.R. and Tokatlidis, K. (2001) Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex. EMBO Journal, 20(15), pp. 4099-4106. (doi:10.1093/emboj/20.15.4099)

2000

Tokatlidis, K. , Vial, S., Luciano, P., Vergnolle, M. and Clémence, S. (2000) Membrane protein import in yeast mitochondria. Biochemical Society Transactions, 28(4), pp. 495-499. (doi:10.1042/0300-5127:0280495)

1999

Tokatlidis, K. and Schatz, G. (1999) Biogenesis of mitochondrial inner membrane proteins. Journal of Biological Chemistry, 274(50), pp. 35285-35288. (doi:10.1074/jbc.274.50.35285)

This list was generated on Sat Dec 15 14:02:06 2018 GMT.
Number of items: 52.

Articles

Tokatlidis, K. (2018) Shaping the import system of mitochondria. eLife, 7, e38209. (doi:10.7554/elife.38209) (PMID:29923828) (PMCID:PMC6010340)

Cardenas-Rodriguez, M., Chatzi, A. and Tokatlidis, K. (2018) Iron–sulfur clusters: from metals through mitochondria biogenesis to disease. Journal of Biological Inorganic Chemistry, 23(4), pp. 509-520. (doi:10.1007/s00775-018-1548-6) (PMID:29511832) (PMCID:PMC6006200)

Egea, J. et al. (2018) Corrigendum to “European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162]. Redox Biology, 14, pp. 694-696. (doi:10.1016/j.redox.2017.10.001) (PMID:29107648)

Egea, J. et al. (2017) European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, 13, pp. 94-162. (doi:10.1016/j.redox.2017.05.007) (PMID:28577489)

Cardenas-Rodriguez, M. and Tokatlidis, K. (2017) Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space. FEBS Letters, 591(17), pp. 2661-2670. (doi:10.1002/1873-3468.12766) (PMID:28746987) (PMCID:PMC5601281)

MacPherson, L. and Tokatlidis, K. (2017) Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease. Biochemical Journal, 474(15), pp. 2533-2545. (doi:10.1042/BCJ20160627) (PMID:28701417) (PMCID:PMC5509380)

Kritsiligkou, P., Chatzi, A., Charalampous, G., Mironov, A., Grant, C. M. and Tokatlidis, K. (2017) Unconventional targeting of a thiol peroxidase to the mitochondrial intermembrane space facilitates oxidative protein folding. Cell Reports, 18(11), pp. 2729-2741. (doi:10.1016/j.celrep.2017.02.053) (PMID:28297675) (PMCID:PMC5368413)

Manganas, P., MacPherson, L. and Tokatlidis, K. (2017) Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space. Cell and Tissue Research, 367(1), pp. 43-57. (doi:10.1007/s00441-016-2488-5) (PMID:27632163) (PMCID:PMC5203823)

Nuebel, E., Manganas, P. and Tokatlidis, K. (2016) Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: new pathways and metabolic cross-talk. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(11), pp. 2613-2623. (doi:10.1016/j.bbamcr.2016.07.004) (PMID:27425144) (PMCID:PMC5404111)

Kalef-Ezra, E., Kotzamani, D., Zaganas, I., Katrakili, N., Plaitakis, A. and Tokatlidis, K. (2016) Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence. Biochemical Journal, 473(18), pp. 2813-2829. (doi:10.1042/BCJ20160535) (PMID:27422783) (PMCID:PMC5095901)

Chatzi, A., Manganas, P. and Tokatlidis, K. (2016) Oxidative folding in the mitochondrial intermembrane space: a regulated process important for cell physiology and disease. Biochimica et Biophysica Acta: Molecular Cell Research, 1863(6 Pt.A), pp. 1298-1306. (doi:10.1016/j.bbamcr.2016.03.023) (PMID:27033519)

Modjtahedi, N., Tokatlidis, K. , Dessen, P. and Kroemer, G. (2016) Mitochondrial proteins containing coiled-coil-helix-coiled-coil-helix (CHCH) domains in health and disease. Trends in Biochemical Sciences, 41(3), pp. 245-260. (doi:10.1016/j.tibs.2015.12.004) (PMID:26782138)

Hangen, E. et al. (2015) Interaction between AIF and CHCHD4 regulates respiratory chain biogenesis. Molecular Cell, 58(6), pp. 1001-1014. (doi:10.1016/j.molcel.2015.04.020) (PMID:26004228)

Mordas, A. and Tokatlidis, K. (2015) The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Accounts of Chemical Research, 48(8), pp. 2191-2199. (doi:10.1021/acs.accounts.5b00150) (PMID:26214018) (PMCID:PMC4551283)

Chatzi, A., Sideris, D.P., Katrakili, N., Pozidis, C. and Tokatlidis, K. (2013) Biogenesis of yeast Mia40 - uncoupling folding from import and atypical recognition features. FEBS Journal, 280(20), pp. 4960-4969. (doi:10.1111/febs.12482)

Tokatlidis, K. and Brown, G.C. (2013) Introduction: focus on mitochondria. FEBS Journal, 280(20), p. 4932. (doi:10.1111/febs.12504)

Chatzi, A. and Tokatlidis, K. (2013) The mitochondrial intermembrane space: a hub for oxidative folding linked to protein biogenesis. Antioxidants and Redox Signaling, 19(1), pp. 54-62. (doi:10.1089/ars.2012.4855) (PMID:22901034)

Kallergi, E., Kalef-Ezra, E., Karagouni-Dalakoura, K. and Tokatlidis, K. (2013) Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis. Neurochemical Research, 39(3), pp. 546-555. (doi:10.1007/s11064-013-1109-x)

Banci, L. et al. (2013) An intrinsically disordered domain has a dual function coupled to compartment-dependent redox control. Journal of Molecular Biology, 425(3), pp. 594-608. (doi:10.1016/j.jmb.2012.11.032)

Banci, L., Bertini, I., Calderone, V., Cefaro, C., Ciofi-Baffoni, S., Gallo, A. and Tokatlidis, K. (2012) An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR. Journal of the American Chemical Society, 134(3), pp. 1442-1445. (doi:10.1021/ja209881f)

Kallergi, E. et al. (2012) Targeting and maturation of Erv1/ALR in the mitochondrial intermembrane space. ACS Chemical Biology, 7(4), pp. 707-714. (doi:10.1021/cb200485b)

Banci, L., Bertini, I., Ciofi-Baffoni, S., Boscaro, F., Chatzi, A., Mikolajczyk, M., Tokatlidis, K. and Winkelmann, J. (2011) Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery. Chemistry and Biology, 18(6), pp. 794-804. (doi:10.1016/j.chembiol.2011.03.015) (PMID:21700214)

Banci, L., Bertini, I., Calderone, V., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Kallergi, E., Lionaki, E., Pozidis, C. and Tokatlidis, K. (2011) Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proceedings of the National Academy of Sciences of the United States of America, 108(12), pp. 4811-4816. (doi:10.1073/pnas.1014542108)

Banci, L. et al. (2010) Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import. Proceedings of the National Academy of Sciences of the United States of America, 107(47), pp. 20190-20195. (doi:10.1073/pnas.1010095107)

Lionaki, E., Aivaliotis, M., Pozidis, C. and Tokatlidis, K. (2010) The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria. Antioxidants and Redox Signaling, 13(9), pp. 1327-1339. (doi:10.1089/ars.2010.3200)

Sideris, D.P. and Tokatlidis, K. (2010) Oxidative protein folding in the mitochondrial intermembrane space. Antioxidants and Redox Signaling, 13(8), pp. 1189-1204. (doi:10.1089/ars.2010.3157)

Sideris, D.P., Petrakis, N., Katrakili, N., Mikropoulou, D., Gallo, A., Ciofi-Baffoni, S., Banci, L., Bertini, I. and Tokatlidis, K. (2009) A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. Journal of Cell Biology, 187(7), pp. 1007-1022. (doi:10.1083/jcb.200905134)

Petrakis, N., Alcock, F. and Tokatlidis, K. (2009) Mitochondrial ATP-independent chaperones. IUBMB Life, 61(9), pp. 909-914. (doi:10.1002/iub.235)

Banci, L., Bertini, I., Ciofi-Baffoni, S. and Tokatlidis, K. (2009) The coiled coil-helix-coiled coil-helix proteins may be redox proteins. FEBS Letters, 583(11), pp. 1699-1702. (doi:10.1016/j.febslet.2009.03.061)

Banci, L., Bertini, I., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Martinelli, M., Sideris, D.P., Katrakili, N. and Tokatlidis, K. (2009) MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nature Structural and Molecular Biology, 16(2), pp. 198-206. (doi:10.1038/nsmb.1553)

Roussakis, E., Voutsadaki, S., Pinakoulaki, E., Sideris, D.P., Tokatlidis, K. and Katerinopoulos, H.E. (2008) ICPBCZin: a red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions. Cell Calcium, 44(3), pp. 270-275. (doi:10.1016/j.ceca.2007.12.008)

Grossmann, J.G., Callaghan, A.J., Marcaida, M.J., Luisi, B.F., Alcock, F.H. and Tokatlidis, K. (2008) Complementing structural information of modular proteins with small angle neutron scattering and contrast variation. European Biophysics Journal with Biophysics Letters, 37(5), pp. 603-611. (doi:10.1007/s00249-008-0278-z)

Alcock, F.H., Grossmann, J.G., Gentle, I.E., Likić, V.A., Lithgow, T. and Tokatlidis, K. (2008) Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space. Biochemical Journal, 409(2), pp. 377-387. (doi:10.1042/BJ20070877)

Lionaki, E., de Marcos Lousa, C., Baud, C., Vougioukalaki, M., Panayotou, G. and Tokatlidis, K. (2008) The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain. Journal of Biological Chemistry, 283(23), pp. 15747-15753. (doi:10.1074/jbc.M800350200)

Sideris, D.P. and Tokatlidis, K. (2007) Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space. Molecular Microbiology, 65(5), pp. 1360-1373. (doi:10.1111/j.1365-2958.2007.05880.x)

Vergnolle, M.A.S., Alcock, F.H., Petrakis, N. and Tokatlidis, K. (2007) Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells. Journal of Molecular Biology, 371(5), pp. 1315-1324. (doi:10.1016/j.jmb.2007.06.025)

Gentle, I.E. et al. (2007) Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space. Molecular Biology and Evolution, 24(5), pp. 1149-1160. (doi:10.1093/molbev/msm031)

Baud, C., de Marcos-Lousa, C. and Tokatlidis, K. (2007) Molecular interactions of the mitochondrial Tim12 translocase subunit. Protein and Peptide Letters, 14(6), pp. 597-600. (doi:10.2174/092986607780990019)

de Marcos-Lousa, C., P Sideris, D. and Tokatlidis, K. (2006) Translocation of mitochondrial inner-membrane proteins: conformation matters. Trends in Biochemical Sciences, 31(5), pp. 259-267. (doi:10.1016/j.tibs.2006.03.006)

Allen, S., Balabanidou, V., Sideris, D.P., Lisowsky, T. and Tokatlidis, K. (2005) Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c. Journal of Molecular Biology, 353(5), pp. 937-944. (doi:10.1016/j.jmb.2005.08.049)

Vergnolle, M.A.S., Baud, C., Golovanov, A.P., Alcock, F., Luciano, P., Lian, L.-Y. and Tokatlidis, K. (2005) Distinct domains of small tims involved in subunit interaction and substrate recognition. Journal of Molecular Biology, 351(4), pp. 839-849. (doi:10.1016/j.jmb.2005.06.010)

Tokatlidis, K. (2005) A disulfide relay system in mitochondria. Cell, 121(7), pp. 965-967. (doi:10.1016/j.cell.2005.06.019)

Sawney, H., Vergnolle, M.A.S., Junne, T., Dolfini, L. and Tokatlidis, K. (2005) A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Biochemical Journal, 385(1), pp. 173-180. (doi:10.1042/BJ20040650)

Lu, H., Allen, S., Wardleworth, L., Savory, P. and Tokatlidis, K. (2004) Functional TIM10 chaperone assembly is redox-regulated in vivo. Journal of Biological Chemistry, 279(18), pp. 18952-18958. (doi:10.1074/jbc.M313045200)

Allen, S., Lu, H., Thornton, D. and Tokatlidis, K. (2003) Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. Journal of Biological Chemistry, 278(40), pp. 38505-38513. (doi:10.1074/jbc.M306027200)

Dyall, S.D., Agius, S.C., De Marcos Lousa, C., Trézéguet, V. and Tokatlidis, K. (2003) The dynamic dimerization of the yeast ADP/ATP carrier in the iunner mitochondrial membrane is affected by conserved cysteine residues. Journal of Biological Chemistry, 278(29), pp. 26757-26764. (doi:10.1074/jbc.M302700200)

Minczuk, M. et al. (2002) Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. Nucleic Acids Research, 30(23), pp. 5074-5086. (doi:10.1093/nar/gkf647)

Vial, S., Lu, H., Allen, S., Savory, P., Thornton, D., Sheerhan, J. and Tokatlidis, K. (2002) Assembly of Tim9 and Tim10 into a functional chaperone. Journal of Biological Chemistry, 277(39), pp. 36100-36108. (doi:10.1074/jbc.M202310200)

Luciano, P., Vial, S., Vegnolle, M.A.S., Dyall, S.D., Robinson, D.R. and Tokatlidis, K. (2001) Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex. EMBO Journal, 20(15), pp. 4099-4106. (doi:10.1093/emboj/20.15.4099)

Tokatlidis, K. , Vial, S., Luciano, P., Vergnolle, M. and Clémence, S. (2000) Membrane protein import in yeast mitochondria. Biochemical Society Transactions, 28(4), pp. 495-499. (doi:10.1042/0300-5127:0280495)

Tokatlidis, K. and Schatz, G. (1999) Biogenesis of mitochondrial inner membrane proteins. Journal of Biological Chemistry, 274(50), pp. 35285-35288. (doi:10.1074/jbc.274.50.35285)

Book Sections

Sideris, D.P. and Tokatlidis, K. (2010) Trapping oxidative folding intermediates during translocation to the intermembrane space of mitochondria: in vivo and in vitro studies. In: Economou, A. (ed.) Protein Secretion. Series: Methods in molecular biology (619). Humana Press: New York, NY, USA, pp. 411-423. ISBN 9781603271677 (doi:10.1007/978-1-60327-412-8_25)

This list was generated on Sat Dec 15 14:02:06 2018 GMT.