University of Glasgow - Schools - School of Molecular Biosciences - Research - Centre for the Cellular Microenvironment

GLASGOW ORTHOPAEDIC RESEARCH INITIATIVE (GLORI)

Founded in 2009 through discussion between Mr Dominic Meek and Prof Matt Dalby, the Glasgow Orthopaedic Research Initiative (GLORI) has been established to encourage collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, biologists, engineers and chemists from Glasgow and Strathclyde Universities.

Prof R.M. Dominic Meek FRCS, MD
Consultant, in Orthopaedics and Trauma Surgery, Southern Glasgow University Hospital, Glasgow; Clinical Director Orthopaedics Greater Glasgow & Clyde; and Honorary Associate Clinical Professor at the University of Glasgow.
He undertook fellowship training in adult reconstruction of the hip and knee at the department of lower limb arthroplasty, Vancouver General Hospital. He has been previously awarded the British and American Hip Societies Travelling Fellow and the ABC Fellowship. With his consultant colleagues has developed the South of Glasgow complex young hip and revision and periprosthetic fractures arthroplasty service. He is President of the West of Scotland Orthopaedic Research Society. His research interests are in the basic science of nanotechnology and cell behaviour / bone regeneration and implant fixation and effects of wear particles particularly metal CoCr particles. Active member of BOA, BHS and BORS.

Prof Matt Dalby, PhD. Professor of Cell Engineering
Became a Lecturer in Cell Engineering at the University of Glasgow after completing a BBSRC David Phillips Fellowship. His research interests are osteogenesis and cellular mechanotransduction. Further information on awards, grants and publications are on Prof Dalby's personal webpage.

Dr P. Monica Tsimbouri, PHD, CBiol MIBiol,FHEA
Scientific Mentor for GLORI and Founding Member of Scottish Sarcoma Research Group (SSRG). She has a PhD in Molecular Genetics, University of Glasgow. She worked on different projects (lymphatic and skin cancer models) studying different aspects of EBV-induced tumourigenesis. She was awarded a 2-year fellowship from Lady Tata Memorial Trust to work on the involvement of Recombination Activating genes (Rag) in EBV-induced tumourigenesis. She then moved to CCE on to a project involving the culture of primary adult human BM stem cells onto different topographical surfaces in the absence of growth factors, investigating the effects of nanotopography on MSC morphology and phenotype canonical and functional pathways and nuclear organisation on plastic and titanium surfaces. She was recently awarded an ISSF welcome Trust fellowship to work on the use of topographical and piezoelectrical cues to manipulate cancer cell phenotype/survival.
Google Scholar
Research Gate
Linked In

Mr Peter Young, MRCS, BMedSci
Clinical Mentor of GLORI and Founding Member of SSRG Specialty Registrar Orthopaedic Surgery training in the West of Scotland. Undertaking higher degree in osteoclast response to nanotopography, with a specialist interest in sarcoma treatment and research.
Research Gate

Clinical collaborators/contributors

Mr Ashish Mahendra, MBBS, DNB(Ortho), MS(Orth), Dipl Ortho Eng, MCh (Orth), FRCS(Gl), FRCS (Tr & Ortho)
Consultant Orthopaedic Surgeon, Glasgow Royal Infirmary and founding member of the SSRG. He has a special interest in bone tumours, both benign and malignant, and soft tissue tumours in extremities. He is a member of the National Musculoskeletal Tumour Service and has experience in diagnosis and treatment of more than three thousand patients of musculoskeletal tumours during the past eight years.

‌
Prof Iain McInnes, MRCP, PhD
Prof McInnnes is a rheumatologist and Professor of Experimental Medicine and Rheumatology at the University of Glasgow. His major interests are in the biology of inflammatory synovitis in rheumatoid arthritis, psoriatic arthritis and septic arthritis.
Personal webpage

Mr Jim Huntley MA DPhil (Oxon) FRCS
Consultant in Paediatric Orthopaedics and trauma at the Royal Hospital for Sick Children, Yorkhill, Glasgow.

Mr Neal Millar
Arc Orthopaedic Clinical Research Fellow.

Scientific collaborators/contributors

Dr Mathis Riehle, PhD
Reader in Cell Engineering at the University of Glasgow. His research interests are in device design for biological systems and durotaxis.
Personal webpage

Prof K. Elizabeth Tanner, FREng, FBSE, MA, DPhil, FIMechE, FIMMM, CEng, CSci
Professor of Mechanics of Materials and Structures at the University of Glasgow. Her research interests are in bone composite materials and mechanical properties of materials.
Personal webpage

Prof Maggie Cusack
Professor of Biomineralisation at the University of Glasgow. Interested in crossing the bone-shell divide between calcium phosphate of vertebrate bone and calcium carbonate of invertebrate shells in order to understand and exploit osteo-induction by nacre (mother of pearl).
Personal webpage

Prof Nikolaj Gadegaard, PhD
Prof in Biomedical engineering. He specialises in micro and nanoscale surfaces.
Personal webpage

Prof M. Helen Grant, PhD
Professor of Bioengineering at the University of Strathclyde. Her interests are in liver and bone tissue engineering and metal toxicology.
Personal webpage

Dr Philip Riches, PhD
Lecturer in Bioengineering at the University of Strathlyde. His research interests are in spinal biomechanics.
Personal webpage

GLORI related Alumni on projects from GLORI related funding

Dr Laura McNamara (postdoctoral scientist) worked on an EPSRC funded project on developing nanostructured titanium materials for bone regeneration.

Andrew Wilkinson, Consultant Orthopedic, undertaking a BOA funded MD on bioactive ceramics.

Alistair Brydone, Registrar Surgeon, Golden Jubilee/InVibio/EPSRC funded PhD on PEEK.

Jingli Yang, PhD student, EPSRC funded PhD on bioactive nanopatterns.

Louisa Lee, PhD student, MVLS funded PhD on bioactive nanopatterns.

Sarah McLaine, Registrar Surgeon, MD on a Scottish Health Executive Funded project on generating living impaction graft in vitro using nanoscaffolds.

Research experience through GLORI

Mansur Halai

Andrew Ker

Robert Silverwood, ST1 orthopedic registrar

Paul Fairhurst, MBBS BSc (Hons), Academic Foundation Programme trainee in the West of Scotland. He has an interest in paediatric orthopaedics and has previously worked with groups at St Mary's Hospital (Imperial College London) and Boston Children's Hospital (Harvard University). He is currently a Clinical Teaching Fellow for the University of Glasgow.

Nick Holloway, Previous West of Scotland Trainee working as a Locum Consultant Arthroplasty Surgeon at the Golden Jubilee National Hospital. Interest in research with active projects with the Cell Engineering Department of Glasgow University and Strathclyde University National Centre for Prosthetics and Orthotics.

Findlay Welsh, working as a Locum Consultant Arthroplasty Surgeon at the Golden Jubilee National Hospital. Interest in research with active projects with the Cell Engineering Department of Glasgow University.

Chris Slinger, Medical School Graduate