Dr Roz Laing

  • Wellcome Research Fellow (Institute of Biodiversity Animal Health & Comparative Medicine)

email: Rosalind.Laing@glasgow.ac.uk

Ri Biodiversity Animal Health & Compmed, College of Medical, Veterinary & Life Sciences, Level 2, Room 242, Henry Wellcome Building, University of Glasgow, G61 1QH

ORCID iDhttps://orcid.org/0000-0002-6191-0759

Research interests

Research interests:

Molecular biology of veterinary parasites; population genetics and genomics of parasitic nematodes; genetic basis of parasite drug resistance; drug metabolism; approaches to the diagnosis and control of anthelmintic resistance

 

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010
Number of items: 24.

2020

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

2019

Antonopoulos, A., Busin, V. , Laing, R. and Devaney, E. (2019) Levamisole Resistance Markers in Haemonchus Contortus. BAVP Winter Meeting 2019, Moredun Research Institute, Edinburgh, 5-6 Dec 2019.

Turnbull, F. , Devaney, E. , Morrison, A. A., Laing, R. and Bartley, D. J. (2019) Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. International Journal for Parasitology: Drugs and Drug Resistance, 11, pp. 59-69. (doi: 10.1016/j.ijpddr.2019.10.002) (PMID:31622822) (PMCID:PMC6796645)

Rezansoff, A. M. et al. (2019) The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 49(11), pp. 847-858. (doi: 10.1016/j.ijpara.2019.05.012) (PMID:31525371)

Doyle, S. R. et al. (2019) Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole-genome sequencing. Frontiers in Genetics, 10, 826. (doi: 10.3389/fgene.2019.00826) (PMID:31616465) (PMCID:PMC6764475)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Doyle, S. R. et al. (2019) Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genomics, 20, p. 218. (doi: 10.1186/s12864-019-5592-6) (PMID:30876405) (PMCID:PMC6420744)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

2018

Matoušková, P. et al. (2018) UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), pp. 420-429. (doi: 10.1016/j.ijpddr.2018.09.005) (PMID:30293057) (PMCID:PMC6174829)

McIntyre, J., Hamer, K., Morrison, A. A., Bartley, D. J., Sargison, N., Devaney, E. and Laing, R. (2018) Hidden in plain sight - multiple resistant species within a strongyle community. Veterinary Parasitology, 258, pp. 79-87. (doi: 10.1016/j.vetpar.2018.06.012) (PMCID:PMC6052248)

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

2017

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)

2016

Laing, R. , Maitland, K. , Lecova, L., Skuce, P. J., Tait, A. and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, 46(10), pp. 621-630. (doi: 10.1016/j.ijpara.2016.03.010) (PMID:27179994) (PMCID:PMC5011429)

Rezansoff, A. M., Laing, R. and Gilleard, J. S. (2016) Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus. International Journal for Parasitology, 46(10), pp. 653-661. (doi: 10.1016/j.ijpara.2016.04.007) (PMID:27216082)

Laing, R. , Martinelli, A., Tracey, A., Holroyd, N., Gilleard, J.S. and Cotton, J.A. (2016) Haemonchus contortus: genome structure, organization and comparative genomics. In: Gasser, R. B. and von Samson-Himmelstjerna, G. (eds.) Haemonchus contortus and Haemonchosis – Past, Present and Future Trends. Series: Advances in parasitology (93). Elsevier: Amsterdam, pp. 569-598. ISBN 9780128103951 (doi:10.1016/bs.apar.2016.02.016)

2015

Laing, R., Bartley, D. J., Morrison, A. A., Rezansoff, A., Martinelli, A., Laing, S. T. and Gilleard, J. S. (2015) The cytochrome P450 family in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 45(4), pp. 243-251. (doi: 10.1016/j.ijpara.2014.12.001) (PMID:25558056) (PMCID:PMC4365919)

Lecova, L., Růžičková, M., Laing, R. , Vogel, H., Szotáková, B., Prchal, L., Lamka, J., Vokřál, I., Skálová, L. and Matoušková, P. (2015) Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus. Molecular and Biochemical Parasitology, 201(2), pp. 123-127. (doi: 10.1016/j.molbiopara.2015.08.001) (PMID:26255779)

2013

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A., Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011)

2012

Laing, S.T., Ivens, A., Butler, V., Ravikumar, S.P., Laing, R. , Woods, D.J. and Gilleard, J.S. (2012) The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake. PLoS ONE, 7(2), e31367. (doi: 10.1371/journal.pone.0031367)

2011

Laing, R. et al. (2011) Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. PLoS ONE, 6(8), e23216. (doi: 10.1371/journal.pone.0023216)

2010

Laing, S., Ivens, A., Laing, R. , Ravikumar, S., Butler, V., Woods, D.J. and Gilleard, J.S. (2010) Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites. Biochemical Journal, 432(3), pp. 505-514. (doi: 10.1042/BJ20101346)

This list was generated on Sun Aug 9 04:25:00 2020 BST.
Number of items: 24.

Articles

Britton, C. , Laing, R. and Devaney, E. (2020) Small RNAs in parasitic nematodes - forms and functions. Parasitology, 147(8), pp. 855-864. (doi: 10.1017/S0031182019001689) (PMID:31843030) (PMCID:PMC7284814)

Turnbull, F. , Devaney, E. , Morrison, A. A., Laing, R. and Bartley, D. J. (2019) Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. International Journal for Parasitology: Drugs and Drug Resistance, 11, pp. 59-69. (doi: 10.1016/j.ijpddr.2019.10.002) (PMID:31622822) (PMCID:PMC6796645)

Rezansoff, A. M. et al. (2019) The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 49(11), pp. 847-858. (doi: 10.1016/j.ijpara.2019.05.012) (PMID:31525371)

Doyle, S. R. et al. (2019) Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole-genome sequencing. Frontiers in Genetics, 10, 826. (doi: 10.3389/fgene.2019.00826) (PMID:31616465) (PMCID:PMC6764475)

Hodgkinson, J. E. et al. (2019) Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology, 10, pp. 51-57. (doi: 10.1016/j.ijpddr.2019.05.001) (PMID:31125837) (PMCID:PMC6531808)

Doyle, S. R. et al. (2019) Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. BMC Genomics, 20, p. 218. (doi: 10.1186/s12864-019-5592-6) (PMID:30876405) (PMCID:PMC6420744)

Marks, N. D. et al. (2019) Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific Reports, 9, 17594. (doi: 10.1038/s41598-019-54154-6) (PMID:31772378) (PMCID:PMC6879476)

Matoušková, P. et al. (2018) UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), pp. 420-429. (doi: 10.1016/j.ijpddr.2018.09.005) (PMID:30293057) (PMCID:PMC6174829)

McIntyre, J., Hamer, K., Morrison, A. A., Bartley, D. J., Sargison, N., Devaney, E. and Laing, R. (2018) Hidden in plain sight - multiple resistant species within a strongyle community. Veterinary Parasitology, 258, pp. 79-87. (doi: 10.1016/j.vetpar.2018.06.012) (PMCID:PMC6052248)

Sallé, G. et al. (2018) Transcriptomic profiling of nematode parasites surviving vaccine exposure. International Journal for Parasitology, 48(5), pp. 395-402. (doi: 10.1016/j.ijpara.2018.01.004) (PMID:29534987) (PMCID:PMC5909036)

Doyle, S. R. et al. (2018) A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Genome Biology and Evolution, 10(2), pp. 396-409. (doi: 10.1093/gbe/evx269) (PMID:29267942) (PMCID:PMC5793844)

Gillan, V. et al. (2017) Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes. Frontiers in Cellular and Infection Microbiology, 7, 452. (doi: 10.3389/fcimb.2017.00452) (PMID:29209592) (PMCID:PMC5701612)

Laing, R. , Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi: 10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)

Laing, R. , Maitland, K. , Lecova, L., Skuce, P. J., Tait, A. and Devaney, E. (2016) Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use. International Journal for Parasitology, 46(10), pp. 621-630. (doi: 10.1016/j.ijpara.2016.03.010) (PMID:27179994) (PMCID:PMC5011429)

Rezansoff, A. M., Laing, R. and Gilleard, J. S. (2016) Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus. International Journal for Parasitology, 46(10), pp. 653-661. (doi: 10.1016/j.ijpara.2016.04.007) (PMID:27216082)

Laing, R., Bartley, D. J., Morrison, A. A., Rezansoff, A., Martinelli, A., Laing, S. T. and Gilleard, J. S. (2015) The cytochrome P450 family in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, 45(4), pp. 243-251. (doi: 10.1016/j.ijpara.2014.12.001) (PMID:25558056) (PMCID:PMC4365919)

Lecova, L., Růžičková, M., Laing, R. , Vogel, H., Szotáková, B., Prchal, L., Lamka, J., Vokřál, I., Skálová, L. and Matoušková, P. (2015) Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus. Molecular and Biochemical Parasitology, 201(2), pp. 123-127. (doi: 10.1016/j.molbiopara.2015.08.001) (PMID:26255779)

Laing, R. et al. (2013) The genome and transcriptome of haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), R88. (doi: 10.1186/gb-2013-14-8-r88)

Saunders, G. I., Wasmuth, J. D., Beech, R., Laing, R. , Hunt, M., Naghra, H., Cotton, J. A., Berriman, M., Britton, C. and Gilleard, J. S. (2013) Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes. International Journal for Parasitology, 43(6), pp. 465-475. (doi: 10.1016/j.ijpara.2012.12.011)

Laing, S.T., Ivens, A., Butler, V., Ravikumar, S.P., Laing, R. , Woods, D.J. and Gilleard, J.S. (2012) The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake. PLoS ONE, 7(2), e31367. (doi: 10.1371/journal.pone.0031367)

Laing, R. et al. (2011) Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. PLoS ONE, 6(8), e23216. (doi: 10.1371/journal.pone.0023216)

Laing, S., Ivens, A., Laing, R. , Ravikumar, S., Butler, V., Woods, D.J. and Gilleard, J.S. (2010) Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites. Biochemical Journal, 432(3), pp. 505-514. (doi: 10.1042/BJ20101346)

Book Sections

Laing, R. , Martinelli, A., Tracey, A., Holroyd, N., Gilleard, J.S. and Cotton, J.A. (2016) Haemonchus contortus: genome structure, organization and comparative genomics. In: Gasser, R. B. and von Samson-Himmelstjerna, G. (eds.) Haemonchus contortus and Haemonchosis – Past, Present and Future Trends. Series: Advances in parasitology (93). Elsevier: Amsterdam, pp. 569-598. ISBN 9780128103951 (doi:10.1016/bs.apar.2016.02.016)

Conference or Workshop Item

Antonopoulos, A., Busin, V. , Laing, R. and Devaney, E. (2019) Levamisole Resistance Markers in Haemonchus Contortus. BAVP Winter Meeting 2019, Moredun Research Institute, Edinburgh, 5-6 Dec 2019.

This list was generated on Sun Aug 9 04:25:00 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Hitting a moving target: genomic and metabolic approaches to improve anthelmintic use in evolving helminth populations
    Wellcome Trust
    2020 - 2024
     
  • United States-UK partnering award:Co-infection and resistance (CORE)
    Biotechnology and Biological Sciences Research Council
    2016 - 2020
     
  • Monepantel: anthelmintic resistance and the development of tools for sustainable use
    Scottish Government
    2016 - 2019
     
  • The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites
    Biotechnology and Biological Sciences Research Council
    2015 - 2020
     

Supervision

  • Brown, Samuel
    Worms, sheep and environment: integrating ecological perspectives into anthelmintic resistance management