Dr Martin Llewellyn

Reader (Institute of Biodiversity Animal Health & Comparative Medicine)
Associate (School of Life Sciences)

telephone: 0141 330 5571
email: Martin.Llewellyn@glasgow.ac.uk

ORCID iD https://orcid.org/0000-0001-9856-1591

Research interests

My research has a broad focus around host-associated microbiota, parasites, molecular epidemiology, and the role of host-associated microbiota in parasitic disease.

My main research theme focuses on the role of commensal microbiota in salmonid energetics and nutrition. Funded by the BBSRC, Science Foundation Ireland and the Scottish Aquaculture Innovations Centre, we are building an in vivo simulator of the Atlantic Salmon gut alongside colleagues in BAHCM (Prof. Neil Metcalfe); Engineering (Prof. Bill Sloan, Dr. Umer Ijaz); University College Cork, Ireland and industrial collaborators Alltech and Marine Harvest.

Other funded interests cover interactions between sea lice (Lepoephtheirus and Caligus sp) and the commensal microbiota of their salmonid hosts, as well as similar interactions between the Leishmania and their human hosts.

My research ‘first love’ is the molecular epidemiology of the protozoan parasite Trpanosoma cruzi and I continue to work on the population genetics of this organism, as well as that of New World Leishmania in North, Central and South America.

To find out more please go to the lab website at: https://llewellynlab.wordpress.com/

To view all my publications

Please see

https://scholar.google.com/citations?user=4H-i9b0AAAAJ&hl=en

and

https://www.researchgate.net/profile/Martin_Llewellyn for reprints

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2011 | 2010 | 2009 | 2005 | 2004

Number of items: 53.

2021

Schwabl, P. et al. (2021) Colonization and genetic diversification processes of Leishmania infantum in the Americas. Communications Biology, 4, 139. (doi: 10.1038/s42003-021-01658-5) (PMID:33514858)

Cheaib, B. , Seghouani, H., Llewellyn, M. , Vandal-Lenghan, K., Mercier, P.-L. and Derome, N. (2021) The yellow perch (Perca flavescens) microbiome revealed resistance to colonisation mostly associated with neutralism driven by rare taxa under cadmium disturbance. Animal Microbiome, 3, 3. (doi: 10.1186/s42523-020-00063-3) (PMID:33499999) (PMCID:PMC7934398)

Grillet, M. E. et al. (2021) Malaria in Southern Venezuela: the hottest hotspot in Latin America. PLoS Neglected Tropical Diseases, 15(1), e0008211. (doi: 10.1371/journal.pntd.0008211) (PMID:33493212) (PMCID:PMC7861532)

2020

Schwabl, P. et al. (2020) Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity. PLoS Genetics, 16(12), e1009170. (doi: 10.1371/journal.pgen.1009170) (PMID:33326438) (PMCID:PMC7743988)

Lindsay, E. C., Metcalfe, N. B. and Llewellyn, M. S. (2020) The potential role of gut microbiota in shaping host energetics and metabolic rate. Journal of Animal Ecology, 89(11), pp. 2415-2426. (doi: 10.1111/1365-2656.13327) (PMID:32858775)

Heys, C. , Cheaib, B. , Busetti, A., Kazlauskaite, R., Maier, L., Sloan, W.T. , Ijaz, U.Z. , Kaufmann, J., McGinnity, P. and Llewellyn, M.S. (2020) Neutral processes dominate microbial community assembly in Atlantic salmon, Salmo salar. Applied and Environmental Microbiology, 86(8), e02283-19. (doi: 10.1128/AEM.02283-19) (PMID:32033945) (PMCID:PMC7117918)

Hollingsworth, P.M. et al. (2020) Scotland’s Biodiversity Progress to 2020 Aichi targets: Aichi target 13 - Genetic Diversity Maintained - Supplementary Report 2020. Technical Report. Scottish Natural Heritage, Inverness.

2019

Schwabl, P., Imamura, H., Van den Broeck, F., Costales, J. A., Maiguashca-Sánchez, J., Miles, M. A., Andersson, B., Grijalva, M. J. and Llewellyn, M. S. (2019) Meiotic sex in Chagas disease parasite Trypanosoma cruzi. Nature Communications, 10, 3972. (doi: 10.1038/s41467-019-11771-z) (PMID:31481692) (PMCID:PMC6722143)

Grillet, M. E. et al. (2019) Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region. Lancet Infectious Diseases, 19(5), e149-e161. (doi: 10.1016/S1473-3099(18)30757-6) (PMID:30799251)

Paniz-Mondolfi, A. E. et al. (2019) Resurgence of vaccine-preventable diseases in Venezuela as a regional public health threat in the Americas. Emerging Infectious Diseases, 25(4), pp. 625-632. (doi: 10.3201/eid2504.181305) (PMID:30698523) (PMCID:PMC6433037)

Perry, W. B. et al. (2019) Evolutionary drivers of kype size in Atlantic salmon (Salmo salar): domestication, age and genetics. Royal Society Open Science, 6(4), 190021. (doi: 10.1098/rsos.190021) (PMID:31183145) (PMCID:PMC6502380)

2018

Peters, L., Spatharis, S. , Dario, M. A., Dwyer, T., Roca, I. J.T., Kintner, A., Kanstad-Hanssen, Ø., Llewellyn, M. S. and Praebel, K. (2018) Environmental DNA: a new low-cost monitoring tool for pathogens in salmonid aquaculture. Frontiers in Microbiology, 9, 3009. (doi: 10.3389/fmicb.2018.03009) (PMID:30581425) (PMCID:PMC6292926)

Jacobs, A., De Noia, M., Praebel, K., Kanstad-Hanssen, Ø., Paterno, M., Jackson, D., McGinnity, P., Sturm, A., Elmer, K. and Llewellyn, M.S. (2018) Genetic fingerprinting of salmon louse (Lepeophtheirus salmonis) populations in the North-East Atlantic using a random forest classification approach. Scientific Reports, 8, 1203. (doi: 10.1038/s41598-018-19323-z) (PMID:29352185) (PMCID:PMC5775277)

2017

Dario, M. A. et al. (2017) High Trypanosoma spp. diversity is maintained by bats and triatomines in Espírito Santo state, Brazil. PLoS ONE, 12(11), e0188412. (doi: 10.1371/journal.pone.0188412) (PMID:29176770) (PMCID:PMC5703495)

Khan, N. H., Sutherland, C. J., Llewellyn, M. S. and Schönian, G. (2017) Variability of cutaneous leishmaniasis lesions is not associated with genetic diversity of Leishmania tropica in Khyber Pakhtunkhwa province of Pakistan. American Journal of Tropical Medicine and Hygiene, 97(5), pp. 1489-1497. (doi: 10.4269/ajtmh.16-0887) (PMID:29016290)

Dario, M. A., da Rocha, R. M. M., Schwabl, P., Jansen, A. M. and Llewellyn, M. S. (2017) Small subunit ribosomal metabarcoding reveals extraordinary trypanosomatid diversity in Brazilian bats. PLoS Neglected Tropical Diseases, 11(7), e0005790. (doi: 10.1371/journal.pntd.0005790) (PMID:28727769) (PMCID:PMC5544246)

Hernandez Castro, L. E. , Paterno, M., Villacís, A. G., Andersson, B., Costales, J. A., De Noia, M., Ocaña-Mayorga, S., Yumiseva, C. A., Grijalva, M. J. and Llewellyn, M. S. (2017) 2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador. PLoS Neglected Tropical Diseases, 11(7), e0005710. (doi: 10.1371/journal.pntd.0005710) (PMID:28723901) (PMCID:PMC5536387)

Acosta, N., Lopez, E., Lewis, M. D., Llewellyn, M. S. , Gomez, A., Roman, F., Miles, M. A. and Yeo, M. (2017) Hosts and vectors of Trypanosoma cruzi discrete typing units in the Chagas disease endemic region of the Paraguayan Chaco. Parasitology, 144(7), pp. 884-898. (doi: 10.1017/S0031182016002663) (PMID:28179034) (PMCID:PMC5471830)

Schwabl, P., Llewellyn, M. S. , Landguth, E. L., Andersson, B., Kitron, U., Costales, J. A., Ocaña, S. and Grijalva, M. J. (2017) Prediction and prevention of parasitic diseases using a landscape genomics framework. Trends in Parasitology, 33(4), pp. 264-275. (doi: 10.1016/j.pt.2016.10.008) (PMID:27863902)

Llewellyn, M.S. et al. (2017) Parasitism perturbs the mucosal microbiome of Atlantic Salmon. Scientific Reports, 7, 43465. (doi: 10.1038/srep43465) (PMID:28266549) (PMCID:PMC5339869)

Lewis, M.D., Llewellyn, M.S. , Yeo, M., Messenger, L.A. and Miles, M.A. (2017) Experimental and natural recombination in Trypanosoma cruzi. In: Telleria, J. and Tibayrenc, M. (eds.) American Trypanosomiasis Chagas Disease: One Hundred Years of Research [2nd ed.]. Elsevier, pp. 455-473. (doi:10.1016/B978-0-12-801029-7.00020-4)

2016

Sylvain, F.-É., Cheaib, B. , Llewellyn, M. , Gabriel Correia, T., Barros Fagundes, D., Luis Val, A. and Derome, N. (2016) pH drop impacts differentially skin and gut microbiota of the Amazonian fish tambaqui (Colossoma macropomum). Scientific Reports, 6, 32032. (doi: 10.1038/srep32032) (PMID:27535789) (PMCID:PMC4989189)

Messenger, L. A., Ramirez, J. D., Llewellyn, M. S. , Guhl, F. and Miles, M. A. (2016) Importation of hybrid human-associated Trypanosoma cruzi strains of Southern South American origin, Colombia. Emerging Infectious Diseases, 22(8), pp. 1452-1455. (doi: 10.3201/eid2208.150786) (PMID:27434772) (PMCID:PMC4982185)

2015

Ramírez, J.D. and Llewellyn, M.S. (2015) Response to Tibayrenc and Ayala: reproductive clonality in protozoan pathogens - truth or artefact? Molecular Ecology, 24(23), pp. 5782-5784. (doi: 10.1111/mec.13442) (PMID:26607215)

Costales, J. A., Jara-Palacios, M. A., Llewellyn, M. S. , Messenger, L. A., Ocaña-Mayorga, S., Villacís, A. G., Tibayrenc, M. and Grijalva, M. J. (2015) Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast. Acta Tropica, 151, pp. 88-93. (doi: 10.1016/j.actatropica.2015.07.017) (PMID:26200787)

Pennington, P.M., Messenger, L.A., Reina, J., Juárez, J.G., Lawrence, G.G., Dotson, E.M., Llewellyn, M.S. and Cordón-Rosales, C. (2015) The Chagas disease domestic transmission cycle in Guatemala: parasite-vector switches and lack of mitochondrial co-diversification between Triatoma dimidiata and Trypanosoma cruzi subpopulations suggest non-vectorial parasite dispersal across the Motagua valley. Acta Tropica, 151, pp. 80-87. (doi: 10.1016/j.actatropica.2015.07.014) (PMID:26215126)

Costales, J.A., Kotton, C.N., Zurita-Leal, A.C., Garcia-Perez, J., Llewellyn, M.S. , Messenger, L.A., Bhattacharyya, T. and Burleigh, B.A. (2015) Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM). Parasites and Vectors, 8, 435. (doi: 10.1186/s13071-015-1039-3) (PMID:26303927) (PMCID:PMC4548706)

Messenger, L.A., Garcia, L., Vanhove, M., Huaranca, C., Bustamante, M., Torrico, M., Torrico, F., Miles, M.A. and Llewellyn, M.S. (2015) Ecological host fitting of Trypanosoma cruziTcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal. Molecular Ecology, 24(10), pp. 2406-2422. (doi: 10.1111/mec.13186) (PMID:25847086)

Llewellyn, M.S. et al. (2015) Deep sequencing of the trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital chagas disease patients. PLoS Neglected Tropical Diseases, 9(4), e0003458. (doi: 10.1371/journal.pntd.0003458) (PMID:25849488) (PMCID:PMC4388557)

Llewellyn, M. S. , McGinnity, P., Dionne, M., Letourneau, J., Thonier, F., Carvalho, G. R., Creer, S. and Derome, N. (2015) The biogeography of the atlantic salmon (Salmo salar) gut microbiome. ISME Journal, 10, pp. 1280-1284. (doi: 10.1038/ismej.2015.189) (PMID:26517698)

Messenger, L.A., Yeo, M., Lewis, M.D., Llewellyn, M.S. and Miles, M. (2015) Molecular genotyping of trypanosoma cruzi for lineage assignment and population genetics. Methods in Molecular Biology, 1201, pp. 297-337. (doi: 10.1007/978-1-4939-1438-8_19) (PMID:25388123)

2014

Diosque, P. et al. (2014) Optimized Multilocus Sequence Typing (MLST) scheme for Trypanosoma cruzi. PLoS Neglected Tropical Diseases, 8(8), e3117. (doi: 10.1371/journal.pntd.0003117) (PMID:25167160) (PMCID:PMC4148231)

Lima, V.S., Jansen, A.M., Messenger, L.A., Miles, M.A. and Llewellyn, M.S. (2014) Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region. Parasites and Vectors, 7, 263. (doi: 10.1186/1756-3305-7-263) (PMID:24903849) (PMCID:PMC4062772)

2012

Franzén, O. et al. (2012) Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. BMC Genomics, 13, 531. (doi: 10.1186/1471-2164-13-531) (PMID:23035642) (PMCID:PMC3507753)

Ramirez, J. D., Guhl, F., Messenger, L. A., Lewis, M. D., Montilla, M., Cucunuba, Z., Miles, M. A. and Llewellyn, M. S. (2012) Contemporary cryptic sexuality in Trypanosoma cruzi. Molecular Ecology, 21(17), pp. 4216-4226. (doi: 10.1111/j.1365-294X.2012.05699.x) (PMID:22774844)

Lauthier, J.J. et al. (2012) Candidate targets for multilocus sequence typing of trypanosoma cruzi: validation using parasite stocks from the Chaco region and a set of reference strains. Infection, Genetics and Evolution, 12(2), pp. 350-358. (doi: 10.1016/j.meegid.2011.12.008) (PMID:22210092)

Zingales, B. et al. (2012) The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications. Infection, Genetics and Evolution, 12(2), pp. 240-253. (doi: 10.1016/j.meegid.2011.12.009) (PMID:22226704)

Carrasco, H.J. et al. (2012) Geographical distribution of Trypanosoma cruzi genotypes in Venezuela. PLoS Neglected Tropical Diseases, 6(6), e1707. (doi: 10.1371/journal.pntd.0001707) (PMID:22745843) (PMCID:PMC3383755)

Traub-Csekö, Y.M., Messenger, L.A., Llewellyn, M.S. , Bhattacharyya, T., Franzén, O., Lewis, M.D., Ramírez, J.D., Carrasco, H.J., Andersson, B. and Miles, M.A. (2012) Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by Maxicircle MLST and next generation sequencing. PLoS Neglected Tropical Diseases, 6(4), e1584. (doi: 10.1371/journal.pntd.0001584) (PMID:22506081) (PMCID:PMC3323513)

2011

Yoshida, N., Tyler, K.M. and Llewellyn, M.S. (2011) Invasion mechanisms among emerging food-borne protozoan parasites. Trends in Parasitology, 27(10), pp. 459-466. (doi: 10.1016/j.pt.2011.06.006) (PMID:21840261)

Llewellyn, M. S. , Rivett-Carnac, J. B., Fitzpatrick, S., Lewis, M. D., Yeo, M., Gaunt, M. W. and Miles, M. A. (2011) Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection. International Journal for Parasitology, 41(6), pp. 609-614. (doi: 10.1016/j.ijpara.2010.12.004) (PMID:21232539) (PMCID:PMC3084450)

Bates, P.A., Franzén, O., Ochaya, S., Sherwood, E., Lewis, M.D., Llewellyn, M.S. , Miles, M.A. and Andersson, B. (2011) Shotgun sequencing analysis of Trypanosoma cruzi I sylvio X10/1 and comparison with T. cruzi VI CL Brener. PLoS Neglected Tropical Diseases, 5(3), e984. (doi: 10.1371/journal.pntd.0000984) (PMID:21408126) (PMCID:PMC3050914)

Carlton, J.M., Lewis, M.D., Llewellyn, M.S. , Yeo, M., Acosta, N., Gaunt, M.W. and Miles, M.A. (2011) Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. PLoS Neglected Tropical Diseases, 5(10), e1363. (doi: 10.1371/journal.pntd.0001363) (PMID:22022633) (PMCID:PMC3191134)

Yeo, M., Mauricio, I.L., Messenger, L.A., Lewis, M.D., Llewellyn, M.S. , Acosta, N., Bhattacharyya, T., Diosque, P., Carrasco, H.J. and Miles, M.A. (2011) Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. PLoS Neglected Tropical Diseases, 5(6), e1049. (doi: 10.1371/journal.pntd.0001049) (PMID:21713026) (PMCID:PMC3119646)

2010

Ocaña-Mayorga, S., Llewellyn, M.S. , Costales, J.A., Miles, M.A. and Grijalva, M.J. (2010) Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern Ecuador. PLoS Neglected Tropical Diseases, 4(12), e915. (doi: 10.1371/journal.pntd.0000915) (PMID:21179502) (PMCID:PMC3001902)

2009

Lewis, M.D., Ma, J., Yeo, M., Carrasco, H.J., Llewellyn, M.S. and Miles, M.A. (2009) Genotyping of trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages. American Journal of Tropical Medicine and Hygiene, 81(6), pp. 1041-1049. (doi: 10.4269/ajtmh.2009.09-0305) (PMID:19996435) (PMCID:PMC2825677)

Marcili, A. et al. (2009) Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clustering. Infection, Genetics and Evolution, 9(6), pp. 1265-1274. (doi: 10.1016/j.meegid.2009.07.003) (PMID:19632356)

Lewis, M.D., Llewellyn, M.S. , Gaunt, M.W., Yeo, M., Carrasco, H.J. and Miles, M.A. (2009) Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. International Journal for Parasitology, 39(12), pp. 1305-1317. (doi: 10.1016/j.ijpara.2009.04.001) (PMID:19393242) (PMCID:PMC2731025)

Miles, M.A., Llewellyn, M.S. , Lewis, M.D., Yeo, M., Baleela, R., Fitpatrick, S., Gaunt, M.W. and Mauricio, I.L. (2009) The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. Parasitology, 136(12), p. 1509. (doi: 10.1017/S0031182009990977) (PMID:19691868)

Llewellyn, M.S. , Lewis, M.D., Acosta, N., Yeo, M., Carrasco, H.J., Segovia, M., Vargas, J., Torrico, F., Miles, M.A. and Gaunt, M.W. (2009) Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential Impact on emergent chagas disease. PLoS Neglected Tropical Diseases, 3(9), e510. (doi: 10.1371/journal.pntd.0000510) (PMID:19721699) (PMCID:PMC2727949)

Llewellyn, M. S. et al. (2009) Genome-scale multilocus microsatellite typing of trypanosoma cruzi discrete typing Unit I reveals phylogeographic structure and specific genotypes linked to human infection. PLoS Pathogens, 5(5), e1000410. (doi: 10.1371/journal.ppat.1000410) (PMID:19412340) (PMCID:PMC2669174)

2005

Yeo, M. et al. (2005) Origins of chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids. International Journal for Parasitology, 35(2), pp. 225-233. (doi: 10.1016/j.ijpara.2004.10.024) (PMID:15710443)

2004

Kassen, R., Llewellyn, M.S. and Rainey, P.B. (2004) Ecological constraints on diversification in a model adaptive radiation. Nature, 431(7011), pp. 984-988. (doi: 10.1038/nature02923) (PMID:15496923)

This list was generated on Sun Apr 11 02:34:39 2021 BST.

Jump to: Articles | Book Sections | Research Reports or Papers

Number of items: 53.

Articles

Llewellyn, M.S. et al. (2017) Parasitism perturbs the mucosal microbiome of Atlantic Salmon. Scientific Reports, 7, 43465. (doi: 10.1038/srep43465) (PMID:28266549) (PMCID:PMC5339869)

Book Sections

Research Reports or Papers

This list was generated on Sun Apr 11 02:34:39 2021 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Parameoba drug development
Biotechnology and Biological Sciences Research Council
2021 - 2024
Beyond 2020 (Burrishoole Ecosystem Observatory Network 2020)
Marine Institute
2017 - 2021
A microbial basis for Atlantic Salmon energetics
Biotechnology and Biological Sciences Research Council
2017 - 2020
Salmon Gut Project
Scottish Aquaculture Innovation Centre
2017 - 2018
SalmoSim: A simulated in vitro Atlantic salmon intestinal microbiome system for pre-screening probiotics and feed additives
Scottish Aquaculture Innovation Centre
2017 - 2018
Mucosal health and microbiota during sea lice parasitism: effect of oral delivery of immunomodulants
Biotechnology and Biological Sciences Research Council
2016 - 2018
RCUK-CONICYT Mucosal health and microbiota during sea lice parasitism: effect of oral delivery of immunomodulants
Biotechnology and Biological Sciences Research Council
2016 - 2018
Leishmaniasis in the Brazilian Amazon: the role of accessory microbiota in disease progression, pathobiology and immunity.
Medical Research Council
2015 - 2016
Landscape genetics guide NTD interventions: Chagas disease in Ecuador and Peru
National Institutes of Health
2015 - 2017

Supervision

De Noia, Michele
Eels study in the Burrishoole System Ireland
Dwyer, Toni
Environmental DNA for low-cost monitoring of disease in Aqua
Kazlauskaite, Raminta
.

Teaching

Course Coordinator

Level 3
Miniproject course

Lecturer

Level 3
Vertebrate Biology
Parasite Biology
Molecular Methods
Evolutionary Genetics

Level 2
Evolutionary Biology

Martin Llewellyn

Institute of Biodiversity, Animal Health & Comparative Medicine