Dr Jean Rodgers

  • Research Fellow (Institute of Biodiversity Animal Health & Comparative Medicine)
  • Associate (Institute of Infection Immunity & Inflammation)
  • Associate (School of Veterinary Medicine)

Research interests

Google Scholar - Publications Profile

Investigating the pathogenesis and chemotherapy of human African trypanosomiasis and animal trypanosomiasis with particular interest in parasite migration into the CNS, the development of neuroinflammation and blood-brain barrier dysfunction.

 


Publications

List by: Type | Date

Jump to: 2019 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2005 | 2003 | 2002 | 1997 | 1993
Number of items: 32.

2019

Rodgers, J. , Steiner, I. and Kennedy, P. G.E. (2019) Generation of neuroinflammation in human African trypanosomiasis. Neurology: Neuroimmunology and Neuroinflammation, 6(6), e610. (doi:10.1212/NXI.0000000000000610) (PMID:31467039)

Raftery, A. G. , Jallow, S., Rodgers, J. and Sutton, D. G.M. (2019) Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Neglected Tropical Diseases, 13(3), e0007175. (doi:10.1371/journal.pntd.0007175) (PMID:30901321) (Early Online Publication)

Kennedy, P. G.E. and Rodgers, J. (2019) Clinical and neuropathogenetic aspects of human African trypanosomiasis. Frontiers in Immunology, 10, 39. (doi:10.3389/fimmu.2019.00039)

2017

Laperchia, C., Tesoriero, C., La Verde, V., Seke-Etet, P. F., Colavito, V., Grassi-Zucconi, G., Rodgers, J. , Montague, P., Kennedy, P. G.E. and Bentivoglio, M. (2017) Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis. PLoS Neglected Tropical Diseases, 11(8), e0005854. (doi:10.1371/journal.pntd.0005854) (PMID:28821016) (PMCID:PMC5576758)

Rodgers, J. , Bradley, B. and Kennedy, P. G.E. (2017) Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis. Methods, 127, pp. 79-87. (doi:10.1016/j.ymeth.2017.06.015) (PMID:28636879) (PMCID:PMC5595161)

Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi:10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)

2016

Laperchia, C., Palomba, M., Etet, P. F. S., Rodgers, J. , Bradley, B., Montague, P., Grassi-Zucconi, G., Kennedy, P. G.E. and Bentivoglio, M. (2016) Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes. PLoS Neglected Tropical Diseases, 10(12), e0005242. (doi:10.1371/journal.pntd.0005242) (PMID:28002454) (PMCID:PMC5217973)

Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi:10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)

2015

Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi:10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)

Burrell-Saward, H., Rodgers, J. , Bradley, B., Croft, S. L. and Ward, T. H. (2015) A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis. Journal of Antimicrobial Chemotherapy, 70(2), pp. 510-517. (doi:10.1093/jac/dku393) (PMID:25298516)

Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi:10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)

2013

MacLean, L., Myburgh, E. , Rodgers, J. and Price, H.P. (2013) Imaging African trypanosomes. Parasite Immunology, 35(9-10), pp. 283-294. (doi:10.1111/pim.12046)

Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi:10.1371/journal.pntd.0002384)

2012

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi:10.1136/heartjnl-2012-301877b.17)

2011

Rodgers, J. , McCabe, C. , Gettinby, G., Bradley, B., Condon, B. and Kennedy, P. G.E. (2011) Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84(2), pp. 344-350. (doi:10.4269/ajtmh.2011.10-0487)

Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. , Croft, S. and Thomas, S.A. (2011) The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers. Journal of Pharmacology and Experimental Therapeutics, 336(2), pp. 506-515. (doi:10.1124/jpet.110.172981)

Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi:10.1371/journal.pntd.0001308)

2010

Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi:10.1017/S0031182009991806)

Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi:10.1017/S0031182009991806)

Carvalho, J.A., Rodgers, J. , Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A. (2010) DNA vaccines: a rational design against parasitic diseases. Expert Review of Vaccines, 9(2), pp. 175-191. (doi:10.1586/ERV.09.158)

2009

Rodgers, J. (2009) Human African trypanosomiasis, chemotherapy and CNS disease. Journal of Neuroimmunology, 211(1-2), pp. 16-22. (doi:10.1016/j.jneuroim.2009.02.007)

Sanderson, L., Dogruel, M., Rodgers, J. , De Koning, H.P. and Thomas, S.A. (2009) Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein. Journal of Pharmacology and Experimental Therapeutics, 329(3), pp. 967-977. (doi:10.1124/jpet.108.149872)

Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi:10.1093/brain/awp074)

2008

Rodgers, J. (2008) The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. Journal of Neurochemistry, 107(4), pp. 1136-1146. (doi:10.1111/j.1471-4159.2008.05706.x)

2005

Sternberg, J.M., Rodgers, J. , Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E. (2005) Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. Journal of Neuroimmunology, 167(1-2), pp. 81-89. (doi:10.1016/j.jneuroim.2005.06.017)

2003

Kennedy, P.G.E., Rodgers, J. , Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M. (2003) Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain, 126(7), pp. 1683-1690. (doi:10.1093/brain/awg160)

2002

Kennedy, P. G. E., Murray, M., Jennings, F. and Rodgers, J. (2002) Response to: 'Uses of error: knowledge gaps' by David Spence. Lancet (North American Edition), 359(9318), pp. 1695-1696.

Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. (2002) Sleeping sickness: new drugs from old? [corrected]. Lancet, 359(9318), pp. 1695-1696. (doi:10.1016/S0140-6736(02)08569-0)

Jennings, F.W., Rodgers, J. , Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M. (2002) Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitology International, 51(4), pp. 381-388. (doi:10.1016/S1383-5769(02)00044-2)

1997

Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. , Hunter, C. A., Murray, M. and Burke, J. M. (1997) The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis. Neuropathology and Applied Neurobiology, 23(3), pp. 225-234. (doi:10.1111/j.1365-2990.1997.tb01206.x)

Kennedy, P. G. E., Rodgers, J. , Jennings, F. W., Murray, M., Leeman, S. E. and Burke, J. M. (1997) A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proceedings of the National Academy of Sciences of the United States of America, 94(8), pp. 4167-4170.

1993

Gichuki, C., Burke, J., N'gure, R., Jennings, F., Hunter, C., Rodgers, J. , Ndung'u, J., Omuse, J., Kennedy, P. and Murray, M. (1993) Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis? In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993, pp. 113-118.

This list was generated on Mon Oct 21 03:22:43 2019 BST.
Number of items: 33.

Articles

Rodgers, J. , Steiner, I. and Kennedy, P. G.E. (2019) Generation of neuroinflammation in human African trypanosomiasis. Neurology: Neuroimmunology and Neuroinflammation, 6(6), e610. (doi:10.1212/NXI.0000000000000610) (PMID:31467039)

Raftery, A. G. , Jallow, S., Rodgers, J. and Sutton, D. G.M. (2019) Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Neglected Tropical Diseases, 13(3), e0007175. (doi:10.1371/journal.pntd.0007175) (PMID:30901321) (Early Online Publication)

Kennedy, P. G.E. and Rodgers, J. (2019) Clinical and neuropathogenetic aspects of human African trypanosomiasis. Frontiers in Immunology, 10, 39. (doi:10.3389/fimmu.2019.00039)

Laperchia, C., Tesoriero, C., La Verde, V., Seke-Etet, P. F., Colavito, V., Grassi-Zucconi, G., Rodgers, J. , Montague, P., Kennedy, P. G.E. and Bentivoglio, M. (2017) Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis. PLoS Neglected Tropical Diseases, 11(8), e0005854. (doi:10.1371/journal.pntd.0005854) (PMID:28821016) (PMCID:PMC5576758)

Rodgers, J. , Bradley, B. and Kennedy, P. G.E. (2017) Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis. Methods, 127, pp. 79-87. (doi:10.1016/j.ymeth.2017.06.015) (PMID:28636879) (PMCID:PMC5595161)

Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi:10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)

Laperchia, C., Palomba, M., Etet, P. F. S., Rodgers, J. , Bradley, B., Montague, P., Grassi-Zucconi, G., Kennedy, P. G.E. and Bentivoglio, M. (2016) Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes. PLoS Neglected Tropical Diseases, 10(12), e0005242. (doi:10.1371/journal.pntd.0005242) (PMID:28002454) (PMCID:PMC5217973)

Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi:10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)

Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi:10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)

Burrell-Saward, H., Rodgers, J. , Bradley, B., Croft, S. L. and Ward, T. H. (2015) A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis. Journal of Antimicrobial Chemotherapy, 70(2), pp. 510-517. (doi:10.1093/jac/dku393) (PMID:25298516)

Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi:10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)

MacLean, L., Myburgh, E. , Rodgers, J. and Price, H.P. (2013) Imaging African trypanosomes. Parasite Immunology, 35(9-10), pp. 283-294. (doi:10.1111/pim.12046)

Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi:10.1371/journal.pntd.0002384)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi:10.1136/heartjnl-2012-301877b.17)

Rodgers, J. , McCabe, C. , Gettinby, G., Bradley, B., Condon, B. and Kennedy, P. G.E. (2011) Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84(2), pp. 344-350. (doi:10.4269/ajtmh.2011.10-0487)

Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. , Croft, S. and Thomas, S.A. (2011) The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers. Journal of Pharmacology and Experimental Therapeutics, 336(2), pp. 506-515. (doi:10.1124/jpet.110.172981)

Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi:10.1371/journal.pntd.0001308)

Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi:10.1017/S0031182009991806)

Rodgers, J. (2010) Trypanosomiasis and the brain. Parasitology, 137(14), pp. 1995-2006. (doi:10.1017/S0031182009991806)

Carvalho, J.A., Rodgers, J. , Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A. (2010) DNA vaccines: a rational design against parasitic diseases. Expert Review of Vaccines, 9(2), pp. 175-191. (doi:10.1586/ERV.09.158)

Rodgers, J. (2009) Human African trypanosomiasis, chemotherapy and CNS disease. Journal of Neuroimmunology, 211(1-2), pp. 16-22. (doi:10.1016/j.jneuroim.2009.02.007)

Sanderson, L., Dogruel, M., Rodgers, J. , De Koning, H.P. and Thomas, S.A. (2009) Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein. Journal of Pharmacology and Experimental Therapeutics, 329(3), pp. 967-977. (doi:10.1124/jpet.108.149872)

Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi:10.1093/brain/awp074)

Rodgers, J. (2008) The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. Journal of Neurochemistry, 107(4), pp. 1136-1146. (doi:10.1111/j.1471-4159.2008.05706.x)

Sternberg, J.M., Rodgers, J. , Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E. (2005) Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. Journal of Neuroimmunology, 167(1-2), pp. 81-89. (doi:10.1016/j.jneuroim.2005.06.017)

Kennedy, P.G.E., Rodgers, J. , Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M. (2003) Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain, 126(7), pp. 1683-1690. (doi:10.1093/brain/awg160)

Kennedy, P. G. E., Murray, M., Jennings, F. and Rodgers, J. (2002) Response to: 'Uses of error: knowledge gaps' by David Spence. Lancet (North American Edition), 359(9318), pp. 1695-1696.

Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. (2002) Sleeping sickness: new drugs from old? [corrected]. Lancet, 359(9318), pp. 1695-1696. (doi:10.1016/S0140-6736(02)08569-0)

Jennings, F.W., Rodgers, J. , Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M. (2002) Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitology International, 51(4), pp. 381-388. (doi:10.1016/S1383-5769(02)00044-2)

Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. , Hunter, C. A., Murray, M. and Burke, J. M. (1997) The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis. Neuropathology and Applied Neurobiology, 23(3), pp. 225-234. (doi:10.1111/j.1365-2990.1997.tb01206.x)

Kennedy, P. G. E., Rodgers, J. , Jennings, F. W., Murray, M., Leeman, S. E. and Burke, J. M. (1997) A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proceedings of the National Academy of Sciences of the United States of America, 94(8), pp. 4167-4170.

Conference Proceedings

Gichuki, C., Burke, J., N'gure, R., Jennings, F., Hunter, C., Rodgers, J. , Ndung'u, J., Omuse, J., Kennedy, P. and Murray, M. (1993) Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis? In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993, pp. 113-118.

Key Findings

Nicolson, L., Rodgers, J. , Dowell, F., Nasir, L., Evans, N. , Robinson, J. and Hammond, J. Personal development plan case study. [Key Findings]

This list was generated on Mon Oct 21 03:22:43 2019 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • ISSF Catalyst: Comparative transcriptomic analysis of central nervous system and bloodstream -resident trypanosomes in a murine model of human African sleeping sickness.
    Wellcome Trust
    2015 - 2017
     
  • Development of a sensitive Taqman PCR based assay for detection of low level trypanosome infections in cattle.
    Department for International Development
    2012 - 2013
     
  • Defining the role of kynurenine pathway metabolites in the inflammatory response to trypanosome invasion of the CNS
    Wellcome Trust
    2012 - 2015
     
  • Defining the role of the chemokine CXCL10 in determining traversal across the blood-brain barrier in experimental and human African trypanosomiasis
    Wellcome Trust
    2011 - 2014
     
  • In vivo imaging models of African trypanosomiasis to support drug discovery programmes.
    Bill and Melinda Gates Foundation
    2010 - 2013
     
  • Defining the therapeutic role of IL-10 in African trypanosomiasis.
    Wellcome Trust
    2008 - 2011
     
  • Combination chemotherapy of human African trypanosomiasis - the potential of drug synergism and the blood-brain barrier
    Medical Research Council
    2007 - 2010
     
  • Production of DNA vaccine prototypes and the study of the humoral and cellular response following immunisation with the candidate DNA vaccines.
    Fundacao para a Cienca e Technologia
    2007 - 2010