Dr Jean Rodgers
- Lecturer (Host-Parasite Interactions & Pathogenesis)
                        telephone: 
                        01413303797
                        email: 
                        Jean.Rodgers@glasgow.ac.uk
                    
R203 a, SBOHVM, Urquhart Building, Garscube Estate, Glasgow, G61 1QH
Research interests
Google Scholar - Publications Profile
Investigating the pathogenesis and chemotherapy of human African trypanosomiasis and animal trypanosomiasis with particular interest in parasite migration into the CNS, the development of neuroinflammation and blood-brain barrier dysfunction.
Research groups
Publications
2023
    
    Paterson, Samantha, Vallatos, Antoine ORCID: https://orcid.org/0000-0002-5202-056X, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Holmes, William M. 
ORCID: https://orcid.org/0000-0002-0942-215X
  
(2023)
  
Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis.
    
    Scientific Reports, 13,
	 
      8684.
    
    (doi: 10.1038/s41598-023-34665-z)
    (PMID:37248398) 
    (PMCID:PMC10227057) 
  
  
2022
    
    Paterson, Samantha, Holmes, William ORCID: https://orcid.org/0000-0002-0942-215X and Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882
  
(2022)
  
Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse.
    
    PLoS Neglected Tropical Diseases, 16(12),
	 
      e0010962.
    
    (doi: 10.1371/journal.pntd.0010962)
    (PMID:36477669) 
    (PMCID:PMC9728833) 
  
  
2021
    
    Montague, Paul, Bradley, Barbara, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882 and Kennedy, Peter G.E.
  
(2021)
  
Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma.b.brucei infected CD1 mouse brains.
    
    PLoS Neglected Tropical Diseases, 15(11),
	 
      e0009892.
    
    (doi: 10.1371/journal.pntd.0009892)
    (PMID:34762691) 
    (PMCID:PMC8584711) 
  
  
2020
    
    Gummery, Lauren, Jallow, Saloum, Raftery, Alexandra G., Bennet, Euan ORCID: https://orcid.org/0000-0001-9049-1920, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2020)
  
Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia.
    
    PLoS ONE, 15(8),
	 
      e0237187.
    
    (doi: 10.1371/journal.pone.0237187)
    (PMID:32833981) 
    (PMCID:PMC7444819) 
  
  
    
    Raftery, Alexandra, Jallow, Saloum, Coultous, Robert M. ORCID: https://orcid.org/0000-0002-6905-3915, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2020)
  
Variation in disease phenotype is marked in equine trypanosomiasis.
    
    Parasites and Vectors, 13,
	 
      148.
    
    (doi: 10.1186/s13071-020-04020-6)
    (PMID:32199454) 
    (PMCID:PMC7085162) 
  
  
2019
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Steiner, Israel and Kennedy, Peter G.E.
  
(2019)
  
Generation of neuroinflammation in human African trypanosomiasis.
    
    Neurology: Neuroimmunology and Neuroinflammation, 6(6),
	 
      e610.
    
    (doi: 10.1212/NXI.0000000000000610)
    (PMID:31467039) 
    (PMCID:PMC6745723) 
  
  
    
    Raftery, Alexandra G., Jallow, Saloum, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2019)
  
Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial.
    
    PLoS Neglected Tropical Diseases, 13(3),
	 
      e0007175.
    
    (doi: 10.1371/journal.pntd.0007175)
    (PMID:30901321) 
    (PMCID:PMC6447232) 
  
  
    
    Kennedy, Peter G.E. and Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2019)
  
Clinical and neuropathogenetic aspects of human African trypanosomiasis.
    
    Frontiers in Immunology, 10,
	 
      39.
    
    (doi: 10.3389/fimmu.2019.00039)
     
     
  
  
2017
    
    Laperchia, Claudia, Tesoriero, Chiara, La Verde, Valentina, Seke-Etet, Paul F., Colavito, Valeria, Grassi-Zucconi, Gigliola, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Montague, Paul, Kennedy, Peter G.E. and Bentivoglio, Marina
  
(2017)
  
Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 11(8),
	 
      e0005854.
    
    (doi: 10.1371/journal.pntd.0005854)
    (PMID:28821016) 
    (PMCID:PMC5576758) 
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara and Kennedy, Peter G.E.
  
(2017)
  
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis.
    
    Methods, 127,
	  pp. 79-87.
     
    
    (doi: 10.1016/j.ymeth.2017.06.015)
    (PMID:28636879) 
    (PMCID:PMC5595161) 
  
  
    
    Sternberg, Jeremy M., Forrest, Caroline M., Dalton, R. Neil, Turner, Charles, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Stone, Trevor W. 
ORCID: https://orcid.org/0000-0002-5532-0031 and Kennedy, Peter G.E.
  
(2017)
  
Kynurenine pathway activation in Human African trypanosomiasis.
    
    Journal of Infectious Diseases, 215(5),
	  pp. 806-812.
     
    
    (doi: 10.1093/infdis/jiw623)
    (PMID:28013248) 
    (PMCID:PMC5388295) 
  
  
2016
    
    Laperchia, Claudia, Palomba, Maria, Etet, Paul F. Seke, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Montague, Paul, Grassi-Zucconi, Gigliola, Kennedy, Peter G.E. and Bentivoglio, Marina
  
(2016)
  
Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes.
    
    PLoS Neglected Tropical Diseases, 10(12),
	 
      e0005242.
    
    (doi: 10.1371/journal.pntd.0005242)
    (PMID:28002454) 
    (PMCID:PMC5217973) 
  
  
    
    Forrest, Caroline, Kennedy, Peter G., Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Dalton, R. Neil, Turner, Charles, Darlington, L. Gail, Cobb, Stuart and Stone, Trevor W. 
ORCID: https://orcid.org/0000-0002-5532-0031
  
(2016)
  
Kynurenine pathway metabolism following prenatal KMO inhibition and in 
Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry.
    
    Neurochemistry International, 100,
	  pp. 110-119.
     
    
    (doi: 10.1016/j.neuint.2016.09.012)
    (PMID:27623092) 
    (PMCID:PMC5115650) 
  
  
2015
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Kennedy, Peter G.E. and Sternberg, Jeremy M.
  
(2015)
  
Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice.
    
    PLoS Neglected Tropical Diseases, 9(10),
	 
      e0004201.
    
    (doi: 10.1371/journal.pntd.0004201)
    (PMID:26505761) 
    (PMCID:PMC4624684) 
  
  
    
    Coles, Jonathan A., Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902, Ritchie, Ryan, Hamilton, Alana, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882, Mottram, Jeremy C. 
ORCID: https://orcid.org/0000-0001-5574-3766, Barrett, Michael P. 
ORCID: https://orcid.org/0000-0001-9447-3519 and Brewer, James M. 
ORCID: https://orcid.org/0000-0001-7933-0915
  
(2015)
  
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.
    
    PLoS Neglected Tropical Diseases, 9(4),
	 
      e0003714.
    
    (doi: 10.1371/journal.pntd.0003714)
    (PMID:25881126) 
    (PMCID:PMC4400075) 
  
  
    
    Burrell-Saward, Hollie, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Croft, Simon L. and Ward, Theresa H.
  
(2015)
  
A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
    
    Journal of Antimicrobial Chemotherapy, 70(2),
	  pp. 510-517.
     
    
    (doi: 10.1093/jac/dku393)
    (PMID:25298516) 
     
  
  
2013
    
    MacLean, L., Myburgh, E. ORCID: https://orcid.org/0000-0002-2007-5902, Rodgers, J. 
ORCID: https://orcid.org/0000-0002-2093-3882 and Price, H.P.
  
(2013)
  
Imaging African trypanosomes.
    
    Parasite Immunology, 35(9-10),
	  pp. 283-294.
     
    
    (doi: 10.1111/pim.12046)
     
     
  
  
    
    Myburgh, E. ORCID: https://orcid.org/0000-0002-2007-5902, Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. 
ORCID: https://orcid.org/0000-0002-2093-3882, Taylor, M., Barrett, M. 
ORCID: https://orcid.org/0000-0001-9447-3519, Brewer, J. 
ORCID: https://orcid.org/0000-0001-7933-0915 and Mottram, J.C. 
ORCID: https://orcid.org/0000-0001-5574-3766
  
(2013)
  
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 7(8),
	  e2384.
     
    
    (doi: 10.1371/journal.pntd.0002384)
     
     
  
  
2012
Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)
2011
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, McCabe, Chris 
ORCID: https://orcid.org/0000-0003-3111-031X, Gettinby, George, Bradley, Barbara, Condon, Barrie and Kennedy, Peter G.E.
  
(2011)
  
Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis.
    
    American Journal of Tropical Medicine and Hygiene, 84(2),
	  pp. 344-350.
     
    
    (doi: 10.4269/ajtmh.2011.10-0487)
     
     
  
  
    
    Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Croft, S. and Thomas, S.A.
  
(2011)
  
The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers.
    
    Journal of Pharmacology and Experimental Therapeutics, 336(2),
	  pp. 506-515.
     
    
    (doi: 10.1124/jpet.110.172981)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Jones, Amy, Gibaud, Stephane, Bradley, Barbara, McCabe, Chris 
ORCID: https://orcid.org/0000-0003-3111-031X, Barrett, Michael P. 
ORCID: https://orcid.org/0000-0001-9447-3519, Gettinby, George and Kennedy, Peter G.E.
  
(2011)
  
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 5(9),
	  e1308.
     
    
    (doi: 10.1371/journal.pntd.0001308)
     
     
  
  
2010
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2010)
  
Trypanosomiasis and the brain.
    
    Parasitology, 137(14),
	  pp. 1995-2006.
     
    
    (doi: 10.1017/S0031182009991806)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2010)
  
Trypanosomiasis and the brain.
    
    Parasitology, 137(14),
	  pp. 1995-2006.
     
    
    (doi: 10.1017/S0031182009991806)
     
     
  
  
    
    Carvalho, J.A., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A.
  
(2010)
  
DNA vaccines: a rational design against parasitic diseases.
    
    Expert Review of Vaccines, 9(2),
	  pp. 175-191.
     
    
    (doi: 10.1586/ERV.09.158)
     
     
  
  
2009
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2009)
  
Human African trypanosomiasis, chemotherapy and CNS disease.
    
    Journal of Neuroimmunology, 211(1-2),
	  pp. 16-22.
     
    
    (doi: 10.1016/j.jneuroim.2009.02.007)
     
     
  
  
    
    Sanderson, L., Dogruel, M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, De Koning, H.P. and Thomas, S.A.
  
(2009)
  
Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein.
    
    Journal of Pharmacology and Experimental Therapeutics, 329(3),
	  pp. 967-977.
     
    
    (doi: 10.1124/jpet.108.149872)
     
     
  
  
    
    Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E.
  
(2009)
  
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
    
    Brain, 132(5),
	  pp. 1259-1267.
     
    
    (doi: 10.1093/brain/awp074)
     
     
  
  
2008
    
    Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882
  
(2008)
  
The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.
    
    Journal of Neurochemistry, 107(4),
	  pp. 1136-1146.
     
    
    (doi: 10.1111/j.1471-4159.2008.05706.x)
     
     
  
  
2005
    
    Sternberg, J.M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E.
  
(2005)
  
Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology.
    
    Journal of Neuroimmunology, 167(1-2),
	  pp. 81-89.
     
    
    (doi: 10.1016/j.jneuroim.2005.06.017)
     
     
  
  
2003
    
    Kennedy, P.G.E., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M.
  
(2003)
  
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice.
    
    Brain, 126(7),
	  pp. 1683-1690.
     
    
    (doi: 10.1093/brain/awg160)
     
     
  
  
2002
    
    Kennedy, Peter G E, Murray, Maxwell, Jennings, Frank and Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2002)
  
Response to: 'Uses of error: knowledge gaps' by David Spence.
    
    Lancet (North American Edition), 359(9318),
	  pp. 1695-1696.
     
    
    
     
     
  
  
    
    Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882
  
(2002)
  
Sleeping sickness: new drugs from old? [corrected].
    
    Lancet, 359(9318),
	  pp. 1695-1696.
     
    
    (doi: 10.1016/S0140-6736(02)08569-0)
     
     
  
  
    
    Jennings, F.W., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M.
  
(2002)
  
Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
    
    Parasitology International, 51(4),
	  pp. 381-388.
     
    
    (doi: 10.1016/S1383-5769(02)00044-2)
     
     
  
  
1997
    
    Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Hunter, C. A., Murray, M. and Burke, J. M.
  
(1997)
  
The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
    
    Neuropathology and Applied Neurobiology, 23(3),
	  pp. 225-234.
     
    
    (doi: 10.1111/j.1365-2990.1997.tb01206.x)
     
     
  
  
    
    Kennedy, Peter G. E., Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Jennings, Francis W., Murray, Max., Leeman, Susan E. and Burke, Joanne M.
  
(1997)
  
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei.
    
    Proceedings of the National Academy of Sciences of the United States of America, 94(8),
	  pp. 4167-4170.
     
    
    
     
     
  
  
1993
    
    Gichuki, CW, Burke, JM, N'gure, RM, Jennings, FW, Hunter, CA, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Ndung'u, JMN, Omuse, JM, Kennedy, PGE and Murray, Maxwell
  
(1993)
  
Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis?
    
    In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993,
     pp. 113-118. 
    
    
  
  
Articles
    
    Paterson, Samantha, Vallatos, Antoine ORCID: https://orcid.org/0000-0002-5202-056X, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Holmes, William M. 
ORCID: https://orcid.org/0000-0002-0942-215X
  
(2023)
  
Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis.
    
    Scientific Reports, 13,
	 
      8684.
    
    (doi: 10.1038/s41598-023-34665-z)
    (PMID:37248398) 
    (PMCID:PMC10227057) 
  
  
    
    Paterson, Samantha, Holmes, William ORCID: https://orcid.org/0000-0002-0942-215X and Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882
  
(2022)
  
Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse.
    
    PLoS Neglected Tropical Diseases, 16(12),
	 
      e0010962.
    
    (doi: 10.1371/journal.pntd.0010962)
    (PMID:36477669) 
    (PMCID:PMC9728833) 
  
  
    
    Montague, Paul, Bradley, Barbara, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882 and Kennedy, Peter G.E.
  
(2021)
  
Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma.b.brucei infected CD1 mouse brains.
    
    PLoS Neglected Tropical Diseases, 15(11),
	 
      e0009892.
    
    (doi: 10.1371/journal.pntd.0009892)
    (PMID:34762691) 
    (PMCID:PMC8584711) 
  
  
    
    Gummery, Lauren, Jallow, Saloum, Raftery, Alexandra G., Bennet, Euan ORCID: https://orcid.org/0000-0001-9049-1920, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2020)
  
Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia.
    
    PLoS ONE, 15(8),
	 
      e0237187.
    
    (doi: 10.1371/journal.pone.0237187)
    (PMID:32833981) 
    (PMCID:PMC7444819) 
  
  
    
    Raftery, Alexandra, Jallow, Saloum, Coultous, Robert M. ORCID: https://orcid.org/0000-0002-6905-3915, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2020)
  
Variation in disease phenotype is marked in equine trypanosomiasis.
    
    Parasites and Vectors, 13,
	 
      148.
    
    (doi: 10.1186/s13071-020-04020-6)
    (PMID:32199454) 
    (PMCID:PMC7085162) 
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Steiner, Israel and Kennedy, Peter G.E.
  
(2019)
  
Generation of neuroinflammation in human African trypanosomiasis.
    
    Neurology: Neuroimmunology and Neuroinflammation, 6(6),
	 
      e610.
    
    (doi: 10.1212/NXI.0000000000000610)
    (PMID:31467039) 
    (PMCID:PMC6745723) 
  
  
    
    Raftery, Alexandra G., Jallow, Saloum, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882 and Sutton, David G.M. 
ORCID: https://orcid.org/0000-0002-7241-8444
  
(2019)
  
Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial.
    
    PLoS Neglected Tropical Diseases, 13(3),
	 
      e0007175.
    
    (doi: 10.1371/journal.pntd.0007175)
    (PMID:30901321) 
    (PMCID:PMC6447232) 
  
  
    
    Kennedy, Peter G.E. and Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2019)
  
Clinical and neuropathogenetic aspects of human African trypanosomiasis.
    
    Frontiers in Immunology, 10,
	 
      39.
    
    (doi: 10.3389/fimmu.2019.00039)
     
     
  
  
    
    Laperchia, Claudia, Tesoriero, Chiara, La Verde, Valentina, Seke-Etet, Paul F., Colavito, Valeria, Grassi-Zucconi, Gigliola, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Montague, Paul, Kennedy, Peter G.E. and Bentivoglio, Marina
  
(2017)
  
Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 11(8),
	 
      e0005854.
    
    (doi: 10.1371/journal.pntd.0005854)
    (PMID:28821016) 
    (PMCID:PMC5576758) 
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara and Kennedy, Peter G.E.
  
(2017)
  
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis.
    
    Methods, 127,
	  pp. 79-87.
     
    
    (doi: 10.1016/j.ymeth.2017.06.015)
    (PMID:28636879) 
    (PMCID:PMC5595161) 
  
  
    
    Sternberg, Jeremy M., Forrest, Caroline M., Dalton, R. Neil, Turner, Charles, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Stone, Trevor W. 
ORCID: https://orcid.org/0000-0002-5532-0031 and Kennedy, Peter G.E.
  
(2017)
  
Kynurenine pathway activation in Human African trypanosomiasis.
    
    Journal of Infectious Diseases, 215(5),
	  pp. 806-812.
     
    
    (doi: 10.1093/infdis/jiw623)
    (PMID:28013248) 
    (PMCID:PMC5388295) 
  
  
    
    Laperchia, Claudia, Palomba, Maria, Etet, Paul F. Seke, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Montague, Paul, Grassi-Zucconi, Gigliola, Kennedy, Peter G.E. and Bentivoglio, Marina
  
(2016)
  
Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes.
    
    PLoS Neglected Tropical Diseases, 10(12),
	 
      e0005242.
    
    (doi: 10.1371/journal.pntd.0005242)
    (PMID:28002454) 
    (PMCID:PMC5217973) 
  
  
    
    Forrest, Caroline, Kennedy, Peter G., Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Dalton, R. Neil, Turner, Charles, Darlington, L. Gail, Cobb, Stuart and Stone, Trevor W. 
ORCID: https://orcid.org/0000-0002-5532-0031
  
(2016)
  
Kynurenine pathway metabolism following prenatal KMO inhibition and in 
Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry.
    
    Neurochemistry International, 100,
	  pp. 110-119.
     
    
    (doi: 10.1016/j.neuint.2016.09.012)
    (PMID:27623092) 
    (PMCID:PMC5115650) 
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Kennedy, Peter G.E. and Sternberg, Jeremy M.
  
(2015)
  
Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice.
    
    PLoS Neglected Tropical Diseases, 9(10),
	 
      e0004201.
    
    (doi: 10.1371/journal.pntd.0004201)
    (PMID:26505761) 
    (PMCID:PMC4624684) 
  
  
    
    Coles, Jonathan A., Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902, Ritchie, Ryan, Hamilton, Alana, Rodgers, Jean 
ORCID: https://orcid.org/0000-0002-2093-3882, Mottram, Jeremy C. 
ORCID: https://orcid.org/0000-0001-5574-3766, Barrett, Michael P. 
ORCID: https://orcid.org/0000-0001-9447-3519 and Brewer, James M. 
ORCID: https://orcid.org/0000-0001-7933-0915
  
(2015)
  
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.
    
    PLoS Neglected Tropical Diseases, 9(4),
	 
      e0003714.
    
    (doi: 10.1371/journal.pntd.0003714)
    (PMID:25881126) 
    (PMCID:PMC4400075) 
  
  
    
    Burrell-Saward, Hollie, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, Barbara, Croft, Simon L. and Ward, Theresa H.
  
(2015)
  
A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
    
    Journal of Antimicrobial Chemotherapy, 70(2),
	  pp. 510-517.
     
    
    (doi: 10.1093/jac/dku393)
    (PMID:25298516) 
     
  
  
    
    MacLean, L., Myburgh, E. ORCID: https://orcid.org/0000-0002-2007-5902, Rodgers, J. 
ORCID: https://orcid.org/0000-0002-2093-3882 and Price, H.P.
  
(2013)
  
Imaging African trypanosomes.
    
    Parasite Immunology, 35(9-10),
	  pp. 283-294.
     
    
    (doi: 10.1111/pim.12046)
     
     
  
  
    
    Myburgh, E. ORCID: https://orcid.org/0000-0002-2007-5902, Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. 
ORCID: https://orcid.org/0000-0002-2093-3882, Taylor, M., Barrett, M. 
ORCID: https://orcid.org/0000-0001-9447-3519, Brewer, J. 
ORCID: https://orcid.org/0000-0001-7933-0915 and Mottram, J.C. 
ORCID: https://orcid.org/0000-0001-5574-3766
  
(2013)
  
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 7(8),
	  e2384.
     
    
    (doi: 10.1371/journal.pntd.0002384)
     
     
  
  
Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, McCabe, Chris 
ORCID: https://orcid.org/0000-0003-3111-031X, Gettinby, George, Bradley, Barbara, Condon, Barrie and Kennedy, Peter G.E.
  
(2011)
  
Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis.
    
    American Journal of Tropical Medicine and Hygiene, 84(2),
	  pp. 344-350.
     
    
    (doi: 10.4269/ajtmh.2011.10-0487)
     
     
  
  
    
    Jeganathan, S., Sanderson, L., Dogruel, M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Croft, S. and Thomas, S.A.
  
(2011)
  
The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-CSF barriers.
    
    Journal of Pharmacology and Experimental Therapeutics, 336(2),
	  pp. 506-515.
     
    
    (doi: 10.1124/jpet.110.172981)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Jones, Amy, Gibaud, Stephane, Bradley, Barbara, McCabe, Chris 
ORCID: https://orcid.org/0000-0003-3111-031X, Barrett, Michael P. 
ORCID: https://orcid.org/0000-0001-9447-3519, Gettinby, George and Kennedy, Peter G.E.
  
(2011)
  
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
    
    PLoS Neglected Tropical Diseases, 5(9),
	  e1308.
     
    
    (doi: 10.1371/journal.pntd.0001308)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2010)
  
Trypanosomiasis and the brain.
    
    Parasitology, 137(14),
	  pp. 1995-2006.
     
    
    (doi: 10.1017/S0031182009991806)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2010)
  
Trypanosomiasis and the brain.
    
    Parasitology, 137(14),
	  pp. 1995-2006.
     
    
    (doi: 10.1017/S0031182009991806)
     
     
  
  
    
    Carvalho, J.A., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Atouguia, J., Prazeres, D.M.F. and Monteiro, G.A.
  
(2010)
  
DNA vaccines: a rational design against parasitic diseases.
    
    Expert Review of Vaccines, 9(2),
	  pp. 175-191.
     
    
    (doi: 10.1586/ERV.09.158)
     
     
  
  
    
    Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2009)
  
Human African trypanosomiasis, chemotherapy and CNS disease.
    
    Journal of Neuroimmunology, 211(1-2),
	  pp. 16-22.
     
    
    (doi: 10.1016/j.jneuroim.2009.02.007)
     
     
  
  
    
    Sanderson, L., Dogruel, M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, De Koning, H.P. and Thomas, S.A.
  
(2009)
  
Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein.
    
    Journal of Pharmacology and Experimental Therapeutics, 329(3),
	  pp. 967-977.
     
    
    (doi: 10.1124/jpet.108.149872)
     
     
  
  
    
    Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E.
  
(2009)
  
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
    
    Brain, 132(5),
	  pp. 1259-1267.
     
    
    (doi: 10.1093/brain/awp074)
     
     
  
  
    
    Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882
  
(2008)
  
The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.
    
    Journal of Neurochemistry, 107(4),
	  pp. 1136-1146.
     
    
    (doi: 10.1111/j.1471-4159.2008.05706.x)
     
     
  
  
    
    Sternberg, J.M., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., MacLean, L., Murray, M. and Kennedy, P.G.E.
  
(2005)
  
Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology.
    
    Journal of Neuroimmunology, 167(1-2),
	  pp. 81-89.
     
    
    (doi: 10.1016/j.jneuroim.2005.06.017)
     
     
  
  
    
    Kennedy, P.G.E., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., Hunt, S.P., Gettinby, G., Leeman, S.E., De Felipe, C. and Murray, M.
  
(2003)
  
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice.
    
    Brain, 126(7),
	  pp. 1683-1690.
     
    
    (doi: 10.1093/brain/awg160)
     
     
  
  
    
    Kennedy, Peter G E, Murray, Maxwell, Jennings, Frank and Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882
  
(2002)
  
Response to: 'Uses of error: knowledge gaps' by David Spence.
    
    Lancet (North American Edition), 359(9318),
	  pp. 1695-1696.
     
    
    
     
     
  
  
    
    Kennedy, P.G.E., Murray, M., Jennings, F. and Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882
  
(2002)
  
Sleeping sickness: new drugs from old? [corrected].
    
    Lancet, 359(9318),
	  pp. 1695-1696.
     
    
    (doi: 10.1016/S0140-6736(02)08569-0)
     
     
  
  
    
    Jennings, F.W., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Bradley, B., Gettinby, G., Kennedy, P.G.E. and Murray, M.
  
(2002)
  
Human African trypanosomiasis: Potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
    
    Parasitology International, 51(4),
	  pp. 381-388.
     
    
    (doi: 10.1016/S1383-5769(02)00044-2)
     
     
  
  
    
    Jennings, F. W., Gichuki, C. W., Kennedy, P. G. E., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Hunter, C. A., Murray, M. and Burke, J. M.
  
(1997)
  
The role of the polyamine inhibitor ef lornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
    
    Neuropathology and Applied Neurobiology, 23(3),
	  pp. 225-234.
     
    
    (doi: 10.1111/j.1365-2990.1997.tb01206.x)
     
     
  
  
    
    Kennedy, Peter G. E., Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Jennings, Francis W., Murray, Max., Leeman, Susan E. and Burke, Joanne M.
  
(1997)
  
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei.
    
    Proceedings of the National Academy of Sciences of the United States of America, 94(8),
	  pp. 4167-4170.
     
    
    
     
     
  
  
Conference Proceedings
    
    Gichuki, CW, Burke, JM, N'gure, RM, Jennings, FW, Hunter, CA, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Ndung'u, JMN, Omuse, JM, Kennedy, PGE and Murray, Maxwell
  
(1993)
  
Do astrocytes have a role in the neuropathogenesis of African trypanosomiasis?
    
    In: 22nd Meeting of The International Scientific Council for Trypanosomiasis Research and Control, Kampala, Uganda, 1993,
     pp. 113-118. 
    
    
  
  
Key Findings
    
    Nicolson, Lesley, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Dowell, Fiona, Nasir, Lubna, Evans, Neil 
ORCID: https://orcid.org/0000-0001-7395-3222, Robinson, Jane 
ORCID: https://orcid.org/0000-0002-4632-1366 and Hammond, Jennifer
  
  
Personal development plan case study.
    
    [Key Findings]
  
  
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- ISSF Catalyst: Comparative transcriptomic analysis of central nervous system and bloodstream -resident trypanosomes in a murine model of human African sleeping sickness.
 Wellcome Trust
 2015 - 2017
 
- Development of a sensitive Taqman PCR based assay for detection of low level trypanosome infections in cattle.
 Department for International Development
 2012 - 2013
 
- Defining the role of kynurenine pathway metabolites in the inflammatory response to trypanosome invasion of the CNS
 Wellcome Trust
 2012 - 2015
 
- Defining the role of the chemokine CXCL10 in determining traversal across the blood-brain barrier in experimental and human African trypanosomiasis
 Wellcome Trust
 2011 - 2014
 
- In vivo imaging models of African trypanosomiasis to support drug discovery programmes.
 Bill and Melinda Gates Foundation
 2010 - 2013
 
- Defining the therapeutic role of IL-10 in African trypanosomiasis.
 Wellcome Trust
 2008 - 2011
 
- Combination chemotherapy of human African trypanosomiasis - the potential of drug synergism and the blood-brain barrier
 Medical Research Council
 2007 - 2010
 
- Production of DNA vaccine prototypes and the study of the humoral and cellular response following immunisation with the candidate DNA vaccines.
 Fundacao para a Cienca e Technologia
 2007 - 2010
 
Research datasets
2020
Jallow, S., Raftery, A. , Bennet, E. , Rodgers, J. , Sutton, D. and Gummery, L. (2020) Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei spp. in equids in The Gambia. [Data Collection] (Unpublished)