Julia Isakova
email: j.isakova.1@research.gla.ac.uk
Research title: Developing RAMAN-based methodology to investigate cell glycosylation signatures
Research summary
Can rheumatoid arthritis diagnosis be made smarter and faster?
Due to its highly variable nature, 5-20% of rhematoid arthritis (RA) patients are considered difficult to treat, often showing poor responses to medication. My research focuses on synovial fibroblasts, which are responsible for maintaining joint health but become activated in RA, leading to local inflammation. This activation is linked to epigenetic changes and reductions in surface sialic acid (SA) levels, affecting cell signaling and inflammation. By studying the glycome of these cells and using Raman spectroscopy to detect changes in SA, I aim to discover how fibroblast activity correlates with different RA phenotypes, providing new insights for personalized treatment approaches.
Conferences
IRDG 232nd Sponsor Meeting – HORIBA
Project presetation
GLORI Symposium 2024
Conference poster
Teaching
Teaching Assistant
- MBChB PBL Facilitator
- MVLS Demonstrator
