2019

Keuss, M. J., Hjerpe, R., Hsia, O., Gourlay, R., Burchmore, R. , Trost, M. and Kurz, T. (2019) Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death. EMBO Journal, 38, e100024. (doi: 10.15252/embj.2018100024) (PMID:30804002) (PMCID:PMC6418418)

2018

Thomas, Y., Scott, D. C., Kristariyanto, Y. A., Rinehart, J., Clark, K., Cohen, P. and Kurz, T. (2018) The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. PLoS ONE, 13(6), e0199197. (doi: 10.1371/journal.pone.0199197) (PMID:29958295) (PMCID:PMC6025869)

2017

Murthy, M., Kurz, T. and O'Shaughnessy, K. M. (2017) WNK signalling pathways in blood pressure regulation. Cellular and Molecular Life Sciences, 74(7), pp. 1261-1280. (doi: 10.1007/s00018-016-2402-z) (PMID:27815594) (PMCID:PMC5346417)

2016

Schumacher, F.-R., Schubert, S., Hannus, M., Sönnichsen, B., Ittrich, C., Kreideweiss, S., Kurz, T. and Rippmann, J. F. (2016) RNAi screen for NRF2 inducers identifies targets that rescue primary lung epithelial cells from cigarette smoke induced radical stress. PLoS ONE, 11(11), e0166352. (doi: 10.1371/journal.pone.0166352) (PMID:27832175) (PMCID:PMC5104413)

Hjerpe, R. et al. (2016) UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome. Cell, 166(4), pp. 935-949. (doi: 10.1016/j.cell.2016.07.001) (PMID:27477512) (PMCID:PMC5003816)

Murthy, M., Kurz, T. and O'Shaughnessy, K. M. (2016) ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403‐459mutation. Physiological Reports, 4(13), e12850. (doi: 10.14814/phy2.12850) (PMID:27378813) (PMCID:PMC4945836)

Keuss, M. J., Thomas, Y., Mcarthur, R., Wood, N. T., Knebel, A. and Kurz, T. (2016) Characterisation of the mammalian family of DCN-type NEDD8 E3 ligases. Journal of Cell Science, 129(7), pp. 1441-1454. (doi: 10.1242/jcs.181784) (PMID:26906416)

2015

Schumacher, F.-R. et al. (2015) Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), pp. 1285-1306. (doi: 10.15252/emmm.201505444) (PMID:26286618) (PMCID:PMC4604684)

Meir, M. et al. (2015) The COP9 signalosome is vital for timely repair of DNA double-strand breaks. Nucleic Acids Research, 43(9), pp. 4517-4530. (doi: 10.1093/nar/gkv270) (PMID:25855810) (PMCID:PMC4482063)

Bett, J.S. et al. (2015) Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. Biochemical Journal, 466(3), pp. 489-498. (doi: 10.1042/BJ20141349) (PMID:25489924) (PMCID:PMC4353193)

2014

Schumacher, F.-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. and Kurz, T. (2014) Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation. Biochemical Journal, 460(2), pp. 237-246. (doi: 10.1042/BJ20140153) (PMID:24641320) (PMCID:PMC4019986)

2013

Ohta, A., Schumacher, F.-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. and Kurz, T. (2013) The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochemical Journal, 451(1), pp. 111-122. (doi: 10.1042/BJ20121903) (PMID:23387299) (PMCID:PMC3632089)

Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. and Kurz, T. (2013) CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Nature Communications, 4, 1641. (doi: 10.1038/ncomms2628) (PMID:23535662)

2012

Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. and Knebel, A. (2012) The Dac-tag, an affinity tag based on penicillin-binding protein 5. Analytical Biochemistry, 428(1), pp. 64-72. (doi: 10.1016/j.ab.2012.06.007) (PMID:22705378)

Hjerpe, R., Thomas, Y. and Kurz, T. (2012) NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway. Journal of Molecular Biology, 421(1), pp. 27-29. (doi: 10.1016/j.jmb.2012.05.013) (PMID:22608973)

Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. and Kurz, T. (2012) Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochemical Journal, 441(3), pp. 927-939. (doi: 10.1042/BJ20111671) (PMID:22004789) (PMCID:PMC3280039)

2011

Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T. , Boone, C., Deshaies, R. J. and Peter, M. (2011) The TFIIH subunit Tfb3 regulates cullin neddylation. Molecular Cell, 43(3), pp. 488-495. (doi: 10.1016/j.molcel.2011.05.032) (PMID:21816351) (PMCID:PMC3186349)

2010

Scott, D. C., Monda, J. K., Grace, C. R.R., Duda, D. M., Kriwacki, R. W., Kurz, T. and Schulman, B. A. (2010) A Dual E3 mechanism for Rub1 ligation to Cdc53. Molecular Cell, 39(5), pp. 784-796. (doi: 10.1016/j.molcel.2010.08.030) (PMID:20832729) (PMCID:PMC3001161)

2009

Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. and Peter, M. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO Journal, 28(24), pp. 3845-3856. (doi: 10.1038/emboj.2009.354) (PMID:19942853) (PMCID:PMC2797064)

Meyer-Schaller, N., Chou, Y.-C., Sumara, I., Martin, D. D.O., Kurz, T. , Katheder, N., Hofmann, K., Berthiaume, L. G., Sicheri, F. and Peter, M. (2009) The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proceedings of the National Academy of Sciences of the United States of America, 106(30), pp. 12365-12370. (doi: 10.1073/pnas.0812528106) (PMID:19617556) (PMCID:PMC2718329)

2008

Kurz, T. , Chou, Y.-C., Willems, A. R., Meyer-Schaller, N., Hecht, M.-L., Tyers, M., Peter, M. and Sicheri, F. (2008) Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Molecular Cell, 29(1), pp. 23-35. (doi: 10.1016/j.molcel.2007.12.012) (PMID:18206966)

2006

Luke, B., Versini, G., Jaquenoud, M., Zaidi, I. W., Kurz, T. , Pintard, L., Pasero, P. and Peter, M. (2006) The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites. Current Biology, 16(8), pp. 786-792. (doi: 10.1016/j.cub.2006.02.071) (PMID:16631586)

Bowerman, B. and Kurz, T. (2006) Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis. Development, 133(5), pp. 773-784. (doi: 10.1242/dev.02276) (PMID:16469970)

2005

Kurz, T. , Özlü, N., Rudolf, F., O'Rourke, S. M., Luke, B., Hofmann, K., Hyman, A. A., Bowerman, B. and Peter, M. (2005) The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature, 435(7046), pp. 1257-1261. (doi: 10.1038/nature03662) (PMID:15988528)

2003

Pintard, L. et al. (2003) The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature, 425(6955), pp. 311-316. (doi: 10.1038/nature01959) (PMID:13679921)

Pintard, L., Kurz, T. , Glaser, S., Willis, J. H., Peter, M. and Bowerman, B. (2003) Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Current Biology, 13(11), pp. 911-921. (doi: 10.1016/S0960-9822(03)00336-1) (PMID:12781129)

2002

Kurz, T. , Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M. and Bowerman, B. (2002) Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science, 295(5558), pp. 1294-1298. (doi: 10.1126/science.1067765) (PMID:11847342)

Articles

Keuss, M. J., Hjerpe, R., Hsia, O., Gourlay, R., Burchmore, R. , Trost, M. and Kurz, T. (2019) Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death. EMBO Journal, 38, e100024. (doi: 10.15252/embj.2018100024) (PMID:30804002) (PMCID:PMC6418418)

Thomas, Y., Scott, D. C., Kristariyanto, Y. A., Rinehart, J., Clark, K., Cohen, P. and Kurz, T. (2018) The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. PLoS ONE, 13(6), e0199197. (doi: 10.1371/journal.pone.0199197) (PMID:29958295) (PMCID:PMC6025869)

Murthy, M., Kurz, T. and O'Shaughnessy, K. M. (2017) WNK signalling pathways in blood pressure regulation. Cellular and Molecular Life Sciences, 74(7), pp. 1261-1280. (doi: 10.1007/s00018-016-2402-z) (PMID:27815594) (PMCID:PMC5346417)

Schumacher, F.-R., Schubert, S., Hannus, M., Sönnichsen, B., Ittrich, C., Kreideweiss, S., Kurz, T. and Rippmann, J. F. (2016) RNAi screen for NRF2 inducers identifies targets that rescue primary lung epithelial cells from cigarette smoke induced radical stress. PLoS ONE, 11(11), e0166352. (doi: 10.1371/journal.pone.0166352) (PMID:27832175) (PMCID:PMC5104413)

Hjerpe, R. et al. (2016) UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome. Cell, 166(4), pp. 935-949. (doi: 10.1016/j.cell.2016.07.001) (PMID:27477512) (PMCID:PMC5003816)

Murthy, M., Kurz, T. and O'Shaughnessy, K. M. (2016) ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403‐459mutation. Physiological Reports, 4(13), e12850. (doi: 10.14814/phy2.12850) (PMID:27378813) (PMCID:PMC4945836)

Keuss, M. J., Thomas, Y., Mcarthur, R., Wood, N. T., Knebel, A. and Kurz, T. (2016) Characterisation of the mammalian family of DCN-type NEDD8 E3 ligases. Journal of Cell Science, 129(7), pp. 1441-1454. (doi: 10.1242/jcs.181784) (PMID:26906416)

Schumacher, F.-R. et al. (2015) Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Molecular Medicine, 7(10), pp. 1285-1306. (doi: 10.15252/emmm.201505444) (PMID:26286618) (PMCID:PMC4604684)

Meir, M. et al. (2015) The COP9 signalosome is vital for timely repair of DNA double-strand breaks. Nucleic Acids Research, 43(9), pp. 4517-4530. (doi: 10.1093/nar/gkv270) (PMID:25855810) (PMCID:PMC4482063)

Bett, J.S. et al. (2015) Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. Biochemical Journal, 466(3), pp. 489-498. (doi: 10.1042/BJ20141349) (PMID:25489924) (PMCID:PMC4353193)

Schumacher, F.-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. and Kurz, T. (2014) Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation. Biochemical Journal, 460(2), pp. 237-246. (doi: 10.1042/BJ20140153) (PMID:24641320) (PMCID:PMC4019986)

Ohta, A., Schumacher, F.-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. and Kurz, T. (2013) The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochemical Journal, 451(1), pp. 111-122. (doi: 10.1042/BJ20121903) (PMID:23387299) (PMCID:PMC3632089)

Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. and Kurz, T. (2013) CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Nature Communications, 4, 1641. (doi: 10.1038/ncomms2628) (PMID:23535662)

Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. and Knebel, A. (2012) The Dac-tag, an affinity tag based on penicillin-binding protein 5. Analytical Biochemistry, 428(1), pp. 64-72. (doi: 10.1016/j.ab.2012.06.007) (PMID:22705378)

Hjerpe, R., Thomas, Y. and Kurz, T. (2012) NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway. Journal of Molecular Biology, 421(1), pp. 27-29. (doi: 10.1016/j.jmb.2012.05.013) (PMID:22608973)

Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. and Kurz, T. (2012) Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochemical Journal, 441(3), pp. 927-939. (doi: 10.1042/BJ20111671) (PMID:22004789) (PMCID:PMC3280039)

Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T. , Boone, C., Deshaies, R. J. and Peter, M. (2011) The TFIIH subunit Tfb3 regulates cullin neddylation. Molecular Cell, 43(3), pp. 488-495. (doi: 10.1016/j.molcel.2011.05.032) (PMID:21816351) (PMCID:PMC3186349)

Scott, D. C., Monda, J. K., Grace, C. R.R., Duda, D. M., Kriwacki, R. W., Kurz, T. and Schulman, B. A. (2010) A Dual E3 mechanism for Rub1 ligation to Cdc53. Molecular Cell, 39(5), pp. 784-796. (doi: 10.1016/j.molcel.2010.08.030) (PMID:20832729) (PMCID:PMC3001161)

Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. and Peter, M. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO Journal, 28(24), pp. 3845-3856. (doi: 10.1038/emboj.2009.354) (PMID:19942853) (PMCID:PMC2797064)

Meyer-Schaller, N., Chou, Y.-C., Sumara, I., Martin, D. D.O., Kurz, T. , Katheder, N., Hofmann, K., Berthiaume, L. G., Sicheri, F. and Peter, M. (2009) The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proceedings of the National Academy of Sciences of the United States of America, 106(30), pp. 12365-12370. (doi: 10.1073/pnas.0812528106) (PMID:19617556) (PMCID:PMC2718329)

Kurz, T. , Chou, Y.-C., Willems, A. R., Meyer-Schaller, N., Hecht, M.-L., Tyers, M., Peter, M. and Sicheri, F. (2008) Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Molecular Cell, 29(1), pp. 23-35. (doi: 10.1016/j.molcel.2007.12.012) (PMID:18206966)

Luke, B., Versini, G., Jaquenoud, M., Zaidi, I. W., Kurz, T. , Pintard, L., Pasero, P. and Peter, M. (2006) The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites. Current Biology, 16(8), pp. 786-792. (doi: 10.1016/j.cub.2006.02.071) (PMID:16631586)

Bowerman, B. and Kurz, T. (2006) Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis. Development, 133(5), pp. 773-784. (doi: 10.1242/dev.02276) (PMID:16469970)

Kurz, T. , Özlü, N., Rudolf, F., O'Rourke, S. M., Luke, B., Hofmann, K., Hyman, A. A., Bowerman, B. and Peter, M. (2005) The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature, 435(7046), pp. 1257-1261. (doi: 10.1038/nature03662) (PMID:15988528)

Pintard, L. et al. (2003) The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature, 425(6955), pp. 311-316. (doi: 10.1038/nature01959) (PMID:13679921)

Pintard, L., Kurz, T. , Glaser, S., Willis, J. H., Peter, M. and Bowerman, B. (2003) Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Current Biology, 13(11), pp. 911-921. (doi: 10.1016/S0960-9822(03)00336-1) (PMID:12781129)

Kurz, T. , Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M. and Bowerman, B. (2002) Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science, 295(5558), pp. 1294-1298. (doi: 10.1126/science.1067765) (PMID:11847342)