Dr Mark Bailey

  • Senior Lecturer (Molecular Biosciences)
  • Associate (School of Health & Wellbeing)

telephone: 01413305994
email: Mark.Bailey@glasgow.ac.uk

R425 Level 4, School of Molecular Biosciences, Davidson Building, Glasgow G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-9788-2278

Biography

Current research by my group focuses on two main areas:

  • Molecular genetics / gene&molecular therapy for disorders of the brain/sensory systems
  • Genetics of normal human traits and their relation to complex disease risk

Additional recent research areas:

  • Genetics of aspen and other native tree species, diversity and conservation
  • The role of meme-gene co-evolution and selection on ‘reputation’ in human brain evolution

Currently less active research interests include:

  • Molecular genetics of idiopathic epilepsy
  • Molecular biology of neuronal regeneration
  • Evolution of gene families involved in brain function and development

Molecular Genetics

We are studying single gene disorders of the brain - Rett syndrome and DDX3X syndrome - and a disorder of the inner ear and brain - Ménière disease.

Rett Syndrome (RTT)

Rett Syndrome is a severe disorder of the brain that affects only girls, leaving them with severe dyspraxia, motor disabilities and possibly cognitive disabilities lifelong, as well as related health problems. It is caused in most cases by sporadic mutations in MECP2, a gene that encodes a protein that participates in epigenetic regulation of genome function and gene expression. My initial studies were in the molecular genetics of RTT and the relationship between genotype (what mutation is carried, and in what gene?) and phenotype (what are the clinical signs and natural history of the disorder in the individual patient?). More recently, I also participated in work to redefine the diagnostic criteria and terminology for RTT as part of the ‘RettSearch’ consortium. This work has been published in a number of papers – Xiang et al., 2000; Jian et al., 2005; Charman et al., 2005; Knudsen et al., 2006; Archer et al., 2007; Neul et al., 2010.

More recently, in collaboration with Dr Stuart Cobb here in Glasgow, we have become interested in the pathway from genotype to phenotype in RTT (how the downstream events in the causal pathway leading to the clinical disorder come to disrupt neuronal functioning and network behavior) and in prospects for novel therapeutic avenues in tackling this disorder. This stems from the seminal paper in 2007 from Prof. Adrian Bird and Dr Cobb, in which they showed that restoration of a normal Mecp2 gene to most brain cells in a mouse knockout (KO) model of RTT could ameliorate and reverse the phenotype. This suggests that RTT may be both reversible after onset and preventable prior to onset (with implications for whether RTT should be considered a neurodevelopmental disorder in the traditional sense). We have demonstrated a number of aspects of the Mecp2 KO mouse phenotype at molecular, cellular, physiological and whole animal phenotypic levels. We have preliminary data to show that almost all measureable aspects of the RTT-like phenotype in the KO mouse are likely to stem from effects of MeCP2 loss of function in the brain, rather than in the periphery (with a few exceptions).

We are also actively developing a gene therapy approach to tackling RTT. We have reviewed the prospects for development of novel therapeutic avenues in RTT from the viewpoint of its unexpected reversibility. We also demonstrated for the first time, in collaboration with Dr Steve Gray (Univ. of North Carolina), that a gene therapy approach, delivering an exogenously derived MECP2 gene via a viral vector, could lead to substantial amelioration of the phenotype in the KO mouse. We are currently funded to carry out projects aimed at optimising delivery vectors and routes – the longer-term objective is to translate this gene augmentation therapy approach for use in humans, and help prepare the ground for clinical trials in patients in due course. My own contribution to this research is reflected in a number of publications from our joint group – Weng et al., 2011; Gadalla et al., 2013; Gadalla et al., 2013; a number of additional papers are in prep.

Most recently, I initiated a project to examine prospects for using a genome editing approach to treat RTT. We are examining whether TALEN or CRISPR/Cas9 reagents can be employed in an approach that targets and repairs specific mutations causing RTT. In collaboration with Dr Adam West and also here at the University of Glasgow, we are developing other novel approaches using genome editing to effect the restoration of functional MeCP2 expression within neurons.

A fuller account of the collaborative work we are doing on RTT here in Glasgow is given at the Cobb group website.

Ménière disease (MD)

Ménière disease affects about 1/2000 people, mostly sporadically, and generally manifests as disorienting and incapacitating episodes of vertigo, tinnitus and hearing loss. We are working with Mr Gavin Morrison, whose father, Andrew, collected a unique set of rarely identified, multiply-affected Ménière families. We have mapped a gene predisposing to familial MD in these families (in prep) and are currently trying to identify the genetic lesion underlying the disease. We are also planning, in collaboration with Jessica Tyrrell and a number of clinicians around the UK, a larger study aimed at identifying predisposing gene variants in patients with sporadic MD. Our published work so far has concentrated on the pattern of inheritance and clinical characteristics in the familial MD cases – Morrison et al., 2009.

Both these project areas will contribute to our understanding of important disorders at the molecular and genetic level, and to knowledge of the genetic disease burden in the UK population.

Genetics of normal traits and disease risk

Over several years now, I have collaborated with Dr Jason Gill (Institute of Cardiovascular & Medical Sciences, MVLS), and with Dr Yannis Pitsiladis (was in Institute of Cardiovascular & Medical Sciences, MVLS; now Univ. of Brighton) and Dr Richard Wilson (now retired, MVLS) to investigate the effect that genes have on body composition, on sporting performance phenotypes and on diabetes risk factor levels in the normal population. We have focused particularly on the interaction of such genes with environmental factors. We are interested particularly in the genes influencing adiposity/obesity and how their influence is modulated by dietary factors and exercise in children, adolescents and adults. Thus far, our analyses have helped to provide an understanding of the roles of such genes as FTO/IRX3, ACE, ADRB2 and ACTN3 in influencing adiposity and performance in the context of different environmental exposures, and further work is planned with other genes and other population samples.

In a study carried out in collaboration with Dr Gill, together with a former PhD student, Dr Carlos Celis Morales and colleagues in Chile, we found that people of different ethnic origins in Chile (the Mapuche, a native Chilean people, and Chileans of European origin) have different risk factor profiles in different environments and we observed profiles associated with type 2 diabetes risk to a much greater extent in Mapuche living a Westernised lifestyle, particularly in those doing less daily exercise. We have also shown that genetic variants with limited influence on diabetes risk factors in Europeans have a much greater influence in the Mapuche, again contingent on levels of daily exercise (in prep). This suggests that there are ethnic differences in the actions of some gene variants contributing to disease risk – we are going on to investigate the possible causes of such differences.

My own contribution to this research is reflected in a number of publications from our groups – Moran et al., 2005/2006/2007; Lagou et al., 2007; Scott et al., 2010; Wilson et al., 2010; Koni et al., 2011; Celis Morales et al., 2011/2012/2013; Giangagna et al., 2013, Wang et al., 2013.

Meme-gene co-evolution and human brain evolution

I have an interest in the process by which the human brain came to be the way it is during the last phase of human evolution since approximately 1 million years ago. The most striking changes during this period involved a massive increase in brain size and the evolution of language capabilities. My research question focuses round the reasons for these changes – why were a very large brain and language of use to early humans, or, rather, in service of what did these capacities evolve? A significant part of the answer may lie in the role played by memes in governing what was and was not useful in the social domain – via gossip, competition, performance, religious practices, etc., and the new facet of human existence that went with the communication facility provided by spoken language – reputation.

Other areas of research

Neuronal regeneration

In collaboration with Dr John Riddell, Institute of Neuroscience & Psychology, MVLS, we have investigated the molecular events underlying successful and failed, or blocked, regeneration of peripheral sensory neurons after injury using a transcriptomics (microarray) approach.

Genetics of idiopathic epilepsy

The term idiopathic epilepsy covers a number of different syndromes in which repeated, spontaneous seizures are exhibited. IE is complex and complicated - more than one gene can predispose to the same epilepsy subtype, and genes that predispose to more than one epilepsy subtype exist, leading to the clustering of complex mixtures of epilepsies within families. We have worked on the identification of genes that cause predisposition to various IE subtypes, either in families or sporadic cases, including idiopathic generalised epilepsy (IGE), juvenile myoclonic epilepsy (JME), generalised epilepsy with febrile seizures plus other seizures ('GEFS+') and 'unclassified' epilepsies. This work has involved collaborations with clinicians including Dr Sameer Zuberi (Royal Hospital for Sick Children, Glasgow) and Prof Martin Brodie and Dr Graeme Sills (Western Infirmary, Glasgow).

Evolution of gene families involved in brain function and development

We have studied the evolution of brain gene families, particularly the family that encodes the subunits of the type A receptor for the neurotransmitter, GABA (GABAA receptors), and what the phylogenomics of such families can tell us about the history of genome evolution in chordates - in particular whether there is evidence for a series of genome duplications early in chordate evolution that can help explain the dominance of this group and the extreme importance of the brain in vertebrates. This has involved gene cloning and bioinformatic/phylogenomic/phylogenetic approaches to investigate when any possible expansions in gene number occurred and their implications. There is also the hope that an understanding of the evolutionary relationships between gene family members will help us in the analysis and prediction of their functional attributes. This information might one day be used in the rational design of new drugs for conditions such as epilepsy, anxiety and many others.

Research interests

Research Interests

Human genetics and molecular genetics: mapping and identification of disease genes in Mendelian and complex disorders; molecular pathology and gene therapy of human genetic disorders; Rett syndrome; Psychiatric disorders and psychological traits; Type 2 diabetes/obesity/body composition/performance; Ménière disease; gene family evolution; meme-gene co-evolution; evolution of the human brain.


Please view further information about our current research.

Research groups

Publications

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Number of items: 76.

2024

Daudali, Hamza, Anderson, Jana ORCID logoORCID: https://orcid.org/0000-0001-7290-6635, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Fradera, Alexander ORCID logoORCID: https://orcid.org/0000-0003-4103-6299, Niedzwiedz, Claire L. ORCID logoORCID: https://orcid.org/0000-0001-6133-4168, Lyall, Donald ORCID logoORCID: https://orcid.org/0000-0003-3850-1487, Lyall, Laura M. and Strawbridge, Rona J. ORCID logoORCID: https://orcid.org/0000-0001-8506-3585 (2024) Genetic variation in circadian regulator gene BMAL1 in psychiatric, psychological and cardiometabolic traits: a trans-ancestry UK Biobank study. BMJ Mental Health, 27(1), e301267. (doi: 10.1136/bmjment-2024-301267) (PMID:39667926) (PMCID:PMC11647332)

2023

Ward, J. et al. (2023) Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts. Scientific Reports, 13, 17262. (doi: 10.1038/s41598-023-43193-9) (PMID:37828061) (PMCID:PMC10570373)

Cullen, B. et al. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80(6), pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716) (PMID:37074691) (PMCID:PMC10116387)

2022

Tank, Rachana, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Flegal, Kristin E. ORCID logoORCID: https://orcid.org/0000-0001-9773-9554, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Cavanagh, Jonathan ORCID logoORCID: https://orcid.org/0000-0003-0640-8050 and Lyall, Donald M. ORCID logoORCID: https://orcid.org/0000-0003-3850-1487 (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47(2), pp. 564-569. (doi: 10.1038/s41386-021-01190-4) (PMID:34621014) (PMCID:PMC8674313)

Lyall, Donald M. ORCID logoORCID: https://orcid.org/0000-0003-3850-1487, Quinn, Terry ORCID logoORCID: https://orcid.org/0000-0003-1401-0181, Lyall, Laura M., Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Anderson, Jana J. ORCID logoORCID: https://orcid.org/0000-0001-7290-6635, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951, Stewart, William ORCID logoORCID: https://orcid.org/0000-0003-2199-2582, Strawbridge, Rona J. ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cullen, Breda ORCID logoORCID: https://orcid.org/0000-0002-7259-9505 (2022) Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. Brain Communications, 4(3), fcac119. (doi: 10.1093/braincomms/fcac119) (PMID:35651593) (PMCID:PMC9150072)

2021

Rendón-Anaya, M. et al. (2021) Adaptive introgression facilitates adaptation to high latitudes in European aspen (Populus tremula L.). Molecular Biology and Evolution, 38(11), pp. 5034-5050. (doi: 10.1093/molbev/msab229) (PMID:34329481) (PMCID:PMC8557470)

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Johnston, K. J.A. et al. (2021) Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank. PLoS Genetics, 17(4), e1009428. (doi: 10.1371/journal.pgen.1009428) (PMID:33830993) (PMCID:PMC8031124)

Strawbridge, R. J. et al. (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Scientific Reports, 11, 632. (doi: 10.1038/s41598-020-79964-x) (PMID:33436761) (PMCID:PMC7804422)

2020

Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)

Mähler, Niklas, Schiffthaler, Bastian, Robinson, Kathryn M., Terebieniec, Barbara K., Vučak, Matej, Mannapperuma, Chanaka, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Jansson, Stefan, Hvidsten, Torgeir R. and Street, Nathaniel R. (2020) Leaf shape in Populus tremula is a complex, omnigenic trait. Ecology and Evolution, 10(21), pp. 11922-11940. (doi: 10.1002/ece3.6691)

Ward, J. et al. (2020) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, 25(11), pp. 3091-3099. (doi: 10.1038/s41380-019-0439-8) (PMID:31168069) (PMCID:PMC7116257)

Strawbridge, R. J. et al. (2020) Carotid intima-media thickness: novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2), pp. 446-461. (doi: 10.1161/ATVBAHA.119.313226) (PMID:31801372) (PMCID:PMC6975521)

2019

Ward, J. et al. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Translational Psychiatry, 9, 327. (doi: 10.1038/s41398-019-0635-y) (PMID:31797917) (PMCID:PMC6892870)

Johnston, Keira J.A., Adams, Mark J., Nicholl, Barbara I. ORCID logoORCID: https://orcid.org/0000-0001-5639-0130, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Strawbridge, Rona ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, McIntosh, Andrew, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951 and Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (2019) Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5. Translational Psychiatry, 9, 310. (doi: 10.1038/s41398-019-0613-4) (PMID:31748543) (PMCID:PMC6868167)

Gray, S. et al. (2019) Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study. International Journal of Obesity, 43, pp. 1526-1538. (doi: 10.1038/s41366-019-0381-5) (PMID:31168053)

Johnston, Keira J.A., Adams, Mark J., Nicholl, Barbara I. ORCID logoORCID: https://orcid.org/0000-0001-5639-0130, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Strawbridge, Rona ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, Ferguson, Amy, McIntosh, Andrew, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951 (2019) Genome-wide association study of multisite chronic pain in UK Biobank. PLoS Genetics, 15(6), e1008164. (doi: 10.1371/journal.pgen.1008164) (PMID:31194737) (PMCID:PMC6592570)

Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi: 10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)

Celis-Morales, C. A. et al. (2019) The combination of physical activity and sedentary behaviors modifies the genetic predisposition to obesity. Obesity, 27(4), pp. 653-661. (doi: 10.1002/oby.22417) (PMID:30900409)

Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi: 10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)

2018

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi: 10.1080/07853890.2018.1472389) (PMID:29724143)

Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)

Boakye, D., Wyse, C.A., Morales-Celis, C.A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Biello, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3497-5215, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Dare, S., Ward, J. ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Gill, J.M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986, Pell, J.P. ORCID logoORCID: https://orcid.org/0000-0002-8898-7035 and Mackay, D.F. ORCID logoORCID: https://orcid.org/0000-0001-5381-7098 (2018) Tobacco exposure and sleep disturbance in 498 208 UK Biobank participants. Journal of Public Health, 40(3), pp. 517-526. (doi: 10.1093/pubmed/fdx102) (PMID:29040744) (PMCID:PMC6166587)

Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)

Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi: 10.1016/S2215-0366(18)30139-1) (PMID:29776774)

Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi: 10.1016/j.jad.2017.12.106) (PMID:29329063)

Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)

2017

Hector, R. D. et al. (2017) CDKL5 variants: improving our understanding of a rare neurological disorder. Neurology Genetics, 3(6), e200. (doi: 10.1212/NXG.0000000000000200) (PMID:29264392) (PMCID:PMC5732004)

Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)

Bahey, Noha G., Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Edgar, Julia M. ORCID logoORCID: https://orcid.org/0000-0002-3869-0962 and Cobb, Stuart R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)

Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Vudhironarit, Thishnapha, Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Sinnett, Sarah, Bahey, Noha G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Gray, Steven J. and Cobb, Stuart R. (2017) Development of a novel AAV gene therapy cassette with improved safety features and efficacy in a mouse model of Rett syndrome. Molecular Therapy: Methods and Clinical Development, 5, pp. 180-190. (doi: 10.1016/j.omtm.2017.04.007) (PMID:28497075) (PMCID:PMC5423329)

Sinnett, Sarah E., Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Heindel, Clifford, Chen, Daphne, Zaric, Violeta, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Cobb, Stuart R. and Gray, Steven J. (2017) Improved MECP2 gene therapy extends the survival of MeCP2-null mice without apparent toxicity after intracisternal delivery. Molecular Therapy: Methods and Clinical Development, 5, pp. 106-115. (doi: 10.1016/j.omtm.2017.04.006) (PMID:28497072) (PMCID:PMC5424572)

Celis-Morales, C. et al. (2017) Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants. American Journal of Clinical Nutrition, 105(4), pp. 980-990. (doi: 10.3945/ajcn.116.147231)

Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Dando, Owen, Ritakari, Tuula E., Kind, Peter C., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2017) Characterisation of Cdkl5 transcript isoforms in rat. Gene, 603, pp. 21-26. (doi: 10.1016/j.gene.2016.12.001) (PMID:27940108)

Gianfagna, F. et al. (2017) The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort. PLoS ONE, 12(2), e0172698. (doi: 10.1371/journal.pone.0172698) (PMID:28235053) (PMCID:PMC5325300)

Celis-Morales, C. et al. (2017) Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. International Journal of Obesity, 41, pp. 1761-1768. (doi: 10.1038/ijo.2017.169) (PMID:28736445)

Wyse, C. A. et al. (2017) Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank. Annals of Medicine, 49(5), pp. 411-420. (doi: 10.1080/07853890.2017.1292045) (PMID:28166415)

2016

Ross, P. D. et al. (2016) Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. Human Molecular Genetics, 25(20), pp. 4389-4404. (doi: 10.1093/hmg/ddw269) (PMID:28173151) (PMCID:PMC5886038)

Shone, Kate, Innes, Aidan, Kilikevicius, Audrius, Statkeviciene, Birute, Stasiulis, Arvydas, Mamkus, Gediminas, Malkova, Dalia ORCID logoORCID: https://orcid.org/0000-0002-8085-0528, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Venckunas, Tomas and Moran, Colin N. (2016) P-87 Acvr1b rs2854464 is Associated with Quantitative Measures of Strength/Power in Lithuanian Athletes and Controls. 34th FIMS World Sports Medicine Congress, Ljubljana, Slovenia, 29 September - 2 October 2016. (doi: 10.1136/bjsports-2016-097120.140)

Lyall, D. M. et al. (2016) Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants. Age and Ageing, 45(4), pp. 511-517. (doi: 10.1093/ageing/afw068) (PMID:27103599)

Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Dando, Owen, Landsberger, Nicola, Kilstrup-Nielsen, Charlotte, Kind, Peter C., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2016) Characterisation of CDKL5 transcript isoforms in human and mouse. PLoS ONE, 11(6), e0157758. (doi: 10.1371/journal.pone.0157758) (PMID:27315173) (PMCID:PMC4912119)

Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi: 10.1038/mp.2016.49) (PMID:27067015)

2015

Qi, Q. et al. (2015) Dietary intake, FTOGenetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents. Diabetes, 64(7), pp. 2467-2476. (doi: 10.2337/db14-1629) (PMID:25720386)

Gadalla, Kamal K. E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Ross, Paul D., Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Bahey, Noha G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2015) Gene therapy for Rett syndrome: prospects and challenges. Future Neurology, 10(5), pp. 467-484. (doi: 10.2217/fnl.15.29)

Wardle, Sophie L., Bailey, Mark E. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Kilikevicius, Audrius, Malkova, Dalia ORCID logoORCID: https://orcid.org/0000-0002-8085-0528, Wilson, Richard H. ORCID logoORCID: https://orcid.org/0000-0001-8018-7730, Venckunas, Tomas and Moran, Colin (2015) Plasma microRNA levels differ between endurance and strength athletes. PLoS ONE, 10(4), e0122107. (doi: 10.1371/journal.pone.0122107) (PMID:25881132) (PMCID:PMC4400105)

2014

Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Ross, Paul D., Riddell, John S. ORCID logoORCID: https://orcid.org/0000-0001-6366-6545, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2014) Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits. PLoS ONE, 9(11), e112889. (doi: 10.1371/journal.pone.0112889) (PMID:25392929) (PMCID:PMC4231076)

2013

Wang, G. et al. (2013) Association analysis of ACE and ACTN3 in elite caucasian and east Asian swimmers. Medicine and Science in Sports and Exercise, 45(5), pp. 892-900. (doi: 10.1249/MSS.0b013e31827c501f)

Gadalla, K.K.E. et al. (2013) Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice. Molecular Therapy, 21(1), pp. 18-30. (doi: 10.1038/mt.2012.200) (PMID:23011033) (PMCID:PMC3536818)

Celis-Morales, Carlos A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Ghouri, Nazim ORCID logoORCID: https://orcid.org/0000-0002-8263-2591, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Sattar, Naveed ORCID logoORCID: https://orcid.org/0000-0002-1604-2593 and Gill, Jason M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2013) Should physical activity recommendations be ethnicity-specific? Evidence from a cross-sectional study of south Asian and European men. PLoS ONE, 8(12), e82568. (doi: 10.1371/journal.pone.0082568) (PMID:24349313) (PMCID:PMC3859604)

Gianfagna, F. et al. (2013) Understanding the links among neuromedin U Gene, beta2-adrenoceptor gene and bone health: an observational study in European children. PLoS ONE, 8(8), e70632. (doi: 10.1371/journal.pone.0070632) (PMID:23936460) (PMCID:PMC3731254)

2012

Celis-Morales, Carlos A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Perez-Bravo, Francisco, Ibanez, Luis, Salas, Carlos, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Gill, Jason M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2012) Objective vs. self-reported physical activity and sedentary time: effects of measurement method on relationships with risk biomarkers. PLoS ONE, 7(5), e36345. (doi: 10.1371/journal.pone.0036345) (PMID:22590532) (PMCID:PMC3348936)

2011

Weng, Shih-Ming, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2011) Rett syndrome: from bed to bench. Pediatrics and Neonatology, 52(6), pp. 309-316. (doi: 10.1016/j.pedneo.2011.08.002)

Gadalla, K.K.E., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, S.R. (2011) MeCP2 and Rett syndrome: reversibility and potential avenues for therapy. Biochemical Journal, 439(1), pp. 1-14. (doi: 10.1042/BJ20110648)

Weng, S.-M., McLeod, F., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, S.R. (2011) Synaptic plasticity deficits in an experimental model of Rett Syndrome: LTP saturation and its pharmacological reversal. Neuroscience, 180, pp. 314-321. (doi: 10.1016/j.neuroscience.2011.01.061)

Koni, A.C., Scott, R.A., Wang, G., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Peplies, J., Bammann, K. and Pitsiladis, Y.P. (2011) DNA yield and quality of saliva samples and suitability for large scale epidemiological studies in children. International Journal of Obesity, 35(Suppl.), S113-S118.

Celis-Morales, C.A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Perez-Bravo, F., Ibañes, L., Sanzana, R., Hormazabal, E., Ulloa, N., Calvo, C., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Gill, J.M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2011) Insulin resistance in Chileans of European and indigenous descent: evidence for an ethnicity x environment interaction. PLoS ONE, 6(9), e24690. (doi: 10.1371/journal.pone.0024690) (PMID:21931814) (PMCID:PMC3169638)

2010

Wilson, R.H., Moran, C.N., Cole, John, Pitsiladis, Y.P. and Bailey, M.E.S. (2010) Evolutionary history of the ADRB2 gene in humans. American Journal of Human Genetics, 86(3), pp. 490-493. (doi: 10.1016/j.ajhg.2010.01.031) (PMID:20215008) (PMCID:PMC2833374)

Neul, J.L. et al. (2010) Rett Syndrome: Revised diagnostic criteria and nomenclature. Annals of Neurology, 68(6), pp. 944-950. (doi: 10.1002/ana.22124)

Scott, R.A. et al. (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. European Journal of Human Genetics, 18(12), pp. 1339-1343. (doi: 10.1038/ejhg.2010.131) (PMID:20717169) (PMCID:PMC3002848)

2009

Todd, Andrew J. ORCID logoORCID: https://orcid.org/0000-0002-3007-6749, Polgár, Erika, Watt, Christine, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Watanabe, Masahiko (2009) Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits. European Journal of Neuroscience, 29(4), pp. 718-726. (doi: 10.1111/j.1460-9568.2009.06633.x) (PMID:19200070) (PMCID:PMC2695158)

Morrison, A W, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Morrison, G A J (2009) Familial Ménière's disease: clinical and genetic aspects. Journal of Laryngology and Otology, 123(01), pp. 29-37. (doi: 10.1017/S0022215108002788)

2007

Archer, H. et al. (2007) Correlation between clinical severity in patients with Rett Syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation. Journal of Medical Genetics, 44, pp. 148-152. (doi: 10.1136/jmg.2006.045260)

Lagou, V, Manios, Y, Moran, CN, Bailey, MES, Grammatikaki, E, Oikonomou, E, Ioannou, E, Moschonis, G, Wilson, RH and Pitsiladis, YP (2007) Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism. International Journal of Obesity, 31, pp. 1052-1060. (doi: 10.1038/sj.ijo.0803605)

Moran, CN, Yang, N, Bailey, MES, Tsiokanos, A, Jamurtas, A, MacArthur, DG, North, K, Pitsiladis, YP and Wilson, RH (2007) Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. European Journal of Human Genetics, 15, pp. 88-93. (doi: 10.1038/sj.ejhg.5201724)

2006

Knudsen, GPS, Neilson, TCS, Pedersen, J, Kerr, A, Schwartz, M, Hulten, M, Bailey, MES and Orstavik, KH (2006) Increased skewing of X chromosome inactivation in Rett syndrome patients and their mothers. European Journal of Human Genetics, 14, pp. 1189-1194. (doi: 10.1038/sj.ejhg.5201682)

Moran, CN, Vassilopoulos, C, Tsiokanos, A, Jamurtas, AZ, Bailey, MES, Montgomery, HE, Wilson, RH and Pitsiladis, YP (2006) The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. European Journal of Human Genetics, 14, pp. 332-339.

2005

Charman, T. et al. (2005) Dimensional phenotypic analysis and functional categorisation of mutations reveal novel genotype-phenotype associations in Rett syndrome. European Journal of Human Genetics, 13, pp. 1121-1130. (doi: 10.1038/sj.ejhg.5201471) (PMID:16077736)

Jian, L, Archer, HL, Ravine, D, Kerr, A, de Klerk, N, Christodoulou, J, Bailey, ME, Laurvick, C and Leonard, H (2005) p.R270X MECP2 mutation and mortality in Rett syndrome. European Journal of Human Genetics, 13, pp. 1235-1238. (doi: 10.1038/sj.ejhg.5201479)

Moran, C.N., Vassilopoulos, C, Tsiokanos, A, Jamurtas, AZ, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Wilson, RH and Pitsiladis, YP (2005) Effects of interaction between angiotensin I-converting enzyme polymorphisms and lifestyle on adiposity in adolescent Greeks. Obesity Research, 13, pp. 1499-1504. (doi: 10.1038/oby.2005.181) (PMID:16222048)

2000

Boucher, Catherine A, Winchester, Catherine L, Hamilton, Graham M, Winter, Alan D, Johnson, Keith J and Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (2000) Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. Gene, 247(1-2), pp. 145-151. (doi: 10.1016/S0378-1119(00)00105-0) (PMID:10773454)

Xiang, Fengqing, Buervenich, Silvia, Nicolao, Piero, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Zhang, Zhiping and Anvret, Marie (2000) Mutation screening in Rett syndrome patients. Journal of Medical Genetics, 37(4), pp. 250-255. (doi: 10.1136/jmg.37.4.250) (PMID:10745042) (PMCID:PMC1734556)

1999

Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Albrecht, Barbara E., Johnson, Keith J. and Darlison, Mark G. (1999) Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1447(2-3), pp. 307-312. (doi: 10.1016/S0167-4781(99)00167-0)

Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Matthews, Deborah A., Riley, Brien P., Albrecht, Barbara E., Kostrzewa, Markus, Hicks, Andrew A., Harris, Robert, Müller, Ulrich, Darlison, Mark G. and Johnson, Keith J. (1999) Genomic mapping and evolution of human GABA A receptor subunit gene clusters. Mammalian Genome, 10(8), pp. 839-843. (doi: 10.1007/s003359901101) (PMID:10430673)

Moncrieff, Colin L., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Morrison, Norma and Johnson, Keith J. (1999) Cloning and chromosomal localization of human Cdc42-binding protein kinase β. Genomics, 57(2), pp. 297-300. (doi: 10.1006/geno.1999.5769)

1998

Burden, A. David, Hodgins, Malcolm, Tillman, David, Javed, Shaban, Connor, Michael and Bailey, Mark ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (1998) Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p. Journal of Investigative Dermatology, 110(6), pp. 958-960. (doi: 10.1046/j.1523-1747.1998.00213.x) (PMID:9620305)

1997

Crowe, Raymond R., Wang, Zhewu, Noyes, Russell, Albrecht, Barbara E., Darlison, Mark G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Johnson, Keith J. and Zoega, Tomas (1997) Candidate gene study of eight GABAA receptor subunits in panic disorder. American Journal of Psychiatry, 154(8), pp. 1096-1100. (doi: 10.1176/ajp.154.8.1096) (PMID:9247395)

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Number of items: 76.

Articles

Daudali, Hamza, Anderson, Jana ORCID logoORCID: https://orcid.org/0000-0001-7290-6635, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Fradera, Alexander ORCID logoORCID: https://orcid.org/0000-0003-4103-6299, Niedzwiedz, Claire L. ORCID logoORCID: https://orcid.org/0000-0001-6133-4168, Lyall, Donald ORCID logoORCID: https://orcid.org/0000-0003-3850-1487, Lyall, Laura M. and Strawbridge, Rona J. ORCID logoORCID: https://orcid.org/0000-0001-8506-3585 (2024) Genetic variation in circadian regulator gene BMAL1 in psychiatric, psychological and cardiometabolic traits: a trans-ancestry UK Biobank study. BMJ Mental Health, 27(1), e301267. (doi: 10.1136/bmjment-2024-301267) (PMID:39667926) (PMCID:PMC11647332)

Ward, J. et al. (2023) Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts. Scientific Reports, 13, 17262. (doi: 10.1038/s41598-023-43193-9) (PMID:37828061) (PMCID:PMC10570373)

Cullen, B. et al. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80(6), pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716) (PMID:37074691) (PMCID:PMC10116387)

Tank, Rachana, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Flegal, Kristin E. ORCID logoORCID: https://orcid.org/0000-0001-9773-9554, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Cavanagh, Jonathan ORCID logoORCID: https://orcid.org/0000-0003-0640-8050 and Lyall, Donald M. ORCID logoORCID: https://orcid.org/0000-0003-3850-1487 (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47(2), pp. 564-569. (doi: 10.1038/s41386-021-01190-4) (PMID:34621014) (PMCID:PMC8674313)

Lyall, Donald M. ORCID logoORCID: https://orcid.org/0000-0003-3850-1487, Quinn, Terry ORCID logoORCID: https://orcid.org/0000-0003-1401-0181, Lyall, Laura M., Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Anderson, Jana J. ORCID logoORCID: https://orcid.org/0000-0001-7290-6635, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951, Stewart, William ORCID logoORCID: https://orcid.org/0000-0003-2199-2582, Strawbridge, Rona J. ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cullen, Breda ORCID logoORCID: https://orcid.org/0000-0002-7259-9505 (2022) Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample. Brain Communications, 4(3), fcac119. (doi: 10.1093/braincomms/fcac119) (PMID:35651593) (PMCID:PMC9150072)

Rendón-Anaya, M. et al. (2021) Adaptive introgression facilitates adaptation to high latitudes in European aspen (Populus tremula L.). Molecular Biology and Evolution, 38(11), pp. 5034-5050. (doi: 10.1093/molbev/msab229) (PMID:34329481) (PMCID:PMC8557470)

Jani, B. D. et al. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4(4), e00283. (doi: 10.1002/edm2.283) (PMID:34505416) (PMCID:PMC8420405)

Johnston, K. J.A. et al. (2021) Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank. PLoS Genetics, 17(4), e1009428. (doi: 10.1371/journal.pgen.1009428) (PMID:33830993) (PMCID:PMC8031124)

Strawbridge, R. J. et al. (2021) The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Scientific Reports, 11, 632. (doi: 10.1038/s41598-020-79964-x) (PMID:33436761) (PMCID:PMC7804422)

Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)

Mähler, Niklas, Schiffthaler, Bastian, Robinson, Kathryn M., Terebieniec, Barbara K., Vučak, Matej, Mannapperuma, Chanaka, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Jansson, Stefan, Hvidsten, Torgeir R. and Street, Nathaniel R. (2020) Leaf shape in Populus tremula is a complex, omnigenic trait. Ecology and Evolution, 10(21), pp. 11922-11940. (doi: 10.1002/ece3.6691)

Ward, J. et al. (2020) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry, 25(11), pp. 3091-3099. (doi: 10.1038/s41380-019-0439-8) (PMID:31168069) (PMCID:PMC7116257)

Strawbridge, R. J. et al. (2020) Carotid intima-media thickness: novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2), pp. 446-461. (doi: 10.1161/ATVBAHA.119.313226) (PMID:31801372) (PMCID:PMC6975521)

Ward, J. et al. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Translational Psychiatry, 9, 327. (doi: 10.1038/s41398-019-0635-y) (PMID:31797917) (PMCID:PMC6892870)

Johnston, Keira J.A., Adams, Mark J., Nicholl, Barbara I. ORCID logoORCID: https://orcid.org/0000-0001-5639-0130, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Strawbridge, Rona ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, McIntosh, Andrew, Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951 and Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (2019) Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5. Translational Psychiatry, 9, 310. (doi: 10.1038/s41398-019-0613-4) (PMID:31748543) (PMCID:PMC6868167)

Gray, S. et al. (2019) Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study. International Journal of Obesity, 43, pp. 1526-1538. (doi: 10.1038/s41366-019-0381-5) (PMID:31168053)

Johnston, Keira J.A., Adams, Mark J., Nicholl, Barbara I. ORCID logoORCID: https://orcid.org/0000-0001-5639-0130, Ward, Joey ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Strawbridge, Rona ORCID logoORCID: https://orcid.org/0000-0001-8506-3585, Ferguson, Amy, McIntosh, Andrew, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Smith, Daniel J. ORCID logoORCID: https://orcid.org/0000-0002-2267-1951 (2019) Genome-wide association study of multisite chronic pain in UK Biobank. PLoS Genetics, 15(6), e1008164. (doi: 10.1371/journal.pgen.1008164) (PMID:31194737) (PMCID:PMC6592570)

Morris, J. et al. (2019) Genetic variation in CADM2 as a link between psychological traits and obesity. Scientific Reports, 9, 7339. (doi: 10.1038/s41598-019-43861-9) (PMID:31089183) (PMCID:PMC6517397)

Celis-Morales, C. A. et al. (2019) The combination of physical activity and sedentary behaviors modifies the genetic predisposition to obesity. Obesity, 27(4), pp. 653-661. (doi: 10.1002/oby.22417) (PMID:30900409)

Strawbridge, R. J. et al. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine, 41, pp. 517-525. (doi: 10.1016/j.ebiom.2019.02.005) (PMID:30745170) (PMCID:PMC6442001)

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi: 10.1080/07853890.2018.1472389) (PMID:29724143)

Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)

Boakye, D., Wyse, C.A., Morales-Celis, C.A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Biello, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3497-5215, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Dare, S., Ward, J. ORCID logoORCID: https://orcid.org/0000-0003-0951-8511, Gill, J.M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986, Pell, J.P. ORCID logoORCID: https://orcid.org/0000-0002-8898-7035 and Mackay, D.F. ORCID logoORCID: https://orcid.org/0000-0001-5381-7098 (2018) Tobacco exposure and sleep disturbance in 498 208 UK Biobank participants. Journal of Public Health, 40(3), pp. 517-526. (doi: 10.1093/pubmed/fdx102) (PMID:29040744) (PMCID:PMC6166587)

Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)

Lyall, L. M. et al. (2018) Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry, 5(6), pp. 507-514. (doi: 10.1016/S2215-0366(18)30139-1) (PMID:29776774)

Lyall, L. M. et al. (2018) Seasonality of depressive symptoms in women but not in men: a cross-sectional study in the UK Biobank cohort. Journal of Affective Disorders, 229, pp. 296-305. (doi: 10.1016/j.jad.2017.12.106) (PMID:29329063)

Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)

Hector, R. D. et al. (2017) CDKL5 variants: improving our understanding of a rare neurological disorder. Neurology Genetics, 3(6), e200. (doi: 10.1212/NXG.0000000000000200) (PMID:29264392) (PMCID:PMC5732004)

Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)

Bahey, Noha G., Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Edgar, Julia M. ORCID logoORCID: https://orcid.org/0000-0002-3869-0962 and Cobb, Stuart R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)

Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Vudhironarit, Thishnapha, Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Sinnett, Sarah, Bahey, Noha G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Gray, Steven J. and Cobb, Stuart R. (2017) Development of a novel AAV gene therapy cassette with improved safety features and efficacy in a mouse model of Rett syndrome. Molecular Therapy: Methods and Clinical Development, 5, pp. 180-190. (doi: 10.1016/j.omtm.2017.04.007) (PMID:28497075) (PMCID:PMC5423329)

Sinnett, Sarah E., Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Heindel, Clifford, Chen, Daphne, Zaric, Violeta, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Cobb, Stuart R. and Gray, Steven J. (2017) Improved MECP2 gene therapy extends the survival of MeCP2-null mice without apparent toxicity after intracisternal delivery. Molecular Therapy: Methods and Clinical Development, 5, pp. 106-115. (doi: 10.1016/j.omtm.2017.04.006) (PMID:28497072) (PMCID:PMC5424572)

Celis-Morales, C. et al. (2017) Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants. American Journal of Clinical Nutrition, 105(4), pp. 980-990. (doi: 10.3945/ajcn.116.147231)

Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Dando, Owen, Ritakari, Tuula E., Kind, Peter C., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2017) Characterisation of Cdkl5 transcript isoforms in rat. Gene, 603, pp. 21-26. (doi: 10.1016/j.gene.2016.12.001) (PMID:27940108)

Gianfagna, F. et al. (2017) The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort. PLoS ONE, 12(2), e0172698. (doi: 10.1371/journal.pone.0172698) (PMID:28235053) (PMCID:PMC5325300)

Celis-Morales, C. et al. (2017) Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants. International Journal of Obesity, 41, pp. 1761-1768. (doi: 10.1038/ijo.2017.169) (PMID:28736445)

Wyse, C. A. et al. (2017) Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank. Annals of Medicine, 49(5), pp. 411-420. (doi: 10.1080/07853890.2017.1292045) (PMID:28166415)

Ross, P. D. et al. (2016) Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. Human Molecular Genetics, 25(20), pp. 4389-4404. (doi: 10.1093/hmg/ddw269) (PMID:28173151) (PMCID:PMC5886038)

Lyall, D. M. et al. (2016) Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants. Age and Ageing, 45(4), pp. 511-517. (doi: 10.1093/ageing/afw068) (PMID:27103599)

Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Dando, Owen, Landsberger, Nicola, Kilstrup-Nielsen, Charlotte, Kind, Peter C., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2016) Characterisation of CDKL5 transcript isoforms in human and mouse. PLoS ONE, 11(6), e0157758. (doi: 10.1371/journal.pone.0157758) (PMID:27315173) (PMCID:PMC4912119)

Smith, D.J. et al. (2016) Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry, 21(6), pp. 749-757. (doi: 10.1038/mp.2016.49) (PMID:27067015)

Qi, Q. et al. (2015) Dietary intake, FTOGenetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents. Diabetes, 64(7), pp. 2467-2476. (doi: 10.2337/db14-1629) (PMID:25720386)

Gadalla, Kamal K. E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Ross, Paul D., Hector, Ralph D. ORCID logoORCID: https://orcid.org/0000-0002-3778-1483, Bahey, Noha G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2015) Gene therapy for Rett syndrome: prospects and challenges. Future Neurology, 10(5), pp. 467-484. (doi: 10.2217/fnl.15.29)

Wardle, Sophie L., Bailey, Mark E. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Kilikevicius, Audrius, Malkova, Dalia ORCID logoORCID: https://orcid.org/0000-0002-8085-0528, Wilson, Richard H. ORCID logoORCID: https://orcid.org/0000-0001-8018-7730, Venckunas, Tomas and Moran, Colin (2015) Plasma microRNA levels differ between endurance and strength athletes. PLoS ONE, 10(4), e0122107. (doi: 10.1371/journal.pone.0122107) (PMID:25881132) (PMCID:PMC4400105)

Gadalla, Kamal K.E. ORCID logoORCID: https://orcid.org/0000-0002-1657-8953, Ross, Paul D., Riddell, John S. ORCID logoORCID: https://orcid.org/0000-0001-6366-6545, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2014) Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits. PLoS ONE, 9(11), e112889. (doi: 10.1371/journal.pone.0112889) (PMID:25392929) (PMCID:PMC4231076)

Wang, G. et al. (2013) Association analysis of ACE and ACTN3 in elite caucasian and east Asian swimmers. Medicine and Science in Sports and Exercise, 45(5), pp. 892-900. (doi: 10.1249/MSS.0b013e31827c501f)

Gadalla, K.K.E. et al. (2013) Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice. Molecular Therapy, 21(1), pp. 18-30. (doi: 10.1038/mt.2012.200) (PMID:23011033) (PMCID:PMC3536818)

Celis-Morales, Carlos A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Ghouri, Nazim ORCID logoORCID: https://orcid.org/0000-0002-8263-2591, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Sattar, Naveed ORCID logoORCID: https://orcid.org/0000-0002-1604-2593 and Gill, Jason M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2013) Should physical activity recommendations be ethnicity-specific? Evidence from a cross-sectional study of south Asian and European men. PLoS ONE, 8(12), e82568. (doi: 10.1371/journal.pone.0082568) (PMID:24349313) (PMCID:PMC3859604)

Gianfagna, F. et al. (2013) Understanding the links among neuromedin U Gene, beta2-adrenoceptor gene and bone health: an observational study in European children. PLoS ONE, 8(8), e70632. (doi: 10.1371/journal.pone.0070632) (PMID:23936460) (PMCID:PMC3731254)

Celis-Morales, Carlos A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Perez-Bravo, Francisco, Ibanez, Luis, Salas, Carlos, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Gill, Jason M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2012) Objective vs. self-reported physical activity and sedentary time: effects of measurement method on relationships with risk biomarkers. PLoS ONE, 7(5), e36345. (doi: 10.1371/journal.pone.0036345) (PMID:22590532) (PMCID:PMC3348936)

Weng, Shih-Ming, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, Stuart R. (2011) Rett syndrome: from bed to bench. Pediatrics and Neonatology, 52(6), pp. 309-316. (doi: 10.1016/j.pedneo.2011.08.002)

Gadalla, K.K.E., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, S.R. (2011) MeCP2 and Rett syndrome: reversibility and potential avenues for therapy. Biochemical Journal, 439(1), pp. 1-14. (doi: 10.1042/BJ20110648)

Weng, S.-M., McLeod, F., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Cobb, S.R. (2011) Synaptic plasticity deficits in an experimental model of Rett Syndrome: LTP saturation and its pharmacological reversal. Neuroscience, 180, pp. 314-321. (doi: 10.1016/j.neuroscience.2011.01.061)

Koni, A.C., Scott, R.A., Wang, G., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Peplies, J., Bammann, K. and Pitsiladis, Y.P. (2011) DNA yield and quality of saliva samples and suitability for large scale epidemiological studies in children. International Journal of Obesity, 35(Suppl.), S113-S118.

Celis-Morales, C.A. ORCID logoORCID: https://orcid.org/0000-0003-2612-3917, Perez-Bravo, F., Ibañes, L., Sanzana, R., Hormazabal, E., Ulloa, N., Calvo, C., Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Gill, J.M.R. ORCID logoORCID: https://orcid.org/0000-0003-3615-0986 (2011) Insulin resistance in Chileans of European and indigenous descent: evidence for an ethnicity x environment interaction. PLoS ONE, 6(9), e24690. (doi: 10.1371/journal.pone.0024690) (PMID:21931814) (PMCID:PMC3169638)

Wilson, R.H., Moran, C.N., Cole, John, Pitsiladis, Y.P. and Bailey, M.E.S. (2010) Evolutionary history of the ADRB2 gene in humans. American Journal of Human Genetics, 86(3), pp. 490-493. (doi: 10.1016/j.ajhg.2010.01.031) (PMID:20215008) (PMCID:PMC2833374)

Neul, J.L. et al. (2010) Rett Syndrome: Revised diagnostic criteria and nomenclature. Annals of Neurology, 68(6), pp. 944-950. (doi: 10.1002/ana.22124)

Scott, R.A. et al. (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. European Journal of Human Genetics, 18(12), pp. 1339-1343. (doi: 10.1038/ejhg.2010.131) (PMID:20717169) (PMCID:PMC3002848)

Todd, Andrew J. ORCID logoORCID: https://orcid.org/0000-0002-3007-6749, Polgár, Erika, Watt, Christine, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Watanabe, Masahiko (2009) Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits. European Journal of Neuroscience, 29(4), pp. 718-726. (doi: 10.1111/j.1460-9568.2009.06633.x) (PMID:19200070) (PMCID:PMC2695158)

Morrison, A W, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 and Morrison, G A J (2009) Familial Ménière's disease: clinical and genetic aspects. Journal of Laryngology and Otology, 123(01), pp. 29-37. (doi: 10.1017/S0022215108002788)

Archer, H. et al. (2007) Correlation between clinical severity in patients with Rett Syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation. Journal of Medical Genetics, 44, pp. 148-152. (doi: 10.1136/jmg.2006.045260)

Lagou, V, Manios, Y, Moran, CN, Bailey, MES, Grammatikaki, E, Oikonomou, E, Ioannou, E, Moschonis, G, Wilson, RH and Pitsiladis, YP (2007) Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism. International Journal of Obesity, 31, pp. 1052-1060. (doi: 10.1038/sj.ijo.0803605)

Moran, CN, Yang, N, Bailey, MES, Tsiokanos, A, Jamurtas, A, MacArthur, DG, North, K, Pitsiladis, YP and Wilson, RH (2007) Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. European Journal of Human Genetics, 15, pp. 88-93. (doi: 10.1038/sj.ejhg.5201724)

Knudsen, GPS, Neilson, TCS, Pedersen, J, Kerr, A, Schwartz, M, Hulten, M, Bailey, MES and Orstavik, KH (2006) Increased skewing of X chromosome inactivation in Rett syndrome patients and their mothers. European Journal of Human Genetics, 14, pp. 1189-1194. (doi: 10.1038/sj.ejhg.5201682)

Moran, CN, Vassilopoulos, C, Tsiokanos, A, Jamurtas, AZ, Bailey, MES, Montgomery, HE, Wilson, RH and Pitsiladis, YP (2006) The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents. European Journal of Human Genetics, 14, pp. 332-339.

Charman, T. et al. (2005) Dimensional phenotypic analysis and functional categorisation of mutations reveal novel genotype-phenotype associations in Rett syndrome. European Journal of Human Genetics, 13, pp. 1121-1130. (doi: 10.1038/sj.ejhg.5201471) (PMID:16077736)

Jian, L, Archer, HL, Ravine, D, Kerr, A, de Klerk, N, Christodoulou, J, Bailey, ME, Laurvick, C and Leonard, H (2005) p.R270X MECP2 mutation and mortality in Rett syndrome. European Journal of Human Genetics, 13, pp. 1235-1238. (doi: 10.1038/sj.ejhg.5201479)

Moran, C.N., Vassilopoulos, C, Tsiokanos, A, Jamurtas, AZ, Bailey, M.E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Wilson, RH and Pitsiladis, YP (2005) Effects of interaction between angiotensin I-converting enzyme polymorphisms and lifestyle on adiposity in adolescent Greeks. Obesity Research, 13, pp. 1499-1504. (doi: 10.1038/oby.2005.181) (PMID:16222048)

Boucher, Catherine A, Winchester, Catherine L, Hamilton, Graham M, Winter, Alan D, Johnson, Keith J and Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (2000) Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. Gene, 247(1-2), pp. 145-151. (doi: 10.1016/S0378-1119(00)00105-0) (PMID:10773454)

Xiang, Fengqing, Buervenich, Silvia, Nicolao, Piero, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Zhang, Zhiping and Anvret, Marie (2000) Mutation screening in Rett syndrome patients. Journal of Medical Genetics, 37(4), pp. 250-255. (doi: 10.1136/jmg.37.4.250) (PMID:10745042) (PMCID:PMC1734556)

Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Albrecht, Barbara E., Johnson, Keith J. and Darlison, Mark G. (1999) Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1447(2-3), pp. 307-312. (doi: 10.1016/S0167-4781(99)00167-0)

Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Matthews, Deborah A., Riley, Brien P., Albrecht, Barbara E., Kostrzewa, Markus, Hicks, Andrew A., Harris, Robert, Müller, Ulrich, Darlison, Mark G. and Johnson, Keith J. (1999) Genomic mapping and evolution of human GABA A receptor subunit gene clusters. Mammalian Genome, 10(8), pp. 839-843. (doi: 10.1007/s003359901101) (PMID:10430673)

Moncrieff, Colin L., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Morrison, Norma and Johnson, Keith J. (1999) Cloning and chromosomal localization of human Cdc42-binding protein kinase β. Genomics, 57(2), pp. 297-300. (doi: 10.1006/geno.1999.5769)

Burden, A. David, Hodgins, Malcolm, Tillman, David, Javed, Shaban, Connor, Michael and Bailey, Mark ORCID logoORCID: https://orcid.org/0000-0002-9788-2278 (1998) Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p. Journal of Investigative Dermatology, 110(6), pp. 958-960. (doi: 10.1046/j.1523-1747.1998.00213.x) (PMID:9620305)

Crowe, Raymond R., Wang, Zhewu, Noyes, Russell, Albrecht, Barbara E., Darlison, Mark G., Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Johnson, Keith J. and Zoega, Tomas (1997) Candidate gene study of eight GABAA receptor subunits in panic disorder. American Journal of Psychiatry, 154(8), pp. 1096-1100. (doi: 10.1176/ajp.154.8.1096) (PMID:9247395)

Conference or Workshop Item

Shone, Kate, Innes, Aidan, Kilikevicius, Audrius, Statkeviciene, Birute, Stasiulis, Arvydas, Mamkus, Gediminas, Malkova, Dalia ORCID logoORCID: https://orcid.org/0000-0002-8085-0528, Bailey, Mark E.S. ORCID logoORCID: https://orcid.org/0000-0002-9788-2278, Venckunas, Tomas and Moran, Colin N. (2016) P-87 Acvr1b rs2854464 is Associated with Quantitative Measures of Strength/Power in Lithuanian Athletes and Controls. 34th FIMS World Sports Medicine Congress, Ljubljana, Slovenia, 29 September - 2 October 2016. (doi: 10.1136/bjsports-2016-097120.140)

This list was generated on Sun Dec 7 02:56:02 2025 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Enhancing efficiency of molecular therapies for Rett syndrome
    Rett Syndrome Association Scotland
    2018 - 2023
     
  • A gene therapy consortium to develop and evaluate next generation gene therapy approaches in Rett syndrome
    Rett Syndrome Research Trust
    2017 - 2018
     
  • Optimising MECP2 trans splicing for human translation
    Rett Syndrome Research Trust
    2017 - 2018
     
  • Trans-Splicing as a novel therapy for CDKL5 disorder
    CDKL5 UK
    2016 - 2017
     
  • Polygenic risk for depression and neuroticism as predictors of antidepressant response
    Chief Scientist Office
    2016 - 2016
     
  • Novel Gene-Based Therapeutic Approaches in Rett Syndrome and Allied Disorders
    Rett Syndrome Association Scotland
    2016 - 2018
     
  • Rett Syndrome Research
    Rett Syndrome Association Scotland
    2016 - 2018
     
  • Spliceosome-Mediated RNA Trans-Splicing Therapy in Rett syndrome
    Rett Syndrome Research Trust
    2016 - 2016
     
  • Developing and evaluating novel gene therapy approaches in Rett syndrome
    Chief Scientist Office
    2014 - 2016
     
  • Gene Therapy Consortium
    Rett Syndrome Research Trust
    2014 - 2017
     
  • Gene Therapy Consortium
    Rosetrees Trust
    2014 - 2017
     
  • Gene Therapy Consortium
    The Stoneygate Trust
    2014 - 2017
     
  • Is Protein Therapy a Viable Strategy in Rett Syndrome?
    Rett Syndrome Association Scotland
    2013 - 2016
     
  • Assessing the potential for gene therapy in Rett syndrome
    Rett Syndrome Association Scotland
    2011 - 2013
     
  • Improving the functioning of neurons in Rett Syndrome - linking basic neurobiology and therapeutic strategies
    Rett Syndrome Association Scotland
    2009 - 2011
     
  • An integrative approach to the identification of novel therapeutic targets in Rett syndrome
    Rett Syndrome Association Scotland
    2007 - 2009
     
  • Continued genotype-phenotype studies of Rett syndrome
    Rett Syndrome Association Scotland
    2006 - 2007
     
  • Molecular mechanisms controlling the regenerative response of dorsal root axons following avulsion injury
    Neurosciences Foundation
    2006 - 2008
     
  • Identification of genes predisposing to Meniere disease
    Deafness Research UK
    2005 - 2008
     
  • Extending genotype-phenotype studies of Rett syndrome using the British Isles Rett Survey database and the Rett Syndrome Behaviour Question.
    Rett Syndrome Research Trust
    2004 - 2006
     
  • Identification of genes predisposing to Meniere disease
    Defeating Deafness
    2003 - 2005
     

Teaching

PGT teaching management: Deputy Programme Director, MSc Bioinformatics

PGT teaching: Course leader, Foundations of Bioinformatics; course leader, Identification of Disease-Causing Genetic Variants

UG teaching: Course leader, Level 4 Human Molecular Genetics option; course leader, Level 4 Genetics of Complex Traits and Disorders option

 

Teaching remit encompasses genetics, molecular genetics and molecular pathology of human disorders and models of disease in other organisms, as well as phylogenetics, genomics and functional genomics.

Research datasets

Jump to: 2021 | 2020 | 2019
Number of items: 9.

2021

Strawbridge, R. , Ward, J., Bailey, M. , Cullen, B. , Ferguson, A., Graham, N., Johnston, K., Lyall, L., Pearsall, R., Pell, J. , Shaw, R. , Tank, R., Lyall, D. and Smith, D. (2021) Summary statistics from a genome-wide association study of carotid intima-media thickness in UK Biobank. [Data Collection]

Johnston, K., Ward, J., Ray, P. R., Adams, M. J., McIntosh, A. M., Smith, B., Strawbridge, R. , Price, T. J., Smith, D. J., Nicholl, B. and Bailey, M. (2021) Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank. [Data Collection]

2020

Ward, J., Strawbridge, R. , Bailey, M. , Graham, N., Ferguson, A., Lyall, D. , Cullen, B. , Pidgeon, L., Cavanagh, J., Mackay, D. , Pell, J. , O'Donovan, M., Escott-Price, V. and Smith, D. (2020) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. [Data Collection]

2019

Strawbridge, R. , Ward, J., Ferguson, A., Graham, N., Shaw, R. , Cullen, B. , Pearsall, R., Lyall, L., Johnston, K., Niedzwiedz, C. , Pell, J. , Mackay, D. , Martin, J., Lyall, D. , Bailey, M. and Smith, D. (2019) Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. [Data Collection]

Ferguson, A., Lyall, L., Ward, J., Strawbridge, R. , Cullen, B. , Graham, N., Niedzwiedz, C. , Johnston, K., Mackay, D. , Biello, S. , Pell, J. , Cavanagh, J., McIntosh, A. M., Doherty, A., Bailey, M. , Lyall, D. , Wyse, C. and Smith, D. (2019) Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. [Data Collection]

Strawbridge, R. , Ward, J., Lyall, L., Tunbridge, E. M., Cullen, B. , Graham, N., Ferguson, A., Johnston, K., Lyall, D. , Mackay, D. , Cavanagh, J., Howard, D. M., Adams, M. J., Deary, I., Escott-Price, V., O’Donovan, M., McIntosh, A. M., Bailey, M. , Pell, J. , Harrison, P. and Smith, D. (2019) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. [Data Collection]

Ward, J., Lyall, L., Bethlehem, R. A. I., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K., Bailey, M. , Murray, G. K. and Smith, D. (2019) Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. [Data Collection]

Ward, J., Tunbridge, E. M., Sandor, C., Lyall, L., Ferguson, A., Strawbridge, R. , Lyall, D. , Cullen, B. , Graham, N., Johnston, K. J.A., Webber, C., Escott-Price, V., O’Donovan, M., Pell, J. , Bailey, M. , Harrison, P. J. and Smith, D. (2019) The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. [Data Collection]

Johnston, K., Adams, M. J., Nicholl, B. , Ward, J., Strawbridge, R. , Ferguson, A., McIntosh, A. M., Bailey, M. and Smith, D. (2019) Genome-wide association summary statistics for a genome-wide association study of multisite chronic pain. [Data Collection]

This list was generated on Sun Dec 7 01:53:47 2025 GMT.

Additional information

Grant Advisory Board

  • 2009 - present: International Rett Syndrome Foundation (IRSF) - Member of Scientific Review Board
  • 2006 - present: RettSearch - Clinical Trials Consortium, Invited Member
  • 2006 - present: Rett Syndrome Association Scotland - Member of Board of Medical Advisors
  • 2004 - present: IRSA International Rett Syndrome Phenotype Database - Member of reference panel of experts

Invited International Presentations

  • 2006: San Francisco, USA - NIH-Sponsored Workshop - Clinical Trials in Rett Syndrome: Potential for Early Intervention.

Prizes, Awards and Distinctions

  • 1998: SHERT/Cruden Scholarship

Professional Learned Society

  • 2005 - present: American Society of Human Genetics - Member
  • 2001 - present: Human Genome Organisation (HUGO) - Member

Research Fellowship

  • 1998 - 2002: Epilepsy Research Foundation - Joy Chisholm Fellowship