Mrs Laura Jenkins

  • Technical Specialist/Lab Manager (Molecular Biosciences)

telephone: 01413306483
email: Laura.Jenkins@glasgow.ac.uk

University of Glasgow, Mvls, Wolfson Link Bldg - Lab 253, Glasgow G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1382-8547

Biography

Key Skills 

Core Funded 

  • Cell Culture: maintain cell lines, transfection, generate stable cell lines, dissection and culture of primary neurons 
  • Molecular biology technique: PCR and RT-PCR, RNA and DNA extraction, gel electrophoresis, subcloning, site-directed mutagenesis, western blotting 
  • Functional assays: 35S GTPys, cAMP, IPone, BRET assay, calcium mobilisation experiments
  • Radioligand binding: saturation and competition binding, kinetic experiments 
  • Microscopy: bright-field and epifluoresence microscopy, live cell imaging, immunocytochemistry 
  • Drug discovery: optimisation and validation of cell based assays for high-throughput screens, handing and analysis of large data sets and spreadsheets 
  • Health and Safety: generate and review lab COSHH forms, create radioisotope risk assessments 

Research interests

Within our Molecular Pharmacology group, focus is on the structure, function and regulation of G protein-coupled receptors (GPCRs) and their interacting proteins. A large part of my role within the group is driving forward drug discovery programmes that Professor Milligan has with industrial partners, aiming to identify novel ligands at orphan GPCRs. 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2010 | 2009 | 2008
Number of items: 32.

2024

Tikhonova, Irina, Zhang, Xuan, Guseinov, Abdul-Akim, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Li, Kunpeng, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Zhang, Cheng (2024) Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science Advances, 10(2), eadj2384. (doi: 10.1126/sciadv.adj2384) (PMID:38198545)

2023

Barki, N. et al. (2023) Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. eLife, 12, RP91861. (doi: 10.7554/eLife.91861) (PMID:38085667) (PMCID:PMC10715726)

Ganguly, A. et al. (2023) G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions. Journal of Biological Chemistry, 299(10), 105218. (doi: 10.1016/j.jbc.2023.105218) (PMID:37660910) (PMCID:PMC10520886)

Zhang, X. et al. (2023) Pro-phagocytic function and structural basis of GPR84 signaling. Nature Communications, 14, 5706. (doi: 10.1038/s41467-023-41201-0) (PMID:37709767) (PMCID:PMC10502086)

Valentini, Alice, Schultz-Knudsen, Katrine, Højgaard Hansen, Anders, Tsakoumagkou, Argyro, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Christensen, Henriette B., Manandhar, Asmita, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Ulven, Trond and Rexen Ulven, Elisabeth (2023) Discovery of potent tetrazole free fatty acid receptor 2 antagonists. Journal of Medicinal Chemistry, 66(9), pp. 6105-6121. (doi: 10.1021/acs.jmedchem.2c01935) (PMID:37129317)

2022

Mahindra, A. et al. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists. Journal of Medicinal Chemistry, 65(16), pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804) (PMID:35948061) (PMCID:PMC9421653)

Marsango, Sara, Barki, Natasja, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2022) Therapeutic validation of an orphan G protein-coupled receptor: the case of GPR84. British Journal of Pharmacology, 179(14), pp. 3529-3541. (doi: 10.1111/bph.15248) (PMID:32869860) (PMCID:PMC9361006)

Marsango, S. et al. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e220110311. (doi: 10.1073/pnas.2201103119) (PMID:35671422) (PMCID:PMC9214538)

Marsango, S. et al. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298(5), 101932. (doi: 10.1016/j.jbc.2022.101932) (PMID:35427647) (PMCID:PMC9118924)

Barki, N. et al. (2022) Chemogenetics defines the roles of short chain fatty acid receptors within the gut-brain axis. eLife, 11, e73777. (doi: 10.7554/eLife.73777) (PMID:35229717) (PMCID:PMC8887895)

Divorty, Nina, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Ganguly, Amlan ORCID logoORCID: https://orcid.org/0000-0002-2507-022X, Butcher, Adrian J., Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Schulz, Stefan, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Nicklin, Stuart A. ORCID logoORCID: https://orcid.org/0000-0002-9691-6210 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. Journal of Biological Chemistry, 298(3), 101655. (doi: 10.1016/j.jbc.2022.101655) (PMID:35101446) (PMCID:PMC8892012)

2021

Scarpa, M. et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118(50), e2107389118. (doi: 10.1073/pnas.2107389118) (PMID:34893539) (PMCID:PMC8685681)

Milligan, G. et al. (2021) Discovery and characterization of novel antagonists of the proinflammatory orphan receptor GPR84. ACS Pharmacology and Translational Science, 4(5), pp. 1598-1613. (doi: 10.1021/acsptsci.1c00151) (PMID:34661077) (PMCID:PMC8506611)

Boleij, A. et al. (2021) G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Communications Biology, 4, 585. (doi: 10.1038/s42003-021-02014-3) (PMID:33990686) (PMCID:PMC8121840)

2020

Labéguère, F. et al. (2020) Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a unique GPR84 negative allosteric modulator undergoing evaluation in a phase II clinical trial. Journal of Medicinal Chemistry, 63(22), pp. 13526-13545. (doi: 10.1021/acs.jmedchem.0c00272) (PMID:32902984)

2019

Mackenzie, Amanda E., Quon, Tezz, Lin, Li-Chiung, Hauser, Alexander S., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Inoue, Asuka, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Gloriam, David E., Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation. FASEB Journal, 33(4), pp. 5005-5017. (doi: 10.1096/fj.201801956R) (PMID:30601679) (PMCID:PMC6436656)

Mancini, Sarah, Mahmud, Zobaer Al, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Bolognini, Daniele, Newman, Robert, Barnes, Matt, Edye, Michelle E., McMahon, Stephen B., Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Scientific Reports, 9, 1861. (doi: 10.1038/s41598-019-38539-1) (PMID:30755705) (PMCID:PMC6372602)

2018

Binti Mohd Amir, Nurul A.S., Mackenzie, Amanda E., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Boustani, Karim, Hillier, Marston C., Tsuchiya, Tomoko, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Pease, James E. (2018) Evidence for the existence of a CXCL17 receptor distinct from GPR35. Journal of Immunology, 201(2), pp. 714-724. (doi: 10.4049/jimmunol.1700884) (PMID:29875152) (PMCID:PMC6036231)

2017

Mahmud, Zobaer Al, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Tikhonova, Irina G. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84. Scientific Reports, 7, 17953. (doi: 10.1038/s41598-017-18159-3) (PMID:29263400) (PMCID:PMC5738391)

Kaspersen, Mads Holmgaard, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Dunlop, Julia ORCID logoORCID: https://orcid.org/0000-0003-3180-6763, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Ulven, Trond (2017) Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. MedChemComm, 8(6), pp. 1360-1365. (doi: 10.1039/c7md00130d)

2016

Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Inoue, Asuka, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Raihan, Sheikh Zahir, Prihandoko, Rudi, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2016) Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling. Journal of Biological Chemistry, 291(53), pp. 27147-27159. (doi: 10.1074/jbc.M116.754887) (PMID:27852822) (PMCID:PMC5207144)

2015

Schrage, R. et al. (2015) The experimental power of FR900359 to study Gq-regulated biological processes. Nature Communications, 6, p. 10156. (doi: 10.1038/ncomms10156) (PMID:26658454) (PMCID:PMC4682109)

Christiansen, E. et al. (2015) Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. British Journal of Nutrition, 113(11), pp. 1677-1688. (doi: 10.1017/S000711451500118X) (PMID:25916176)

2014

Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Christiansen, Elisabeth, Murdoch, Hannah, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Hansen, Anders Højgaard, Madsen, Ole, Ulven, Trond and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Molecular Pharmacology, 86(2), pp. 200-210. (doi: 10.1124/mol.114.093294)

Mackenzie, A.E. et al. (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat gpr35. Molecular Pharmacology, 85(1), pp. 91-104. (doi: 10.1124/mol.113.089482)

2013

Christiansen, E. et al. (2013) Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes. ACS Medicinal Chemistry Letters, 4(5), pp. 441-445. (doi: 10.1021/ml4000673)

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Harries, N., Lappin, J.E., MacKenzie, A.E., Neetoo-Isseljee, Z., Southern, C., McIver, E.G., Nicklin, S.A. ORCID logoORCID: https://orcid.org/0000-0002-9691-6210, Taylor, D.L. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2013) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. Journal of Pharmacology and Experimental Therapeutics, 343(3), pp. 683-695. (doi: 10.1124/jpet.112.198945) (PMID:22967846) (PMCID:PMC3500541)

2010

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Alvarez-Curto, E. ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Campbell, Kate, De Munnik, Sabrina, Canals Buj, M., Schlyer, Sabine and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2010) Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2. British Journal of Pharmacology, 162(3), pp. 733-748. (doi: 10.1111/j.1476-5381.2010.01082.x)

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Brea, J., Smith, N.J., Hudson, B.D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Reilly, G., Bryant, N.J., Castro, M., Loza, M.I. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2010) Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13. Biochemical Journal, 432(3), pp. 451-459. (doi: 10.1042/BJ20101287)

2009

Smith, N.J., Stoddart, L.A., Devine, N.M., Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. Journal of Biological Chemistry, 284(26), pp. 17527-17539. (doi: 10.1074/jbc.M109.012849) (PMID:19398560) (PMCID:PMC2719392)

Ward, Richard J., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin. Journal of Neurochemistry, 109(1), pp. 182-192. (doi: 10.1111/j.1471-4159.2009.05918.x)

2008

Stoddart, L. A., Smith, N. J., Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Brown, A. J. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2008) Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids. Journal of Biological Chemistry, 283(47), pp. 32913-32924. (doi: 10.1074/jbc.M805601200) (PMID:18801738)

This list was generated on Sat Jun 14 01:35:49 2025 BST.
Jump to: Articles
Number of items: 32.

Articles

Tikhonova, Irina, Zhang, Xuan, Guseinov, Abdul-Akim, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Li, Kunpeng, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Zhang, Cheng (2024) Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science Advances, 10(2), eadj2384. (doi: 10.1126/sciadv.adj2384) (PMID:38198545)

Barki, N. et al. (2023) Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. eLife, 12, RP91861. (doi: 10.7554/eLife.91861) (PMID:38085667) (PMCID:PMC10715726)

Ganguly, A. et al. (2023) G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions. Journal of Biological Chemistry, 299(10), 105218. (doi: 10.1016/j.jbc.2023.105218) (PMID:37660910) (PMCID:PMC10520886)

Zhang, X. et al. (2023) Pro-phagocytic function and structural basis of GPR84 signaling. Nature Communications, 14, 5706. (doi: 10.1038/s41467-023-41201-0) (PMID:37709767) (PMCID:PMC10502086)

Valentini, Alice, Schultz-Knudsen, Katrine, Højgaard Hansen, Anders, Tsakoumagkou, Argyro, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Christensen, Henriette B., Manandhar, Asmita, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Ulven, Trond and Rexen Ulven, Elisabeth (2023) Discovery of potent tetrazole free fatty acid receptor 2 antagonists. Journal of Medicinal Chemistry, 66(9), pp. 6105-6121. (doi: 10.1021/acs.jmedchem.2c01935) (PMID:37129317)

Mahindra, A. et al. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists. Journal of Medicinal Chemistry, 65(16), pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804) (PMID:35948061) (PMCID:PMC9421653)

Marsango, Sara, Barki, Natasja, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2022) Therapeutic validation of an orphan G protein-coupled receptor: the case of GPR84. British Journal of Pharmacology, 179(14), pp. 3529-3541. (doi: 10.1111/bph.15248) (PMID:32869860) (PMCID:PMC9361006)

Marsango, S. et al. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e220110311. (doi: 10.1073/pnas.2201103119) (PMID:35671422) (PMCID:PMC9214538)

Marsango, S. et al. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298(5), 101932. (doi: 10.1016/j.jbc.2022.101932) (PMID:35427647) (PMCID:PMC9118924)

Barki, N. et al. (2022) Chemogenetics defines the roles of short chain fatty acid receptors within the gut-brain axis. eLife, 11, e73777. (doi: 10.7554/eLife.73777) (PMID:35229717) (PMCID:PMC8887895)

Divorty, Nina, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Ganguly, Amlan ORCID logoORCID: https://orcid.org/0000-0002-2507-022X, Butcher, Adrian J., Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Schulz, Stefan, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Nicklin, Stuart A. ORCID logoORCID: https://orcid.org/0000-0002-9691-6210 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. Journal of Biological Chemistry, 298(3), 101655. (doi: 10.1016/j.jbc.2022.101655) (PMID:35101446) (PMCID:PMC8892012)

Scarpa, M. et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118(50), e2107389118. (doi: 10.1073/pnas.2107389118) (PMID:34893539) (PMCID:PMC8685681)

Milligan, G. et al. (2021) Discovery and characterization of novel antagonists of the proinflammatory orphan receptor GPR84. ACS Pharmacology and Translational Science, 4(5), pp. 1598-1613. (doi: 10.1021/acsptsci.1c00151) (PMID:34661077) (PMCID:PMC8506611)

Boleij, A. et al. (2021) G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Communications Biology, 4, 585. (doi: 10.1038/s42003-021-02014-3) (PMID:33990686) (PMCID:PMC8121840)

Labéguère, F. et al. (2020) Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a unique GPR84 negative allosteric modulator undergoing evaluation in a phase II clinical trial. Journal of Medicinal Chemistry, 63(22), pp. 13526-13545. (doi: 10.1021/acs.jmedchem.0c00272) (PMID:32902984)

Mackenzie, Amanda E., Quon, Tezz, Lin, Li-Chiung, Hauser, Alexander S., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Inoue, Asuka, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Gloriam, David E., Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation. FASEB Journal, 33(4), pp. 5005-5017. (doi: 10.1096/fj.201801956R) (PMID:30601679) (PMCID:PMC6436656)

Mancini, Sarah, Mahmud, Zobaer Al, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Bolognini, Daniele, Newman, Robert, Barnes, Matt, Edye, Michelle E., McMahon, Stephen B., Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Scientific Reports, 9, 1861. (doi: 10.1038/s41598-019-38539-1) (PMID:30755705) (PMCID:PMC6372602)

Binti Mohd Amir, Nurul A.S., Mackenzie, Amanda E., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Boustani, Karim, Hillier, Marston C., Tsuchiya, Tomoko, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Pease, James E. (2018) Evidence for the existence of a CXCL17 receptor distinct from GPR35. Journal of Immunology, 201(2), pp. 714-724. (doi: 10.4049/jimmunol.1700884) (PMID:29875152) (PMCID:PMC6036231)

Mahmud, Zobaer Al, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Tikhonova, Irina G. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84. Scientific Reports, 7, 17953. (doi: 10.1038/s41598-017-18159-3) (PMID:29263400) (PMCID:PMC5738391)

Kaspersen, Mads Holmgaard, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Dunlop, Julia ORCID logoORCID: https://orcid.org/0000-0003-3180-6763, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Ulven, Trond (2017) Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. MedChemComm, 8(6), pp. 1360-1365. (doi: 10.1039/c7md00130d)

Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Inoue, Asuka, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Raihan, Sheikh Zahir, Prihandoko, Rudi, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2016) Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling. Journal of Biological Chemistry, 291(53), pp. 27147-27159. (doi: 10.1074/jbc.M116.754887) (PMID:27852822) (PMCID:PMC5207144)

Schrage, R. et al. (2015) The experimental power of FR900359 to study Gq-regulated biological processes. Nature Communications, 6, p. 10156. (doi: 10.1038/ncomms10156) (PMID:26658454) (PMCID:PMC4682109)

Christiansen, E. et al. (2015) Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. British Journal of Nutrition, 113(11), pp. 1677-1688. (doi: 10.1017/S000711451500118X) (PMID:25916176)

Hudson, Brian D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Christiansen, Elisabeth, Murdoch, Hannah, Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Hansen, Anders Højgaard, Madsen, Ole, Ulven, Trond and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Molecular Pharmacology, 86(2), pp. 200-210. (doi: 10.1124/mol.114.093294)

Mackenzie, A.E. et al. (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat gpr35. Molecular Pharmacology, 85(1), pp. 91-104. (doi: 10.1124/mol.113.089482)

Christiansen, E. et al. (2013) Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes. ACS Medicinal Chemistry Letters, 4(5), pp. 441-445. (doi: 10.1021/ml4000673)

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Harries, N., Lappin, J.E., MacKenzie, A.E., Neetoo-Isseljee, Z., Southern, C., McIver, E.G., Nicklin, S.A. ORCID logoORCID: https://orcid.org/0000-0002-9691-6210, Taylor, D.L. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2013) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. Journal of Pharmacology and Experimental Therapeutics, 343(3), pp. 683-695. (doi: 10.1124/jpet.112.198945) (PMID:22967846) (PMCID:PMC3500541)

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Alvarez-Curto, E. ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Campbell, Kate, De Munnik, Sabrina, Canals Buj, M., Schlyer, Sabine and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2010) Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2. British Journal of Pharmacology, 162(3), pp. 733-748. (doi: 10.1111/j.1476-5381.2010.01082.x)

Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Brea, J., Smith, N.J., Hudson, B.D. ORCID logoORCID: https://orcid.org/0000-0001-7059-0091, Reilly, G., Bryant, N.J., Castro, M., Loza, M.I. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2010) Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13. Biochemical Journal, 432(3), pp. 451-459. (doi: 10.1042/BJ20101287)

Smith, N.J., Stoddart, L.A., Devine, N.M., Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. Journal of Biological Chemistry, 284(26), pp. 17527-17539. (doi: 10.1074/jbc.M109.012849) (PMID:19398560) (PMCID:PMC2719392)

Ward, Richard J., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin. Journal of Neurochemistry, 109(1), pp. 182-192. (doi: 10.1111/j.1471-4159.2009.05918.x)

Stoddart, L. A., Smith, N. J., Jenkins, L. ORCID logoORCID: https://orcid.org/0000-0003-1382-8547, Brown, A. J. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2008) Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids. Journal of Biological Chemistry, 283(47), pp. 32913-32924. (doi: 10.1074/jbc.M805601200) (PMID:18801738)

This list was generated on Sat Jun 14 01:35:49 2025 BST.

Research datasets

Jump to: 2023 | 2022 | 2021
Number of items: 3.

2023

Barki, N., Jenkins, L. , Marsango, S., Dedeo, D. , Bolognini, D., Dwomoh, L. , Nilsen, M., Stoffels, M., Nagel, F., Schulz, S., Tobin, A. and Milligan, G. (2023) Phosphorylation bar-coding of Free Fatty Acid receptor 2 is generated in a tissue-specific manner. [Data Collection]

2022

Marsango, S., Jenkins, L. , Pediani, J. , Bradley, S. , Ward, R., Hesse, S. and Milligan, G. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. [Data Collection]

2021

Scarpa, M., Molloy, C. , Jenkins, L. , Strellis, B., Budgett, R., Hesse, S., Dwomoh, L. , Marsango, S., Tejeda, G. , Rossi, M., Ahmed, Z., Milligan, G. , Hudson, B. , Tobin, A. , Bradley, S. and Heptares, S. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. [Data Collection]

This list was generated on Sat Jun 14 18:32:59 2025 BST.

19 - 152 MVLS Staff Profiles Laura Jenkins 131