Professor Hugh Nimmo

Honorary Senior Research Fellow (School of Molecular Biosciences)

Bower Building, University of Glasgow, Glasgow, G12 8QQ

Biography

Hugh obtained his BA and PhD in biochemistry at the University of Cambridge. In 1973 he joined Philip Cohen at the University of Dundee as the first postdoc in the group and contributed to the early work on the roles of protein phosphorylation. After one year as a temporary lecturer in Dundee he moved to the University of Glasgow as a lecturer in Biochemistry in January 1977. Since 1992 he has been Professor of Plant Biochemistry. His research interests concern the molecular mechanisms responsible for biological control. He has studied systems in bacteria, fungi, plants and mammals with funding from agencies including MRC, SERC, AFRC, NERC, BBSRC and the Leverhulme Trust. Current interests cover the organ specificity of the plant circadian clock and the mechanisms by which plants sense time and temperature. His administrative roles have included Assistant Director of IBLS (1999-2001), Head of Division of Biochemistry & Molecular Biology (2002-2008) and Head of Subject in Biomolecular Sciences (2009-2014). In 2015 he reduced his workload to 3 days per week, keeping on his own research, and much of his teaching (lectures, tutorials and project supervision).

Research interests

• How is time communicated between different plant organs?
• How do plants sense time and temperature?

Research interests – further information

Publications

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Number of items: 116.

2023

James, A. B. , Sharples, C., Laird, J., Armstrong, E. M., Guo, W., Tzioutziou, N., Zhang, R., Brown, J. W.S., Nimmo, H. and Jones, M. (2023) REVEILLE2 thermosensitive splicing: a molecular basis for the integration of nocturnal temperature information by the Arabidopsis circadian clock. New Phytologist, (doi: 10.1111/nph.19339) (PMID:37897048) (Early Online Publication)

2021

Nimmo, H. G. and Laird, J. (2021) Arabidopsis thaliana PRR7 provides circadian input to the CCA1 promoter in shoots but not roots. Frontiers in Plant Science, 12, 750367. (doi: 10.3389/fpls.2021.750367) (PMCID:PMC8559795)

Tzioutziou, N. A., James, A. B. , Guo, W., Calixto, C. P.G., Zhang, R., Nimmo, H. G. and Brown, J. W.S. (2021) Experimental design for time-series RNA-seq analysis of gene expression and alternative splicing. In: Staiger, D., Davis, S. and Davis, A. M. (eds.) Plant Circadian Networks: Methods and Protocols. Series: Methods in molecular biology (2398). Humana: New York, pp. 173-188. ISBN 9781071619117 (doi: 10.1007/978-1-0716-1912-4_14)

2020

Nimmo, H. G. , Laird, J., Bindbeutel, R. and Nusinow, D. A. (2020) The evening complex is central to the difference between the circadian clocks of Arabidopsis thaliana shoots and roots. Physiologia Plantarum, 169(3), pp. 442-451. (doi: 10.1111/ppl.13108) (PMID:32303120)

2019

Calixto, C. P.G., Tzioutziou, N. A., James, A. B. , Hornyik, C., Guo, W., Zhang, R., Nimmo, H. G. and Brown, J. W.S. (2019) Cold-dependent expression and alternative splicing of Arabidopsis long non-coding RNAs. Frontiers in Plant Science, 10, 235. (doi: 10.3389/fpls.2019.00235) (PMID:30891054) (PMCID:PMC6413719)

2018

Calixto, C. P.G., Guo, W., James, A. B. , Tzioutziou, N. A., Entizne, J. C., Panter, P. E., Knight, H., Nimmo, H. , Zhang, R. and Brown, J. W.S. (2018) Rapid and dynamic alternative splicing impacts the Arabidopsis cold response transcriptome. Plant Cell, 30, pp. 1424-1444. (doi: 10.1105/tpc.18.00177) (PMID:29764987)

Nimmo, H. G. (2018) Entrainment of Arabidopsis roots to the light:dark cycle by light piping. Plant, Cell and Environment, 41(8), pp. 1742-1748. (doi: 10.1111/pce.13137) (PMID:29314066)

James, A. B. , Sullivan, S. and Nimmo, H. G. (2018) Global spatial analysis of Arabidopsis natural variants implicates 5’UTR splicing of LATE ELONGATED HYPOCOTYL in responses to temperature. Plant, Cell and Environment, 41(7), pp. 1524-1538. (doi: 10.1111/pce.13188) (PMID:29520807) (PMCID:PMC6033021)

James, A. B. , Calixto, C. P.G., Tzioutziou, N. A., Guo, W., Zhang, R., Simpson, C. G., Jiang, W., Nimmo, G. A., Brown, J. W.S. and Nimmo, H. (2018) How does temperature affect splicing events? Isoform switching of splicing factors regulates splicing of LATE ELONGATED HYPOCOTYL (LHY). Plant, Cell and Environment, 41(7), pp. 1539-1550. (doi: 10.1111/pce.13193) (PMID:29532482) (PMCID:PMC6033173)

Nimmo, H. G. (2018) Control of phosphoenolpyruvate carboxylase in plants. In: Roberts, J. (ed.) Annual Plant Reviews. John Wiley & Sons, Ltd, pp. 219-233. ISBN 9781119312994 (doi: 10.1002/9781119312994.apr0223)

2017

Zhang, R. et al. (2017) A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing. Nucleic Acids Research, 45(9), pp. 5061-5073. (doi: 10.1093/nar/gkx267) (PMID:28402429) (PMCID:PMC5435985)

2016

Bordage, S., Sullivan, S. , Laird, J., Millar, A. J. and Nimmo, H. G. (2016) Organ specificity in the plant circadian system is explained by different light inputs to the shoot and root clocks. New Phytologist, 212(1), pp. 136-149. (doi: 10.1111/nph.14024) (PMID:27240972) (PMCID:PMC5006879)

2015

Zhang, R. et al. (2015) AtRTD - a comprehensive reference transcript dataset resource for accurate quantification of transcript-specific expression in Arabidopsis thaliana. New Phytologist, 208(1), pp. 96-101. (doi: 10.1111/nph.13545) (PMID:26111100) (PMCID:PMC4744958)

2012

James, A.B. , Syed, N.H., Brown, J.W.S. and Nimmo, H.G. (2012) Thermoplasticity in the plant circadian clock: how plants tell the time-perature. Plant Signaling and Behavior, 7(10), pp. 1219-1223. (doi: 10.4161/psb.21491)

James, A.B. , Syed, N.H., Bordage, S., Marshall, J., Nimmo, G.M., Jenkins, G.I. , Herzyk, P. , Brown, J.W.S. and Nimmo, H.G. (2012) Alternative splicing mediates responses of the arabidopsis circadian clock to temperature changes. Plant Cell, 24(3), pp. 961-981. (doi: 10.1105/tpc.111.093948) (PMID:22408072) (PMCID:PMC3336117)

2008

James, A.B. , Monreal, J.A., Nimmo, G.A., Kelly, C.L., Herzyk, P. , Jenkins, G.I. and Nimmo, H.G. (2008) The circadian clock in Arabidopsis roots is a simplified slave version of the clock in shoots. Science, 322(5909), pp. 1832-1835. (doi: 10.1126/science.1161403)

Chen, Z.-H., Jenkins, G.I. and Nimmo, H.G. (2008) Identification of an F box protein that negatively regulates P_i starvation responses. Plant and Cell Physiology, 49(12), pp. 1902-1906. (doi: 10.1093/pcp/pcn157)

Chen, Z.-H., Jenkins, G.I. and Nimmo, H.G. (2008) pH and carbon supply control the expression of phosphoenolpyruvate carboxylase kinase genes in Arabidopsis thaliana. Plant, Cell and Environment, 31(12), pp. 1844-1850. (doi: 10.1111/j.1365-3040.2008.01885.x) (PMID:18771573)

2007

Chen, Z.-H., Nimmo, G.A., Jenkins, G.I. and Nimmo, H.G. (2007) BHLH32 modulates several biochemical and morphological processes that respond to P_i starvation in Arabidopsis. Biochemical Journal, 405(1), pp. 191-198. (doi: 10.1042/BJ20070102) (PMID:17376028) (PMCID:PMC1925254)

MacGregor, D., Mallon, A., Harvey, A., Young, L., Nimmo, H. and Stone, T.W. (2007) Group S8A serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices. European Journal of Neuroscience, 26, pp. 1870-1880. (doi: 10.1111/j.1460-9568.2007.05808.x)

2006

Fukayama, H., Tamai, T., Taniguchi, Y., Sullivan, S. , Miyao, M. and Nimmo, H. (2006) Characterization and functional analysis of phosphoenolpyruvate carboxylase kinase genes in rice. Plant Journal, 47, pp. 258-268. (doi: 10.1111/j.1365-313X.2006.02779.x)

Shenton, M., Fontaine, V., Hartwell, J., Marsh, J., Jenkins, G. and Nimmo, H. (2006) Distinct patterns of control and expression amongst members of the PEP carboxylase kinase gene family in C-4 plants. Plant Journal, 48, pp. 45-53. (doi: 10.1111/j.1365-313X.2006.02850.x)

2005

Sullivan, S. , Shenton, M. and Nimmo, H.G. (2005) Organ specificity in the circadian control of plant gene expression. Biochemical Society Transactions, 33(5), pp. 943-944. (doi: 10.1042/BST0330943) (PMID:16246016)

Boxall, S., Foster, J., Bohnert, H., Cushman, J., Nimmo, H. and Hartwell, J. (2005) Conservation and divergence of circadian clock operation in a stress-inducible crassulacean acid metabolism species reveals clock compensation against stress. Plant Physiology, 137, pp. 969-982. (doi: 10.1104/pp.104.054577)

Fukayama, H., Sullivan, S. , Nimmo, H. G. and Miyao-Tokutomi, M. (2005) Nocturnal phosphorylation of phosphoeno/pyruvate carboxylase in rice leaves unlike in other C-3 plants. Plant and Cell Physiology, 46(Suppl), S76-S76.

2004

Taybi, T., Nimmo, H.G. and Borland, A.M. (2004) Expression of phosphoenolpyruvate carboxylase and phosphoenolpyruvate carboxylase kinase genes. Implications for genotypic capacity and phenotypic plasticity in the expression of crassulacean acid metabolism. Plant Physiology, 135(1), pp. 587-598. (doi: 10.1104/pp.103.036962) (PMID:15133148)

Sullivan, S. , Jenkins, G. and Nimmo, H. (2004) Roots, cycles and leaves. Expression of the phosphoenolpyruvate carboxylase kinase gene family in soybean. Plant Physiology, 135, pp. 2078-2087. (doi: 10.1104/pp.104.042762)

Taybi, T., Nimmo, H. and Borland, A. (2004) Expression of phosphoenolpyruvate carboxylase and phosphoenolpyruvate carboxylase kinase genes. Implications for genotypic cavacity and phenotypic plasticity in the expression of crassulacean acid metabolism. Plant Physiology, 135, pp. 587-598. (doi: 10.1104/pp.103.036962)

2003

Nimmo, H.G. (2003) How to tell the time: the regulation of phosphoenolpyruvate carboxylase in Crassulacean acid metabolism (CAM) plants. Biochemical Society Transactions, 31(3), pp. 728-730. (doi: 10.1042/bst0310728) (PMID:12773193)

Hrabak, E. et al. (2003) The Arabidopsis CDPK-SnRK superfamily of protein kinases. Plant Physiology, 132, pp. 666-680. (doi: 10.1104/pp.102.011999)

Marsh, J., Sullivan, S. , Hartwell, J. and Nimmo, H. (2003) Structure and expression of phosphoenolpyruvate carboxylase kinase genes in solanaceae. A novel gene exhibits alternative splicing. Plant Physiology, 133, pp. 2021-2028. (doi: 10.1104/pp.103.030775)

Nimmo, H. (2003) Control of the phosphorylation of phosphoenolpyruvate carboxylase in higher plants. Archives of Biochemistry and Biophysics, 414, pp. 189-196. (doi: 10.1016/S0003-9861(03)00115-2)

2002

Fontaine, V., Hartwell, J., Jenkins, G. and Nimmo, H. (2002) Arabidopsis thaliana contains two phosphoenolpyruvate carboxylase kinase genes with different expression patterns. Plant, Cell and Environment, 25(1), pp. 115-122. (doi: 10.1046/j.0016-8025.2001.00805.x)

Hartwell, J., Nimmo, G., Wilkins, M., Jenkins, G. and Nimmo, H. (2002) Probing the circadian control of phosphoenolpyruvate carboxylase kinase expression in Kalanchoe fedtschenkoi. Functional Plant Biology, 29, pp. 663-668. (doi: 10.1071/PP01208)

2001

Nimmo, H.G., Fontaine, V., Hartwell, J., Jenkins, G.I., Nimmo, G.A. and Wilkins, M.B. (2001) PEP carboxylase kinase is a novel protein kinase controlled at the level of expression. New Phytologist, 151(1), pp. 91-97. (doi: 10.1046/j.1469-8137.2001.00155.x)

Nimmo, G. A., Wilkins, M. B. and Nimmo, H. G. (2001) Partial purification and characterization of a protein inhibitor of phosphoenolpyruvate carboxylase kinase. Planta, 213(2), pp. 250-257. (doi: 10.1007/s004250000501) (PMID:11469590)

2000

Paterson, K. M. and Nimmo, H. G. (2000) Effects of pH on the induction of phosphoenolpyruvate carboxylase kinase in Kalanchoë fedtschenkoi. Plant Science, 154(2), pp. 135-141. (doi: 10.1016/S0168-9452(99)00249-6) (PMID:10729612)

Nimmo, H. G. (2000) The regulation of phosphoenolpyruvate carboxylase in CAM plants. Trends in Plant Science, 5(2), pp. 75-80. (doi: 10.1016/S1360-1385(99)01543-5) (PMID:10664617)

1999

Borland, A. M., Hartwell, J., Jenkins, G. I. , Wilkins, M. B. and Nimmo, H. G. (1999) Metabolite control overrides circadian regulation of phosphoenolpyruvate carboxylase kinase and CO2 fixation in crassulacean acid metabolism. Plant Physiology, 121(3), pp. 889-896. (doi: 10.1104/pp.121.3.889) (PMID:10557237)

Hartwell, J., Gill, A., Nimmo, G. A., Wilkins, M. B., Jenkins, G. I. and Nimmo, H. G. (1999) Phosphoenolpyruvate carboxylase kinase is a novel protein kinase regulated at the level of expression. Plant Journal, 20(3), pp. 333-342. (PMID:10571893)

Hartwell, J., Jenkins, G.I. , Wilkins, M.B. and Nimmo, H.G. (1999) The light induction of maize phosphoenolpyruvate carboxylase kinase translatable mRNA requires transcription but not translation. Plant, Cell and Environment, 22(7), pp. 883-889. (doi: 10.1046/j.1365-3040.1999.00455.x)

1998

Nimmo, H. G. (1998) Circadian regulation of a plant protein kinase. Chronobiology International, 15(2), pp. 109-118. (doi: 10.3109/07420529808998676) (PMID:9562916)

1996

Hartwell, J., Smith, L. H., Wilkins, M. B., Jenkins, G. I. and Nimmo, H. G. (1996) Higher plant phosphoenolpyruvate carboxylase kinase is regulated at the level of translatable mRNA in response to light or a circadian rhythm. Plant Journal, 10(6), pp. 1071-1078. (doi: 10.1046/j.1365-313X.1996.10061071.x)

Lillo, C., Smith, L. H., Nimmo, H. G. and Wilkins, M. B. (1996) Regulation of nitrate reductase and phosphoenolpyruvate carboxylase activities in barley leaf protoplasts. Planta, 200(2), pp. 181-185. (doi: 10.1007/BF00208307)

Smith, L. H., Lillo, C., Nimmo, H. G. and Wilkins, M. B. (1996) Light regulation of phosphoenolpyruvate carboxylase in barley mesophyll protoplasts is modulated by protein synthesis and calcium, and not necessarily correlated with phosphoenolpyruvate carboxylase kinase activity. Planta, 200(2), pp. 174-180. (doi: 10.1007/BF00208306)

Lillo, C., Smith, L. H., Nimmo, H. G. and Wilkins, M. B. (1996) Rhythms in magnesium ion inhibition and hysteretic properties of nitrate reductase in the CAM plant Bryophyllum fedtschenkoi. Physiologia Plantarum, 98(1), pp. 140-146. (doi: 10.1111/j.1399-3054.1996.tb00685.x)

Walker, G. E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1996) Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa. Microbiology, 142(8), pp. 1973-1982. (doi: 10.1099/13500872-142-8-1973) (PMID:8760910)

Bramwell, H., Hunter, I. S., Coggins, J. R. and Nimmo, H. G. (1996) Propionyl-CoA carboxylase from Streptomyces coelicolor A3(2): cloning of the gene encoding the biotin-containing subunit. Microbiology, 142(3), pp. 649-655. (doi: 10.1099/13500872-142-3-649) (PMID:8868440)

1995

Cook, R.M., Lindsay, J.G., Wilkins, M.B. and Nimmo, H.G. (1995) Decarboxylation of malate in the Crassulacean acid metabolism plant Bryophyllum (Kalanchoe) fedtschenkoi (role of NAD-malic enqyme). Plant Physiology, 109(4), pp. 1301-1307. (doi: 10.1104/pp.109.4.1301) (PMID:12228671)

Walker, G.E., Dunbar, B., Hunter, I. S., Nimmo, H. G. and Coggins, J. R. (1995) A catalase from Streptomyces coelicolor A3(2). Microbiology, 141(6), pp. 1377-1383. (doi: 10.1099/13500872-141-6-1377) (PMID:7670639)

Carter, P. J., Wilkins, M. B., Nimmo, H. G. and Fewson, C. A. (1995) Effects of temperature on the activity of phosphoenolpyruvate carboxylase and on the control of CO2 fixation in Bryophyllum fedtschenkoi. Planta, 196(2), pp. 375-380. (doi: 10.1007/BF00201398)

Carter, P. J., Wilkins, M. B., Nimmo, H. G. and Fewson, C. A. (1995) The role of temperature in the regulation of the circadian rhythm of CO2 fixation in Bryophyllum fedtschenkoi. Planta, 196(2), pp. 381-386. (doi: 10.1007/BF00201399)

Robertson, A.G.S. and Nimmo, H.G. (1995) Site-directed mutagenesis of cysteine-195 in isocitrate lyase from Escherichia coli ML308. Biochemical Journal, 305(1), pp. 239-244. (doi: 10.1042/bj3050239) (PMID:7826335) (PMCID:PMC1136455)

1993

Bramwell, H., Nimmo, H.G. , Hunter, I.S. and Coggins, J.R. (1993) Phosphoenolpyruvate carboxylase from Streptomyces coelicolor A3(2): purification of the enzyme, cloning of the ppc gene and over-expression of the protein in a streptomycete. Biochemical Journal, 293(1), pp. 131-136. (doi: 10.1042/bj2930131) (PMID:8328954) (PMCID:PMC1134330)

1992

Rua, J., Robertson, A. G.S. and Nimmo, H. G. (1992) Identification of the histidine residue in Escherichia coli isocitrate lyase that reacts with diethylpyrocarbonate. Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology, 1122(2), pp. 212-218. (doi: 10.1016/0167-4838(92)90326-9) (PMID:1643095)

White, P.J., Nairn, J., Price, N.C., Nimmo, H.G. , Coggins, J.R. and Hunter, I.S. (1992) Phosphoglycerate mutase from Streptomyces coelicolor A3(2): Purification and characterization of the enzyme and cloning and sequence analysis of the gene. Journal of Bacteriology, 174(2), pp. 434-440. (doi: 10.1128/jb.174.2.434-440.1992) (PMID:1530847) (PMCID:PMC205734)

1991

Carter, P.J., Nimmo, H.G. , Fewson, C.A. and Wilkins, M.B. (1991) Circadian rhythms in the activity of a plant protein kinase. EMBO Journal, 10(8), pp. 2063-2068. (doi: 10.1002/j.1460-2075.1991.tb07737.x) (PMID:2065654) (PMCID:PMC452889)

McNaughton, G. A.L., MacKintosh, C., Fewson, C. A., Wilkins, M. B. and Nimmo, H. G. (1991) Illumination increases the phosphorylation state of maize leaf phosphoenolpyruvate carboxylase by causing an increase in the activity of a protein kinase. Biochimica et Biophysica Acta: Molecular Cell Research, 1093(2-3), pp. 189-195. (doi: 10.1016/0167-4889(91)90122-E) (PMID:1863599)

Abeysinghe, S. I.B., Baker, P. J., Rice, D. W., Rodgers, H. F., Stillman, T. J., Ko, Y. H., McFadden, B. A. and Nimmo, H. G. (1991) Use of chemical modification in the crystallization of isocitrate lyase from Escherichia coli. Journal of Molecular Biology, 220(1), pp. 13-16. (doi: 10.1016/0022-2836(91)90376-H) (PMID:2067012)

1990

Carter, P.J., Nimmo, H.G. , Fewson, C.A. and Wilkins, M.B. (1990) Bryophyllum fedtschenkoi protein phosphatase type 2A can dephosphorylate phosphoenolpyruvate carboxylase. FEBS Letters, 263(2), pp. 233-236. (doi: 10.1016/0014-5793(90)81381-W)

White, P.J., Young, J., Hunter, I.S., Nimmo, H.G. and Coggins, J.R. (1990) The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor. Biochemical Journal, 265(3), pp. 735-738. (doi: 10.1042/bj2650735) (PMID:2306211) (PMCID:PMC1133695)

Nimmo, H. G. , Carter, P. J., Fawson, C. A., McNaughton, G. A.L., Nimmo, G. A. and Wilkins, M. B. (1990) Regulation of phosphoenolpyruvate carboxylase: an example of signal transduction via protein phosphorylation in higher plants. Advances in Enzyme Regulation, 30, pp. 121-126. (doi: 10.1016/0065-2571(90)90013-R) (PMID:2169694)

1989

McKee, J. S., Hlodan, R. and Nimmo, H. G. (1989) Studies of the phosphorylation of Escherichia coli isocitrate dehydrogenase. Recognition of the enzyme by isocitrate dehydrogenase kinase/phosphatase and effects of phosphorylation on its structure and properties. Biochimie, 71(9-10), pp. 1059-1064. (doi: 10.1016/0300-9084(89)90111-9) (PMID:2557094)

Pyne, N.J., Cushley, W., Nimmo, H.G. and Houslay, M.D. (1989) Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes. Biochemical Journal, 261(3), pp. 897-904. (doi: 10.1042/bj2610897) (PMID:2478121) (PMCID:PMC1138914)

McKee, J.S. and Nimmo, H.G. (1989) Evidence for an arginine residue at the coenzyme-binding site of Escherichia coli isocitrate dehydrogenase. Biochemical Journal, 261(1), pp. 301-304. (doi: 10.1042/bj2610301) (PMID:2673216) (PMCID:PMC1138819)

McNaughton, G.A.L., Fewson, C.A., Wilkins, M.B. and Nimmo, H.G. (1989) Purification, oligomerization state and malate sensitivity of maize leaf phosphoenolpyruvate carboxylase. Biochemical Journal, 261(2), pp. 349-355. (doi: 10.1042/bj2610349) (PMID:2775222) (PMCID:PMC1138832)

Nimmo, H.G. , Douglas, F., Kleanthous, C., Campbell, D.G. and MacKintosh, C. (1989) Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase. Biochemical Journal, 261(2), pp. 431-435. (doi: 10.1042/bj2610431) (PMID:2673221) (PMCID:PMC1138844)

Nimmo, H. G. and Craig, J. S. (1989) Structure and regulation of Escherichia coli isocitrate dehydrogenase. Biochemical Society Transactions, 17(2), pp. 311-313. (doi: 10.1042/bst0170311) (PMID:2666187)

1988

Varela, I. and Nimmo, H. G. (1988) Photoaffinity labelling shows that Escherichia coli isocitrate dehydrogenase kinase/phosphatase contains a single ATP-binding site. FEBS Letters, 231(2), pp. 361-365. (doi: 10.1016/0014-5793(88)80850-0) (PMID:2834232)

MacKintosh, C. and Nimmo, H.G. (1988) Purification and regulatory properties of isocitrate lyase from Escherichia coli ML308. Biochemical Journal, 250(1), pp. 25-31. (doi: 10.1042/bj2500025) (PMID:3281659) (PMCID:PMC1148809)

1987

Pyne, N.J., Anderson, N., Lavan, B.E., Milligan, G. , Nimmo, H.G. and Houslay, M.D. (1987) Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. Biochemical Journal, 248(3), pp. 897-901. (doi: 10.1042/bj2480897) (PMID:2829845) (PMCID:PMC1148634)

Nimmo, H.G. and Cohen, P.T.W. (1987) Applications of recombinant DNA technology to studies of metabolic regulation. Biochemical Journal, 247(1), pp. 1-13. (doi: 10.1042/bj2470001) (PMID:3318812) (PMCID:PMC1148361)

Nimmo, G. A., McNaughton, G. A.L., Fewson, C. A., Wilkins, M. B. and Nimmo, H. G. (1987) Changes in the kinetic properties and phosphorylation state of phosphoenolpyruvate carboxylase in Zea mays leaves in reponse to light and dark. FEBS Letters, 213(1), pp. 18-22. (doi: 10.1016/0014-5793(87)81457-6)

el-Mansi, E.M.T., MacKintosh, C., Duncan, K., Holms, W.H. and Nimmo, H.G. (1987) Molecular cloning and over-expression of the glyoxylate bypass operon from Escherichia coli ML308. Biochemical Journal, 242(3), pp. 661-665. (doi: 10.1042/bj2420661) (PMID:3297049) (PMCID:PMC1147762)

Nimmo, G.A., Wilkins, M.B., Fewson, C.A. and Nimmo, H.G. (1987) Persistent circadian rhythms in the phosphorylation state of phosphoenolpyruvate carboxylase from Bryophyllum fedtschenkoi leaves and in its sensitivity to inhibition by malate. Planta, 170(3), pp. 408-415. (doi: 10.1007/BF00395034) (PMID:24232972)

Nimmo, H.G. , Borthwick, A.C., el-Mansi, E.M., Holms, W.H., MacKintosh, C. and Nimmo, G.A. (1987) Regulation of the enzymes at the branchpoint between the citric acid cycle and the glyoxylate bypass in Escherichia coli. Biochemical Society Symposia, 54, pp. 93-101. (PMID:3333001)

Nimmo, H. G. (1987) Regulation of bacterial metabolism by protein phosphorylation. Essays in Biochemistry, 23, pp. 1-27. (PMID:3331365)

1986

Pyne, N. J., Cooper, M. E., Nimmo, H. G. and Houslay, M. D. (1986) A novel method for the purification of the insulin-activated peripheral plasma membrane, high-affinity cyclic AMP phosphodiesterase. Biochemical Society Transactions, 14(6), p. 1016. (doi: 10.1042/bst0141016)

Nimmo, G.A., Nimmo, H.G. , Hamilton, I.D., Fewson, C.A. and Wilkins, M.B. (1986) Purification of the phosphorylated night form and dephosphorylated day form of phosphoenolpyruvate carboxylase from Bryophyllum fedtschenkoi. Biochemical Journal, 239(1), pp. 213-220. (doi: 10.1042/bj2390213) (PMID:3800979) (PMCID:PMC1147262)

El-Mansi, E.M.T., Nimmo, H.G. and Holms, W.H. (1986) Pyruvate metabolism and the phosphorylation state of isocitrate dehydrogenase in Escherichia coli. Journal of General Microbiology, 132(3), pp. 797-806. (doi: 10.1099/00221287-132-3-797) (PMID:3525743)

Nimmo, H.G. (1986) Kinetic mechanism of Escherichia coli isocitrate dehydrogenase and its inhibition by glyoxylate and oxaloacetate. Biochemical Journal, 234(2), pp. 317-323. (doi: 10.1042/bj2340317) (PMID:3521584) (PMCID:PMC1146568)

1985

El-Mansi, E.M.T., Nimmo, H.G. and Holms, W.H. (1985) The role of isocitrate in control of the phosphorylation of isocitrate dehydrogenase in Escherichia coli ML308. FEBS Letters, 183(2), pp. 251-255. (doi: 10.1016/0014-5793(85)80787-0)

Houston, B. and Nimmo, H. G. (1985) Effects of phosphorylation on the kinetic properties of rat liver ATP-citrate lyase. Biochimica et Biophysica Acta: Molecular Cell Research, 844(2), pp. 233-239. (doi: 10.1016/0167-4889(85)90095-3) (PMID:3871637)

1984

Nimmo, G.A., Nimmo, H.G. , Fewson, C.A. and Wilkins, M.B. (1984) Diurnal changes in the properties of phosphoenolpyruvate carboxylase in Bryophyllum leaves: a possible co valent modification. FEBS Letters, 178(2), pp. 199-203. (doi: 10.1016/0014-5793(84)80600-6)

Houston, B. and Nimmo, H.G. (1984) Purification and some kinetic properties of rat liver ATP citrate lyase. Biochemical Journal, 224(2), pp. 437-443. (doi: 10.1042/bj2240437) (PMID:6335031) (PMCID:PMC1144450)

Nimmo, G.A. and Nimmo, H.G. (1984) Studies of rat adipose-tissue microsomal glycerol phosphate acyltransferase. Biochemical Journal, 224(1), pp. 101-108. (doi: 10.1042/bj2240101) (PMID:6508751) (PMCID:PMC1144402)

Nimmo, H.G. (1984) Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote. Trends in Biochemical Sciences, 9(11), pp. 475-478. (doi: 10.1016/0968-0004(84)90315-3)

Borthwick, A.C., Holms, W.H. and Nimmo, H.G. (1984) Amino acid sequence round the site of phosphorylation in isocitrate dehydrogenase from Escherichia coli ML308. FEBS Letters, 174(1), pp. 112-115. (doi: 10.1016/0014-5793(84)81087-X) (PMID:6381094)

Meek, D.W. and Nimmo, H.G. (1984) The allosteric properties of rat liver fructose-1,6-bisphosphatase. Biochemical Journal, 222(1), pp. 131-138. (doi: 10.1042/bj2220131) (PMID:6089752) (PMCID:PMC1144153)

Meek, D.W. and Nimmo, H.G. (1984) Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase. Biochemical Journal, 222(1), pp. 125-130. (doi: 10.1042/bj2220125) (PMID:6089751) (PMCID:PMC1144152)

Borthwick, A. C., Holms, W. H. and Nimmo, H. G. (1984) Isolation of active and inactive forms of isocitrate dehydrogenase from Escherichia coli ML308. European Journal of Biochemistry, 141(2), pp. 393-400. (doi: 10.1111/j.1432-1033.1984.tb08204.x) (PMID:6376125)

Nimmo, G. A., Borthwick, A. C., Holms, W. H. and Nimmo, H. G. (1984) Partial purification and properties of isocitrate dehydrogenase kinase/phosphatase from Escherichia coli ML308. European Journal of Biochemistry, 141(2), pp. 401-408. (doi: 10.1111/j.1432-1033.1984.tb08205.x) (PMID:6329756)

Nimmo, G. A. and Nimmo, H. G. (1984) The regulatory properties of isocitrate dehydrogenase kinase and isocitrate dehydrogenase phosphatase from Escherichia coli ML308 and the roles of these activities in the control of isocitrate dehydrogenase. European Journal of Biochemistry, 141(2), pp. 409-414. (doi: 10.1111/j.1432-1033.1984.tb08206.x) (PMID:6329757)

Garland, D. and Nimmo, H.G. (1984) A comparison of the phosphorylated and unphosphorylated forms of isocitrate dehydrogenase from Escherichia coli ML308. FEBS Letters, 165(2), pp. 259-264. (doi: 10.1016/0014-5793(84)80181-7) (PMID:6363122)

1983

Meek, D.W. and Nimmo, H.G. (1983) The interaction of fructose 2,6-bisphosphate with an allosteric site of rat liver fructose 1,6-bisphosphatase. FEBS Letters, 160(1-2), pp. 105-109. (doi: 10.1016/0014-5793(83)80946-6) (PMID:6309560)

1982

Holms, W.H. and Nimmo, H.G. (1982) Reversible inactivation of isocitrate dehydrogenase in Escherichia coli. Biochemical Society Transactions, 10(5), pp. 319-320. (doi: 10.1042/bst0100319) (PMID:6754502)

Nimmo, H.G. and Nimmo, G.A. (1982) A general method for the localization of enzymes that produce phosphate, pyrophosphate, or CO2 after polyacrylamide gel electrophoresis. Analytical Biochemistry, 121(1), pp. 17-22. (doi: 10.1016/0003-2697(82)90551-6) (PMID:6178319)

Nimmo, H.G. and Tipton, K.F. (1982) [54] Fructose-bisphosphatase from ox liver. In: Wood, W. A. (ed.) Carbohydrate Metabolism: Part E. Series: Methods in enzymology (90). Academic Press: New York, pp. 330-334. ISBN 9780121819903 (doi: 10.1016/S0076-6879(82)90150-1)

1980

Nimmo, H.G. and Holms, W.H. (1980) The purification of isocitrate dehydrogenase from Escherichia coli using immobilized dyes. Biochemical Society Transactions, 8(3), pp. 390-391. (doi: 10.1042/bst0080390) (PMID:6995211)

1979

Nimmo, H.G. (1979) The location of glycerol phosphate acyltransferase and fatty acyl CoA synthase on the inner surface of the mitochondrial outer membrane. FEBS Letters, 101(2), pp. 262-264. (doi: 10.1016/0014-5793(79)81021-2) (PMID:446750)

Nimmo, H.G. (1979) Evidence for the existence of isoenzymes of glycerol phosphate acyltransferase. Biochemical Journal, 177(1), pp. 283-288. (doi: 10.1042/bj1770283) (PMID:426773) (PMCID:PMC1186367)

1978

Nimmo, H.G. and Houston, B. (1978) Rat adipose-tissue glycerol phosphate acyltransferase can be inactivated by cyclic AMP-dependent protein kinase. Biochemical Journal, 176(2), pp. 607-610. (doi: 10.1042/bj1760607) (PMID:217367) (PMCID:PMC1186273)

Cohen, P., Nimmo, H.G. and Proud, C.G. (1978) How does insulin stimulate glycogen synthesis? Biochemical Society Symposia, 43, pp. 69-95. (PMID:219866)

1977

Anoniw, J.F., Nimmo, H.G. , Yeaman, S.J. and Cowen, P. (1977) Comparison of the substrate specificities of protein phosphatases involved in the regulation of glycogen metabolism in rabbit skeletal muscle. Biochemical Journal, 162(23), pp. 423-433. (doi: 10.1042/bj1620423) (PMID:192224) (PMCID:PMC1164616)

Nimmo, H.G. and Cohen, P. (1977) Hormonal control of protein phosphorylation. Advances in Cyclic Nucleotide Research, 8, pp. 145-266. (PMID:200126)

1976

Nimmo, H.G. and Sloane, L. Z. (1976) Separation of glycogen synthase kinase 2 from casein kinase. Biochemical Society Transactions, 4(6), pp. 1024-1027. (doi: 10.1042/bst0041024) (PMID:191307)

Nimmo, H. G. , Proud, C. G. and Cohen, P. (1976) The phosphorylation of rabbit skeletal muscle glycogen synthase by glycogen synthase kinase‐2 and adenosine‐3′: 5′‐monophosphate‐dependent protein kinase. European Journal of Biochemistry, 68(1), pp. 31-44. (doi: 10.1111/j.1432-1033.1976.tb10762.x) (PMID:183955)

Nimmo, H. G. , Proud, C. G. and Cohen, P. (1976) The purification and properties of rabbit skeletal muscle glycogen synthase. European Journal of Biochemistry, 68(1), pp. 21-30. (doi: 10.1111/j.1432-1033.1976.tb10761.x) (PMID:823021)

Cohen, P., Antoniw, J. F., Nimmo, H. G. and Yeaman, S. J. (1976) Protein phosphorylation and hormone action. In: Porter, R. and Fitzsimons, D. W. (eds.) Polypeptide Hormones: Molecular and Cellular Aspects. Series: Ciba Foundation symposium (41). Elsevier: New York, pp. 281-295. ISBN 9780470663332 (doi: 10.1002/9780470720233.ch15)

1975

Cohen, P., Antoniw, J. F., Nimmo, H. G. and Proud, C. G. (1975) Structure and regulation of enzymes for the degradation and resynthesis of glycogen. Biochemical Society Transactions, 3(6), pp. 849-854. (doi: 10.1042/bst0030849)

Nimmo, H. G. and Tipton, K. F. (1975) The allosteric properties of beef‐liver fructose bisphosphatase. European Journal of Biochemistry, 58(2), pp. 575-585. (doi: 10.1111/j.1432-1033.1975.tb02408.x) (PMID:171160)

Nimmo, H. G. and Tipton, K. F. (1975) The effect of pH on the kinetics of beef‐liver fructose bisphosphatase. European Journal of Biochemistry, 58(2), pp. 567-574. (doi: 10.1111/j.1432-1033.1975.tb02407.x) (PMID:241647)

Nimmo, H.G. and Cohen, P. (1975) Glycogen synthetase kinase 2 and adenosine 3':5' cyclic monophosphate independent protein kinase activities in rabbit skeletal muscle. Biochemical Society Transactions, 3(1), pp. 85-86. (doi: 10.1042/bst0030085) (PMID:236205)

Nimmo, H.G. and Tipton, K.F. (1975) The purification of fructose 1,6 diphosphatase from ox liver and its activation by ethylenediaminetetra acetate. Biochemical Journal, 145(2), pp. 323-334. (doi: 10.1042/bj1450323) (PMID:239683) (PMCID:PMC1165221)

1974

Nimmo, H.G. and Cohen, P. (1974) Glycogen synthetase kinase 2 (GSK 2); the identification of a new protein kinase in skeletal muscle. FEBS Letters, 47(1), pp. 162-166. (doi: 10.1016/0014-5793(74)80450-3) (PMID:4372086)

1972

Nimmo, H.G. and Tipton, K.F. (1972) Preliminary investigations on bovine hepatic fructose 1,6-diphosphatase. Biochemical Journal, 130(1), 22P-23P. (doi: 10.1042/bj1300022P) (PMID:4347784) (PMCID:PMC1174370)

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