Dr Alasdair MacDonald
- Research Technician (Molecular Biosciences)
telephone:
01413307555
email:
Alasdair.MacDonald@glasgow.ac.uk
Room 492, Advanced Research Centre, 11 Chapel Lane, College of Medical, Veterinary & Life Sciences, University Avenue, Glasgow, G11 6EW
Publications
2024
MacDonald, Alasdair I., Baksh, Aron, Holland, Alexandria, Shin, Heewhan, Rice, Phoebe A., Stark, W. Marshall ORCID: https://orcid.org/0000-0001-8086-2572 and Olorunniji, Femi J.
(2024)
Variable orthogonality of serine integrase interactions within the ϕC31 family.
Scientific Reports, 14(1),
26280.
(doi: 10.1038/s41598-024-77570-9)
(PMID:39487291)
2023
Scott, Harry ORCID: https://orcid.org/0009-0008-0107-1261, Dong, Li, Stevenson, Andrew, MacDonald, Alasdair I., Srinivasan, Sharmila, Massimi, Paola, Banks, Lawrence, Martin, Patricia E., Johnstone, Scott R. and Graham, Sheila V.
ORCID: https://orcid.org/0000-0002-7140-8279
(2023)
The human Discs large protein (Dlg1) interacts with and maintains Connexin 43 at the plasma membrane in keratinocytes.
Journal of Cell Science, 136(11),
jcs259984.
(doi: 10.1242/jcs.259984)
(PMID:37288673)
(PMCID:PMC10309592)
Montaño, Sherwin P., Rowland, Sally-J., Fuller, James R., Burke, Mary E., MacDonald, Alasdair I., Boocock, Martin R., Stark, W. Marshall ORCID: https://orcid.org/0000-0001-8086-2572 and Rice, Phoebe A.
(2023)
Structural basis for topological regulation of Tn3 resolvase.
Nucleic Acids Research, 51(3),
pp. 1001-1018.
(doi: 10.1093/nar/gkac733)
(PMID:36100255)
(PMCID:PMC9943657)
2017
Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)
Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair I., Barrett, Michael P.
ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S.
ORCID: https://orcid.org/0000-0002-7838-8362
(2017)
Metabolomics on integrated circuit.
Procedia Technology, 27,
pp. 53-54.
(doi: 10.1016/j.protcy.2017.04.025)
2016
McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Anthony, Diana F., Moulisova, Vladimira
ORCID: https://orcid.org/0000-0003-0700-2837, MacDonald, Alasdair I., Macintyre, Alan, Thomson, Jacqueline, Nag, Abhijeet, Davies, R. Wayne and Shiels, Paul G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2016)
Microvesicles but not exosomes from Pathfinder Cells stimulate functional recovery of the pancreas in a mouse streptozotocin-induced diabetes model.
Rejuvenation Research, 19(3),
pp. 223-232.
(doi: 10.1089/rej.2015.1723)
Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair Iain, Martin, Christopher, Streklas, Angelos J., Campbell, Gordon, Al-Rawhani, Mohammed A., Nemeth, Balazs, Grant, James P.
ORCID: https://orcid.org/0000-0003-3562-393X, Barrett, Michael P.
ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S.
ORCID: https://orcid.org/0000-0002-7838-8362
(2016)
An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification.
IEEE Transactions on Biomedical Circuits and Systems, 10(3),
pp. 721-730.
(doi: 10.1109/TBCAS.2015.2487603)
(PMID:26742138)
Klymenko, T., Hernandez-Lopez, H., MacDonald, A.I., Bodily, J. M. and Graham, S. V. ORCID: https://orcid.org/0000-0002-7140-8279
(2016)
Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes.
Journal of Virology, 90(10),
pp. 5047-5058.
(doi: 10.1128/JVI.03073-15)
(PMID:26962216)
Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564, Qayyum, Tahir, Lim, Zhi, Hammond, Rachel, MacDonald, Alasdair I., Fraser, Siobhan, Oades, Grenville M., Aitchison, Michael, Jones, Robert J.
ORCID: https://orcid.org/0000-0002-2904-6980 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2016)
Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients.
BMC Cancer, 16,
p. 229.
(doi: 10.1186/s12885-016-2254-9)
(PMID:26984511)
(PMCID:PMC4794832)
2015
Sun, Peng, Dong, Li, MacDonald, Alasdair I., Akbari, Shahrzad, Edward, Michael, Hodgins, Malcolm B., Johnstone, Scott R. and Graham, Sheila V. ORCID: https://orcid.org/0000-0002-7140-8279
(2015)
HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells.
Viruses, 7(10),
pp. 5243-5256.
(doi: 10.3390/v7102871)
(PMID:26445057)
(PMCID:PMC4632379)
McGlynn, Liane M., McCluney, Simon, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725, Thomson, Jackie, MacDonald, Alasdair I., Oien, Karin
ORCID: https://orcid.org/0000-0002-5237-275X, Dickson, Euan J., Carter, C. Ross, McKay, Colin J. and Shiels, Paul G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2015)
SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients.
PLoS ONE, 10(6),
e0131344.
(doi: 10.1371/journal.pone.0131344)
(PMID:26121130)
(PMCID:PMC4487247)
McFarlane, Melanie ORCID: https://orcid.org/0000-0002-8392-2291, MacDonald, Alasdair I., Stevenson, Andrew and Graham, Sheila V.
ORCID: https://orcid.org/0000-0002-7140-8279
(2015)
Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35).
Journal of Virology, 89(10),
pp. 5276-5287.
(doi: 10.1128/JVI.03434-14)
(PMID:25717103)
2014
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
2013
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. ORCID: https://orcid.org/0000-0002-6342-2222 and Shiels, P.G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2013)
Pathfinder cells provide a novel therapeutic intervention for acute kidney injury.
Rejuvenation Research, 16(1),
pp. 11-20.
(doi: 10.1089/rej.2012.1350)
McCusker, S.M., Macqueen, I., Lough, G., MacDonald, A.I., Campbell, C. and Graham, S.V. ORCID: https://orcid.org/0000-0002-7140-8279
(2013)
Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland.
BMC Public Health, 13(264),
(doi: 10.1186/1471-2458-13-264)
Roxburgh, C.S. ORCID: https://orcid.org/0000-0002-2649-6695, Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C.
ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G.
ORCID: https://orcid.org/0000-0001-5557-7905, Edwards, J.
ORCID: https://orcid.org/0000-0002-7192-6906 and Shiels, P.G
ORCID: https://orcid.org/0000-0002-7577-9843
(2013)
The in situ local immune response, tumour senescence and proliferation in colorectal cancer.
British Journal of Cancer, 109(8),
pp. 2207-2216.
(doi: 10.1038/bjc.2013.556)
2012
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
MacDonald, A.I. et al. (2012) A functional interaction between the MAGUK protein hDlg and the gap junction protein Connexin 43 in cervical tumour cells. Biochemical Journal, 446(1), pp. 9-21. (doi: 10.1042/BJ20111144)
2010
Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. ORCID: https://orcid.org/0000-0002-7140-8279
(2010)
Poly(A)-binding protein 1 (PABP1) partially relocalises to the nucleus during HSV-1 infection in an ICP27-independent manner and does not inhibit virus replication.
Journal of Virology, 84(17),
pp. 8539-8548.
(doi: 10.1128/JVI.00668-10)
(PMID:20573819)
(PMCID:PMC2919032)
2008
MacDonald, A.I, Lu, Y., Kilbride, E.A., Akopian, A. and Colloms, S.D. ORCID: https://orcid.org/0000-0003-2369-8168
(2008)
PepA and ArgR do not regulate Cre recombination at the bacteriophage P1 loxP site.
Plasmid, 59(2),
pp. 119-126.
(doi: 10.1016/j.plasmid.2007.12.001)
(PMID:18226834)
(PMCID:PMC2409434)
2004
Zhang, M., MacDonald, A. I., Hoyt, M. A. and Coffino, P. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. Journal of Biological Chemistry, 279(20), pp. 20959-20965. (doi: 10.1074/jbc.M314043200) (PMID:15016805)
2002
Chen, Hui, MacDonald, Alasdair and Coffino, Philip (2002) Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Journal of Biological Chemistry, 277(48), pp. 45957-45961. (doi: 10.1074/jbc.M206799200) (PMID:12359729)
Articles
MacDonald, Alasdair I., Baksh, Aron, Holland, Alexandria, Shin, Heewhan, Rice, Phoebe A., Stark, W. Marshall ORCID: https://orcid.org/0000-0001-8086-2572 and Olorunniji, Femi J.
(2024)
Variable orthogonality of serine integrase interactions within the ϕC31 family.
Scientific Reports, 14(1),
26280.
(doi: 10.1038/s41598-024-77570-9)
(PMID:39487291)
Scott, Harry ORCID: https://orcid.org/0009-0008-0107-1261, Dong, Li, Stevenson, Andrew, MacDonald, Alasdair I., Srinivasan, Sharmila, Massimi, Paola, Banks, Lawrence, Martin, Patricia E., Johnstone, Scott R. and Graham, Sheila V.
ORCID: https://orcid.org/0000-0002-7140-8279
(2023)
The human Discs large protein (Dlg1) interacts with and maintains Connexin 43 at the plasma membrane in keratinocytes.
Journal of Cell Science, 136(11),
jcs259984.
(doi: 10.1242/jcs.259984)
(PMID:37288673)
(PMCID:PMC10309592)
Montaño, Sherwin P., Rowland, Sally-J., Fuller, James R., Burke, Mary E., MacDonald, Alasdair I., Boocock, Martin R., Stark, W. Marshall ORCID: https://orcid.org/0000-0001-8086-2572 and Rice, Phoebe A.
(2023)
Structural basis for topological regulation of Tn3 resolvase.
Nucleic Acids Research, 51(3),
pp. 1001-1018.
(doi: 10.1093/nar/gkac733)
(PMID:36100255)
(PMCID:PMC9943657)
Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)
Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair I., Barrett, Michael P.
ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S.
ORCID: https://orcid.org/0000-0002-7838-8362
(2017)
Metabolomics on integrated circuit.
Procedia Technology, 27,
pp. 53-54.
(doi: 10.1016/j.protcy.2017.04.025)
McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Anthony, Diana F., Moulisova, Vladimira
ORCID: https://orcid.org/0000-0003-0700-2837, MacDonald, Alasdair I., Macintyre, Alan, Thomson, Jacqueline, Nag, Abhijeet, Davies, R. Wayne and Shiels, Paul G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2016)
Microvesicles but not exosomes from Pathfinder Cells stimulate functional recovery of the pancreas in a mouse streptozotocin-induced diabetes model.
Rejuvenation Research, 19(3),
pp. 223-232.
(doi: 10.1089/rej.2015.1723)
Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair Iain, Martin, Christopher, Streklas, Angelos J., Campbell, Gordon, Al-Rawhani, Mohammed A., Nemeth, Balazs, Grant, James P.
ORCID: https://orcid.org/0000-0003-3562-393X, Barrett, Michael P.
ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S.
ORCID: https://orcid.org/0000-0002-7838-8362
(2016)
An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification.
IEEE Transactions on Biomedical Circuits and Systems, 10(3),
pp. 721-730.
(doi: 10.1109/TBCAS.2015.2487603)
(PMID:26742138)
Klymenko, T., Hernandez-Lopez, H., MacDonald, A.I., Bodily, J. M. and Graham, S. V. ORCID: https://orcid.org/0000-0002-7140-8279
(2016)
Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes.
Journal of Virology, 90(10),
pp. 5047-5058.
(doi: 10.1128/JVI.03073-15)
(PMID:26962216)
Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564, Qayyum, Tahir, Lim, Zhi, Hammond, Rachel, MacDonald, Alasdair I., Fraser, Siobhan, Oades, Grenville M., Aitchison, Michael, Jones, Robert J.
ORCID: https://orcid.org/0000-0002-2904-6980 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2016)
Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients.
BMC Cancer, 16,
p. 229.
(doi: 10.1186/s12885-016-2254-9)
(PMID:26984511)
(PMCID:PMC4794832)
Sun, Peng, Dong, Li, MacDonald, Alasdair I., Akbari, Shahrzad, Edward, Michael, Hodgins, Malcolm B., Johnstone, Scott R. and Graham, Sheila V. ORCID: https://orcid.org/0000-0002-7140-8279
(2015)
HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells.
Viruses, 7(10),
pp. 5243-5256.
(doi: 10.3390/v7102871)
(PMID:26445057)
(PMCID:PMC4632379)
McGlynn, Liane M., McCluney, Simon, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725, Thomson, Jackie, MacDonald, Alasdair I., Oien, Karin
ORCID: https://orcid.org/0000-0002-5237-275X, Dickson, Euan J., Carter, C. Ross, McKay, Colin J. and Shiels, Paul G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2015)
SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients.
PLoS ONE, 10(6),
e0131344.
(doi: 10.1371/journal.pone.0131344)
(PMID:26121130)
(PMCID:PMC4487247)
McFarlane, Melanie ORCID: https://orcid.org/0000-0002-8392-2291, MacDonald, Alasdair I., Stevenson, Andrew and Graham, Sheila V.
ORCID: https://orcid.org/0000-0002-7140-8279
(2015)
Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35).
Journal of Virology, 89(10),
pp. 5276-5287.
(doi: 10.1128/JVI.03434-14)
(PMID:25717103)
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. ORCID: https://orcid.org/0000-0002-6342-2222 and Shiels, P.G.
ORCID: https://orcid.org/0000-0002-7577-9843
(2013)
Pathfinder cells provide a novel therapeutic intervention for acute kidney injury.
Rejuvenation Research, 16(1),
pp. 11-20.
(doi: 10.1089/rej.2012.1350)
McCusker, S.M., Macqueen, I., Lough, G., MacDonald, A.I., Campbell, C. and Graham, S.V. ORCID: https://orcid.org/0000-0002-7140-8279
(2013)
Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland.
BMC Public Health, 13(264),
(doi: 10.1186/1471-2458-13-264)
Roxburgh, C.S. ORCID: https://orcid.org/0000-0002-2649-6695, Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C.
ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G.
ORCID: https://orcid.org/0000-0001-5557-7905, Edwards, J.
ORCID: https://orcid.org/0000-0002-7192-6906 and Shiels, P.G
ORCID: https://orcid.org/0000-0002-7577-9843
(2013)
The in situ local immune response, tumour senescence and proliferation in colorectal cancer.
British Journal of Cancer, 109(8),
pp. 2207-2216.
(doi: 10.1038/bjc.2013.556)
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
MacDonald, A.I. et al. (2012) A functional interaction between the MAGUK protein hDlg and the gap junction protein Connexin 43 in cervical tumour cells. Biochemical Journal, 446(1), pp. 9-21. (doi: 10.1042/BJ20111144)
Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. ORCID: https://orcid.org/0000-0002-7140-8279
(2010)
Poly(A)-binding protein 1 (PABP1) partially relocalises to the nucleus during HSV-1 infection in an ICP27-independent manner and does not inhibit virus replication.
Journal of Virology, 84(17),
pp. 8539-8548.
(doi: 10.1128/JVI.00668-10)
(PMID:20573819)
(PMCID:PMC2919032)
MacDonald, A.I, Lu, Y., Kilbride, E.A., Akopian, A. and Colloms, S.D. ORCID: https://orcid.org/0000-0003-2369-8168
(2008)
PepA and ArgR do not regulate Cre recombination at the bacteriophage P1 loxP site.
Plasmid, 59(2),
pp. 119-126.
(doi: 10.1016/j.plasmid.2007.12.001)
(PMID:18226834)
(PMCID:PMC2409434)
Zhang, M., MacDonald, A. I., Hoyt, M. A. and Coffino, P. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. Journal of Biological Chemistry, 279(20), pp. 20959-20965. (doi: 10.1074/jbc.M314043200) (PMID:15016805)
Chen, Hui, MacDonald, Alasdair and Coffino, Philip (2002) Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Journal of Biological Chemistry, 277(48), pp. 45957-45961. (doi: 10.1074/jbc.M206799200) (PMID:12359729)
Research datasets
2017
Al-Rawhani, M., Cheah, B. C., MacDonald, A., Martin, C., Hu, C. , Beeley, J., Gouveia, L., Grant, J. , Campbell, G., Barrett, M. and Cumming, D. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. [Data Collection]
2015
Cheah, B. C., MacDonald, A., Martin, C., Streklas, A.J., Campbell, G., Al-Rawhani, M., Nemeth, B., Grant, J. , Barrett, M. and Cumming, D. (2015) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. [Data Collection]