Dr Tomoko Iwata

  • Senior Lecturer (Undergraduate Medical School)

telephone: 01413549438
email: Tomoko.Iwata@glasgow.ac.uk

School of Medicine, Dentistry & Nursing, Laboratory Medicine Building, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF

Biography

Dr Tomoko Iwata is a senior lecturer in University of Glasgow since 2002. Dr Iwata obtained PhD in Biochemistry from ETH-Zurich. Her postdoctoral work, conducted in the NIH, USA, and in Max-Planck Institute, Germany, aimed to understand the roles of FGFR3 gene mutations in genetic diseases using in vivo models and transcriptome analysis. 

Dr Iwata’s research interest is to understand the role of growth factor/cytokine signalling in regulation of inflammation in tumour immune microenvironment during bladder cancer progression, with a goal to improve immunotherapy response with better biomarkers.

Dr Iwata also contributes in the Innovate UK funded “Integrated TeChnologies for Improved Polyp SurveillancE (INCISE)” project that aims to better predict polyp recurrence, by investigating the potential utility of inflammatory markers in colorectal polyps by multiplex immunofluorescence (mIF) and quantitative pathology imaging.

Research interests

For better diagnosis and treatment of bladder cancer and colorectal cancer, we are interested in:

  • Multiplex Immunofluorescence (mIF) and quantitative pathology imaging analysis of tumour immune microenvironment and signalling pathways
  • A driver role of FGFR3 in bladder cancer
  • Role of inflammation and myeloid cells in cancer progression and immunotherapy
  • Characterization of COX2 expression in colorectal polyps by QuPath (INCISE)

 Current PhD projects are offered from the above topic.

PhD research projects offered in Molecular Pathology

Dr Iwata is also a co-supervisor of Medical Research Scotland (MRS) funded PhD project “Examining the colonic polyp microbiome and its association with future colorectal neoplasia risk in a bowel screening population” with Professor Joanne Edwards (PI), Dr Stephen McSorley, and Dr Ditte Andersen.

Publications

List by: Type | Date

Jump to: 2022 | 2020 | 2018 | 2016 | 2015 | 2014 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2004 | 2001 | 2000 | 1999
Number of items: 22.

2022

Ismail, N. F. B., Foth, M., Yousef, A. R. E., Cui, N., Leach, J. D.G., Jamieson, T., Karim, S. A., Salmond, J. M., Morton, J. P. and Iwata, T. (2022) Loss of Cxcr2 in myeloid cells promotes tumour progression and T cell infiltration in invasive bladder cancer. Bladder Cancer, 8(3), pp. 277-290. (doi: 10.3233/BLC-211645)

2020

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J. , Leung, H. Y. and Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, 38(9), 731.e1-737.e10. (doi: 10.1016/j.urolonc.2020.05.012) (PMID:32532529)

2018

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J. and Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, 246(3), pp. 331-343. (doi: 10.1002/path.5143) (PMID:30043421) (PMCID:PMC6334176)

2016

Rehbini, O., Mohan, G., Sindi, A., Garza Manero, S., Gurden, R., Iwata, T. and West, K. (2016) Knockdown High Mobility Nucleosomal Binding Proteins 2 (HMGN2) Alter the Histone Modification H4K4me3 and H3K27me3 and Regulates Stem Cells Pluripotency. 9th Saudi Student Conference, Birmingham, UK, 13-14 Feb 2016.

2015

Rehbini, O., Sindi, A., Mohan, G., Garza Manero, S., Iwata, T. and West, K. L. (2015) The Hmgn Family of Chromatin Binding Proteins Regulates Stem Cells Pluripotency and Neuronal Differentiation. Wellcome Trust-Waddington Symposium: Epigenetics in Dialogue with THE GENOME, Edinburgh, UK, 01-05 Jun 2015.

2014

Foth, M. et al. (2014) Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. Journal of Pathology, 233(2), pp. 148-158. (doi: 10.1002/path.4334)

2012

Mohan, G., Rehbini, O., Iwata, T. and West, K. (2012) The Hmgn Family of Chromatin Binding Proteins Regulate Stem Cell Pluripotency and Neuronal Differentiation. Biochemical Society Annual Symposium: Epigenetic Mechanisms in Development and Disease, Leeds, UK, 11-13 Dec 2012.

Ahmad, I. , Iwata, T. and Leung, H.Y. (2012) Mechanisms of FGFR-mediated carcinogenesis. Biochimica et Biophysica Acta: Molecular Cell Research, 1823(4), pp. 850-860. (doi: 10.1016/j.bbamcr.2012.01.004)

2011

Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi: 10.1242/dmm.006874)

Moldrich, R.X. et al. (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240(6), pp. 1586-1599. (doi: 10.1002/dvdy.22636) (PMID:21491541)

2010

Pellicano, F., Thomson, R.E., Inman, G.J. and Iwata, T. (2010) Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene. BMC Cancer, 10(1), 657. (doi: 10.1186/1471-2407-10-657) (PMID:21118521) (PMCID:PMC3001724)

2009

Iwata, T. and Hevner, R. (2009) Fibroblast growth factor signaling in development of the cerebral cortex. Development Growth and Differentiation, 51(3), pp. 299-323.

Thomson, R., Kind, P.C., Graham, N.A., Etherson, M.L., Kennedy, J., Fernandes, A.C., Marques, C.S., Hevner, R.F. and Iwata, T. (2009) Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Development, 4(4), (doi: 10.1186/1749-8104-4-4) (PMID:19192266) (PMCID:PMC2661882)

2007

Thomson, R. E., Pellicano, F. and Iwata, T. (2007) Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogen-activated protein kinase activation. Journal of Neurochemistry, 100(6), pp. 1565-1578. (doi: 10.1111/j.1471-4159.2006.04285.x) (PMID:17181553)

2006

Ambrosino, C., Iwata, T., Scafoglio, C., Mallardo, M., Klein, R. and Nebreda, A. (2006) TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes. Biochemical Journal, 396(1), pp. 163-172.

Pellicano, F., Inglis-Broadgate, S. L., Pante, G., Ansorge, W. and Iwata, T. (2006) Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain. Gene Expression Patterns, 6(3), pp. 285-293. (doi: 10.1016/j.modgep.2005.07.004)

2005

Inglis-Broadgate, S. L., Thomson, R. E., Pellicano, F., Tartaglia, M. A., Pontikis, C. C., Cooper, J. D. and Iwata, T. (2005) FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Developmental Biology, 279(1), pp. 73-85. (doi: 10.1016/j.ydbio.2004.11.035)

Pante, G., Thompson, J., Lamballe, F., Iwata, T., Ferby, I., Barr, F., Davies, A., Maina, F. and Klein, R. (2005) Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. Journal of Cell Biology, 171, pp. 337-348.

2004

Cho, J., Guo, C., Torello, M., Lunstrum, G., Iwata, T., Deng, C. and Horton, W. (2004) Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A, 101(2), pp. 609-614.

2001

Iwata, T., Li, C., Deng, C. and Francomano, C. (2001) Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Human Molecular Genetics, 10(12), pp. 1255-1264.

2000

Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A. and Deng, C.X. (2000) A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Human Molecular Genetics, 9(11), pp. 1603-13.

1999

Li, C., Chen, L., Iwata, T., Kitagawa, M., Fu, X.Y. and Deng, C.X. (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Human Molecular Genetics, 8(1), pp. 35-44.

This list was generated on Fri Dec 2 20:40:51 2022 GMT.
Number of items: 22.

Articles

Ismail, N. F. B., Foth, M., Yousef, A. R. E., Cui, N., Leach, J. D.G., Jamieson, T., Karim, S. A., Salmond, J. M., Morton, J. P. and Iwata, T. (2022) Loss of Cxcr2 in myeloid cells promotes tumour progression and T cell infiltration in invasive bladder cancer. Bladder Cancer, 8(3), pp. 277-290. (doi: 10.3233/BLC-211645)

Pritchard, J. J.G., Hamilton, G., Hurst, C. D., Fraser, S., Orange, C., Knowles, M. A., Jones, R. J. , Leung, H. Y. and Iwata, T. (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, 38(9), 731.e1-737.e10. (doi: 10.1016/j.urolonc.2020.05.012) (PMID:32532529)

Foth, M., Ismail, N. F. B., Kung, J. S. C., Tomlinson, D., Knowles, M. A., Eriksson, P., Sjödahl, G., Salmond, J. M., Sansom, O. J. and Iwata, T. (2018) FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation. Journal of Pathology, 246(3), pp. 331-343. (doi: 10.1002/path.5143) (PMID:30043421) (PMCID:PMC6334176)

Foth, M. et al. (2014) Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. Journal of Pathology, 233(2), pp. 148-158. (doi: 10.1002/path.4334)

Ahmad, I. , Iwata, T. and Leung, H.Y. (2012) Mechanisms of FGFR-mediated carcinogenesis. Biochimica et Biophysica Acta: Molecular Cell Research, 1823(4), pp. 850-860. (doi: 10.1016/j.bbamcr.2012.01.004)

Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi: 10.1242/dmm.006874)

Moldrich, R.X. et al. (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240(6), pp. 1586-1599. (doi: 10.1002/dvdy.22636) (PMID:21491541)

Pellicano, F., Thomson, R.E., Inman, G.J. and Iwata, T. (2010) Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene. BMC Cancer, 10(1), 657. (doi: 10.1186/1471-2407-10-657) (PMID:21118521) (PMCID:PMC3001724)

Iwata, T. and Hevner, R. (2009) Fibroblast growth factor signaling in development of the cerebral cortex. Development Growth and Differentiation, 51(3), pp. 299-323.

Thomson, R., Kind, P.C., Graham, N.A., Etherson, M.L., Kennedy, J., Fernandes, A.C., Marques, C.S., Hevner, R.F. and Iwata, T. (2009) Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Development, 4(4), (doi: 10.1186/1749-8104-4-4) (PMID:19192266) (PMCID:PMC2661882)

Thomson, R. E., Pellicano, F. and Iwata, T. (2007) Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogen-activated protein kinase activation. Journal of Neurochemistry, 100(6), pp. 1565-1578. (doi: 10.1111/j.1471-4159.2006.04285.x) (PMID:17181553)

Ambrosino, C., Iwata, T., Scafoglio, C., Mallardo, M., Klein, R. and Nebreda, A. (2006) TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes. Biochemical Journal, 396(1), pp. 163-172.

Pellicano, F., Inglis-Broadgate, S. L., Pante, G., Ansorge, W. and Iwata, T. (2006) Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain. Gene Expression Patterns, 6(3), pp. 285-293. (doi: 10.1016/j.modgep.2005.07.004)

Inglis-Broadgate, S. L., Thomson, R. E., Pellicano, F., Tartaglia, M. A., Pontikis, C. C., Cooper, J. D. and Iwata, T. (2005) FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Developmental Biology, 279(1), pp. 73-85. (doi: 10.1016/j.ydbio.2004.11.035)

Pante, G., Thompson, J., Lamballe, F., Iwata, T., Ferby, I., Barr, F., Davies, A., Maina, F. and Klein, R. (2005) Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. Journal of Cell Biology, 171, pp. 337-348.

Cho, J., Guo, C., Torello, M., Lunstrum, G., Iwata, T., Deng, C. and Horton, W. (2004) Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A, 101(2), pp. 609-614.

Iwata, T., Li, C., Deng, C. and Francomano, C. (2001) Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Human Molecular Genetics, 10(12), pp. 1255-1264.

Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A. and Deng, C.X. (2000) A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Human Molecular Genetics, 9(11), pp. 1603-13.

Li, C., Chen, L., Iwata, T., Kitagawa, M., Fu, X.Y. and Deng, C.X. (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Human Molecular Genetics, 8(1), pp. 35-44.

Conference or Workshop Item

Rehbini, O., Mohan, G., Sindi, A., Garza Manero, S., Gurden, R., Iwata, T. and West, K. (2016) Knockdown High Mobility Nucleosomal Binding Proteins 2 (HMGN2) Alter the Histone Modification H4K4me3 and H3K27me3 and Regulates Stem Cells Pluripotency. 9th Saudi Student Conference, Birmingham, UK, 13-14 Feb 2016.

Rehbini, O., Sindi, A., Mohan, G., Garza Manero, S., Iwata, T. and West, K. L. (2015) The Hmgn Family of Chromatin Binding Proteins Regulates Stem Cells Pluripotency and Neuronal Differentiation. Wellcome Trust-Waddington Symposium: Epigenetics in Dialogue with THE GENOME, Edinburgh, UK, 01-05 Jun 2015.

Mohan, G., Rehbini, O., Iwata, T. and West, K. (2012) The Hmgn Family of Chromatin Binding Proteins Regulate Stem Cell Pluripotency and Neuronal Differentiation. Biochemical Society Annual Symposium: Epigenetic Mechanisms in Development and Disease, Leeds, UK, 11-13 Dec 2012.

This list was generated on Fri Dec 2 20:40:51 2022 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Use of cell-free plasma DNA as a biomarker of canine cancer
    The Humanimal Trust
    2017 - 2018
     
  • Cortical Development Meeting (Crete) and ISDB/JSDB [International Society of Developmental Biologists/Japanese Society of Developmental Biologists] Meeting (Japan)
    Scottish Stem Cell Network
    2008 - 2008
     
  • Control of cell cycle & apoptosis in cortical progenitors by Fgf receptor 3
    Biotechnology and Biological Sciences Research Council
    2004 - 2007
     

Teaching

Dr Iwata is PG Convener of School of Medicine, Dentistry and Nursing.

Other teaching activities include;

  • MSc/PgCert/PgDip (blended online) Molecular Pathology (Programme Director)
  • BScMedSci Clinical Medicine, Molecular Pathology specialist course (course coordinator)
  • Lectures: Targeting Cancer Signalling (Best Lectures voted by students – 2nd place 2022), Bladder cancer
  • Project Supervision: Molecular Pathology projects (wet and dry)

Dr Iwata is also an EDI lead and attends College of MVLS Race Subcommittee.