Dr Jennifer Malcolm

Lecturer (Dental School)

telephone: 01412119763
email: Jennifer.Malcolm@glasgow.ac.uk

School of Medicine, Dentistry & Nursing, Level 9, L14, Glasgow Dental School, Glasgow, G2 3JZ

Biography

I graduated with a 1st Class BSc/Hons in Microbiology from Glasgow Caledonian University, where I first sparked an interest in host-pathogen interactions in health and disease. I pursued this interest during my PhD at the University of Glasgow, School of Medicine, Dentistry and Nursing, where I investigated oral biofilm development in young children coincident with the maturation of salivary immune responses.

After my PhD, I worked as a Post-Doctoral Research Associate at the University of Glasgow, School of Infection and Immunity, where I developed a discovery pipeline for therapeutic targets for periodontal disease. This work has formed the basis of further investigations of cellular mechanisms in oral health and disease. Subsequently, I was the lead post-doctoral researcher on a Versus Arthritis Research grant. In this project, I identified a novel mechanism of breach of immune tolerance related to non-endogenous bacterial citrullination. These data have implications for understanding how oral bacterial infection can drive autoimmune responses.

In 2018, I took up a teaching position at the University of Glasgow Dental School. Here, I am exploring how oral bacteria exploit innate immunity to subvert adaptive immune responses, and how this impacts the maintenance of immune tolerance in the oral mucosa.

Publications

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Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2018 | 2016 | 2015 | 2014 | 2011

Number of items: 20.

2024

Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 and Culshaw, Shauna ORCID: https://orcid.org/0000-0002-9653-5629 (2024) Aberrant immunity in the oral cavity—a link with rheumatoid arthritis? Frontiers in Oral Health, 5, 1430886. (doi: 10.3389/froh.2024.1430886) (PMID:38948089)

Lopez‐Oliva, Isabel, Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 and Culshaw, Shauna ORCID: https://orcid.org/0000-0002-9653-5629 (2024) Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases. Periodontology 2000, (doi: 10.1111/prd.12530) (Early Online Publication)

2023

Malcolm, J. et al. (2023) C-Terminal Citrullinated Peptide Alters APC-CD4 T Cell Interactions Leading to Breach of Immune Tolerance. Mastering Immunity ProImmune Conference, February 2023.

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

Makki, Zayneb, Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 and Miguel, Joao Carlos ORCID: https://orcid.org/0000-0002-3371-5630 (2023) COVID-19 adaptations with virtual microscopy. In: Varsu, Ourania, Rea, Paul M. and Welsh, Michelle (eds.) Biomedical Visualisation. Series: Advances in experimental medicine and biology, vol 1397. Springer: Cham, pp. 173-197. ISBN 9783031171345 (doi: 10.1007/978-3-031-17135-2_10)

2022

Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 (2022) Using Microsoft Teams to Support Active Small Group Learning and Teaching of Biomedical Sciences. Early Career Lecturers in Biosciences Workshop: Lessons Learned during the pandemic, exploring how we continue to use good blended teaching practices and innovations, 14 January 2022.

2021

McKerlie, Robert Allen ORCID: https://orcid.org/0000-0003-4910-2764, Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283, Varsou, Ourania ORCID: https://orcid.org/0000-0002-7789-1185, Kennedy, Christopher Edward ORCID: https://orcid.org/0000-0001-7548-7413, Colgan, Laura, Harper, Victoria, McAllan, Wendy, Forgie, Andrew, Rea, Paul ORCID: https://orcid.org/0000-0002-8486-373X and Bell, Aileen ORCID: https://orcid.org/0000-0001-5701-7012 (2021) A rapid transition to blended learning: the journey of a dental degree programme pivoting online. Journal of Perspectives in Applied Academic Practice, 9(2), pp. 169-180. (doi: 10.14297/jpaap.v9i2.475)

Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 and Rea, Paul ORCID: https://orcid.org/0000-0002-8486-373X (2021) Using Microsoft Teams to Support Active Small Group Learning and Teaching. 14th Annual University of Glasgow Learning and Teaching Conference: Transforming Teaching and Taking Stock, University of Glasgow, 18th July 2021.

2020

Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283 (2020) Using Threshold Concepts to Enhance Integration and Application of Science in Healthcare Curricula. Association of Medical Education in Europe Annual Conference 2020, 7-9 September 2020.

2018

Brown, J.L. ORCID: https://orcid.org/0000-0002-8168-5333, Campbell, L., Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283, Adrados Planell, A., Butcher, J.P. and Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Simon-Soro, A., Sherriff, A. ORCID: https://orcid.org/0000-0002-1016-037X, Sadique, S., Ramage, G. ORCID: https://orcid.org/0000-0002-0932-3514, Macpherson, L. ORCID: https://orcid.org/0000-0002-7227-2991, Mira, A., Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 and Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283 (2018) Combined analysis of the salivary microbiome and host defence peptides predicts dental disease. Scientific Reports, 8, 1484. (doi: 10.1038/s41598-018-20085-x) (PMID:29367728) (PMCID:PMC5784018)

2016

Ramage, G. ORCID: https://orcid.org/0000-0002-0932-3514, Lappin, D.F., Millhouse, E., Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283, Jose, A., Yang, J., Bradshaw, D.J., Pratten, J.R. and Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 (2016) The epithelial cell response to health and disease associated oral biofilm models. Journal of Periodontal Research, 52(3), pp. 325-333. (doi: 10.1111/jre.12395) (PMID:27330034) (PMCID:PMC5412879)

Malcolm, J. et al. (2016) Mast cells contribute to Porphyromonas gingivalis–induced bone loss. Journal of Dental Research, 95(6), pp. 704-710. (doi: 10.1177/0022034516634630) (PMID:26933137)

Campbell, L., Millhouse, E., Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283 and Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi: 10.1111/omi.12144) (PMID:26505640)

2015

O'Donnell, Lindsay E., Millhouse, Emma, Sherry, Leighann ORCID: https://orcid.org/0000-0002-0493-6135, Kean, Ryan, Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283, Nile, Christopher J. ORCID: https://orcid.org/0000-0001-8218-2167, Ramage, Gordon ORCID: https://orcid.org/0000-0002-0932-3514 and Munro, Carol (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi: 10.1177/0022034515577815) (PMID:25808546)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283, Macleod, M.K.L. ORCID: https://orcid.org/0000-0003-1843-8580, Adrados Planell, A., Campbell, L., Nibbs, R.J.B. ORCID: https://orcid.org/0000-0002-8150-0044, Garside, P. ORCID: https://orcid.org/0000-0001-5944-0287, McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280 and Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi: 10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

2014

Malcolm, Jennifer ORCID: https://orcid.org/0000-0003-0020-0283, Sherriff, Andrea ORCID: https://orcid.org/0000-0002-1016-037X, Lappin, David F, Ramage, Gordon ORCID: https://orcid.org/0000-0002-0932-3514, Conway, David I ORCID: https://orcid.org/0000-0001-7762-4063, Macpherson, Lorna MD ORCID: https://orcid.org/0000-0002-7227-2991 and Culshaw, Shauna ORCID: https://orcid.org/0000-0002-9653-5629 (2014) Salivary antimicrobial proteins associate with age-related changes in streptococcal composition in dental plaque. Molecular Oral Microbiology, 29(6), pp. 284-293. (doi: 10.1111/omi.12058)

2011

Butcher, J.P., Malcolm, J. ORCID: https://orcid.org/0000-0003-0020-0283, Benson, R.A. ORCID: https://orcid.org/0000-0003-3687-0481, Deng, D.M., Brewer, J.M. ORCID: https://orcid.org/0000-0001-7933-0915, Garside, P. ORCID: https://orcid.org/0000-0001-5944-0287 and Culshaw, S. ORCID: https://orcid.org/0000-0002-9653-5629 (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)

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