2024

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, (doi: 10.1016/S2213-8587(23)00385-6) (Early Online Publication)

2023

Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)

Sattar, N. , Welsh, P. , Leslie, W. S., Thom, G. , McCombie, L., Brosnahan, N. , Richardson, J., Gill, J. M. R. , Crawford, L. and Lean, M. E. J. (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)

2022

Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)

Noronha, J. C., Thom, G. and Lean, M. E.J. (2022) Total diet replacement within an integrated intensive lifestyle intervention for remission of type 2 diabetes: lessons from DiRECT. Frontiers in Endocrinology, 13, 888557. (doi: 10.3389/fendo.2022.888557) (PMID:35721753) (PMCID:PMC9202990)

Rehackova, L., Taylor, R., Lean, M. , Barnes, A., McCombie, L., Thom, G. , Brosnahan, N. , Leslie, W. S. and Sniehotta, F. F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)

Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)

2021

Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)

Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)

Brosnahan, N. , Leslie, W., McCombie, L., Barnes, A., Thom, G. , McConnachie, A. , Messow, C. M. , Sattar, N. , Taylor, R. and Lean, M. E.J. (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Thom, G. , Lean, M. E.J. , Brosnahan, N. , Algindan, Y. Y., Malkova, D. and Dombrowski, S. U. (2021) ‘I have been all in, I have been all out and I have been everything in-between’: a 2-year longitudinal qualitative study of weight-loss maintenance. Journal of Human Nutrition and Dietetics, 34(1), pp. 199-214. (doi: 10.1111/jhn.12826) (PMID:33089558)

2020

Thom, G. , Dombrowski, S. U., Brosnahan, N. , Algindan, Y. Y., Lopez-Gonzalez, M. R., Roditi, G., Lean, M. E.J. and Malkova, D. (2020) Response to comments on "The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed methods study". European Journal of Clinical Nutrition, 74(7), pp. 1115-1116. (doi: 10.1038/s41430-020-0651-2) (PMID:32393752)

Thom, G. , Dombrowski, S. U., Brosnahan, N. , Algindan, Y. Y., Rosario Lopez-Gonzalez, M., Roditi, G., Lean, M. E.J. and Malkova, D. (2020) The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study. European Journal of Clinical Nutrition, 74(4), pp. 622-632. (doi: 10.1038/s41430-020-0568-9) (PMID:32020057)

Thom, G. , Gerasimidis, K. , Rizou, E., Alfheeaid, H. , Barwell, N., Manthou, E., Fatima, S., Gill, J. M.R. , Lean, M. E.J. and Malkova, D. (2020) Validity of predictive equations to estimate RMR in females with varying BMI. Journal of Nutritional Science, 9, e17. (doi: 10.1017/jns.2020.11)

2019

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

2018

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

2017

Thom, G. and Lean, M. (2017) Is there an optimal diet for weight management and metabolic health? Gastroenterology, 152(7), pp. 1739-1751. (doi: 10.1053/j.gastro.2017.01.056) (PMID:28214525)

2016

Thom, G. and Lean, M. (2016) Who wants weight loss? What do they need? Time to re-think non-surgical approaches in obesity management. Clinical Obesity, 6(6), pp. 361-364. (doi: 10.1111/cob.12172) (PMID:27984851)

Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)

Articles

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, (doi: 10.1016/S2213-8587(23)00385-6) (Early Online Publication)

Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)

Sattar, N. , Welsh, P. , Leslie, W. S., Thom, G. , McCombie, L., Brosnahan, N. , Richardson, J., Gill, J. M. R. , Crawford, L. and Lean, M. E. J. (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)

Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)

Noronha, J. C., Thom, G. and Lean, M. E.J. (2022) Total diet replacement within an integrated intensive lifestyle intervention for remission of type 2 diabetes: lessons from DiRECT. Frontiers in Endocrinology, 13, 888557. (doi: 10.3389/fendo.2022.888557) (PMID:35721753) (PMCID:PMC9202990)

Rehackova, L., Taylor, R., Lean, M. , Barnes, A., McCombie, L., Thom, G. , Brosnahan, N. , Leslie, W. S. and Sniehotta, F. F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)

Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)

Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)

Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)

Brosnahan, N. , Leslie, W., McCombie, L., Barnes, A., Thom, G. , McConnachie, A. , Messow, C. M. , Sattar, N. , Taylor, R. and Lean, M. E.J. (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Thom, G. , Lean, M. E.J. , Brosnahan, N. , Algindan, Y. Y., Malkova, D. and Dombrowski, S. U. (2021) ‘I have been all in, I have been all out and I have been everything in-between’: a 2-year longitudinal qualitative study of weight-loss maintenance. Journal of Human Nutrition and Dietetics, 34(1), pp. 199-214. (doi: 10.1111/jhn.12826) (PMID:33089558)

Thom, G. , Dombrowski, S. U., Brosnahan, N. , Algindan, Y. Y., Lopez-Gonzalez, M. R., Roditi, G., Lean, M. E.J. and Malkova, D. (2020) Response to comments on "The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed methods study". European Journal of Clinical Nutrition, 74(7), pp. 1115-1116. (doi: 10.1038/s41430-020-0651-2) (PMID:32393752)

Thom, G. , Dombrowski, S. U., Brosnahan, N. , Algindan, Y. Y., Rosario Lopez-Gonzalez, M., Roditi, G., Lean, M. E.J. and Malkova, D. (2020) The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study. European Journal of Clinical Nutrition, 74(4), pp. 622-632. (doi: 10.1038/s41430-020-0568-9) (PMID:32020057)

Thom, G. , Gerasimidis, K. , Rizou, E., Alfheeaid, H. , Barwell, N., Manthou, E., Fatima, S., Gill, J. M.R. , Lean, M. E.J. and Malkova, D. (2020) Validity of predictive equations to estimate RMR in females with varying BMI. Journal of Nutritional Science, 9, e17. (doi: 10.1017/jns.2020.11)

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

Thom, G. and Lean, M. (2017) Is there an optimal diet for weight management and metabolic health? Gastroenterology, 152(7), pp. 1739-1751. (doi: 10.1053/j.gastro.2017.01.056) (PMID:28214525)

Thom, G. and Lean, M. (2016) Who wants weight loss? What do they need? Time to re-think non-surgical approaches in obesity management. Clinical Obesity, 6(6), pp. 361-364. (doi: 10.1111/cob.12172) (PMID:27984851)

Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)