Professor Alastair Gracie

  • Professor of Medical Sciences Education (Medicine)

telephone: 01413308130
email: Alastair.Gracie@glasgow.ac.uk

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • PAR2 as a therapeutic target in osteoarthritis
    Arthritis Research UK
    2010 - 2013
     
  • Exploiting the host-parasite relationship to develop novel safe anti-inflammatory therapies
    Arthritis Research UK
    2009 - 2012
     
  • PAR2 in the pathogenesis of osteoarthritis
    Arthritis Research UK
    2007 - 2010
     
  • Therapeutic potential of a humanised PAR2 antibody to alleviate chronic joint inflammation
    Scottish Executive Health Department
    2006 - 2009
     
  • PAR-2 in the pathogenesis of rheumatoid arthritis
    Arthritis Research UK
    2005 - 2006
     
  • Study of Multiple Inflammatory Mediators from Small Clinical Research Samples: Approach to Better Understanding of Disease Mechanisms
    Tenovus Scotland
    2005 - 2006
     
  • Unrecognised herpes virus infections in the intensive therapy unit
    West Research Endowment Funds
    2004 - 2005
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2008 | 2007 | 2005 | 2004 | 2003 | 2001 | 2000
Number of items: 18.

2015

Agarwal, P. K., Rotchford, A. P., Gracie, A., Lim, L. T., Cameron, A. D. and Ramaesh, K. (2015) Does amniotic membrane absorb cytokines and growth factors from the local engrafted environment? A novel mechanism of therapeutic action. Clinical and Experimental Ophthalmology, 45(9), pp. 586-589. (doi:10.1111/ceo.12507) (PMID:25676083)

2014

Gracie, J. A. and Farrell, A. (2014) The immune response. In: Baynes, J. W. and Dominiczak, M. H. (eds.) Medical Biochemistry. Saunders/Elsevier: Edinburgh, pp. 496-512. ISBN 9781455745807

2013

Cameron, K. R., Grosset, A., Gracie, A. and Burke, J. (2013) Evaluating a Medical Curriculum: How Best to Proceed? AMEE 2013: Colouring Outside the Lines, Prague, Czech Republic, 24-28 Aug 2013.

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi:10.1136/annrheumdis-2012-202872) (PMID:23434566)

2012

Pineda, M.A., McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi:10.1002/art.34581) (PMID:22729944)

Crilly, A. et al. (2012) PAR2 expression in peripheral blood monocytes of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(6), pp. 1049-1054. (doi:10.1136/annrheumdis-2011-200703) (PMID:22294632)

Jagger, A. L. et al. (2012) FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells. Journal of Autoimmunity, 38(1), pp. 29-38. (doi:10.1016/j.jaut.2011.11.015) (PMID:22197557)

2011

Crilly, A., Robertson, S.E., Reilly, J.H., Gracie, J.A., Lai, W.-Q., Leung, B.P., Life, P.F. and McInnes, I.B. (2011) Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Annals of the Rheumatic Diseases, 70(6), pp. 1130-1137. (doi:10.1136/ard.2010.134825) (PMID:21342916)

2008

Wong, S.C., Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi:10.1016/j.ghir.2008.01.006) (PMID:18378173)

Harnett, M. et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67(4), pp. 518-523. (doi:10.1136/ard.2007.073502) (PMID:17704067)

2007

Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. and McInnes, I. B. (2007) Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis and Rheumatism, 56(3), pp. 765-771. (doi:10.1002/art.22423) (PMID:17328048)

2005

Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi:10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)

2004

McInnes, I. B. and Gracie, J. A. (2004) Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Current Opinion in Pharmacology, 4(4), pp. 392-397. (doi:10.1016/j.coph.2004.04.003) (PMID:15251134)

2003

McInnes, I. B. , Leung, B.P., Harnett, M. , Gracie, J.A., Liew, F. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. Journal of Immunology, 171(4), pp. 2127-2133. (doi:10.4049/jimmunol.171.4.2127) (PMID:12902519)

Gracie, J.A., Robertson, S.E. and McInnes, I.B. (2003) Interleukin-18. Journal of Leukocyte Biology, 73(2), pp. 213-224. (doi:10.1189/jlb.0602313) (PMID:12554798)

2001

Leung, B. P., Culshaw, S. , Gracie, J. A., Hunter, D., Canetti, C. A., Campbell, C., Cunha, F., Liew, F. Y. and McInnes, I. B. (2001) A role for IL-18 in neutrophil activation. Journal of Immunology, 167, pp. 2879-2886. (doi:10.4049/jimmunol.167.5.2879) (PMID:11509635)

McInnes, I. B. , Gracie, J. A. and Liew, F. Y. (2001) Interleukin-18: A novel cytokine in inflammatory rheumatic disease. Arthritis and Rheumatism, 44(7), pp. 1481-1483. (doi:10.1002/1529-0131(200107)44:7<1481::AID-ART268>3.0.CO;2-1) (PMID:11465697)

2000

Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B. and Liew, F. Y. (2000) IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. European Journal of Immunology, 30(11), pp. 3147-3156. (doi:10.1002/1521-4141(200011)30:11<3147::AID-IMMU3147>3.0.CO;2-J) (PMID:11093129)

This list was generated on Sun Sep 23 23:05:47 2018 BST.
Number of items: 18.

Articles

Agarwal, P. K., Rotchford, A. P., Gracie, A., Lim, L. T., Cameron, A. D. and Ramaesh, K. (2015) Does amniotic membrane absorb cytokines and growth factors from the local engrafted environment? A novel mechanism of therapeutic action. Clinical and Experimental Ophthalmology, 45(9), pp. 586-589. (doi:10.1111/ceo.12507) (PMID:25676083)

Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi:10.1136/annrheumdis-2012-202872) (PMID:23434566)

Pineda, M.A., McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi:10.1002/art.34581) (PMID:22729944)

Crilly, A. et al. (2012) PAR2 expression in peripheral blood monocytes of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(6), pp. 1049-1054. (doi:10.1136/annrheumdis-2011-200703) (PMID:22294632)

Jagger, A. L. et al. (2012) FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells. Journal of Autoimmunity, 38(1), pp. 29-38. (doi:10.1016/j.jaut.2011.11.015) (PMID:22197557)

Crilly, A., Robertson, S.E., Reilly, J.H., Gracie, J.A., Lai, W.-Q., Leung, B.P., Life, P.F. and McInnes, I.B. (2011) Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Annals of the Rheumatic Diseases, 70(6), pp. 1130-1137. (doi:10.1136/ard.2010.134825) (PMID:21342916)

Wong, S.C., Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi:10.1016/j.ghir.2008.01.006) (PMID:18378173)

Harnett, M. et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67(4), pp. 518-523. (doi:10.1136/ard.2007.073502) (PMID:17704067)

Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. and McInnes, I. B. (2007) Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis and Rheumatism, 56(3), pp. 765-771. (doi:10.1002/art.22423) (PMID:17328048)

Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi:10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)

McInnes, I. B. and Gracie, J. A. (2004) Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Current Opinion in Pharmacology, 4(4), pp. 392-397. (doi:10.1016/j.coph.2004.04.003) (PMID:15251134)

McInnes, I. B. , Leung, B.P., Harnett, M. , Gracie, J.A., Liew, F. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. Journal of Immunology, 171(4), pp. 2127-2133. (doi:10.4049/jimmunol.171.4.2127) (PMID:12902519)

Gracie, J.A., Robertson, S.E. and McInnes, I.B. (2003) Interleukin-18. Journal of Leukocyte Biology, 73(2), pp. 213-224. (doi:10.1189/jlb.0602313) (PMID:12554798)

Leung, B. P., Culshaw, S. , Gracie, J. A., Hunter, D., Canetti, C. A., Campbell, C., Cunha, F., Liew, F. Y. and McInnes, I. B. (2001) A role for IL-18 in neutrophil activation. Journal of Immunology, 167, pp. 2879-2886. (doi:10.4049/jimmunol.167.5.2879) (PMID:11509635)

McInnes, I. B. , Gracie, J. A. and Liew, F. Y. (2001) Interleukin-18: A novel cytokine in inflammatory rheumatic disease. Arthritis and Rheumatism, 44(7), pp. 1481-1483. (doi:10.1002/1529-0131(200107)44:7<1481::AID-ART268>3.0.CO;2-1) (PMID:11465697)

Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B. and Liew, F. Y. (2000) IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. European Journal of Immunology, 30(11), pp. 3147-3156. (doi:10.1002/1521-4141(200011)30:11<3147::AID-IMMU3147>3.0.CO;2-J) (PMID:11093129)

Book Sections

Gracie, J. A. and Farrell, A. (2014) The immune response. In: Baynes, J. W. and Dominiczak, M. H. (eds.) Medical Biochemistry. Saunders/Elsevier: Edinburgh, pp. 496-512. ISBN 9781455745807

Conference or Workshop Item

Cameron, K. R., Grosset, A., Gracie, A. and Burke, J. (2013) Evaluating a Medical Curriculum: How Best to Proceed? AMEE 2013: Colouring Outside the Lines, Prague, Czech Republic, 24-28 Aug 2013.

This list was generated on Sun Sep 23 23:05:47 2018 BST.