Professor Joseph Gray

  • Professor of Bioscience Education (Life Sciences Biomolecular Sciences)
  • Associate (Institute of Molecular Cell & Systems Biology)

telephone: 01413305114
email: Joseph.Gray@glasgow.ac.uk

Research interests

Understanding and Exploiting Eukaryotic Signaling Mechanisms using Yeast as a Model System

  • Nutrient Signaling: the TORC1 Pathway
  • Morphogenesis and Stress: the Rho1 GTPase Pathway
  • Synthetic Biology

Click here for more on Dr Gray's research.......


Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2012 | 2011 | 2009 | 2008 | 2007 | 2004 | 2002 | 2001 | 1997 | 1994 | 1990
Number of items: 26.

2015

Sykes, A. , Morrison, D. and Gray, J. (2015) Half as Much but Twice as Good: LEAF and New Directions in Assessment and Feedback. 8th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 14 Apr 2015.

2014

Evans, S., Burgess, K. E.V. and Gray, J. V. (2014) Recovery from Rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (torc1) supports residual proliferation that dilutes rapamycin among progeny cells. Journal of Biological Chemistry, 289(38), pp. 26554-26565. (doi:10.1074/jbc.M114.589754) (PMID:25104356) (PMCID:PMC4176226)

Gray, J. V. (2014) Case study 15.2: supporting a large undergraduate class using an asynchronous online forum. In: Fry, H., Ketteridge, S. and Marshall, S. (eds.) A Handbook for Teaching and Learning in Higher Education: Enhancing Academic Practice [4th Edition]. Routledge: Abingdon, Oxon, pp. 218-219. ISBN 9780415709958

Coward, K. and Gray, J. V. (2014) Audit of Practical Work Undertaken by Undergraduate Bioscience Students Across the UK Higher Education Sector. Project Report. Royal Society of Biology.

2012

Krause, S. , Cundell, M., Poon, P., McGhie, J., Johnston, G., Price, C. and Gray, J. (2012) Functional specialization of the yeast Rho1 GTP exchange factors. Journal of Cell Science, 125(11), pp. 2721-2731. (doi:10.1242/​jcs.100685)

Finlay, C., Tierney, A., McVey, M. and Gray, J. (2012) Online peer review of scientific writing - Aropa. In: 5th Annual University of Glasgow Learning and Teaching Conference: Empowering Student Learners in Higher Education, Glasgow, Scotland, 17th Apr 2012,

Krause, S. A. , Cundell, M. J., Poon, P. P., McGhie, J., Johnston, G. C., Price, C. and Gray, J. V. (2012) Functional specialisation of yeast Rho1 GTP exchange factors. Journal of Cell Science, 125(11), pp. 2721-2731. (doi:10.1242/jcs.100685) (PMID:22344253)

2011

O'Dell, K., Gray, J. and Finlay, C. (2011) Marking level 1 and level 2 essays via Turnitin on an industrial scale. In: 4th Annual University of Glasgow Learning and Teaching Conference: Learning in a global research-intensive university: developing graduate attributes, Glasgow, Scotland, 21st Apr 2011,

2009

Gray, J.V. and Krause, S.A. (2009) Chapter 3 synthetic genetic interactions: allele dependence, uses, and conservation. Advances in Genetics, 66, pp. 61-84. (doi:10.1016/S0065-2660(09)66003-X)

Krause, S.A. and Gray, J.V. (2009) The functional relationships underlying a synthetic genetic network. Communicative and Integrative Biology, 2(1), pp. 4-6. (doi:10.4161/cib.2.1.7298)

2008

Krause, S.A. , Xu, H. and Gray, J.V. (2008) The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Eukaryotic Cell, 7(11), pp. 1880-1887. (doi:10.1128/EC.00222-08)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A. , Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi:10.1242/jcs.033084)

2007

Gray, J.V. and Krause, S.A. (2007) Identifying in vivo pathways using genome-wide genetic networks. Biochemical Society Transactions, 35(Pt6), pp. 1538-1541. (doi:10.1042/BST0351538) (PMID:18031262)

Stewart, M.S., Krause, S.A. , McGhie, J. and Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryotic Cell, 6(2), pp. 262-270.

Stewart, M.S., Krause, S.A., McGhie, J. and Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryotic Cell, 6(2), pp. 262-270. (doi:10.1128/EC.00188-06)

2004

Gray, J., Petsko, G., Johnston, G., Ringe, D., Singer, R. and Werner-Washburne, M. (2004) "Sleeping beauty": Quiescence in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews, 68, 187-+. (doi:10.1128/MMBR.68.2.187-206.2004)

2002

Krause, S.A. and Gray, J.V. (2002) The protein kinase C pathway is required for viability in quiescence in Saccharomyces cerevisiae. Current Biology, 12, pp. 588-593.

Rayner, T., Gray, J. and Thorner, J. (2002) Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3. Journal of Biological Chemistry, 277, pp. 16814-16822. (doi:10.1074/jbc.M112349200)

Trotter, E., Kao, C., Berenfeld, L., Botstein, D., Petsko, G. and Gray, J. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. Journal of Biological Chemistry, 277, pp. 44817-44825. (doi:10.1074/jbc.M204686200)

2001

Trotter, E.W., Berenfeld, L., Krause, S.A. , Petsko, G.A. and Gray, J.V. (2001) Protein misfolding and temperature up-shift cause G(1) arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 98(13), pp. 7313-7318. (doi:10.1073/pnas.121172998)

1997

Gray, J. V., Ogas, J. P., Kamada, Y., Stone, M., Levin, D. E. and Herskowitz, I. (1997) A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO Journal, 16(16), pp. 4924-4937. (doi:10.1093/emboj/16.16.4924) (PMID:9305635) (PMCID:PMC1170128)

Gray, J. V. and Johnson, K. J. (1997) Waiting for frataxin. Nature Genetics, 16(4), pp. 323-325. (doi:10.1038/ng0897-383) (PMID:9241261)

1994

Gray, J. V. and Knowles, J. R. (1994) Monofunctional chorismate mutase from Bacillus subtilis: FTIR studies and the mechanism of action of the enzyme. Biochemistry, 33(33), pp. 9953-9959. (doi:10.1021/bi00199a018) (PMID:8061004)

Chook, Y. M., Gray, J. V., Ke, H. and Lipscomb, W. N. (1994) The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. Journal of Molecular Biology, 240(5), pp. 476-500. (doi:10.1006/jmbi.1994.1462) (PMID:8046752)

1990

Gray, J. V., Eren, D. and Knowles, J. R. (1990) Monofunctional chorismate mutase from Bacillus subtilis: kinetic and 13C NMR studies on the interactions of the enzyme with its ligands. Biochemistry, 29(37), pp. 8872-8878. (doi:10.1021/bi00489a051) (PMID:2125470)

Gray, J. V., Golinelli-Pimpaneau, B. and Knowles, J. R. (1990) Monofunctional chorismate mutase from Bacillus subtilis: purification of the protein, molecular cloning of the gene, and overexpression of the gene product in Escherichia coli. Biochemistry, 29(2), pp. 376-383. (doi:10.1021/bi00454a011) (PMID:2105742)

This list was generated on Mon Nov 18 17:16:08 2019 GMT.
Number of items: 26.

Articles

Evans, S., Burgess, K. E.V. and Gray, J. V. (2014) Recovery from Rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (torc1) supports residual proliferation that dilutes rapamycin among progeny cells. Journal of Biological Chemistry, 289(38), pp. 26554-26565. (doi:10.1074/jbc.M114.589754) (PMID:25104356) (PMCID:PMC4176226)

Krause, S. , Cundell, M., Poon, P., McGhie, J., Johnston, G., Price, C. and Gray, J. (2012) Functional specialization of the yeast Rho1 GTP exchange factors. Journal of Cell Science, 125(11), pp. 2721-2731. (doi:10.1242/​jcs.100685)

Krause, S. A. , Cundell, M. J., Poon, P. P., McGhie, J., Johnston, G. C., Price, C. and Gray, J. V. (2012) Functional specialisation of yeast Rho1 GTP exchange factors. Journal of Cell Science, 125(11), pp. 2721-2731. (doi:10.1242/jcs.100685) (PMID:22344253)

Gray, J.V. and Krause, S.A. (2009) Chapter 3 synthetic genetic interactions: allele dependence, uses, and conservation. Advances in Genetics, 66, pp. 61-84. (doi:10.1016/S0065-2660(09)66003-X)

Krause, S.A. and Gray, J.V. (2009) The functional relationships underlying a synthetic genetic network. Communicative and Integrative Biology, 2(1), pp. 4-6. (doi:10.4161/cib.2.1.7298)

Krause, S.A. , Xu, H. and Gray, J.V. (2008) The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Eukaryotic Cell, 7(11), pp. 1880-1887. (doi:10.1128/EC.00222-08)

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A. , Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi:10.1242/jcs.033084)

Gray, J.V. and Krause, S.A. (2007) Identifying in vivo pathways using genome-wide genetic networks. Biochemical Society Transactions, 35(Pt6), pp. 1538-1541. (doi:10.1042/BST0351538) (PMID:18031262)

Stewart, M.S., Krause, S.A. , McGhie, J. and Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryotic Cell, 6(2), pp. 262-270.

Stewart, M.S., Krause, S.A., McGhie, J. and Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryotic Cell, 6(2), pp. 262-270. (doi:10.1128/EC.00188-06)

Gray, J., Petsko, G., Johnston, G., Ringe, D., Singer, R. and Werner-Washburne, M. (2004) "Sleeping beauty": Quiescence in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews, 68, 187-+. (doi:10.1128/MMBR.68.2.187-206.2004)

Krause, S.A. and Gray, J.V. (2002) The protein kinase C pathway is required for viability in quiescence in Saccharomyces cerevisiae. Current Biology, 12, pp. 588-593.

Rayner, T., Gray, J. and Thorner, J. (2002) Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3. Journal of Biological Chemistry, 277, pp. 16814-16822. (doi:10.1074/jbc.M112349200)

Trotter, E., Kao, C., Berenfeld, L., Botstein, D., Petsko, G. and Gray, J. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. Journal of Biological Chemistry, 277, pp. 44817-44825. (doi:10.1074/jbc.M204686200)

Trotter, E.W., Berenfeld, L., Krause, S.A. , Petsko, G.A. and Gray, J.V. (2001) Protein misfolding and temperature up-shift cause G(1) arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 98(13), pp. 7313-7318. (doi:10.1073/pnas.121172998)

Gray, J. V., Ogas, J. P., Kamada, Y., Stone, M., Levin, D. E. and Herskowitz, I. (1997) A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO Journal, 16(16), pp. 4924-4937. (doi:10.1093/emboj/16.16.4924) (PMID:9305635) (PMCID:PMC1170128)

Gray, J. V. and Johnson, K. J. (1997) Waiting for frataxin. Nature Genetics, 16(4), pp. 323-325. (doi:10.1038/ng0897-383) (PMID:9241261)

Gray, J. V. and Knowles, J. R. (1994) Monofunctional chorismate mutase from Bacillus subtilis: FTIR studies and the mechanism of action of the enzyme. Biochemistry, 33(33), pp. 9953-9959. (doi:10.1021/bi00199a018) (PMID:8061004)

Chook, Y. M., Gray, J. V., Ke, H. and Lipscomb, W. N. (1994) The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. Journal of Molecular Biology, 240(5), pp. 476-500. (doi:10.1006/jmbi.1994.1462) (PMID:8046752)

Gray, J. V., Eren, D. and Knowles, J. R. (1990) Monofunctional chorismate mutase from Bacillus subtilis: kinetic and 13C NMR studies on the interactions of the enzyme with its ligands. Biochemistry, 29(37), pp. 8872-8878. (doi:10.1021/bi00489a051) (PMID:2125470)

Gray, J. V., Golinelli-Pimpaneau, B. and Knowles, J. R. (1990) Monofunctional chorismate mutase from Bacillus subtilis: purification of the protein, molecular cloning of the gene, and overexpression of the gene product in Escherichia coli. Biochemistry, 29(2), pp. 376-383. (doi:10.1021/bi00454a011) (PMID:2105742)

Book Sections

Gray, J. V. (2014) Case study 15.2: supporting a large undergraduate class using an asynchronous online forum. In: Fry, H., Ketteridge, S. and Marshall, S. (eds.) A Handbook for Teaching and Learning in Higher Education: Enhancing Academic Practice [4th Edition]. Routledge: Abingdon, Oxon, pp. 218-219. ISBN 9780415709958

Research Reports or Papers

Coward, K. and Gray, J. V. (2014) Audit of Practical Work Undertaken by Undergraduate Bioscience Students Across the UK Higher Education Sector. Project Report. Royal Society of Biology.

Conference or Workshop Item

Sykes, A. , Morrison, D. and Gray, J. (2015) Half as Much but Twice as Good: LEAF and New Directions in Assessment and Feedback. 8th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 14 Apr 2015.

Conference Proceedings

Finlay, C., Tierney, A., McVey, M. and Gray, J. (2012) Online peer review of scientific writing - Aropa. In: 5th Annual University of Glasgow Learning and Teaching Conference: Empowering Student Learners in Higher Education, Glasgow, Scotland, 17th Apr 2012,

O'Dell, K., Gray, J. and Finlay, C. (2011) Marking level 1 and level 2 essays via Turnitin on an industrial scale. In: 4th Annual University of Glasgow Learning and Teaching Conference: Learning in a global research-intensive university: developing graduate attributes, Glasgow, Scotland, 21st Apr 2011,

This list was generated on Mon Nov 18 17:16:08 2019 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A new direction for insect control: transporters as novel targets for insecticidal compunds.
    Scottish Universities Life Sciences Alliance
    2012 - 2013
     
  • Wellcome VIP award
    Wellcome Trust
    2010 - 2010
     
  • Analysis of the structure, function and regulation of the Rho1-specific GTP exchange proteins in the yeast call wall integrity pathway
    Biotechnology and Biological Sciences Research Council
    2007 - 2009
     
  • A novel post-genomic approach to identify the functions of an essential protein - yeast protein kinase C
    Biotechnology and Biological Sciences Research Council
    2003 - 2006
     

Additional information

Grant Advisory Board

  • 2005: Vlaams Interuniversitaire Instituut Voor Biotechnologie - Departmental Evaluation Board to review the Department of Molecular Microbiology of the VIB, Flanders, Belgium

Invited International Presentations

  • 2008: Glasgow, UK - Institute of Brewing and Distilling, Invited talk - "Yeast: the genome and beyond"
  • 2007: Buxton, UK - British Yeast Meeting. Platform talk - "Post-transcriptional control of signalling and lifespan"
  • 2003: Leicester, UK. - Platform talk: "Response of cells to protein misfolding", British Yeast Meeting.