Dr Chris McInerny

  • Reader (Life Sciences Biomolecular Sciences)
  • Associate (Institute of Molecular Cell & Systems Biology)

Research interests

Research Interests

My research interests focus on the regulation the cell division cycle, using the fission yeast Schizosaccharomyces pombe as a model organism. We study the role of gene expression in regulating progression through the cell cycle, and are particularly interested in the processes that mediate cytokinesis and cell separation.

The role of cell and life cycle specific transcription in fission yeast.

Click here for more information about Chris's research interests.


Publications

List by: Type | Date

Jump to: 2019 | 2017 | 2015 | 2014 | 2012 | 2011 | 2010 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1997 | 1996 | 1995 | 1992
Number of items: 30.

2019

Rezig, I. M., Bremner, S. K., Bhutta, M. S., Salt, I. P. , Gould, G. W. and McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast. In: Culetto, E. and Legouis, R. (eds.) The ESCRT Complexes: Methods and Protocols. Series: Methods in molecular biology (1998). Humana Press: New York, pp. 239-250. ISBN 9781493994915 (doi:10.1007/978-1-4939-9492-2_18)

2017

Szilagyi, Z., Banyai, G., Davila Lopez, M., McInerny, C. J. and Gustafsson, C. M. (2017) Correction for Szilagyi et al., "Cyclin-Dependent Kinase 8 Regulates Mitotic Commitment in Fission Yeast". Molecular and Cellular Biology, 37(17), e00262-17. (doi:10.1128/MCB.00262-17) (PMID:28801453)

2015

Suárez, M. B., Alonso-Nuñez, M. L., del Rey, F., McInerny, C. J. and Vázquez de Aldana, C. R. (2015) Regulation of Ace2-dependent genes requires components of the PBF complex in schizosaccharomyces pombe. Cell Cycle, 14(19), pp. 3124-3137. (doi:10.1080/15384101.2015.1078035) (PMID:26237280)

2014

Bhutta, M. S., Roy, B., Gould, G. W. and McInerny, C. J. (2014) A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe. PLoS ONE, 9(10), e111789. (doi:10.1371/journal.pone.0111789) (PMID:25356547) (PMCID:PMC4214795)

Bhutta, M. S., McInerny, C. J. and Gould, G. W. (2014) ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases. International Journal of Molecular Sciences, 15(12), pp. 21723-21739. (doi:10.3390/ijms151221723)

2012

Szilagyi, Z., Banyai, G., Lopez, M.D., McInerny, C.J. and Gustafsson, C.M. (2012) Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast. Molecular and Cellular Biology, 32(11), pp. 2099-2109. (doi:10.1128/MCB.06316-11)

Penney, M., Samejima, I., Wilkinson, C.R., McInerny, C.J. , Mathiassen, S.G., Wallace, M., Toda, T., Hartmann-Petersen, R. and Gordon, C. (2012) Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor. PLoS ONE, 7(11), e50796. (doi:10.1371/journal.pone.0050796) (PMID:23209828) (PMCID:PMC3507774)

2011

McInerny, C.J. (2011) Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast. Cell Cycle, 10(8), pp. 1184-1185. (doi:10.4161/cc.10.8.15346)

Purtill, F.S., Whitehall, S.K., Williams, E.S., McInerny, C.J. , Sharrocks, A.D. and Morgan, B.A. (2011) A homeodomain transcription factor regulates the DNA replication checkpoint in yeast. Cell Cycle, 10(4), pp. 664-670. (doi:10.4161/cc.10.4.14824)

McInerny, C.J. (2011) Cell cycle regulated gene expression in yeasts. Advances in Genetics, 73, pp. 51-85. (doi:10.1016/B978-0-12-380860-8.00002-1)

2010

Agarwall, M., Papadopoulou, K., Mayeux, A., Vajrala, V., Quintana-Rincon, D.M., Paoletti, A. and McInerny, C.J. (2010) Mid1p-dependent regulation of the M–G1 transcription wave in fission yeast. Journal of Cell Science, 123(24), pp. 4366-4373. (doi:10.1242/jcs.073049)

Papadopoulou, K. et al. (2010) Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p. Journal of Cell Science, 123(24), pp. 4374-4381. (doi:10.1242/jcs.073056)

2008

Papadopoulou, K., Ng, S. S., Ohkura, H., Geymonat, M., Sedgwick, S. G. and McInerny, C. J. (2008) Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors. Journal of Cell Science, 121(1), pp. 38-47. (doi:10.1242/jcs.019489)

Papadopoulou, K., Ng, S. S., Ohkura, H., Geymonat, M., Sedgwick, S. G. and McInerny, C. J. (2008) Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors. Journal of Cell Science, 121(1), pp. 38-47. (doi:10.1242/jcs.019489)

2006

Ng, S.S., Papadopoulou, K. and McInerny, C.J. (2006) Regulation of gene expression and cell division by Polo-like kinases. Current Genetics, 50(2), pp. 73-80. (doi:10.1007/s00294-006-0077-y)

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A. , McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi:10.1242/jcs.02983)

Nadeem, F.K., Blair, D. and McInerny, C.J. (2006) Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production. Molecular Genetics and Genomics, 276(4), pp. 391-401. (doi:10.1007/s00438-006-0144-6)

2005

Ilyushik, E., Pryce, D.W., Walerych, D., Riddell, T., Wakeman, J.A., McInerny, C.J. and McFarlane, R.J. (2005) Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms. Biological Chemistry, 386(7), pp. 613-621. (doi:10.1515/BC.2005.072)

2004

Buck, V., Ng, S.S., Ruiz-Garcia, A.B., Papadopoulou, K., Bhatti, S., Samuel, J.M., Anderson, M., Millar, J.B.A. and McInerny, C.J. (2004) Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast. Journal of Cell Science, 117(23), pp. 5623-5632. (doi:10.1242/jcs.01473)

Cunliffe, L., White, S. and McInerny, C.J. (2004) DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe. Molecular Genetics and Genomics, 271(1), pp. 60-71. (doi:10.1007/s00438-003-0956-6)

McInerny, C. (2004) Cell cycle-regulated transcription in fission yeast. Biochemical Society Transactions, 32, pp. 967-972.

2003

Maqbool, Z., Kersey, P.J., Fantes, P.A. and McInerny, C.J. (2003) MCB-mediated regulation of cell cycle-specific cdc22(+) transcription in fission yeast. Molecular Genetics and Genomics, 269(6), pp. 765-775. (doi:10.1007/s00438-003-0885-4)

Yoshida, S.H., Al-Amodi, H., Nakamura, T., McInerny, C.J. and Shimoda, C. (2003) The Schizosaccharomyces pombe cdt2+ gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication. Genetics, 164(3), pp. 881-893.

2002

Anderson, M., Ng, S.S., Marchesi, V., MacIver, F.H., Stevens, F.E., Riddell, T., Glover, D.M., Hagan, I.M. and McInerny, C.J. (2002) plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle. EMBO Journal, 21, pp. 5745-5755. (doi:10.1093/emboj/cdf564)

2001

Ng, S.S., Anderson, M., White, S. and McInerny, C.J. (2001) mik1+ G1-S transcription regulates mitotic entry in fission yeast. FEBS Letters, 503(2/3), pp. 131-134. (doi:10.1016/S0014-5793(01)02720-X)

White, S., Khaliq, F., Sotiriou, S. and McInerny, C.J. (2001) The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast. Current Genetics, 40(4), pp. 251-259. (doi:10.1007/s002940100248)

1997

McInerny, C.J. , Partridge, J.F., Mikesell, G.E., Creemer, D.P. and Breeden, L.L. (1997) A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription. Genes and Development, 11(10), pp. 1277-1288. (doi:10.1101/gad.11.10.1277)

1996

Harris, P., Kersey, P.J., McInerny, C.J. and Fantes, P.A. (1996) Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast. Molecular and General Genetics, 252(3), pp. 284-291. (doi:10.1007/BF02173774)

1995

McInerny, C.J. , Kersey, P.J., Creanor, J. and Fantes, P.A. (1995) Positive and negative roles for cdc10 in cell cycle gene expression. Nucleic Acids Research, 23(23), pp. 4761-4768. (doi:10.1093/nar/23.23.4761)

1992

Lowndes, N.F., McInerny, C.J. , Johnson, A.L., Fantes, P.A. and Johnston, L.H. (1992) Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+. Nature, 355(6359), pp. 449-453. (doi:10.1038/355449a0)

This list was generated on Thu Nov 21 15:52:12 2019 GMT.
Number of items: 30.

Articles

Szilagyi, Z., Banyai, G., Davila Lopez, M., McInerny, C. J. and Gustafsson, C. M. (2017) Correction for Szilagyi et al., "Cyclin-Dependent Kinase 8 Regulates Mitotic Commitment in Fission Yeast". Molecular and Cellular Biology, 37(17), e00262-17. (doi:10.1128/MCB.00262-17) (PMID:28801453)

Suárez, M. B., Alonso-Nuñez, M. L., del Rey, F., McInerny, C. J. and Vázquez de Aldana, C. R. (2015) Regulation of Ace2-dependent genes requires components of the PBF complex in schizosaccharomyces pombe. Cell Cycle, 14(19), pp. 3124-3137. (doi:10.1080/15384101.2015.1078035) (PMID:26237280)

Bhutta, M. S., Roy, B., Gould, G. W. and McInerny, C. J. (2014) A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe. PLoS ONE, 9(10), e111789. (doi:10.1371/journal.pone.0111789) (PMID:25356547) (PMCID:PMC4214795)

Bhutta, M. S., McInerny, C. J. and Gould, G. W. (2014) ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases. International Journal of Molecular Sciences, 15(12), pp. 21723-21739. (doi:10.3390/ijms151221723)

Szilagyi, Z., Banyai, G., Lopez, M.D., McInerny, C.J. and Gustafsson, C.M. (2012) Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast. Molecular and Cellular Biology, 32(11), pp. 2099-2109. (doi:10.1128/MCB.06316-11)

Penney, M., Samejima, I., Wilkinson, C.R., McInerny, C.J. , Mathiassen, S.G., Wallace, M., Toda, T., Hartmann-Petersen, R. and Gordon, C. (2012) Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor. PLoS ONE, 7(11), e50796. (doi:10.1371/journal.pone.0050796) (PMID:23209828) (PMCID:PMC3507774)

McInerny, C.J. (2011) Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast. Cell Cycle, 10(8), pp. 1184-1185. (doi:10.4161/cc.10.8.15346)

Purtill, F.S., Whitehall, S.K., Williams, E.S., McInerny, C.J. , Sharrocks, A.D. and Morgan, B.A. (2011) A homeodomain transcription factor regulates the DNA replication checkpoint in yeast. Cell Cycle, 10(4), pp. 664-670. (doi:10.4161/cc.10.4.14824)

McInerny, C.J. (2011) Cell cycle regulated gene expression in yeasts. Advances in Genetics, 73, pp. 51-85. (doi:10.1016/B978-0-12-380860-8.00002-1)

Agarwall, M., Papadopoulou, K., Mayeux, A., Vajrala, V., Quintana-Rincon, D.M., Paoletti, A. and McInerny, C.J. (2010) Mid1p-dependent regulation of the M–G1 transcription wave in fission yeast. Journal of Cell Science, 123(24), pp. 4366-4373. (doi:10.1242/jcs.073049)

Papadopoulou, K. et al. (2010) Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p. Journal of Cell Science, 123(24), pp. 4374-4381. (doi:10.1242/jcs.073056)

Papadopoulou, K., Ng, S. S., Ohkura, H., Geymonat, M., Sedgwick, S. G. and McInerny, C. J. (2008) Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors. Journal of Cell Science, 121(1), pp. 38-47. (doi:10.1242/jcs.019489)

Papadopoulou, K., Ng, S. S., Ohkura, H., Geymonat, M., Sedgwick, S. G. and McInerny, C. J. (2008) Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors. Journal of Cell Science, 121(1), pp. 38-47. (doi:10.1242/jcs.019489)

Ng, S.S., Papadopoulou, K. and McInerny, C.J. (2006) Regulation of gene expression and cell division by Polo-like kinases. Current Genetics, 50(2), pp. 73-80. (doi:10.1007/s00294-006-0077-y)

Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A. , McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi:10.1242/jcs.02983)

Nadeem, F.K., Blair, D. and McInerny, C.J. (2006) Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production. Molecular Genetics and Genomics, 276(4), pp. 391-401. (doi:10.1007/s00438-006-0144-6)

Ilyushik, E., Pryce, D.W., Walerych, D., Riddell, T., Wakeman, J.A., McInerny, C.J. and McFarlane, R.J. (2005) Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms. Biological Chemistry, 386(7), pp. 613-621. (doi:10.1515/BC.2005.072)

Buck, V., Ng, S.S., Ruiz-Garcia, A.B., Papadopoulou, K., Bhatti, S., Samuel, J.M., Anderson, M., Millar, J.B.A. and McInerny, C.J. (2004) Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast. Journal of Cell Science, 117(23), pp. 5623-5632. (doi:10.1242/jcs.01473)

Cunliffe, L., White, S. and McInerny, C.J. (2004) DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe. Molecular Genetics and Genomics, 271(1), pp. 60-71. (doi:10.1007/s00438-003-0956-6)

McInerny, C. (2004) Cell cycle-regulated transcription in fission yeast. Biochemical Society Transactions, 32, pp. 967-972.

Maqbool, Z., Kersey, P.J., Fantes, P.A. and McInerny, C.J. (2003) MCB-mediated regulation of cell cycle-specific cdc22(+) transcription in fission yeast. Molecular Genetics and Genomics, 269(6), pp. 765-775. (doi:10.1007/s00438-003-0885-4)

Yoshida, S.H., Al-Amodi, H., Nakamura, T., McInerny, C.J. and Shimoda, C. (2003) The Schizosaccharomyces pombe cdt2+ gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication. Genetics, 164(3), pp. 881-893.

Anderson, M., Ng, S.S., Marchesi, V., MacIver, F.H., Stevens, F.E., Riddell, T., Glover, D.M., Hagan, I.M. and McInerny, C.J. (2002) plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle. EMBO Journal, 21, pp. 5745-5755. (doi:10.1093/emboj/cdf564)

Ng, S.S., Anderson, M., White, S. and McInerny, C.J. (2001) mik1+ G1-S transcription regulates mitotic entry in fission yeast. FEBS Letters, 503(2/3), pp. 131-134. (doi:10.1016/S0014-5793(01)02720-X)

White, S., Khaliq, F., Sotiriou, S. and McInerny, C.J. (2001) The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast. Current Genetics, 40(4), pp. 251-259. (doi:10.1007/s002940100248)

McInerny, C.J. , Partridge, J.F., Mikesell, G.E., Creemer, D.P. and Breeden, L.L. (1997) A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription. Genes and Development, 11(10), pp. 1277-1288. (doi:10.1101/gad.11.10.1277)

Harris, P., Kersey, P.J., McInerny, C.J. and Fantes, P.A. (1996) Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast. Molecular and General Genetics, 252(3), pp. 284-291. (doi:10.1007/BF02173774)

McInerny, C.J. , Kersey, P.J., Creanor, J. and Fantes, P.A. (1995) Positive and negative roles for cdc10 in cell cycle gene expression. Nucleic Acids Research, 23(23), pp. 4761-4768. (doi:10.1093/nar/23.23.4761)

Lowndes, N.F., McInerny, C.J. , Johnson, A.L., Fantes, P.A. and Johnston, L.H. (1992) Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+. Nature, 355(6359), pp. 449-453. (doi:10.1038/355449a0)

Book Sections

Rezig, I. M., Bremner, S. K., Bhutta, M. S., Salt, I. P. , Gould, G. W. and McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast. In: Culetto, E. and Legouis, R. (eds.) The ESCRT Complexes: Methods and Protocols. Series: Methods in molecular biology (1998). Humana Press: New York, pp. 239-250. ISBN 9781493994915 (doi:10.1007/978-1-4939-9492-2_18)

This list was generated on Thu Nov 21 15:52:12 2019 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Cell and life cycle specific transcription in fission yeast
    Medical Research Council
    2003 - 2006
     
  • Plo1+ regulation of M-G1 transcription in fission yeast
    Wellcome Trust
    2003 - 2006
     

Teaching

I help run the MRes in Biomedical Sciences, which is proving to be very popular with students who wish to pursue a career in biomedical research.


Additional information

Grant Advisory Board

  • 2009 - present: Faculty of 1000 - Faculty Member

Invited International Presentations

  • 2009: Gothenburg, Sweden - Invited seminar Institute of Biomedicine, University of Gothenburg. "Regulation of M-G1 specific gene expression in fission yeast"
  • 2008: Singapore - Invited Seminar at University
  • 2008: Kyiv, Ukraine - 12th International Congress on Yeasts
  • 2007: Copenhagen, Denmark - Chair of Session, Fourth International Fission Yeast Meeting
  • 2007: Salamanca, Spain - Invited Seminar at University
  • 2005: Crete, Greece - Chair and Plenary oral presentation, 10th World Congress on Advances in Oncology
  • 2004: San Diego, USA - Third International Fission Yeast Meeting UC San Diego
  • 2004: Glasgow, Scotland - BioScience2004
  • 2004: San Francisco, USA - Invited seminar at Raven Biotechnologies
  • 2002: Kyoto, Japan - Second international Fission yeast Meeting