Dr Vanessa Herder

Research Fellow, Veterinary Experimental Pathologist (Virology)

telephone: 0044 141 3302184
email: Vanessa.Herder@glasgow.ac.uk

Sir Michael Stoker Building, Level 3, Garscube Campus, 464 Bearsden Road, Glasgow, G61 1QH

ORCID iD https://orcid.org/0000-0003-4814-1382

Biography

Vanessa has more than 15 years of experience in veterinary pathology, she is a board-certified pathologist (Dipl. ECVP) since 2007 and publications she co-authored have more than 1500 citations in internationally reviewed journals in 2022.

Research interests

Fascinated by how a virus infection shapes tissue-specific and systemic inflammation, my work focuses on how host-specific immune reactions contribute to a mild versus a severe clinical outcome and eventually to death. To address this, I study disease pathogenesis in vivo by applying various approaches including animal studies (rodent and large animal models) with clinical scoring, gross and histo-pathology, immunohistochemistry, immunofluorescence (confocal microscopy), light sheet microscopy, software-assisted image analysis of whole scanned slides (bright field and IF), in situ-hybridisation, cytokine measurements using the Luminex system, ex vivo systems like 2D and 3D cell culture systems in BSL2 (Theiler’s murine encephalomyelitis virus) and BSL3 (Bluetongue virus and SARS CoV-2). For multiplexing markers in FFPE tissue the PhenoCycler (Akoya) is a newcomer in our lab. We also work in collaborations with spatial transcriptomics using the Nanostring technology. To identify mechanisms, which are conserved in mammalian speices, I study humans, mice, hamsters and sheep.

Publications

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Number of items: 52.

2023

Ho, A. et al. (2023) Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature, 617, pp. 555-563. (doi: 10.1038/s41586-023-05948-2) (PMID:36996873)

2022

Matthews, P. C. et al. (2022) Acute severe hepatitis outbreak in children: a perfect storm. What do we know, and what questions remain? Frontiers in Pharmacology, 13, 1062408. (doi: 10.3389/fphar.2022.1062408) (PMID:36506522) (PMCID:PMC9732095)

2021

Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)

Hülskötter, K., Jin, W., Allnoch, L., Hansmann, F., Schmidtke, D., Rohn, K., Flügel, A., Lühder, F., Baumgärtner, W. and Herder, V. (2021) Double‐edged effects of tamoxifen‐in‐oil‐gavage on an infectious murine model for multiple sclerosis. Brain Pathology, 31(6), e12994. (doi: 10.1111/bpa.12994) (PMID:34137105) (PMCID:PMC8549030)

Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)

Hülskötter, K., Lühder, F., Flügel, A., Herder, V. and Baumgärtner, W. (2021) Tamoxifen application is associated with transiently increased loss of hippocampal neurons following virus infection. International Journal of Molecular Sciences, 22(16), 8486. (doi: 10.3390/ijms22168486) (PMID:34445189) (PMCID:PMC8395206)

Dee, K., Goldfarb, D. M., Haney, J., Amat, J. A.R., Herder, V. , Stewart, M., Szemiel, A. M., Baguelin, M. and Murcia, P. R. (2021) Human rhinovirus infection blocks SARS-CoV-2 replication within the respiratory epithelium: implications for COVID-19 epidemiology. Journal of Infectious Diseases, 224(1), pp. 31-38. (doi: 10.1093/infdis/jiab147) (PMID:33754149) (PMCID:PMC8083659)

Hosie, M. J. et al. (2021) Detection of SARS-CoV-2 in respiratory samples from cats in the UK associated with human-to-cat transmission. Veterinary Record, 188(8), e247. (doi: 10.1002/vetr.247) (PMID:33890314) (PMCID:PMC8251078)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

2020

Ciurkiewicz, M., Herder, V. and Beineke, A. (2020) Beneficial and detrimental effects of regulatory T cells in neurotropic virus infections. International Journal of Molecular Sciences, 21(5), 1705. (doi: 10.3390/ijms21051705)

2019

Einhellig, S., Bartke, S. and Herder, V. (2019) Der klinische Fall: Intraokulares Melanom bei einer Ponystute. Pferde Spiegel, 22(3), pp. 120-125. (doi: 10.1055/a-0977-8827)

Klemens, J. et al. (2019) Neurotoxic potential of reactive astrocytes in canine distemper demyelinating leukoencephalitis. Scientific Reports, 9, 11689. (doi: 10.1038/s41598-019-48146-9) (PMID:31406213) (PMCID:PMC6690900)

Brezina, T., Thole, M., Klotz, D., Herder, V. and Fehr, M. (2019) Surgical therapy of a non-deslorelin-responsive adrenal gland adenocarcinoma in a four-year-old ferret (Mustela putorius furo) = Chirurgische Therapie eines nicht Deslorelin-responsiven Nebennierenkarzinoms bei einem vierjährigen Frettchen (Mustela putorius furo). Kleintierpraxis, 64(5), pp. 280-290. (doi: 10.2377/0023-2076-64-280)

Hansmann, F., Zhang, N., Herder, V. , Leitzen, E. and Baumgärtner, W. (2019) Delayed astrogliosis associated with reduced M1 microglia activation in matrix metalloproteinase 12 knockout mice during theiler’s murine encephalomyelitis. International Journal of Molecular Sciences, 20(7), 1702. (doi: 10.3390/ijms20071702) (PMID:30959793) (PMCID:PMC6480673)

Leitzen, E., Jin, W., Herder, V. , Beineke, A., Elmarabet, S. A., Baumgärtner, W. and Hansmann, F. (2019) Comparison of reported spinal cord lesions in progressive multiple sclerosis with theiler’s murine encephalomyelitis virus induced demyelinating disease. International Journal of Molecular Sciences, 20(4), 989. (doi: 10.3390/ijms20040989) (PMID:30823515) (PMCID:PMC6413032)

2018

Stanelle-Bertram, S. et al. (2018) Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood. Nature Microbiology, 3(10), pp. 1161-1174. (doi: 10.1038/s41564-018-0236-1) (PMID:30202017)

Koestner, W. et al. (2018) Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLoS Pathogens, 14(8), e1007235. (doi: 10.1371/journal.ppat.1007235) (PMID:30075026) (PMCID:PMC6107283)

Ciurkiewicz, M., Herder, V. , Khan, M. A., Uhde, A.-K., Teich, R., Floess, S., Baumgärtner, W., Huehn, J. and Beineke, A. (2018) Cytotoxic CD8+ T cell ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis. Brain Pathology, 28(3), pp. 349-368. (doi: 10.1111/bpa.12518) (PMID:28452087) (PMCID:PMC8028623)

Uhde, A.-K. et al. (2018) Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Scientific Reports, 8, 6106. (doi: 10.1038/s41598-018-24378-z) (PMID:29666403) (PMCID:PMC5904160)

Klotz, D., Hirzmann, J., Bauer, C., Schöne, J., Iseringhausen, M., Wohlsein, P., Baumgärtner, W. and Herder, V. (2018) Subcutaneous merocercoids of Clistobothrium sp. in two Cape fur seals (Arctocephalus pusillus pusillus). International Journal for Parasitology: Parasites and Wildlife, 7(1), pp. 99-105. (doi: 10.1016/j.ijppaw.2018.02.003) (PMID:29988787) (PMCID:PMC6032031)

Hetzel, M. et al. (2018) Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections. Blood, 131(5), pp. 533-545. (doi: 10.1182/blood-2017-10-812859) (PMID:29233822)

2017

Kussmann, I., Zimmermann, U. and Herder, V. (2017) Eosinophilic granuloma in a Pug dog = Eosinophiles Granulom bei einem Mops. Kleintierpraxis, 62(12), pp. 744-747. (doi: 10.2377/0023-2076-62-744)

Herder, V. , Ciurkiewicz, M., Baumgärtner, W., Jagannathan, V. and Leeb, T. (2017) Frame-shift variant in the CHRNE gene in a juvenile dog with suspected myasthenia gravis-like disease. Animal Genetics, 48(5), p. 625. (doi: 10.1111/age.12558) (PMID:28508416)

Hülskötter, K., Schmidtke, D., Dubicanac, M., Siesenop, U., Zimmermann, E., Gerhauser, I., Baumgärtner, W. and Herder, V. (2017) Spontaneous listeriosis in grey mouse lemurs (Microcebus murinus), but not in Goodman's mouse lemurs (Microcebus lehilahytsara) of the same colony. Veterinary Microbiology, 208, pp. 94-96. (doi: 10.1016/j.vetmic.2017.07.023) (PMID:28888657)

Spitzbarth, I., Heinrich, F., Herder, V. , Recker, T., Wohlsein, P. and Baumgärtner, W. (2017) Canine central nervous system neoplasm phenotyping using tissue microarray technique. Veterinary Pathology, 54(3), pp. 369-379. (doi: 10.1177/0300985816688745) (PMID:28060678)

Gudi, V. et al. (2017) Synaptophysin is a reliable marker for axonal damage. Journal of Neuropathology and Experimental Neurology, 76(2), pp. 109-125. (doi: 10.1093/jnen/nlw114) (PMID:28177496)

2016

Uhde, A.-K., Herder, V. , Khan, M. A., Ciurkiewicz, M., Schaudien, D., Teich, R., Floess, S., Baumgärtner, W., Huehn, J. and Beineke, A. (2016) Viral infection of the central nervous system exacerbates interleukin-10 receptor deficiency-mediated colitis in SJL mice. PLoS ONE, 11(9), e0161883. (doi: 10.1371/journal.pone.0161883) (PMID:27611574) (PMCID:PMC5017624)

Postel, A. et al. (2016) Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor. Scientific Reports, 6, 27735. (doi: 10.1038/srep27735) (PMID:27292119) (PMCID:PMC4904412)

2015

Herder, V. et al. (2015) Dynamic changes of microglia/macrophage M1 and M2 polarization in Theiler's murine encephalomyelitis. Brain Pathology, 25(6), pp. 712-723. (doi: 10.1111/bpa.12238) (PMID:25495532) (PMCID:PMC8029129)

Herder, V. , van de Velde, N., Højer Kristensen, J., van Elk, C., Peters, M., Kilwinski, J., Schares, G., Siebert, U. and Wohlsein, P. (2015) Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena). Journal of Comparative Pathology, 153(4), pp. 357-362. (doi: 10.1016/j.jcpa.2015.08.004) (PMID:26381675)

Cana, A., Herder, V. , Hansmann, F., Beineke, A., Baumgärtner, W. and Spitzbarth, I. (2015) Characterization of periodic acid-Schiff-positive granular deposits in the hippocampus of SJL/J mice. Toxicologic Pathology, 43(5), pp. 737-742. (doi: 10.1177/0192623314564254) (PMID:25694088)

Junginger, J., Hansmann, F., Herder, V. , Lehmbecker, A., Peters, M., Beyerbach, M., Wohlsein, P. and Baumgärtner, W. (2015) Pathology in captive wild felids at German zoological gardens. PLoS ONE, 10(6), e0130573. (doi: 10.1371/journal.pone.0130573) (PMID:26086731) (PMCID:PMC4472349)

Herder, V. , Kummrow, M., Leeb, T., Sewell, A.C., Hansmann, F., Lehmbecker, A., Wohlsein, P. and Baumgärtner, W. (2015) Polycystic kidneys and GM2 gangliosidosis-like disease in neonatal springboks (Antidorcas marsupialis). Veterinary Pathology, 52(3), pp. 543-552. (doi: 10.1177/0300985814549210) (PMID:25232033)

2014

Prajeeth, C. K. et al. (2014) Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. Journal of Neuroinflammation, 11, 180. (doi: 10.1186/s12974-014-0180-9) (PMID:25391297) (PMCID:PMC4236492)

Fechner, S., Rosa, S., Herder, V. and Baumgärtner, W. (2014) Fibrodysplasia ossificans progressiva-like condition located in the forearm muscles of a European shorthair sat = Fibrodysplasia ossificans progressiva-ähnliche Veränderung im Bereich der Unterarmmuskulatur bei einer Europäisch-Kurzhaar-Katze. Kleintierpraxis, 59(11), pp. 612-618. (doi: 10.2377/0023-2076-59-612)

Qeska, V., Barthel, Y., Herder, V. , Stein, V. M., Tipold, A., Urhausen, C., Günzel-Apel, A.-R., Rohn, K., Baumgärtner, W. and Beineke, A. (2014) Canine distemper virus infection leads to an inhibitory phenotype of monocyte-derived dendritic cells in vitro with reduced expression of co-stimulatory molecules and increased interleukin-10 transcription. PLoS ONE, 9(4), e96121. (doi: 10.1371/journal.pone.0096121) (PMID:24769532) (PMCID:PMC4000198)

2013

Hahn, K., Habierski, A., Herder, V. , Wohlsein, P., Peters, M., Hansmann, F. and Baumgärtner, W. (2013) Schmallenberg virus in central nervous system of ruminants. Emerging Infectious Diseases, 19(1), pp. 154-155. (doi: 10.3201/eid1901.120764) (PMID:23260872) (PMCID:PMC3557993)

2012

Kummerfeld, M., Seehusen, F., Klein, S., Ulrich, R., Kreutzer, R., Gerhauser, I., Herder, V. , Baumgrtner, W. and Beineke, A. (2012) Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis. Intervirology, 55(6), pp. 401-416. (doi: 10.1159/000336563) (PMID:22538300)

Herder, V. et al. (2012) Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis. Journal of Neuroimmunology, 249(1-2), pp. 27-39. (doi: 10.1016/j.jneuroim.2012.04.010) (PMID:22591945)

Herder, V. , Wohlsein, P., Peters, M., Hansmann, F. and Baumgärtner, W. (2012) Salient lesions in domestic ruminants infected with the emerging so-called Schmallenberg virus in Germany. Veterinary Pathology, 49(4), pp. 588-591. (doi: 10.1177/0300985812447831) (PMID:22610033)

Hansmann, F., Herder, V. , Kalkuhl, A., Haist, V., Zhang, N., Schaudien, D., Deschl, U., Baumgärtner, W. and Ulrich, R. (2012) Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis. Acta Neuropathologica, 124(1), pp. 127-142. (doi: 10.1007/s00401-012-0942-3) (PMID:22271152)

Hansmann, F., Pringproa, K., Ulrich, R., Sun, Y., Herder, V. , Kreutzer, M., Baumgärtner, W. and Wewetzer, K. (2012) Highly malignant behavior of a murine oligodendrocyte precursor cell line following transplantation into the demyelinated and nondemyelinated central nervous system. Cell Transplantation, 21(6), pp. 1161-1175. (doi: 10.3727/096368911X627444) (PMID:22420305)

Herder, B. , Barsnick, R., Walliser, U., Teifke, J.-P., König, P., Czerwinski, G., Hansmann, F., Baumgärtner, W. and Hewicker-Trautwein, M. (2012) Equid herpesvirus 5-associated dermatitis in a horse-Resembling herpes-associated erythema multiforme. Veterinary Microbiology, 155(2-4), pp. 420-424. (doi: 10.1016/j.vetmic.2011.09.020) (PMID:21996546)

Herder, V. , Hansmann, F., Stangel, M., Schaudien, D., Rohn, K., Baumgärtner, W. and Beineke, A. (2012) Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis. Journal of Neuroimmunology, 244(1-2), pp. 84-93. (doi: 10.1016/j.jneuroim.2012.01.010) (PMID:22329906)

2011

Hansmann, F., Herder, V. , Ernst, H. and Baumgärtner, W. (2011) Spinal epidermoid cyst in a SJL mouse: case report and literature review. Journal of Comparative Pathology, 145(4), pp. 373-377. (doi: 10.1016/j.jcpa.2011.03.002) (PMID:21511270)

Herder, V. , Hansmann, F., Stangel, M., Skripuletz, T., Baumgärtner, W. and Beineke, A. (2011) Lack of cuprizone-induced demyelination in the murine spinal cord despite oligodendroglial alterations substantiates the concept of site-specific susceptibilities of the central nervous system. Neuropathology and Applied Neurobiology, 37(6), pp. 676-684. (doi: 10.1111/j.1365-2990.2011.01168.x) (PMID:21366663)

Herder, V. , König, A., Seehusen, F. and Wohlsein, P. (2011) Avian polyomavirus infection of a fledgling budgerigar (Melopsittacus undulatus) and differential diagnoses of viral inclusions in psittacine birds - case report and mini-review = Aviäre Polyomavirusinfektion bei einem jungen Wellensittich (Melopsittacus undulatus) und Differenzialdiagnostik viraler Einschlusskörperchen in Psittaciden - Fallbericht und Mini- Review. Berliner und Munchener Tierarztliche Wochenschrift, 124(5-6), pp. 209-216. (doi: 10.2376/0005-9366-124-209)

Herder, V. , Wohlsein, P., Grunwald, D., Janssen, H., Meyer, H., Kaysser, P., Baumgärtner, W. and Beineke, A. (2011) Poxvirus infection in a cat with presumptive human transmission. Veterinary Dermatology, 22(2), pp. 220-224. (doi: 10.1111/j.1365-3164.2010.00947.x) (PMID:21375609)

Müller, J.-M. V., Schulze, M., Herder, V. , Lautenschläger, I., Baumgärtner, W. and Feige, K. (2011) Ataxia and weakness as uncommon primary manifestations of hepatic encephalopathy in a 15-year-old trotter gelding. Equine Veterinary Education, 23(1), pp. 5-10. (doi: 10.1111/j.2042-3292.2010.00132.x)

2010

Ulrich, R., Böer, M., Herder, V. , Spitzbarth, I., Hewicker-Trautwein, M., Baumgärtner, W. and Wohlsein, P. (2010) Epizootic fatal amebiasis in an outdoor group of Old World monkeys. Journal of Medical Primatology, 39(3), pp. 160-165. (doi: 10.1111/j.1600-0684.2010.00405.x) (PMID:20202078)

Hansmann, F., Herder, V. , Von Altrock, A., Dühlmeier, R. and Wohlsein, P. (2010) Expression of p53 in a malignant melanoma of a goat. Berliner und Munchener Tierarztliche Wochenschrift, 123(3-4), pp. 174-176. (doi: 10.2376/0005-9366-123-174)

2007

Herder, V. and Wohlsein, P. (2007) Progressive dyspnoe infolge lungenlappentorsion bei einem mops. Kleintierpraxis, 52(12), pp. 780-784.

This list was generated on Fri Jun 2 21:49:41 2023 BST.

Jump to: Articles

Number of items: 52.

Articles

Ho, A. et al. (2023) Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature, 617, pp. 555-563. (doi: 10.1038/s41586-023-05948-2) (PMID:36996873)

Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)

Einhellig, S., Bartke, S. and Herder, V. (2019) Der klinische Fall: Intraokulares Melanom bei einer Ponystute. Pferde Spiegel, 22(3), pp. 120-125. (doi: 10.1055/a-0977-8827)

Kussmann, I., Zimmermann, U. and Herder, V. (2017) Eosinophilic granuloma in a Pug dog = Eosinophiles Granulom bei einem Mops. Kleintierpraxis, 62(12), pp. 744-747. (doi: 10.2377/0023-2076-62-744)

Gudi, V. et al. (2017) Synaptophysin is a reliable marker for axonal damage. Journal of Neuropathology and Experimental Neurology, 76(2), pp. 109-125. (doi: 10.1093/jnen/nlw114) (PMID:28177496)

Herder, V. and Wohlsein, P. (2007) Progressive dyspnoe infolge lungenlappentorsion bei einem mops. Kleintierpraxis, 52(12), pp. 780-784.

This list was generated on Fri Jun 2 21:49:41 2023 BST.

Research datasets

Jump to: 2021

Number of items: 1.

2021

Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]

This list was generated on Fri Jun 2 21:49:43 2023 BST.

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Hotjar and Clarity

Dr Vanessa Herder

Biography

Research interests

Publications

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2007

Articles

Research datasets

2021