Dr Nardus Mollentze

  • Research Associate (Virology)

Biography

I am a computational virologist studying the dynamics of cross-species transmission and host shifts. Much of my work takes a comparative approach, aiming to discover generalisable patterns which may help us to anticipate and prepare for future outbreaks of infectious disease. I also often use rabies virus as a model system, given it’s wide host range, frequent cross-species transmission, and the consequences of these events for public and animal health.

Research interests

  • Cross-species transmission
  • Zoonotic risk prediction
  • Host shifts
  • Virus evolution

Personal website | Google Scholar profile

Publications

Selected publications

Mollentze, N. , Babayan, S. A. and Streicker, D. G. (2021) Identifying and prioritizing potential human-infecting viruses from their genome sequences. PLoS Biology, 19(9), e3001390. (doi: 10.1371/journal.pbio.3001390) (PMID:34582436) (PMCID:PMC8478193)

Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)

Mollentze, N. and Streicker, D. G. (2020) Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts. Proceedings of the National Academy of Sciences of the United States of America, 117(17), pp. 9423-9430. (doi: 10.1073/pnas.1919176117) (PMID:32284401) (PMCID:PMC7196766)

Mollentze, N. , Streicker, D. G. , Murcia, P. R. , Hampson, K. and Biek, R. (2020) Virulence mismatches in index hosts shape the outcomes of cross-species transmission. Proceedings of the National Academy of Sciences of the United States of America, 117(46), pp. 28859-28866. (doi: 10.1073/pnas.2006778117) (PMID:33122433) (PMCID:PMC7682402)

All publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2018 | 2014 | 2013
Number of items: 17.

2023

Mollentze, N. and Streicker, D. G. (2023) Predicting zoonotic potential of viruses: where are we? Current Opinion in Virology, 61, 101346. (doi: 10.1016/j.coviro.2023.101346) (PMID:37515983)

2022

Mollentze, N. , Keen, D., Munkhbayar, U., Biek, R. and Streicker, D. G. (2022) Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction. eLife, 11, e80329. (doi: 10.7554/eLife.80329) (PMID:36416537) (PMCID:PMC9683784)

Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)

Meza, D. K. et al. (2022) Ecological determinants of rabies virus dynamics in vampire bats and spillover to livestock. Proceedings of the Royal Society of London Series B: Biological Sciences, 289(1982), 20220860. (doi: 10.1098/rspb.2022.0860) (PMID:36069012) (PMCID:PMC9449476)

Guth, S., Mollentze, N. , Renault, K., Streicker, D. G. , Visher, E., Boots, M. and Brook, C. E. (2022) Bats host the most virulent-but not the most dangerous-zoonotic viruses. Proceedings of the National Academy of Sciences of the United States of America, 119(14), e2113628119. (doi: 10.1073/pnas.2113628119) (PMID:35349342) (PMCID:PMC9168486)

Gibb, R., Albery, G. F., Mollentze, N. , Eskew, E. A., Brierley, L., Ryan, S. J., Seifert, S. N. and Carlson, C. J. (2022) Mammal virus diversity estimates are unstable due to accelerating discovery effort. Biology Letters, 18(1), 20210427. (doi: 10.1098/rsbl.2021.0427) (PMID:34982955) (PMCID:PMC8727147)

2021

Albery, G. F. et al. (2021) The science of the host–virus network. Nature Microbiology, 6, pp. 1483-1492. (doi: 10.1038/s41564-021-00999-5) (PMID:34819645)

Carlson, C. J. et al. (2021) The future of zoonotic risk prediction. Philosophical Transactions of the Royal Society B: Biological Sciences, 376(1837), 20200358. (doi: 10.1098/rstb.2020.0358) (PMID:34538140)

Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)

Mollentze, N. , Babayan, S. A. and Streicker, D. G. (2021) Identifying and prioritizing potential human-infecting viruses from their genome sequences. PLoS Biology, 19(9), e3001390. (doi: 10.1371/journal.pbio.3001390) (PMID:34582436) (PMCID:PMC8478193)

Bergner, L. M. , Mollentze, N. , Orton, R. J. , Tello, C., Broos, A. , Biek, R. and Streicker, D. G. (2021) Characterizing and evaluating the zoonotic potential of novel viruses discovered in vampire bats. Viruses, 13(2), 252. (doi: 10.3390/v13020252) (PMID:33562073) (PMCID:PMC7914986)

2020

Mollentze, N. , Streicker, D. G. , Murcia, P. R. , Hampson, K. and Biek, R. (2020) Virulence mismatches in index hosts shape the outcomes of cross-species transmission. Proceedings of the National Academy of Sciences of the United States of America, 117(46), pp. 28859-28866. (doi: 10.1073/pnas.2006778117) (PMID:33122433) (PMCID:PMC7682402)

Mollentze, N. and Streicker, D. G. (2020) Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts. Proceedings of the National Academy of Sciences of the United States of America, 117(17), pp. 9423-9430. (doi: 10.1073/pnas.1919176117) (PMID:32284401) (PMCID:PMC7196766)

2018

Brunker, K. and Mollentze, N. (2018) Rabies virus. Trends in Microbiology, 26(10), pp. 886-887. (doi: 10.1016/j.tim.2018.07.001) (PMID:30072086)

2014

Mollentze, N., Biek, R. and Streicker, D. G. (2014) The role of viral evolution in rabies host shifts and emergence. Current Opinion in Virology, 8, pp. 68-72. (doi: 10.1016/j.coviro.2014.07.004) (PMID:25064563) (PMCID:PMC4199325)

Mollentze, N., Nel, L. H., Townsend, S., le Roux, K., Hampson, K. , Haydon, D. T. and Soubeyrand, S. (2014) A Bayesian approach for inferring the dynamics of partially observed endemic infectious diseases from space-time-genetic data. Proceedings of the Royal Society of London Series B: Biological Sciences, 281(1782), p. 20133251. (doi: 10.1098/rspb.2013.3251)

2013

Mollentze, N., Weyer, J., Markotter, W., le Roux, K. and Nel, L.H. (2013) Dog rabies in southern Africa: regional surveillance and phylogeographical analyses are an important component of control and elimination strategies. Virus Genes, 47(3), pp. 569-573. (doi: 10.1007/s11262-013-0974-3) (PMID:23996607)

This list was generated on Sat Sep 30 14:16:57 2023 BST.
Jump to: Articles
Number of items: 17.

Articles

Mollentze, N. and Streicker, D. G. (2023) Predicting zoonotic potential of viruses: where are we? Current Opinion in Virology, 61, 101346. (doi: 10.1016/j.coviro.2023.101346) (PMID:37515983)

Mollentze, N. , Keen, D., Munkhbayar, U., Biek, R. and Streicker, D. G. (2022) Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction. eLife, 11, e80329. (doi: 10.7554/eLife.80329) (PMID:36416537) (PMCID:PMC9683784)

Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)

Meza, D. K. et al. (2022) Ecological determinants of rabies virus dynamics in vampire bats and spillover to livestock. Proceedings of the Royal Society of London Series B: Biological Sciences, 289(1982), 20220860. (doi: 10.1098/rspb.2022.0860) (PMID:36069012) (PMCID:PMC9449476)

Guth, S., Mollentze, N. , Renault, K., Streicker, D. G. , Visher, E., Boots, M. and Brook, C. E. (2022) Bats host the most virulent-but not the most dangerous-zoonotic viruses. Proceedings of the National Academy of Sciences of the United States of America, 119(14), e2113628119. (doi: 10.1073/pnas.2113628119) (PMID:35349342) (PMCID:PMC9168486)

Gibb, R., Albery, G. F., Mollentze, N. , Eskew, E. A., Brierley, L., Ryan, S. J., Seifert, S. N. and Carlson, C. J. (2022) Mammal virus diversity estimates are unstable due to accelerating discovery effort. Biology Letters, 18(1), 20210427. (doi: 10.1098/rsbl.2021.0427) (PMID:34982955) (PMCID:PMC8727147)

Albery, G. F. et al. (2021) The science of the host–virus network. Nature Microbiology, 6, pp. 1483-1492. (doi: 10.1038/s41564-021-00999-5) (PMID:34819645)

Carlson, C. J. et al. (2021) The future of zoonotic risk prediction. Philosophical Transactions of the Royal Society B: Biological Sciences, 376(1837), 20200358. (doi: 10.1098/rstb.2020.0358) (PMID:34538140)

Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)

Mollentze, N. , Babayan, S. A. and Streicker, D. G. (2021) Identifying and prioritizing potential human-infecting viruses from their genome sequences. PLoS Biology, 19(9), e3001390. (doi: 10.1371/journal.pbio.3001390) (PMID:34582436) (PMCID:PMC8478193)

Bergner, L. M. , Mollentze, N. , Orton, R. J. , Tello, C., Broos, A. , Biek, R. and Streicker, D. G. (2021) Characterizing and evaluating the zoonotic potential of novel viruses discovered in vampire bats. Viruses, 13(2), 252. (doi: 10.3390/v13020252) (PMID:33562073) (PMCID:PMC7914986)

Mollentze, N. , Streicker, D. G. , Murcia, P. R. , Hampson, K. and Biek, R. (2020) Virulence mismatches in index hosts shape the outcomes of cross-species transmission. Proceedings of the National Academy of Sciences of the United States of America, 117(46), pp. 28859-28866. (doi: 10.1073/pnas.2006778117) (PMID:33122433) (PMCID:PMC7682402)

Mollentze, N. and Streicker, D. G. (2020) Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts. Proceedings of the National Academy of Sciences of the United States of America, 117(17), pp. 9423-9430. (doi: 10.1073/pnas.1919176117) (PMID:32284401) (PMCID:PMC7196766)

Brunker, K. and Mollentze, N. (2018) Rabies virus. Trends in Microbiology, 26(10), pp. 886-887. (doi: 10.1016/j.tim.2018.07.001) (PMID:30072086)

Mollentze, N., Biek, R. and Streicker, D. G. (2014) The role of viral evolution in rabies host shifts and emergence. Current Opinion in Virology, 8, pp. 68-72. (doi: 10.1016/j.coviro.2014.07.004) (PMID:25064563) (PMCID:PMC4199325)

Mollentze, N., Nel, L. H., Townsend, S., le Roux, K., Hampson, K. , Haydon, D. T. and Soubeyrand, S. (2014) A Bayesian approach for inferring the dynamics of partially observed endemic infectious diseases from space-time-genetic data. Proceedings of the Royal Society of London Series B: Biological Sciences, 281(1782), p. 20133251. (doi: 10.1098/rspb.2013.3251)

Mollentze, N., Weyer, J., Markotter, W., le Roux, K. and Nel, L.H. (2013) Dog rabies in southern Africa: regional surveillance and phylogeographical analyses are an important component of control and elimination strategies. Virus Genes, 47(3), pp. 569-573. (doi: 10.1007/s11262-013-0974-3) (PMID:23996607)

This list was generated on Sat Sep 30 14:16:57 2023 BST.

Supervision

  • Arnold, Matthew
    The Wellcome Trust - Integrative Infection Biology programme

Research datasets

Jump to: 2022 | 2021
Number of items: 2.

2022

Sugrue, E. , Wickenhagen, A., Mollentze, N. , Aziz, M. A., Sreenu, V. B., Truxa, S., Tong, L., Da Silva Filipe, A. , Robertson, D. , Hughes, J. , Rihn, S. and Wilson, S. (2022) The Interferon Resistance of Transmitted HIV-1 is Possibly a Consequence of Enhanced Replicative Fitness. [Data Collection]

2021

Shaw, A., Rihn, S. , Mollentze, N. , Wickenhagen, A., Stewart, D., Orton, R. , Kuchi, S., Bakshi, S., Collados Rodriguez, M. , Turnbull, M. , Busby, J., Gu, Q. , Smollett, K., Bamford, C., Sugrue, E. , Johnson, P. , Da Silva Filipe, A. , Castello, A. , Streicker, D. , Robertson, D. , Palmarini, M. and Wilson, S. (2021) The 'antiviral state' has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. [Data Collection] (Unpublished)

This list was generated on Fri Sep 29 16:03:03 2023 BST.

Nardus Mollentze