Mr Moeed Akbar
- Research Fellow (Immunology & Infection)
email:
Moeed.Akbar@glasgow.ac.uk
Level 4, Iii - Gbrc, University Place, Glasgow G12 8TA
Publications
2023
Orchard, K. J.A., Akbar, M., Crower, L. A.N., Cole, J., Millar, N. L. and Raleigh, S. M. (2023) Characterization of histone modifications in late-stage rotator cuff tendinopathy. Genes, 14(2), 496. (doi: 10.3390/genes14020496) (PMID:36833423) (PMCID:PMC9956879)
2022
Thümmler, K. , Williams, M. T.S., Kitson, S., Sood, S., Akbar, M., Cole, J. J., Goodyear, C. S. , Hunter, E. and Soutar, R. (2022) Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis. OncoImmunology, 11(1), 2104070. (doi: 10.1080/2162402X.2022.2104070) (PMID:35936985) (PMCID:PMC9348127)
Millar, N. L. et al. (2022) Frozen shoulder. Nature Reviews Disease Primers, 8, 59. (doi: 10.1038/s41572-022-00386-2) (PMID:36075904)
2021
Shi, Z. et al. (2021) Targeting the CCR6/CCL20 axis in entheseal and cutaneous inflammation. Arthritis and Rheumatology, 73(12), pp. 2271-2281. (doi: 10.1002/art.41882) (PMID:34081845)
Akbar, M., MacDonald, L., Crowe, L. A.N., Carlberg, K., Kurowska-Stolarska, M. , Ståhl, P. L., Snelling, S. J.B., McInnes, I. B. and Millar, N. L. (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)
Akbar, M. et al. (2021) Translational targeting of inflammation and fibrosis in frozen shoulder: Molecular dissection of the T cell/IL-17A axis. Proceedings of the National Academy of Sciences of the United States of America, 118(39), e210271511. (doi: 10.1073/pnas.2102715118) (PMID:34544860) (PMCID:PMC8488623)
Garcia-Melchor, E., Cafaro, G., MacDonald, L., Crowe, L. A.N., Sood, S., McLean, M., Fazzi, U., McInnes, I. B. , Akbar, M. and Millar, N. L. (2021) Novel self-amplificatory loop between T cells and tenocytes as a driver of chronicity in tendon disease. Annals of the Rheumatic Diseases, 80(8), pp. 1075-1085. (doi: 10.1136/annrheumdis-2020-219335) (PMID:33692018)
Crowe, L. A.N., Melchor, E. G., Murrell, G. A.C., McInnes, I. B. , Akbar, M. and Millar, N. (2021) Stromal ‘activation’ markers do not confer pathogenic activity in tendinopathy. Translational Sports Medicine, 4(2), pp. 268-279. (doi: 10.1002/tsm2.204)
Atherton, C. M. et al. (2021) Vancomycin wrap for anterior cruciate ligament surgery. American Journal of Sports Medicine, 49(2), pp. 426-434. (doi: 10.1177/0363546520981570) (PMID:33406371) (PMCID:PMC7859666)
2020
Akbar, M., Garcia-Melchor, E., Chilaka, S., Little, K. J., Sood, S., Reilly, J. H., Liew, F. Y., McInnes, I. B. and Millar, N. L. (2020) Attenuation of Dupuytren’s fibrosis via targeting of the STAT-1 modulated IL-13RA1 response. Science Advances, 6(28), eaaz8272. (doi: 10.1126/sciadv.aaz8272) (PMID:32695877) (PMCID:PMC7351483)
2019
Akbar, M. et al. (2019) Fibroblast activation and inflammation in frozen shoulder. PLoS ONE, 14(4), e0215301. (doi: 10.1371/journal.pone.0215301) (PMID:31013287) (PMCID:PMC6478286)
Abraham, A. C. et al. (2019) Targeting the NF-κB signaling pathway in chronic tendon disease. Science Translational Medicine, 11(481), eaav4319. (doi: 10.1126/scitranslmed.aav4319) (PMID:30814338) (PMCID:PMC6534967)
Crowe, L. A.N. et al. (2019) S100A8 & S100A9: alarmin mediated inflammation in tendinopathy. Scientific Reports, 9, 1463. (doi: 10.1038/s41598-018-37684-3) (PMID:30728384) (PMCID:PMC6365574)
McLean, M. et al. (2019) Tranexamic acid toxicity in human periarticular tissues. Bone and Joint Research, 8(1), pp. 11-18. (doi: 10.1302/2046-3758.81.BJR-2018-0181.R1) (PMID:30800295) (PMCID:PMC6359888)
2018
Cher, J. Z.B. et al. (2018) Alarmins in frozen shoulder: a molecular association between inflammation and pain. American Journal of Sports Medicine, 46(3), pp. 671-678. (doi: 10.1177/0363546517741127) (PMID:29190116)
2017
Watts, A. E. et al. (2017) MicroRNA29a treatment improves early tendon injury. Molecular Therapy, 25(10), pp. 2415-2426. (doi: 10.1016/j.ymthe.2017.07.015) (PMID:28822690)
Akbar, M. et al. (2017) Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis. RMD Open, 3(2), e000456. (doi: 10.1136/rmdopen-2017-000456) (PMID:28879051) (PMCID:PMC5574425)
2016
Millar, N. L. et al. (2016) IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy. Scientific Reports, 6, 27149. (doi: 10.1038/srep27149) (PMID:27263531) (PMCID:PMC4893609)
2015
Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)
2014
Colombo, M. et al. (2014) Notch signaling drives multiple myeloma induced osteoclastogenesis. Oncotarget, 5(21), pp. 10393-10406. (doi: 10.18632/oncotarget.2084) (PMID:25257302) (PMCID:PMC4279381)
2012
Akbar, M., Fraser, A. R., Graham, G. J. , Brewer, J. M. and Grant, M. H. (2012) Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model. Journal of the Royal Society: Interface, 9(74), pp. 2109-2119. (doi: 10.1098/rsif.2012.0006)
Afolaranmi, G.A., Akbar, M., Brewer, J. and Grant, M.H. (2012) Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice. Journal of Biomedical Materials Research Part A, 100A(6), pp. 1529-1538. (doi: 10.1002/jbm.a.34091)
2011
Akbar, M., Brewer, J.M. and Grant, M.H. (2011) Effect of chromium and cobalt ions on primary human lymphocytesin vitro. Journal of Immunotoxicology, 8(2), pp. 140-149. (doi: 10.3109/1547691X.2011.553845)
Articles
Orchard, K. J.A., Akbar, M., Crower, L. A.N., Cole, J., Millar, N. L. and Raleigh, S. M. (2023) Characterization of histone modifications in late-stage rotator cuff tendinopathy. Genes, 14(2), 496. (doi: 10.3390/genes14020496) (PMID:36833423) (PMCID:PMC9956879)
Thümmler, K. , Williams, M. T.S., Kitson, S., Sood, S., Akbar, M., Cole, J. J., Goodyear, C. S. , Hunter, E. and Soutar, R. (2022) Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis. OncoImmunology, 11(1), 2104070. (doi: 10.1080/2162402X.2022.2104070) (PMID:35936985) (PMCID:PMC9348127)
Millar, N. L. et al. (2022) Frozen shoulder. Nature Reviews Disease Primers, 8, 59. (doi: 10.1038/s41572-022-00386-2) (PMID:36075904)
Shi, Z. et al. (2021) Targeting the CCR6/CCL20 axis in entheseal and cutaneous inflammation. Arthritis and Rheumatology, 73(12), pp. 2271-2281. (doi: 10.1002/art.41882) (PMID:34081845)
Akbar, M., MacDonald, L., Crowe, L. A.N., Carlberg, K., Kurowska-Stolarska, M. , Ståhl, P. L., Snelling, S. J.B., McInnes, I. B. and Millar, N. L. (2021) Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Annals of the Rheumatic Diseases, 80(11), pp. 1494-1497. (doi: 10.1136/annrheumdis-2021-220256) (PMID:34001518) (PMCID:PMC8522454)
Akbar, M. et al. (2021) Translational targeting of inflammation and fibrosis in frozen shoulder: Molecular dissection of the T cell/IL-17A axis. Proceedings of the National Academy of Sciences of the United States of America, 118(39), e210271511. (doi: 10.1073/pnas.2102715118) (PMID:34544860) (PMCID:PMC8488623)
Garcia-Melchor, E., Cafaro, G., MacDonald, L., Crowe, L. A.N., Sood, S., McLean, M., Fazzi, U., McInnes, I. B. , Akbar, M. and Millar, N. L. (2021) Novel self-amplificatory loop between T cells and tenocytes as a driver of chronicity in tendon disease. Annals of the Rheumatic Diseases, 80(8), pp. 1075-1085. (doi: 10.1136/annrheumdis-2020-219335) (PMID:33692018)
Crowe, L. A.N., Melchor, E. G., Murrell, G. A.C., McInnes, I. B. , Akbar, M. and Millar, N. (2021) Stromal ‘activation’ markers do not confer pathogenic activity in tendinopathy. Translational Sports Medicine, 4(2), pp. 268-279. (doi: 10.1002/tsm2.204)
Atherton, C. M. et al. (2021) Vancomycin wrap for anterior cruciate ligament surgery. American Journal of Sports Medicine, 49(2), pp. 426-434. (doi: 10.1177/0363546520981570) (PMID:33406371) (PMCID:PMC7859666)
Akbar, M., Garcia-Melchor, E., Chilaka, S., Little, K. J., Sood, S., Reilly, J. H., Liew, F. Y., McInnes, I. B. and Millar, N. L. (2020) Attenuation of Dupuytren’s fibrosis via targeting of the STAT-1 modulated IL-13RA1 response. Science Advances, 6(28), eaaz8272. (doi: 10.1126/sciadv.aaz8272) (PMID:32695877) (PMCID:PMC7351483)
Akbar, M. et al. (2019) Fibroblast activation and inflammation in frozen shoulder. PLoS ONE, 14(4), e0215301. (doi: 10.1371/journal.pone.0215301) (PMID:31013287) (PMCID:PMC6478286)
Abraham, A. C. et al. (2019) Targeting the NF-κB signaling pathway in chronic tendon disease. Science Translational Medicine, 11(481), eaav4319. (doi: 10.1126/scitranslmed.aav4319) (PMID:30814338) (PMCID:PMC6534967)
Crowe, L. A.N. et al. (2019) S100A8 & S100A9: alarmin mediated inflammation in tendinopathy. Scientific Reports, 9, 1463. (doi: 10.1038/s41598-018-37684-3) (PMID:30728384) (PMCID:PMC6365574)
McLean, M. et al. (2019) Tranexamic acid toxicity in human periarticular tissues. Bone and Joint Research, 8(1), pp. 11-18. (doi: 10.1302/2046-3758.81.BJR-2018-0181.R1) (PMID:30800295) (PMCID:PMC6359888)
Cher, J. Z.B. et al. (2018) Alarmins in frozen shoulder: a molecular association between inflammation and pain. American Journal of Sports Medicine, 46(3), pp. 671-678. (doi: 10.1177/0363546517741127) (PMID:29190116)
Watts, A. E. et al. (2017) MicroRNA29a treatment improves early tendon injury. Molecular Therapy, 25(10), pp. 2415-2426. (doi: 10.1016/j.ymthe.2017.07.015) (PMID:28822690)
Akbar, M. et al. (2017) Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis. RMD Open, 3(2), e000456. (doi: 10.1136/rmdopen-2017-000456) (PMID:28879051) (PMCID:PMC5574425)
Millar, N. L. et al. (2016) IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy. Scientific Reports, 6, 27149. (doi: 10.1038/srep27149) (PMID:27263531) (PMCID:PMC4893609)
Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)
Colombo, M. et al. (2014) Notch signaling drives multiple myeloma induced osteoclastogenesis. Oncotarget, 5(21), pp. 10393-10406. (doi: 10.18632/oncotarget.2084) (PMID:25257302) (PMCID:PMC4279381)
Akbar, M., Fraser, A. R., Graham, G. J. , Brewer, J. M. and Grant, M. H. (2012) Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model. Journal of the Royal Society: Interface, 9(74), pp. 2109-2119. (doi: 10.1098/rsif.2012.0006)
Afolaranmi, G.A., Akbar, M., Brewer, J. and Grant, M.H. (2012) Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice. Journal of Biomedical Materials Research Part A, 100A(6), pp. 1529-1538. (doi: 10.1002/jbm.a.34091)
Akbar, M., Brewer, J.M. and Grant, M.H. (2011) Effect of chromium and cobalt ions on primary human lymphocytesin vitro. Journal of Immunotoxicology, 8(2), pp. 140-149. (doi: 10.3109/1547691X.2011.553845)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Common translational mechanisms in fibrosis
Medical Research Council
2023 - 2024