Dr Melanie McDonald

  • Research Associate (Virology)

Research interests

CVR logo 

Member of the Kohl Group.

Publications

List by: Type | Date

Jump to: 2025 | 2021 | 2020 | 2017 | 2016 | 2015 | 2014 | 2013 | 2010 | 2009
Number of items: 21.

2025

Reuter, M. et al. (2025) The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs. RNA, 31(5), pp. 679-691. (doi: 10.1261/rna.080149.124) (PMID:39947927) (PMCID:PMC12001973)

Dummunee, Krittika, Parry, Rhys H., Redecke, Lars, Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, Brennan, Benjamin ORCID logoORCID: https://orcid.org/0000-0003-4707-726X, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 (2025) The catalytic tetrad of Aedes aegypti Argonaute 2 is critical for the antiviral activity of the exogenous siRNA pathway. Journal of Biological Chemistry, 301(4), 108332. (doi: 10.1016/j.jbc.2025.108332) (PMID:39984048) (PMCID:PMC11968273)

2021

Almire, Floriane, Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Terry, Sandra, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Gestuveo, Rommel J., Szemiel, Agnieszka M., Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, McDonald, Alma, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Laureti, M., Levée, T., Terry, S., Kohl, A. ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. Insect Molecular Biology, 30(3), pp. 355-365. (doi: 10.1111/imb.12700) (PMID:33715239)

2020

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

2017

Dietrich, Isabelle, Shi, Xiaohong ORCID logoORCID: https://orcid.org/0000-0002-5289-7222, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Watson, Mick, Blomström, Anne-Lie, Skelton, Jessica K., Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Elliott, Richard M. and Schnettler, Esther (2017) The antiviral RNAi response in vector and non-vector cells against orthobunya viruses. PLoS Neglected Tropical Diseases, 11(1), e0005272. (doi: 10.1371/journal.pntd.0005272) (PMID:28060823) (PMCID:PMC5245901)

2016

Schnettler, Esther, Sreenu, Vattipally B. ORCID logoORCID: https://orcid.org/0000-0001-6673-4697, Mottram, Timothy and McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 (2016) Wolbachia restricts insect specific flavivirus infection in Aedes aegypti cells. Journal of General Virology, 97(11), pp. 3024-3029. (doi: 10.1099/jgv.0.000617) (PMID:27692043) (PMCID:PMC5120408)

Wijayanti, Siwi P. M., Porphyre, Thibaud, Chase-Topping, Margo, Rainey, Stephanie M. ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Schnettler, Esther, Biek, Roman ORCID logoORCID: https://orcid.org/0000-0003-3471-5357 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2016) The importance of socio-economic versus environmental risk factors for reported dengue cases in Java, Indonesia. PLoS Neglected Tropical Diseases, 10(9), e0004964. (doi: 10.1371/journal.pntd.0004964) (PMID:27603137) (PMCID:PMC5014450)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi: 10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

Wijayanti, Siwi P. M., Sunaryo, Sunaryo, Suprihatin, Suprihatin, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Rainey, Stephanie M. ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, Dietrich, Isabelle, Schnettler, Esther, Biek, Roman ORCID logoORCID: https://orcid.org/0000-0003-3471-5357 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2016) Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors. PLoS Neglected Tropical Diseases, 10(3), e0004500. (doi: 10.1371/journal.pntd.0004500) (PMID:26967524) (PMCID:PMC4788303)

2015

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, MacDonald, Alasdair I., Stevenson, Andrew and Graham, Sheila V. ORCID logoORCID: https://orcid.org/0000-0002-7140-8279 (2015) Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35). Journal of Virology, 89(10), pp. 5276-5287. (doi: 10.1128/JVI.03434-14) (PMID:25717103)

Blomström, A.-L. et al. (2015) Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein. BMC Genomics, 16, 324. (doi: 10.1186/s12864-015-1538-9) (PMID:25896169) (PMCID:PMC4404599)

Carissimo, G. et al. (2015) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi: 10.1073/pnas.1412984112) (PMID:25548172) (PMCID:PMC4299212)

Kean, Joy, Rainey, Stephanie ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Donald, Claire ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E. et al. (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses. Nucleic Acids Research, 42(14), pp. 9436-9446. (doi: 10.1093/nar/gku657)

2013

Schnettler, Esther, Donald, Claire L. ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Human, Stacey, Watson, Mick, Siu, Ricky W. C., McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Fazakerley, John K., Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Fragkoudis, Rennos (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Schnettler, Esther, Ratinier, Maxime, Watson, Mick, Shaw, Andrew E., McFarlane, Melanie, Varela, Mariana, Elliott, Richard M., Palmarini, Massimo ORCID logoORCID: https://orcid.org/0000-0001-7007-4070 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2013) RNA interference targets arbovirus replication in Culicoides cells. Journal of Virology, 87(5), pp. 2441-2454. (doi: 10.1128/JVI.02848-12) (PMID:23269795) (PMCID:PMC3571378)

Varela, M. et al. (2013) Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathogens, 9(1), e1003133. (doi: 10.1371/journal.ppat.1003133) (PMID:23326235) (PMCID:PMC3542112)

2010

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 and Graham, S.V. ORCID logoORCID: https://orcid.org/0000-0002-7140-8279 (2010) Human papillomavirus regulation of SR proteins. Biochemical Society Transactions, 38(4), pp. 1116-1121. (doi: 10.1042/BST0381116)

2009

Mole, S., McFarlane, M. ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Chuen-Im, T., Milligan, S.G., Millan, D. and Graham, S.V. (2009) RNA splicing factors regulated by HPV16 during cervical tumour progression. Journal of Pathology, 219(3), pp. 383-391. (doi: 10.1002/path.2608) (PMID:19718710) (PMCID:PMC2779514)

This list was generated on Tue Jul 15 01:28:48 2025 BST.
Jump to: Articles
Number of items: 21.

Articles

Reuter, M. et al. (2025) The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs. RNA, 31(5), pp. 679-691. (doi: 10.1261/rna.080149.124) (PMID:39947927) (PMCID:PMC12001973)

Dummunee, Krittika, Parry, Rhys H., Redecke, Lars, Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, Brennan, Benjamin ORCID logoORCID: https://orcid.org/0000-0003-4707-726X, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 (2025) The catalytic tetrad of Aedes aegypti Argonaute 2 is critical for the antiviral activity of the exogenous siRNA pathway. Journal of Biological Chemistry, 301(4), 108332. (doi: 10.1016/j.jbc.2025.108332) (PMID:39984048) (PMCID:PMC11968273)

Almire, Floriane, Terhzaz, Selim ORCID logoORCID: https://orcid.org/0000-0002-6192-6558, Terry, Sandra, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Gestuveo, Rommel J., Szemiel, Agnieszka M., Varjak, Margus ORCID logoORCID: https://orcid.org/0000-0003-2608-5148, McDonald, Alma, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2021) Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti. PLoS Pathogens, 17(9), e1009870. (doi: 10.1371/journal.ppat.1009870) (PMID:34473801) (PMCID:PMC8412342)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Laureti, M., Levée, T., Terry, S., Kohl, A. ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. Insect Molecular Biology, 30(3), pp. 355-365. (doi: 10.1111/imb.12700) (PMID:33715239)

McFarlane, M. et al. (2020) The Aedes aegypti Domino orthologue p400 regulates antiviral exogenous small interfering RNA pathway activity and ago-2 expression. mSphere, 5(2), e00081-20. (doi: 10.1128/mSphere.00081-20) (PMID:32269152) (PMCID:PMC7142294)

Dietrich, Isabelle, Shi, Xiaohong ORCID logoORCID: https://orcid.org/0000-0002-5289-7222, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Watson, Mick, Blomström, Anne-Lie, Skelton, Jessica K., Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458, Elliott, Richard M. and Schnettler, Esther (2017) The antiviral RNAi response in vector and non-vector cells against orthobunya viruses. PLoS Neglected Tropical Diseases, 11(1), e0005272. (doi: 10.1371/journal.pntd.0005272) (PMID:28060823) (PMCID:PMC5245901)

Schnettler, Esther, Sreenu, Vattipally B. ORCID logoORCID: https://orcid.org/0000-0001-6673-4697, Mottram, Timothy and McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 (2016) Wolbachia restricts insect specific flavivirus infection in Aedes aegypti cells. Journal of General Virology, 97(11), pp. 3024-3029. (doi: 10.1099/jgv.0.000617) (PMID:27692043) (PMCID:PMC5120408)

Wijayanti, Siwi P. M., Porphyre, Thibaud, Chase-Topping, Margo, Rainey, Stephanie M. ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Schnettler, Esther, Biek, Roman ORCID logoORCID: https://orcid.org/0000-0003-3471-5357 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2016) The importance of socio-economic versus environmental risk factors for reported dengue cases in Java, Indonesia. PLoS Neglected Tropical Diseases, 10(9), e0004964. (doi: 10.1371/journal.pntd.0004964) (PMID:27603137) (PMCID:PMC5014450)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi: 10.1371/journal.ppat.1005536) (PMID:27089431) (PMCID:PMC4835223)

Wijayanti, Siwi P. M., Sunaryo, Sunaryo, Suprihatin, Suprihatin, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Rainey, Stephanie M. ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, Dietrich, Isabelle, Schnettler, Esther, Biek, Roman ORCID logoORCID: https://orcid.org/0000-0003-3471-5357 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2016) Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors. PLoS Neglected Tropical Diseases, 10(3), e0004500. (doi: 10.1371/journal.pntd.0004500) (PMID:26967524) (PMCID:PMC4788303)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, MacDonald, Alasdair I., Stevenson, Andrew and Graham, Sheila V. ORCID logoORCID: https://orcid.org/0000-0002-7140-8279 (2015) Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35). Journal of Virology, 89(10), pp. 5276-5287. (doi: 10.1128/JVI.03434-14) (PMID:25717103)

Blomström, A.-L. et al. (2015) Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein. BMC Genomics, 16, 324. (doi: 10.1186/s12864-015-1538-9) (PMID:25896169) (PMCID:PMC4404599)

Carissimo, G. et al. (2015) Antiviral immunity of Anopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota. Proceedings of the National Academy of Sciences of the United States of America, 112(2), E176-E185. (doi: 10.1073/pnas.1412984112) (PMID:25548172) (PMCID:PMC4299212)

Kean, Joy, Rainey, Stephanie ORCID logoORCID: https://orcid.org/0000-0001-9504-5495, McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Donald, Claire ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Schnettler, Esther, Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Pondeville, Emilie (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi: 10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi: 10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E. et al. (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses. Nucleic Acids Research, 42(14), pp. 9436-9446. (doi: 10.1093/nar/gku657)

Schnettler, Esther, Donald, Claire L. ORCID logoORCID: https://orcid.org/0000-0002-4370-0707, Human, Stacey, Watson, Mick, Siu, Ricky W. C., McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Fazakerley, John K., Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 and Fragkoudis, Rennos (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi: 10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Schnettler, Esther, Ratinier, Maxime, Watson, Mick, Shaw, Andrew E., McFarlane, Melanie, Varela, Mariana, Elliott, Richard M., Palmarini, Massimo ORCID logoORCID: https://orcid.org/0000-0001-7007-4070 and Kohl, Alain ORCID logoORCID: https://orcid.org/0000-0002-1523-9458 (2013) RNA interference targets arbovirus replication in Culicoides cells. Journal of Virology, 87(5), pp. 2441-2454. (doi: 10.1128/JVI.02848-12) (PMID:23269795) (PMCID:PMC3571378)

Varela, M. et al. (2013) Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathogens, 9(1), e1003133. (doi: 10.1371/journal.ppat.1003133) (PMID:23326235) (PMCID:PMC3542112)

McFarlane, Melanie ORCID logoORCID: https://orcid.org/0000-0002-8392-2291 and Graham, S.V. ORCID logoORCID: https://orcid.org/0000-0002-7140-8279 (2010) Human papillomavirus regulation of SR proteins. Biochemical Society Transactions, 38(4), pp. 1116-1121. (doi: 10.1042/BST0381116)

Mole, S., McFarlane, M. ORCID logoORCID: https://orcid.org/0000-0002-8392-2291, Chuen-Im, T., Milligan, S.G., Millan, D. and Graham, S.V. (2009) RNA splicing factors regulated by HPV16 during cervical tumour progression. Journal of Pathology, 219(3), pp. 383-391. (doi: 10.1002/path.2608) (PMID:19718710) (PMCID:PMC2779514)

This list was generated on Tue Jul 15 01:28:48 2025 BST.

Research datasets

Jump to: 2025 | 2021 | 2020
Number of items: 3.

2025

Dummunee, K., Parry, R. H., Redecke, L., Varjak, M., Brennan, B. , Kohl, A. and McFarlane, M. (2025) The slicer activity of Aedes aegypti Argonaute 2 is critical for the antiviral activity of the antiviral exogenous siRNA pathway. [Data Collection]

2021

McFarlane, M. , Laureti, M., Levée, T., Terry, S., Kohl, A. and Pondeville, E. (2021) Improved transient silencing of gene expression in the mosquito female Aedes aegypti. [Data Collection]

2020

Mcdonald, M. , Pondeville, E. and Kohl, A. (2020) The Aedes aegypti Domino ortholog, p400 regulates antiviral exogenous siRNA pathway activity through control of ago-2 levels. [Data Collection]

This list was generated on Mon Jul 14 11:06:13 2025 BST.